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Blackrock Microsystems Cerebus Instructions For Use Manual

Neural processing system
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Blackrock Microsystems, Inc.
630 Komas Drive | Suite 200
Salt Lake City, UT 84108
P +1 801.582.5533 | F +1 801.582.1509
www.blackrockneuro.com
Cerebus Neural Processing
System
Instructions for Use
Device for investigational use in laboratory animals or other tests
that do not involve human subjects.
Caution
Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11
© 2024 Blackrock Microsystems, Inc.

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Summary of Contents for Blackrock Microsystems Cerebus

  • Page 1 System Instructions for Use Device for investigational use in laboratory animals or other tests that do not involve human subjects. Caution Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 2: Table Of Contents

    7.2.3 Patient ground 7.2.4 Fiber-optic link 7.2.5 Fast Settle 7.3 Gemini Hub 7.3.1 Front panel ports and status LEDs 7.3.2 Digital inputs Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 3 9.3 Spike panel 9.3.1 Spike panel settings 9.4 Raster plot 9.4.1 Configure raster plot 9.5 Single Neural Channel screen 9.5.1 Visualizing a channel Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 4 10 Setup 10.1 Hardware setup 10.1.1 Gemini Cerebus system 10.2 Software setup 10.2.1 Installing Central Suite 10.2.2 Setting up the Ethernet connection Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 5 12.2 Disposal 13 Magnetic resonance 14 Complaints, issues, and questions 15 Warranty 16 Support 16.1 Downloads 17 Returned merchandise authorization (RMA) Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 6: Scope Of This Manual

    The Cerebus Neural Processing System is not a monitoring system. No physiological alarms are provided. The acquisition and display of biopotential signals are for the interpretation and use of the clinician.

  • Page 7: System Description

    2.1 Cerebus system Figure 2-1: Analog Cerebus system diagram Figure 2-2: Digital Cerebus system diagram Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 8: Intended Use

    Biopotential signals include electrocorticography (ECoG), electroencephalography (EEG), electromyography (EMG), electrocardiography (ECG), electrooculography (EOG), action potentials (AP), and evoked potentials (EP). Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 9: Contraindications, Warnings, Precautions, And Adverse Effects

    PROVIDED POWER CABLE TO REDUCE THE RISK OF ELECTRICAL SHOCK OR MALFUNCTION OF PRODUCT O NOT USE AN ADAPTER FOR UNGROUNDED ARNING WALL OUTLETS Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 10 SAFETY COMPLIANCE WITH ARNING EREBUS SYSTEM SHOULD BE DISCONNECTED FROM ANY ELECTRODES DURING CARDIAC DEFIBRILLATION AND OTHER LIFE SUPPORTING DEVICES ARNING Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 11 ISABLING FIREWALLS AND ANTIVIRUS SOFTWARE COULD LEAVE YOUR SYSTEM VULNERABLE TO CYBERATTACKS ARNING O NOT TOUCH ANY EXPOSED ELECTRICAL CONDUCTORS OR USE DAMAGED DATA CABLES WHEN USING THE ARNING Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 12: Precautions

    Fiber-optic cable is easily damaged. Do not bend it (bend radius of 5.0 cm) or crush it. Caution 3.4 Adverse effects There are no adverse effects associated with the Cerebus Neural Processing System. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 13: Symbols

    The Do Not Use if Package is Damaged symbol indicates that a medical device should not be used if the package has been damaged or opened. Reference Number: ISO 15223-1:2021 5.2.8 Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 14 The Type BF Applied Part symbol identifies a type BF applied part complying with IEC 60601-1. Reference Number: BS EN ISO 60411:2002 IEC 60417- 5333 Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 15 The MR Unsafe symbol indicates that the product poses unacceptable risks to the patient, medical staff, or other persons in the MR environment. Reference Number: ASTM F2503-20 Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 16: System Requirements

    Do not connect the computer hosting the Central software to the internet. Ensure no malware and antivirus background processes are running. Ensure that the Windows firewall is not blocking access to IP addresses used by the Cerebus system. Require a Windows system password for the host computer.

