Agilent Technologies 709-DS Operator's Manual
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Agilent Technologies 709-DS Operator's Manual

Dissolution apparatus
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708-DS / 709-DS
Dissolution Apparatus
Operator's Manual
Agilent Technologies

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Summary of Contents for Agilent Technologies 709-DS

  • Page 1 708-DS / 709-DS Dissolution Apparatus Operator’s Manual Agilent Technologies...
  • Page 2 Software and technical data pursuant to FAR 12.211 (Technical Data) and 12.212 (Computer Software) and, for the Department of Defense, DFARS 252.227-7015 (Techni- cal Data - Commercial Items) and DFARS 227.7202-3 (Rights in Commercial Com- 708-DS / 709-DS Operator’s Manual...

  • Page 3: Table Of Contents

    Warning Caution Note Information Symbols Introduction Conventions Used in this Manual Serial Number Format Setting Up the 708-DS / 709-DS Initial Setup Unpacking Procedure Environmental Requirements for Installation Clearance Equipment, Parts, and Accessories As Shipped Parts and Accessories Tubing / Cable Connections...
  • Page 4 DVH Power Controller Setup (709-DS) Temperature Probe Installation (708-DS) EVT Probe Installation (708-DS) Power Cord Connections 708-DS / 709-DS Initial Power Up Filling the Water Bath (708-DS) Level Instrument - Re-verification Heater / Circulator Power-up (708-DS) Agilent 708-DS / 709-DS Setup...
  • Page 5 Menu Screen - Instrument Menu Screen - Calibration Menu Screen - Diagnostics Menu Screen - User Access General 708-DS / 709-DS Conventions Alphanumeric Data Entry Numeric and Time / Date Entry Parameter Limits / Ranges Agilent 708-DS / 709-DS Notifications...
  • Page 6 Removing the Manifold Accessing the Top Cover Removing Top Cover Replacing the Top Cover Printer Maintenance Removing a Thermal Paper Roll Inserting a Thermal Paper Roll (5095-0307) Thermal Printer Test Obtaining Warranty and Other Services Index 708-DS / 709-DS Operator’s Manual...

  • Page 7: Figures

    Figure 23. Inserting Height Spheres Figure 24. Main Screen - Display Parameters Figure 25. Manual Lift Knob Figure 26. Taking a Manual Sample Figure 27. Agilent 708-DS / 709-DS Standard Evaporation Cover Figure 28. Rinse Cup 708-DS / 709-DS Operator’s Manual...
  • Page 8 Figure 33. Removing the Thermal Paper Roll Figure 34. Inserting a Thermal New Paper Roll Figure 35. Leading Paper and Closing the Lid Figure 36. Closing the Printer Chamber Figure 37. Feeding Paper Figure 38. Printer Test 708-DS / 709-DS Operator’s Manual...

  • Page 9: Tables

    Table 12. Diagnostics - DVH Diagnostics Screen 1 Table 13. Numeric and Time / Date Entry Table 14. Parameter Limits / Ranges Table 15. Dialog Screens (Green / Blue) Table 16. Warning Screens (Yellow) Table 17. Error Screens (Red) 708-DS / 709-DS Operator’s Manual...
  • Page 10 Tables This page was intentionally left blank, except for this message. 708-DS / 709-DS Operator’s Manual...

  • Page 11: Safety

    Operator’s Manual Safety Electrical Hazards The Agilent 708-DS / 709-DS has been designed and tested so that when used properly you have an accurate, fast, flexible, and safe instrument. If the equipment is used in a manner not specified by the manufacturer, the protection provided by the equipment may be impaired.
  • Page 12 Do not connect the instrument to the main power supply until you have made sure that the operating voltage is correctly set for the main power supply in the specific outlet in your laboratory to which the equipment will be connected. 708-DS / 709-DS Operator’s Manual...

  • Page 13: Warning

    A ‘Caution’ message appears in the manual when failure to observe instructions could result in damage to equipment (Agilent supplied and / or other associated equipment). Note NOT E A ‘Note’ appears in the manual to give advice or information. 708-DS / 709-DS Operator’s Manual...

  • Page 14: Information Symbols

    European Standard EN 50419. For more information on collection, reuse, and recycling systems, please contact your local/regional waste administration, your local distributor, or Agilent. Indicates the product complies with regulatory compliance requirements of New Zealand and Australia. 708-DS / 709-DS Operator’s Manual...

