SCIEX X500 System User's Manual
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SCIEX X500 System User's Manual

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SCIEX X500 QTOF System
System User Guide
RUO-IDV-05-9349-B
January 2022

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Summary of Contents for SCIEX X500

  • Page 1 SCIEX X500 QTOF System System User Guide RUO-IDV-05-9349-B January 2022...
  • Page 2 SCIEX warranties are limited to those express warranties provided at the time of sale or license of its products and are the sole and exclusive representations, warranties, and obligations of SCIEX. SCIEX...

  • Page 3: Table Of Contents

    3 Operating Instructions — Hardware..................23 Start Up the System........................ 23 Shut Down and Vent the System.................... 24 Diverter Valve..........................25 Plumb the Diverter Valve in Injector Mode................. 26 Plumb the Diverter Valve in Diverter Mode................ 27 System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 3/82...
  • Page 4 Open the Dress Panel......................60 7 Mass Spectrometer Troubleshooting...................61 A Recommended Calibration Ions................... 67 APCI Calibration Ions......................67 ESI Calibration Ions........................ 69 B Exact Masses and Chemical Formulas................71 C Glossary of Symbols......................73 SCIEX X500 QTOF System System User Guide 4/82 RUO-IDV-05-9349-B...
  • Page 5 Contents D Glossary of Warnings......................79 Contact Us..........................81 Customer Training........................81 Online Learning Center......................81 SCIEX Support........................81 CyberSecurity..........................81 Documentation........................81 System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 5/82...

  • Page 6: Operational Precautions And Limitations

    Refer to the appropriate laboratory reference material and standard operating procedures. Documentation Symbols and Conventions The following symbols and conventions are used throughout the guide. DANGER! Danger signifies an action that leads to severe injury or death. SCIEX X500 QTOF System System User Guide 6/82 RUO-IDV-05-9349-B...

  • Page 7: Regulatory Compliance

    Canadian ICES-001. Refer to the section: Electromagnetic Interference. • Safety: • CAN/CSA C22.2 No. 61010-1 • CAN/CSA C22.2 No 61010-2-061 Europe • Electromagnetic Compatibility (EMC): Electromagnetic Compatibility Directive 2014/30/EU as implemented in these standards: System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 7/82...

  • Page 8: United States

    • Electromagnetic Compatibility (EMC): • IEC 61326-1 • IEC CISPR 11 (Class A) • IEC 61000-3-2 • IEC 61000-3-3 Refer to the section: Electromagnetic Compatibility. • Safety: • IEC 61010-1 • IEC 61010-2-061 SCIEX X500 QTOF System System User Guide 8/82 RUO-IDV-05-9349-B...

  • Page 9: Electrical Precautions

    The covers need not be removed for routine maintenance, inspection, or adjustment. Contact a SCIEX Field Service Employee (FSE) for repairs that require the covers to be removed. • Follow required electrical safe work practices.

  • Page 10: Chemical Precautions

    For the health and safety precautions that must be followed for a chemical, refer to the document: Safety Data Sheet. For storage information, refer to the document: Certificate of Analysis. To find a SCIEX Safety Data Sheet or Certificate of Analysis, go to sciex.com/tech-regulatory.

  • Page 11: System Safe Fluids

    CAUTION: Potential System Damage. Do not use any other fluid until confirmation is received from SCIEX that it does not present a hazard. This is not an exhaustive list. Note: Use only new, freshly prepared LC-MS-grade or better solvents for the LC mobile phases.

  • Page 12: Ventilation Precautions

    WARNING! Ionizing Radiation Hazard, Biohazard, or Toxic Chemical Hazard. Do not use the ion source without knowledge of and training in the proper use, containment, and evacuation of toxic or injurious materials used with the ion source. SCIEX X500 QTOF System System User Guide 12/82 RUO-IDV-05-9349-B...

  • Page 13: Physical Precautions

    WARNING! Puncture Hazard, Ionizing Radiation Hazard, Biohazard, or Toxic Chemical Hazard. Discontinue use of the ion source if the ion source window is cracked or broken, and then contact a SCIEX Field Service Employee (FSE). Any toxic or injurious materials introduced in the equipment will be present in the source exhaust output.