  • Page 17: Specifications

    The Cerebus system is intended for use in the electromagnetic environment specified below. The customer or the user of the Cerebus system should ensure that it is used in such an environment. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11...
  • Page 18 2. These guidelines may not apply in all situations. Electromagnetic propagation is affected by absorption and reflection from structures, objects, and people. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 19 RF transmitters, an electromagnetic site survey should be considered. If the measured field strength in the location in which the Cerebus system is used exceeds the applicable RF compliance level above, the Cerebus system should be observed to verify normal operation.

  • Page 20: Hardware

    3. Analog inputs 4. Digital inputs 5. Serial I/O 6. Analog outputs 7. Audio outputs 8. Digital outputs 9. Sync port. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 21 Currently, the software only supports this port as an input. Pin 2 is “Receive Data” Pin 3 is “Transmit Data” Pin 5 is “Ground”. The configuration of the port is: Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 22 Rated Voltage: +5 V Rated Current: +20 mA Rated Power: 100 mW Maximum Frequency: 15 kHz Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 23 7 Hardware Figure 7-4: NSP Back Neural Signal Processor Neural Signal Processor I Neural Signal Processor 1.75 Neural Signal Processor II Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 24 15. Network Link - On Gemini NSPs, the four Ethernet jacks on the back of the unit allow for connection between NSP and host computer, and NSP and Gemini Hub. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 25: Digital Hub

    NSP through a fiber-optic cable. This optical data is immune to electromagnetic field interference. Figure 7-6: Digital Hub front panel Figure 7-7: Digital Hub back panel Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 26: Front Panel Status Leds

    The green GND connector is located on the back panel of the Digital Hub. It is the patient ground connector, which can be used for a reference ground if needed. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 27: Fiber-Optic Link

    When the fast settle input receives a TTL high it will blank the signal, causing the signal to flatline. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 28: Gemini Hub

    The Gemini Hub receives digital signals from attached digital headstage accessory devices. Figure 7-10: Gemini Hub Figure 7-11: Gemini Hub front panel Figure 7-12: Gemini Hub back panel Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 29: Front Panel Ports And Status Leds

    Green / Blue cycle - The connection between the host computer and the Gemini Hub is absent or unstable. Note: Contact Support for the manufacture date of your device. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 30: Digital Inputs

    When the fast settle input receives a TTL high it will blank the signal, causing the signal to flatline. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 31: Neural Signal Front-End Amplifier

    If channels on all banks are to be electrically measured with respect to a common reference, this reference needs to be connected to the reference input on every bank. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 32: Front-End Amplifier Power Supply (Aps)

    When the power switch is turned off; this sequence will be reversed and the output of the APS will be tied to ground. To reset the APS following a voltage or power delivery error: Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 33: Cables

    NSP to the host computer. One cable connects the Gemini Hub to the host computer. Figure 7-20: Crossover Cable Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 34 Front-end Amplifier Power Supply cable Use this cable to connect the Front-end Amplifier to its power supply. Figure 7-21: Front-end Amplifier Power Supply Cable Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 35: Accessories

    64-Channel Splitter Box (1-64) 64-Channel Splitter Box (65-128) 16-Ch Macro Cabrio Butterfly Adapter 32-Ch Cabrio Butterfly Adapter Cabrio Butterfly Adapter Quad IDC-10 Adapter Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 36: Digital Neural Signal Simulator (Dnss)

    (spikes) as well as sine waves at different frequencies. It can be used to test a recording system without being connected to a patient or subject. Figure 8-1: Digital Neural Signal Simulator Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 37: Software

    Incoming data can be processed and visualized in various ways before being saved for future analysis. 9.1 Central main screen Select the following options on the Central main screen to use the Cerebus Central Suite's functions, features, and settings: Figure 9-1: Central main screen...
  • Page 38 System Load - This area graphs the volume of incoming data (MBps) from the Neural Signal Processor. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 39: File Menu

    Central and its associated applications and shut down the NSP. Turn off the system power switch manually to shut down the hardware. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 40: Tools Menu