  • Page 15: Introduction

    708-DS / 709-DS Dissolution Apparatus Operator’s Manual Introduction Conventions Used in this Manual Serial Number Format Agilent Technologies...
  • Page 16 Introduction Agilent’s 708-DS and 709-DS Dissolution Apparatus are designed for dissolution testing of a variety of pharmaceutical products, including tablets, capsules, and transdermal patches. Using a common platform, both models are available with an intuitive, color touch screen interface. Likewise, you may select the 708-DS for traditional water bath vessel heating, or choose the 709-DS for simplified, bath-free, self-heating vessels with Agilent’s Direct Vessel Heating (DVH).

  • Page 17: Conventions Used In This Manual

    Conventions Used in this Manual • Items you are asked to press are in bold. For example, “press H on the keypad”. • Key sequences you are asked to press appear like this: MENU > 7. 708-DS / 709-DS Operator’s Manual...

  • Page 18: Serial Number Format

    2 alpha characters matching the required trade designation for the country of origin Year of manufacture ‘09’ for 2009, ‘10’ for 2010, etc. Week of manufacture ‘01’ for week 1 to ‘52’ for week 52 708-DS / 709-DS Operator’s Manual...

  • Page 19: Setting Up The 708-Ds / 709-Ds

    708-DS / 709-DS Dissolution Apparatus Operator’s Manual Setting Up the 708-DS / 709-DS Initial Setup Equipment, Parts, and Accessories As Shipped Tubing / Cable Connections Instrument Level / Water Bath Setup Agilent 708-DS / 709-DS Setup Agilent Technologies...

  • Page 20: Initial Setup

    Setting Up the 708-DS / 709-DS Initial Setup Complete the following sections to initially set up the Agilent 708-DS / 709-DS and all other system components. Unpacking Procedure Figure 1 Unpacking 708-DS / 709-DS Operator’s Manual...

  • Page 21: Figure 2 Removing The Apparatus

    Setting Up the 708-DS / 709-DS 1 Remove the Agilent 708-DS / 709-DS and all other system components from the packing material. Figure 2 Removing the Apparatus 2 Inspect the equipment and accessories to ensure there has been no damage during shipment.

  • Page 22: Environmental Requirements For Installation

    2 Ensure a minimum clearance of 30 cm above the unit (when fully raised) and 10 cm at the rear and on both sides of the Agilent 708-DS / 709-DS. Approximately 82 cm x 82 cm total bench space is required per apparatus.

  • Page 23: Equipment, Parts, And Accessories As Shipped

    Setting Up the 708-DS / 709-DS Equipment, Parts, and Accessories As Shipped Parts and Accessories Locate the following items, as applicable, for your system configuration: Agilent 708-DS / 709-DS Dissolution Apparatus Alignment Posts or Evaporation Plugs Heater / Circulator (708-DS)

  • Page 24: Tubing / Cable Connections

    Tubing / Cable Connections Complete the following sections to connect the necessary tubing and cables for the Agilent 708-DS / 709-DS. Heater / Circulator Setup (708-DS) Do not turn on the heater / circulator before filling the water bath to CAUTION avoid damaging the internal heating elements of the circulator.

  • Page 25: Instrument Level / Water Bath Setup

    Setting Up the 708-DS / 709-DS Instrument Level / Water Bath Setup Complete the following sections to properly level the instrument and fill the water bath. Level Instrument Figure 4 Levelers and Stability Feet 708-DS / 709-DS Operator’s Manual...

  • Page 26: Figure 5 Level-Adjustment Screw Caps

    Setting Up the 708-DS / 709-DS 1 Remove the black caps from the five (5) screws located on the front, side, and rear of the base plate of the dissolution apparatus. Figure 5 Level-Adjustment Screw Caps 2 Raise the side stability feet located toward the back on either side of the base plate so they are not touching the laboratory bench.

  • Page 27: Figure 6 Raising The Stability Feet

    Setting Up the 708-DS / 709-DS Figure 6 Raising the Stability Feet 3 Using the 90º Allen key in the top of the front level-adjustment screws, adjust the screws to achieve left-to-right level within tolerance. It may be necessary to loosen the nut(s) beneath the base plate to allow for adjustment.

  • Page 28: Dvh Power Controller Setup (709-Ds)

    Setting Up the 708-DS / 709-DS DVH Power Controller Setup (709-DS) 1 Install the DVH Power Controller box in the back of the 709-DS, beneath the vessel plate. Ensure that the rubber feet of the control box do not sit in any holes on the vessel plate.

  • Page 29: Temperature Probe Installation (708-Ds)

    Setting Up the 708-DS / 709-DS Temperature Probe Installation (708-DS) 1 Insert the water bath temperature probe into the BATH TEMP jack on the rear of the dissolution apparatus drive unit. Figure 8 BATH TEMP Connector 2 Place the other end of the temperature probe through the hole in the center of the vessel plate in the water bath.

  • Page 30: Evt Probe Installation (708-Ds)

    Setting Up the 708-DS / 709-DS EVT Probe Installation (708-DS) 1 If applicable, insert the EVT Probe cable into the VESSEL TEMP jack on the rear of the dissolution apparatus drive unit. 2 Place the vessel temperature probe in the hole in the vessel plate, at the left side rear of the apparatus.

  • Page 31: Filling The Water Bath (708-Ds)

    Setting Up the 708-DS / 709-DS Filling the Water Bath (708-DS) 1 If necessary, press and hold Drive on the Main screen to allow for access to the water bath. 2 Fill the water bath to an appropriate level with purified water, using the label affixed to the bath as a guide.

  • Page 32: Level Instrument - Re-Verification

    Setting Up the 708-DS / 709-DS Level Instrument - Re-verification 1 With the water bath filled (if applicable), re-verify the instrument level front to back and right to left using a bubble or digital level. Heater / Circulator Power-up (708-DS)

  • Page 33: Agilent 708-Ds / 709-Ds Setup

    Setting Up the 708-DS / 709-DS Agilent 708-DS / 709-DS Setup Complete the following sections to set up the Agilent 708-DS / 709-DS. Vessel Isolation Chamber Installation (709-DS) 1 Insert a vessel isolation chamber for each applicable position between the vessel plate and the base plate of the 709-DS.

  • Page 34: Vessel Installation

    3 For the 708-DS vessel, engage the clips for each position over the rim of the vessel to secure it in place. For the 709-DS vessel, open the clip, install the vessel, and close the clip. Ensure the connection pins in the vessel socket are aligned with the CAUTION holes on the vessel.

  • Page 35: Sample Manifold Installation

    Setting Up the 708-DS / 709-DS Sample Manifold Installation 1 From the Main screen, press Menu > Diagnostics. 2 Position the sample manifold so the center screw is aligned with the center receptor beneath the drive unit. Ensure the left and right alignment shafts are also positioned correctly.

  • Page 36: Figure 13 Connecting Autotemp

    Setting Up the 708-DS / 709-DS Figure 13 Connecting AutoTemp 6 If the unit is equipped with autosampling, locate the black sample tubing fasteners and attach the fastener to the sample tubing wrap. 7 If applicable, affix the fasteners to the underside of the drive unit. A fastener is affixed to the left and to the right of the center drive unit lift.

  • Page 37: Accessory Installation

    Figure 14 Affixing the Fasteners Accessory Installation 1 Locate the appropriate accessories from the following list to be configured with the Agilent 708-DS / 709-DS: evaporation covers, Dosage Delivery Modules (DDMs), alignment posts, receptor shafts, paddle shafts, basket shafts, and shaft locking collars.

  • Page 38: Figure 15 Proper Sample Tubing Position

    Setting Up the 708-DS / 709-DS Ensure that all sample tubing is behind the shaft and clear from all NOT E cables. See Figure 15 below. Figure 15 Proper Sample Tubing Position 708-DS / 709-DS Operator’s Manual...

  • Page 39: Figure 16 Installing Evaporation Covers On Shafts

    Setting Up the 708-DS / 709-DS Figure 16 Installing Evaporation Covers on Shafts 5 Place a shaft locking collar on the top of each shaft and slide in down until it rests on top of the drive unit. Figure 17 Shaft Locking Collars...

  • Page 40: Figure 18 Dosage Delivery Module And Alignment Post

    Setting Up the 708-DS / 709-DS 6 Insert a DDM or alignment post into the DDM Alignment Shaft hanging from the underside of the drive unit. Figure 18 Dosage Delivery Module and Alignment Post 708-DS / 709-DS Operator’s Manual...

  • Page 41: Figure 19 Inserting Ddm Into Ddm Alignment Shaft

    Setting Up the 708-DS / 709-DS Figure 19 Inserting DDM into DDM Alignment Shaft 7 Repeat the previous step for all applicable positions. 8 Attach the DDM or alignment post to the evaporation cover by aligning the notch with the locking pin of the cover and pushing until fully seated.

  • Page 42: Figure 20 Attaching Ddm To Alignment Post

    Setting Up the 708-DS / 709-DS Figure 20 Attaching DDM to Alignment Post 9 Repeat the previous step for all applicable positions. 10 Ensure that the sampling port of the evaporation cover is aligned properly with the sample manifold probes, if applicable.

  • