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Summary of Contents for Thermo Scientific HyPerforma G3Pro
- Page 1 HyPerforma G3Pro Universal Bioreactor Controller User’s Guide DOC0143 • Revision A July 2021...
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Page 2: Table Of Contents
Contents Warnings, safety, and warranty information How to use this guide Chapter 1 G3Pro overview 1.1 Introduction 1.2 G3Pro components 1.2.1 Overview 1.2.2 Left side panel 1.2.3 Right side panel 1.2.4 Vessel Adapter Box Chapter 2 Gas and liquid handling 2.1 TruFlow gas manifold 2.1.1 Connecting the TruFlow 2.1.2 Connecting the DeviceNet cable to the TruFlow... -
Page 3: Warnings, Safety, And Warranty Information
Warnings, safety, and warranty information ™ Thank you for purchasing this high-quality Thermo Scientific equipment. We have included safety information in this guide, based on our knowledge and experience. It is important, however, for you to work with your safety management personnel to ensure that this equipment is integrated into your safety practices. - Page 4 Contents under pressure • Do not exceed 0.03 bar (0.5 psi) BPC pressure • Do not exceed 0.345 bar (5 psi) inlet pressure • Ensure vent filter is properly positioned and working properly Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide...
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Page 5: Protective Earth Grounding
Caution should be used to avoid pinching an operator or causing damage to the equipment. WARNING: The Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller may not be installed in a potentially explosive atmosphere as set forth in the applicable EU ATEX Directive. -
Page 6: Handling Equipment
Keep hands away from the pump when running, such as when “jogging” the pump to feed tubing through or when priming the tubing. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... -
Page 7: Warranty Information
RESPECT TO THE AFFECTED EQUIPMENT. IF THE EQUIPMENT IS TO BE USED IN THE UNITED STATES, WE MAY VOID YOUR WARRANTY IF YOU SHIP THE EQUIPMENT OUTSIDE OF THE UNITED STATES. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... -
Page 8: Use Restrictions
Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... -
Page 9: How To Use This Guide
If you have any questions or concerns about the content of this publication, please contact technicaldocumentation@ thermofisher.com and your Thermo Fisher Scientific sales team. Related publications Other publications related to the Thermo Scientific G3Pro Universal Bioreactor Controller are listed below. Publication Document number TruBio Bioprocess Control Software Version 5.0 User’s Guide... - Page 10 Electrical control panel E-Stop Emergency stop button GFCI Ground fault circuit interrupter Human-machine interface Resistance temperature detector S.U.B. Single-Use Bioreactor S.U.M. Single-Use Mixer Temperature control unit Vessel Adapter Box Variable frequency drive Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide...
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Page 11: G3Pro Overview
DV Control Software. The G3Pro Universal Controller is designed to operate vessels, up to 2000 L, from Thermo Scientific as well as other major brands. The controller consists of a utility tower and a Vessel Adapter Box (VAB). The stainless-steel utility tower enclosure is rated NEMA12 or optionally NEMA4X. -
Page 12: G3Pro Components
The top of the cart is designed to hold the TruFlow gas manifold(s). The cart and the utility tower are pre-assembled by Thermo Scientific personnel and shipped together. The utility tower contains the pH and DO sensor transmitters, temperature sensors, the SmartPump controls, and the vent heater power and control. - Page 13 TruFlow gas manifolds on top. The associated VAB contains the pressure transmitter, the agitator transmitter, load cell transmitters, and the electric blanket control (used to heat vessels smaller than 250 L). Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide...
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Page 14: Left Side Panel
See section 1.2.4. 1.2.2 Left side panel For clarity, the left side panel is shown in two separate figures. Figure 1.3 shows the upper portion of the panel. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... - Page 15 Main Power In—Used to supply power to the unit and is either 120 VAC or 240 VAC based on facility requirements. Ensure that adequate power is supplied to the Controller (15 A at 120 VAC or 6 A at 240 VAC). Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide...
- Page 16 • Main Power Switch (On)—Turns main power on and off. • Ground Stud–Used to connect a permanent true earth bonding conductor (see section 2.4.2). • Power-indicator/Status light—Illuminates green when power is Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide...
- Page 17 TruFlow—Used to connect the TruFlow gas manifold (see • section 2.1). • Alarm Relay—Dry contact relay that can be used to activate a building alarm if a user-configured alarm condition is detected by the system. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide...
- Page 18 The connectors marked AI 1 through 8 are input-only and are used for auxiliaries such as CO sensors. ² 1. +24 V 2. 24 V Return 3. Process Value + 4. Process Value Return 5. Shield Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide...
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Page 19: Right Side Panel
Emergency Stop button, audible alarm, and four pumps and four pump jog buttons. Emergency Stop Start/Reset (E-Stop) Alarm buzzer Pump jogs Figure 1.6. Upper half of the right side panel with pump heads. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... - Page 20 Temp 1 and 2 connectors Spares DO-1 connector DO-2 connector pH-1 connector pH-2 connector DO-3 connector Spares pH-3 connector Figure 1.7. Lower half of the right side panel with sensor connections. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide...
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Page 21: Vessel Adapter Box
Port 6—For a pressure sensor. • Ports 7 and 9—Connect to the utility tower. Port 7 is the power inlet; port 9 provides control and communications. • Port 8—For an agitator motor connection. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... -
Page 22: Gas And Liquid Handling
Remove the plastic caps from all ports to be used. The TruFlow available comes with six inlets, one headspace (HS) outlet, as well as two sparger outlets (SPG-1, SPG-2), as shown in Figure 2.1 below. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... -
Page 23: Connecting The Truflow
Note: The TruFlow must be placed on top of the utility tower. 2. Use the respective TruFlow communication cable to connect the controller to the TruFlow. Refer to Figure 2.2 and Figure 2.3. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... - Page 24 6. Use a 9/16 in. or adjustable wrench (spanner) to tighten the nut by a full turn (Figure 2.6). 7. Ensure the tubing is properly connected to facility gas. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide...
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Page 25: Connecting The Devicenet Cable To The Truflow
Thermo Scientific representative for assistance. The TruFlow is connected to the Controller by a single DeviceNet ™ cable that attaches to the side of the TruFlow and the second connector panel of the controller. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... -
Page 26: Sensors And Auxiliaries
Both the 114-series (Figure 2.8) and 313-series (Figure 2.9) pump heads are opened by raising the curved top cover. The 520-series pump (Figure 2.10) is larger and requires a flathead screwdriver to open. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... -
Page 27: Installing Pump Tubing
2. Lay the tubing into the pump over the driver (Figure 2.11). 3. Close the pump by bringing the top of the pump head down and pressing firmly so it snaps closed. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... - Page 28 Bioprocessing Software User’s Guide Version 5.0 (DOC0088) to calibrate the pumps. • Ensure the tubing is not in danger of being kinked or occluded by other equipment. Figure 2.12. Feeding tubing through the side of the 500-series pump. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide...
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Page 29: Pump Tubing Flow Rates
(Figure 1.3). The utility tower should not be powered on until this earth bonding conductor is in place and connected to true earth ground. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... -
Page 30: System Assembly
All cabling should be protected from moving parts, foot traffic, chairs/stools, and any other source of abrasion that might compromise the cable integrity. Damage to the cables will result in system malfunction. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... -
Page 31: Maintenance
Maintenance Maintenance Each G3Pro Universal Controller is fully tested before leaving the factory. The unit requires minimal maintenance; Thermo Scientific provides support, repair, maintenance, and refurbishment services for all G3-series systems sold. Any servicing of the unit should be done by Thermo Fisher Scientific personnel only. -
Page 32: Cleaning
Spare gas manifold (TruFlow) • Swagelock tubing ferrules and nuts (for TruFlow) • RTDs • pH and DO sensors • Sensor cables • Watson-Marlow series 114, 313, and/or 520 pump heads • Pump tubing Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... -
Page 33: G3Pro Specifications
Four (4) variable-speed Watson-Marlow peristaltic pumps Pump head options Watson Marlow 114, 313, or 520 series Thermo Scientific TruFlow mass flow controller (MFC): option of up to six (6) MFCs (up to six gas inlets and three gas Gas control (TruFlow) outlets) Option of high flow and very high flow rates available–up to... - Page 34 254 cm (100 in.) 335.28 cm (132 in.) Maximum extension 213.36 cm (84 in.) Minimum extension 71.12 cm (28 in.) 101.6 cm (40 in.) Figure 4.1. Front view of G3Pro dimensions. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide...
- Page 35 Chapter 4 G3Pro specifications 144.78 cm (57 in.) Display line of sight 81.28 cm (32 in.) 124.46 cm (49 in.) Maximum width Figure 4.2. Side view of G3Pro dimensions. Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide...
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Page 36: Appendix A-Complete List Of Certifications
IEC61010-081 Part 2-081 - Particular requirements for automatic and semi-automatic laboratory equipment for analysis and other purposes EN61326/-1 - Electrical control and measurement, EMC 2003/94/EC - EU GMP regulations 2012/19/EC - WEEE 2011/65/EC - RoHS directives Thermo Scientific HyPerforma G3Pro Universal Bioreactor Controller User’s Guide... - Page 37 Find out more at thermofisher.com/sut For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals. © 2021 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
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