  • Page 14: Electromagnetic Environment

    Class A limits. CAUTION: Potential Radio Interference. This equipment is not intended for use in residential environments and may not provide adequate protection to radio reception in such environments. SCIEX X500 QTOF System System User Guide 14/82 RUO-IDV-05-9349-B...

  • Page 15: Decommissioning And Disposal

    Refer to the section: Storage and Handling. Note: SCIEX will not accept any system returns without a completed Decontamination Form. Contact an FSE to obtain a copy of the form. Do not dispose of system components or subassemblies, including computer parts, as unsorted municipal waste.

  • Page 16: Laboratory Conditions

    2 °C (3.6 °F) per hour. Ambient temperature fluctuations exceeding the limits might result in mass shifts in spectra. • Relative humidity from 20% to 80%, non-condensing SCIEX X500 QTOF System System User Guide 16/82...

  • Page 17: Equipment Use And Modification

    WARNING! Personal Injury Hazard. Use SCIEX-recommended parts only. Use of parts not recommended by SCIEX or use of parts for any purpose other than their intended purpose can put the user at risk of harm or negatively impact system performance.

  • Page 18: Principles Of Operation

    (APCI) probe. Refer to the document: Turbo V Ion Source Operator Guide. • A SCIEX-supplied computer and monitor with the control software for instrument optimization, acquisition method development, data acquisition, and processing. For computer specifications and requirements, refer to the software documentation.

  • Page 19: Hardware Overview

    Alternate (left) location for diverter valve. For more information, contact an FSE. Ion source. Refer to the ion source Operator Guide. Calibrant bottles. Refer to Replace the CDS Bottle. Panel symbols. Refer to Panel Symbols. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 19/82...
  • Page 20 Shut Down and Vent the System. Sources connection. Some ion sources connect to this port. AUX IO connection. Not used. Ethernet connection. Used for communication with the acquisition computer. Zero air gas supply SCIEX X500 QTOF System System User Guide 20/82 RUO-IDV-05-9349-B...
  • Page 21 After the system is turned on, the power LED illuminates, and the fault LED flashes for a few seconds. Then the vacuum LED begins to flash. After the operating vacuum level is achieved, this LED remains illuminated. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 21/82...

  • Page 22: Theory Of Operation

    Mass spectrometry measures the mass-to-charge ratio of ions to identify and quantify compounds. The X500 QTOF system has a series of quadrupole filters that select or transmit ions according to their mass-to-charge ratio (m/z). The first quadrupole in this series is the QJet ion guide, which is located between the orifice plate and the Q0 region.

  • Page 23: Operating Instructions - Hardware

    WARNING! Personal Injury Hazard. Follow the instructions in the documentation when using the system. The protection provided by the equipment might be impaired if the equipment is used in a manner not specified by SCIEX. Start Up the System WARNING! Electrical Shock Hazard. Make sure that the system can be disconnected from the mains supply outlet in an emergency.

  • Page 24: Shut Down And Vent The System

    Open SCIEX OS. After Venting the Mass Spectrometer • Perform a Quick Status Check in the MS Tune workspace of SCIEX OS. Refer to the document: Software User Guide. • If resolution drift occurs 16 to 24 hours after startup, then perform a Quick Status Check again.

  • Page 25: Diverter Valve

    LC run. CAUTION: Potential Wrong Result. Do not press the diverter valve button during a run. Doing so might result in incorrect data. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 25/82...

  • Page 26: Plumb The Diverter Valve In Injector Mode

    When the valve is in Position A, the sample flows through the external loop. When the valve switches to Position B, the sample is injected. Plumb the valve for Injector mode. Figure 3-2 Diverter Valve—Injector Mode Position A SCIEX X500 QTOF System System User Guide 26/82 RUO-IDV-05-9349-B...

  • Page 27: Plumb The Diverter Valve In Diverter Mode

    When the valve is in Position A, the sample flow goes to the mass spectrometer. When the valve switches to Position B, the flow goes to waste. Plumb the valve for Diverter mode. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 27/82...
  • Page 28 Operating Instructions — Hardware Figure 3-4 Diverter Valve—Diverter Mode Position A Figure 3-5 Diverter Valve—Diverter Mode Position B SCIEX X500 QTOF System System User Guide 28/82 RUO-IDV-05-9349-B...

  • Page 29: Calibrant Delivery System

    Use the direct control function to start the CDS manually when flushing the CDS or when introducing solutions during tuning. In SCIEX OS, on the status panel, click Direct CDS control ( The Device Control dialog opens. System User Guide...

  • Page 30: Stop The Cds

    Operating Instructions — Hardware Figure 3-6 Device Control (CDS) Click Start. Stop the CDS In SCIEX OS, on the status panel, click Direct CDS control ( Click Stop. Flush the CDS WARNING! Toxic Chemical Hazard. Refer to the chemical product Safety Data Sheets and follow all of the recommended safety procedures when handling, storing, and disposing of chemicals.
  • Page 31 Start the pump by pressing and holding the bottle sensor switch for 1 minute. The CDS draws in air and discharges liquid. To stop the pump, stop pressing the switch. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 31/82...
  • Page 32 Press the bottle sensor switch for 1 minute or until 20 mL of solvent accumulates into the waste container. 10. Discard the waste. 11. Repeat step to step to purge the wash solution. SCIEX X500 QTOF System System User Guide 32/82 RUO-IDV-05-9349-B...
  • Page 33 Tip! We recommend that the tubing be flushed with the new calibrant solution before the new calibrant is allowed to recirculate back into the calibrant bottle. 13. Clear Wash Mode. 14. Put the return tubing into the calibrant bottle, and then install the bottle. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 33/82...

  • Page 34: Operating Instructions - User Workflows

    Configure the LIMS Software User Guide or Help System. Add users to the software and assign roles Laboratory Director Guide or Help System. Archive logs Software User Guide or Help System. Reviewer SCIEX X500 QTOF System System User Guide 34/82 RUO-IDV-05-9349-B...
  • Page 35 Operating Instructions — User Workflows Task Reference Review processed results Software User Guide or Help System. Explore data Software User Guide or Help System. Review logs Software User Guide or Help System. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 35/82...

  • Page 36: Operating Instructions-Device Configuration

    11. Click Test Device to verify that the device is configured correctly and available for use. 12. Click Save. 13. Repeat step to step 12, to add other devices, selecting the appropriate type. SCIEX X500 QTOF System System User Guide 36/82 RUO-IDV-05-9349-B...

  • Page 37: Deactivate Devices

    14. Select the Activate check box beside each device to be activated, and then click Activate Devices. All of the selected devices are activated. 15. To edit or delete devices, refer to the Help System. Deactivate Devices Open the Configuration workspace. Click Devices. Click Deactivate. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 37/82...

  • Page 38: Service And Maintenance Information

    The covers need not be removed for routine maintenance, inspection, or adjustment. Contact a SCIEX Field Service Employee (FSE) for repairs that require the covers to be removed. WARNING! Ionizing Radiation Hazard, Biohazard, or Toxic Chemical Hazard.
  • Page 39 • Overall system run time To order consumable parts and for basic service and maintenance requirements, contact a QMP or refer to the document: Parts and Equipment Guide. Contact a SCIEX FSE for all other service and maintenance requirements. Table 6-1 Mass Spectrometer Maintenance Tasks...

  • Page 40: Clean The Surfaces

    Wipe the external surfaces with a soft cloth dampened with warm, soapy water. Wipe the external surfaces with a soft cloth dampened with water to remove any soap residue. SCIEX X500 QTOF System System User Guide 40/82 RUO-IDV-05-9349-B...

  • Page 41: Clean The Front-End

    If any of these issues are observed, then clean the mass spectrometer front-end. Required Materials Note: U.S. customers can call 877-740-2129 for ordering information and inquiries. International customers can visit sciex.com/contact-us. • Powder-free gloves, nitrile or neoprene recommended • Safety glasses System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 41/82...

  • Page 42: Cleaning Best Practices

    WARNING! Toxic Chemical Hazard. Refer to the chemical product safety data sheets and follow all of the recommended safety procedures when handling, storing, and disposing of chemicals. SCIEX X500 QTOF System System User Guide 42/82 RUO-IDV-05-9349-B...
  • Page 43 • Only dampen the wipe or swab slightly when applying water or cleaning solution. Water, more often than organic solvents, might cause the wipe to deteriorate, leaving residue on the mass spectrometer. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 43/82...