    Build PCA - Builds the PCA basis vectors for all channels with PCA based spike sorting. Assisted Spike Sorting - Enable k-means, DBSCAN, or all PCA methods for spike sorting. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 41: Options

    Configure on Window - Select to change the channel configuration in the Edit > Properties menu. Auto Impedance Interface - Select this option to configure the impedance testing for digital headstages. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 42: Windows Menu

    2. Click the categories in the left window pane to filter the channels. 3. Click Settings in the left pane to access additional settings. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 43: Configuring Channel Properties

    There are three sections on this screen : Location, Continuous Acquisition, and Enable Spike Processing (see below). Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 44 Label - If you selected only one channel, enter a user-defined name. If you selected multiple channels, select Edit and use the Edit Multiple Labels dialog box to automatically assign labels to them. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 45 Estimate Time Constant - The period over which line noise parameters are determined. LNC Method - Select software or hardware line noise cancellation. Continuous Acquisition Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 46 RMS voltage multiplier or user-defined voltage. Auto-thresholding algorithmically adjusts the threshold voltage value based on Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 47 Each modality has the following output and triggering parameters: Label - Shows the user-defined channel label. Function - Select the function to be assigned to an analog channel. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 48 An analog output channel configured as a sine waveform generator will produce a user-defined sine wave on a user-defined trigger stimulus. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 49 Analog output: custom waveform An analog output channel configured as a custom waveform generator will produce a user-defined waveform on a user-defined trigger stimulus. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 50 NeuroMotive ROI - Triggers when a subject enters or exits a selected region of interest. Recording Start - Triggers when a recording is started. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 51 3. Use the Digital Input Properties dialog box to configure the digital input port. Note: Digital inputs can synchronize external hardware and pass digital data into neural recordings. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 52 A digital output in monitor electrode mode will send a high pulse when a sorted spike unit is detected on a defined channel. Use the dialog box shown below to configure the digital output settings. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 53 Digital output: Triggered A digital output in triggered mode will send a pulse when the selected trigger stimulus occurs. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 54: Nsp Channels

    Analog inputs and outputs (including audio) Digital inputs and outputs Serial inputs and outputs To change the display mode, select an option on the toolbar: Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 55 For example, select NSP > Channels > Digital Out to narrow the list of channels by the digital output function. Figure 9-24: Hardware Configuration screen showing NSP channel sorting options Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 56: Nsp Settings

    The extracted line noise template for each channel can be viewed in Single Neural Channel when the Raw/LNC button is checked. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 57 The Filter Properties screen displays the details of a selected digital filter in a bode plot and key numerical parameters. Figure 9-27: Filter Properties screen Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 58 9.2.4.4 Sampling Sampling provides a combined interface dedicated to visualizing and assigning continuous data sampling rates. Figure 9-28: Sampling Properties screen Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 59 Apply to All - Applies the same settings to all channels, not just the channel selected in the Channel dropdown menu. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 60 DBSCAN PCA Histogram Peak Count The Central software provides automatic and manual methods of real-time spike sorting. Figure 9-30: PC Space Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 61 File > Save Sorting Rules. To load Histogram Peak Counts sorting rules, go to the Central main screen and select File > Load Sorting Rule. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 62 Each selection handle corresponds to a unit: Unit 1 (magenta / pink) Unit 2 (cyan / light blue) Unit 3 (yellow) Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 63 Artifact Rejection. For more information, see Artifact Rejection on page 63 Click OK to apply the settings and close the dialog box. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 64 1. Feature button 2. A 3-D graph showing a data cluster defined as Unit 1 inside a shaded ellipsoid 3. Build PCA button Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 65 Minimum Group Size - Removes any groups that have fewer than the number of spikes you enter . Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 66 Density-Based Spatial Clustering of Application with Noise (DBSCAN) is a principal component analysis method that automatically chooses the quantity, radius, and position of each cluster based on point density. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 67 If the Online Classification pane is hidden, select the View Classification button on the top menu bar. 6. Select the Feature tab and then select Build PCA. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 68 Update Rate (# spikes) - The number of spikes that must be collected within each unit before the histogram is updated. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 69 4. On the Adaptive Filtering dialog box, select an operation type (2 Chan Spike + Continuous Data, for example). 5. Under Reference Channels, select the analog inputs that will be used for the noise sources. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 70 (chan3, for example). To assign all available electrodes, click ─>>. Assigned electrodes are listed under Assigned Sites. Figure 9-40: N-Trode Properties dialog box Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 71: Renaming Multiple Channels

    If spike-sorting rules are defined, the spikes belonging to different units will display in different colors. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 72 Cerebus Neural Processing System Instructions for Use 9 Software Figure 9-43: Spike Panel dialog box Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 73: Spike Panel Settings

    13. Level of Criticality - Icon represents the current application load. Click the icon to view a list of the levels of criticality (see the figure below). Figure 9-45: Level of Criticality Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 74: Raster Plot

    11. Minimize - Minimize the size of selected channels. 12. Maximize - Maximize the size of selected channels. 13. Delete - Remove selected channel from the plot. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 75: Configure Raster Plot

    7. Adjust the Seconds per Division of the markers on the plot. 8. Click Increase / Decrease Font Size to adjust the channel labels font size to be easily read. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 76: Single Neural Channel Screen

    9. Send Channel Selections to PCs on Instrument Network - Duplicate the channel selection on other instances of Central running on computers connected to the Ethernet switch. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 77: Visualizing A Channel

    Continuous Data Display - View the Continuous or Raw / LNC chart in this pane. Select the View Continuous toggle on the toolbar to hide or show this pane. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 78: Spike Display Pane

    A color-coded selection handle will appear at the lower right of the Spike Display pane. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 79 Select a channel of interest in Channel ID to visualize its data on the Single Neural Channel Configuration screen. Figure 9-52: Channel ID selection on the Single Neural Channel Configuration screen Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 80: Continuous Data Display Pane

    Raw / LNC.- Select this option to display a constant subtracted waveform generated by line noise cancellation. Note: This option must be enabled. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 81: Online Classification Pane

    1. Unit Mapping - Select this option and use the dialog box that opens to select the unit definitions you want to remap, combine, or map to noise (see the image below). Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 82: Configuration Pane (Optional)

    2. Select Filter Rate Separate and Configuration on Window on the Windows Options dialog box. 3. Click OK to apply the settings. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 83: File Storage

    The Research Interface allows you to specify a file name and path for the next data set for research settings. Use this window to start or stop recording or to stop recording after a specified duration. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 84: Toc Interface

    2. Record For - Specify an amount of time that Central will record data. Once the time has expired, the recording will stop automatically. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 85 File size limit is defined in the View > Options menu. 5. Record - Begin recording data. 6. Stop - Stop recording and save file. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 86: File Storage Options

    When using the Research Interface file format, the recording can be remotely started, stopped, paused, and resumed. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 87 For example, to begin recording remotely when digital bit D3 on the digital input port is set high, configure as shown below. Figure 9-61: Example Settings for Remote Recording Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 88: Activity Map

    16 x 8 grid map file. 6. Pause - Pause the display until unchecked. 7. Reset - Clear current activity data and refresh visualization. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 89: Change Electrode Map (Create A Map File)

    "elec04". This channel is located in the fourth column (3) from the left and on the second row from the bottom (1). Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 90 The line following the last set of slashes names the map file (as referenced in the apps) and it is also ignored: //8 Channel NSP mapping. Figure 9-64: Sample Spike Panel referenced in the map file Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 91: Signal-To-Noise Ratio

    In the example below, the SNR for elec11 unit 3 is 9.50, which means that the signal is 9.5 times greater than the noise. Figure 9-65: Signal to Noise Ratio screen Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 92: Neural Modulation

    The Impedance Tester measures and reports electrode impedance on each channel. Note: Special equipment may be required for impedance measurements. Contact Blackrock Microsystems sales at sales@blackrockneuro.com for more information. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 93 Enter Array S/N - Select the applicable serial number. Enter Date of Implantation - Select the applicable date of device implantation. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 94 Comments - Enter any pertinent comments. 3. Select Finish> Next. The Auto Impedance screen displays (see the figure below). Figure 9-69: Auto Impedance screen Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 95: Crosstalk

    N-Trode channels to be subject to refractory periods caused by a neural event detected on any N-Trode channel. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 96 12. Options- Select to view a list of the keyboard and mouse actions you can use to manipulate the N-Trode GUI. For example, press Z to reset the camera. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 97: Oscilloscope

    0.1 milliseconds (ms) per division. Signals can be viewed continuously or on a specified trigger. Frequency spectra can also be displayed. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 98 A negative value displays the trigger point to the right of its previous position. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 99: Display An Input Channel On The Digital Oscilloscope

    Single - A single trace is captured as soon as it crosses the trigger level. To capture another threshold-crossed trace, click Single again. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 100: Digital Filter Editor

    Note: If the filter is unstable, the filter design tool will display a warning and suggest ways to stabilize the filter. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 101: Add Comment

    When in the Raster Plot view, press any standard letter key on the keyboard to open the Add Comment window and start dictating a comment. Press Enter when the comment is complete. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 102: Nplay Server

    An NSP does not need to be connected to the computer to use this utility. Figure 9-75: nPlay Server Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 103: Setup

    10.2.2 Setting up the Ethernet connection Note: If you purchased the host computer from Blackrock Microsystems, the computer contains a preinstalled, preconfigured Ethernet adapter. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 104 8. Select OK to save the changes. Figure 10-2: Local Area Connections Figure 10-3: IPv4 Properties Properties dialog box dialog box Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 105 IP addresses for each additional Host PC. For example, use 192.168.137.2, 192.168.137.3, …. The NSP’s IP address is 192.168.137.128. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 106: Troubleshooting

    Amplifier or front of the Digital Hub to verify that it has power. There may be a compatibility issue or damaged cable. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 107 NSP back on. minutes, or NSP. If the NSP is still not initializing, then contact Central displays support@blackrockneuro.com The System is Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 108 Check the Ethernet data packets. CPU load. connection and reduce the CPU load. Allow Central to communicate through the firewall. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 109: Central Messages

    This message displays when insufficient detected spikes have been recorded to create ellipsoid groupings on the PCA space. To address this issue, wait until more spikes are recorded before attempting to define ellipsoids. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 110 The system is initializing, please wait. If the system doesn’t respond, click the Reset NSP button below. This error message occurs when Central recognizes an NSP that is not initialized. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 111 Check your electrode configuration and Impedance File settings to address the issue. If you need additional assistance, contact Blackrock Support at support@blackrockneuro.com. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.
  • Page 112 This message displays when Central and the NSP use different versions of the protocol. If you need additional assistance, contact Blackrock Support at support@blackrockneuro.com. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 113: Cleaning, Maintenance, And Disposal

    Return all devices (used and unused) to a recycling point for electric and electronic devices for disposal. Do not dispose of them with household waste. Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 114: Magnetic Resonance

    Cerebus Neural Processing System Instructions for Use 13 Magnetic resonance 13 M AGNETIC RESONANCE The Cerebus Neural Processing System is MR unsafe. The devices comprising the system present a projectile hazard. PROJECTILE HAZARD ARNING Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11...

  • Page 115: Complaints, Issues, And Questions

    Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 116: Warranty

    Blackrock’s entire liability shall be limited to providing the remedy set forth in the previous paragraph.  Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 117: Support

    Complaints, issues, and questions on page 109. 16.1 Downloads Access support materials including software and application notes on the Blackrock Microsystems Support website: https://blackrockneurotech.com/support/ Revision 20.0 / LB-0028 - Cerebus Neural Processing System Instructions for Use – 2024-11 © 2024 Blackrock Microsystems, Inc.

  • Page 118: Returned Merchandise Authorization (Rma)

    RMA or complaint and address, and the nature of the RMA and complaint. In the unlikely event that your device needs to be returned to Blackrock Microsystems for repair or maintenance, do not send any equipment back without a Return Merchandise Authorization Number (RMA).