  • Page 44: Prepare The Mass Spectrometer

    CAUTION: Potential System Damage. Do not drop anything in the source drain when the ion source is removed. Figure 6-2 Source Drain on the Vacuum Interface SCIEX X500 QTOF System System User Guide 44/82 RUO-IDV-05-9349-B...

  • Page 45: Clean The Curtain Plate

    90 degrees, to release the ball spring latches. Dampen a lint-free wipe with LC-MS-grade water and then clean both sides of the curtain plate. Note: Use multiple wipes, as required. Repeat step using the cleaning solution. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 45/82...

  • Page 46: Clean The Front Of The Orifice Plate

    Install the ion source on the mass spectrometer. Tighten the ion source by turning the source latches down in the locking position. Activate the devices. Refer to the document: Software User Guide. SCIEX X500 QTOF System System User Guide 46/82...

  • Page 47: Empty The Source Exhaust Drain Bottle

    Follow the steps in this procedure to empty the bottle. Remove the ion source. Refer to the document: Turbo V Ion Source Operator Guide. Loosen the clamps connecting the hoses to the cap of the source exhaust drain bottle. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 47/82...
  • Page 48 Source exhaust drain bottle Make sure that the bottle is secured to prevent spillage. Source exhaust connection to the mass spectrometer: 1.6 cm (0.625 inch) i.d. Roughing pump vacuum inlet hose. SCIEX X500 QTOF System System User Guide 48/82 RUO-IDV-05-9349-B...

  • Page 49: Replace The Check Valve And Flow Module

    10 cm length of black tubing that controls the flow rate of the calibrant into the ion source. Figure 6-5 Check Valve and Flow Module Item Description To the CDS System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 49/82...

  • Page 50: Replace The Cds Bottle Intake Filters

    Replace the CDS Bottle Intake Filters WARNING! Toxic Chemical Hazard. Refer to the chemical product Safety Data Sheets and follow all of the recommended safety procedures when handling, storing, and disposing of chemicals. SCIEX X500 QTOF System System User Guide 50/82 RUO-IDV-05-9349-B...

  • Page 51: Inspect The Roughing Pump Oil Level

    Inspect the sight glass on the roughing pump to verify that the oil is above the minimum level. If the oil is below the minimum level, then contact the Qualified Maintenance Person (QMP) or SCIEX Field Service Employee (FSE). System User Guide...

  • Page 52: Storage And Handling

    Service and Maintenance Information Figure 6-7 Sight Glass Storage and Handling WARNING! Environmental Hazard. Do not dispose of system components in municipal waste. Follow local regulations when disposing of components. SCIEX X500 QTOF System System User Guide 52/82 RUO-IDV-05-9349-B...

  • Page 53: Move The Mass Spectrometer

    If the mass spectrometer must be stored for a long time or prepared for shipping, then contact a SCIEX FSE for decommissioning information. To disconnect power from the mass spectrometer, remove the mains supply connector from the AC mains supply.
  • Page 54 Install a short block on each lifting bar, and then secure it with a locking pin. CAUTION: Potential System Damage. Make sure that all locking pins are fully inserted, to avoid dropping the mass spectrometer while it is being moved. SCIEX X500 QTOF System System User Guide 54/82...
  • Page 55 Note: The end of the bar with the longest extension past the block must be at the front of the mass spectrometer. Repeat step on the left side of the mass spectrometer. 10. Install the locking pins in the long rods. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 55/82...
  • Page 56 Figure 6-11 Installing the Locking Pin on the Log Rod 11. Install the tall blocks on the ends of the long rods, and then secure the blocks with two locking pins. Figure 6-12 Tall Block Installed SCIEX X500 QTOF System System User Guide 56/82 RUO-IDV-05-9349-B...
  • Page 57 12. At the front of the mass spectrometer, insert a short rod through the tall blocks. 13. Secure the short rods with two locking pins. Figure 6-13 Installing the Locking Pin on the Short Rod System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 57/82...
  • Page 58 10 is at the front of the system, and must move aside to allow the system to be taken off and put onto the bench. For X500R systems, only positions 1 through 9 are required. SCIEX X500 QTOF System System User Guide 58/82...
  • Page 59 19. Install the left and right skirts. 20. Close the dress panel. 21. Connect the vacuum hose, gas tubing, source exhaust tubing, power cable, Ethernet cable, and the TDC cable to the mass spectrometer. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 59/82...

  • Page 60: Open The Dress Panel

    • Remove the ion source. Refer to the ion source Operator Guide. Required Materials • 3 mm hex key Remove the 3 mm hex screw on the bottom right side of the dress panel, between the calibrant bottles. Open the dress panel. SCIEX X500 QTOF System System User Guide 60/82 RUO-IDV-05-9349-B...

  • Page 61: Mass Spectrometer Troubleshooting

    Mass Spectrometer Troubleshooting This section contains information for troubleshooting basic system issues. Certain activities can only be carried out by a SCIEX-trained Qualified Maintenance Person (QMP) in the laboratory. For advanced troubleshooting, contact a SCIEX Field Service Employee (FSE). Table 7-1 System Issues...
  • Page 62 The mass spectrometer The mass spectrometer is not Use the control software resolution is poor. tuned. to optimize the mass spectrometer. Refer to the document: Software User Guide for the control software. SCIEX X500 QTOF System System User Guide 62/82 RUO-IDV-05-9349-B...
  • Page 63 Operator Guide. Refer to the document: Turbo V Ion Source Operator Guide. Table 7-2 Sensitivity Issues Possible Cause Corrective Action Sensitivity is Decreased The ion source parameters are not optimized. Optimize the ion source parameters. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 63/82...
  • Page 64 Optimize DP. optimized. The electrode is dirty or blocked. Replace the electrode. Refer to the document: Turbo V Ion Source Operator Guide. There is No Signal or the Signal is Unstable SCIEX X500 QTOF System System User Guide 64/82 RUO-IDV-05-9349-B...
  • Page 65 Contact the local QMP or FSE. The Q0 region is dirty. Clean the Q0 region. Contact the QMP or FSE. Mobile phase is contaminated. Replace the mobile phase. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 65/82...
  • Page 66 Curtain Gas interface to 45 or 50. Run for a minimum of 2 hours or preferably overnight for best results. For sales, technical assistance, or service, contact an FSE or visit the SCIEX website at sciex.com for contact information. SCIEX X500 QTOF System...

  • Page 67: A Recommended Calibration Ions

    Recommended Calibration Ions Recommended Calibration Ions The following table list the standards recommended by SCIEX for calibrating the X500 QTOF LC-MS/MS system. CAUTION: Potential Wrong Result. Do not use expired solutions or solutions that have not been stored at the indicated storage temperature.
  • Page 68 Fragment Ion 2 249.1033 277.0983 Fragment Ion 3 217.0771 158.0611 Fragment Ion 4 200.0591 125.0067 Fragment Ion 5 158.0611 93.0344 Fragment Ion 6 130.0662 Fragment Ion 7 116.0506 Fragment Ion 8 77.0397 SCIEX X500 QTOF System System User Guide 68/82 RUO-IDV-05-9349-B...

  • Page 69: Esi Calibration Ions

    397.212 706.486 Fragment ion 5 227.05 365.186 607.418 Fragment ion 6 220.112 236.128 532.334 Fragment ion 7 86.0964 195.065 512.344 Fragment ion 8 58.0651 174.091 494.334 411.297 399.26 381.25 298.213 268.166 System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 69/82...
  • Page 70 520.9100 928.8344 Fragment Ion 112.9856 154.9738 204.9706 384.9352 792.8596 Fragment Ion 68.99576 112.9856 154.9738 248.9604 656.8848 Fragment Ion 112.9856 204.9706 520.9100 Fragment Ion 154.9738 384.9352 Fragment Ion 112.9856 248.9604 204.9706 154.9738 SCIEX X500 QTOF System System User Guide 70/82 RUO-IDV-05-9349-B...

  • Page 71: B Exact Masses And Chemical Formulas

    Table B-2 Peptide ALILTLVS Exact Mass Name Sequence Mass Charge State Precursor Ion ALILTLVS 829.5393 ALILTLVS 811.5288 ALILTLV 724.4967 b7-18 ALILTLV 706.4862 b6-18 ALILTLV 607.4178 LTLVS 532.3341 ALILT 512.3443 b5-18 ALILT 494.3337 ALIL 411.2966 298.2125 System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 71/82...
  • Page 72 Table B-2 Peptide ALILTLVS Exact Mass (continued) Name Sequence Mass Charge State Internal fragment y|b IL or LI 227.1754 Internal fragment y|b LT or TL 215.139 185.1285 157.1335 Immonium Ions I or L 86.09643 SCIEX X500 QTOF System System User Guide 72/82 RUO-IDV-05-9349-B...

  • Page 73: C Glossary Of Symbols

    Australian Communications Media Authority (ACMA) EMC Requirements. Alternating current Amperes (current) Asphyxiation Hazard Authorized representative in the European community Biohazard CE Marking of Conformity cCSAus mark. Indicates electrical safety certification for Canada and USA. Catalog number System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 73/82...
  • Page 74 Symbol Description Caution. Consult the instructions for information about a possible hazard. Note: In SCIEX documentation, this symbol identifies a personal injury hazard. China RoHS Caution Label. The electronic information product contains certain toxic or hazardous substances. The center number is the Environmentally Friendly Use Period (EFUP) date, and indicates the number of calendar years the product can be in operation.
  • Page 75 Hertz International safety symbol "Caution, risk of electric shock" (ISO 3864), also known as High Voltage symbol If the main cover must be removed, then contact a SCIEX representative to prevent electric shock. Hot Surface Hazard In Vitro Diagnostic Device...
  • Page 76 Relative humidity must not exceed 99%. Keep upright. Lacerate/Sever Hazard Laser Radiation Hazard Lifting Hazard Magnetic Hazard Manufacturer Moving Parts Hazard Pacemaker Hazard. No access to people with pacemakers. Pinching Hazard SCIEX X500 QTOF System System User Guide 76/82 RUO-IDV-05-9349-B...
  • Page 77 Transport and store the system within the specified minimum (min) and maximum (max) levels of relative humidity, noncondensing. Transport and store the system within –30 °C to +45 °C. Transport and store the system within –30 °C to +60 °C. System User Guide SCIEX X500 QTOF System RUO-IDV-05-9349-B 77/82...
  • Page 78 USB 3.0 connection Ultraviolet Radiation Hazard United Kingdom Conformity Assessment Mark Volt Ampere (power) Volts (voltage) WEEE. Do not dispose of equipment as unsorted municipal waste. Environmental Hazard Watts yyyy-mm-dd Date of manufacture SCIEX X500 QTOF System System User Guide 78/82 RUO-IDV-05-9349-B...
  • Page 79 INCLUDING TRIPPED IMPACT-O-GRAPH OR TIP-N-TELL INDICATORS, ON THE OR TIP-N-TELL INDICATORS, ON THE WAYBILL BEFORE ACCEPTING SHIPMENT. WAYBILL BEFORE ACCEPTING SHIPMENT. NOTIFY YOUR LOCAL SCIEX CUSTOMER NOTIFY YOUR LOCAL SCIEX CUSTOMER SUPPORT ENGINEER IMMEDIATELY. SUPPORT ENGINEER IMMEDIATELY. TIP & TELL...
  • Page 80 TEN PERSONS REQUIRED TO LIFT THIS EQUIPMENT. WARNING: NO USER SERVICEABLE PARTS WARNING: NO USER SERVICEABLE PARTS INSIDE. REFER SERVICING TO QUALIFIED INSIDE. REFER SERVICING TO QUALIFIED PERSONNEL. PERSONNEL. Note: Consult instructions for use. SCIEX X500 QTOF System System User Guide 80/82 RUO-IDV-05-9349-B...
  • Page 81 SCIEX Now Learning Hub SCIEX Support SCIEX and its representatives maintain a staff of fully-trained service and technical specialists located throughout the world. They can answer questions about the system or any technical issues that might arise. For more information, visit the SCIEX website at sciex.com...
  • Page 82 To find hardware product documentation, refer to the Customer Reference DVD that comes with the system or component. The latest versions of the documentation are available on the SCIEX website, at sciex.com/ customer-documents. Note: To request a free, printed version of this document, contact sciex.com/contact-us.

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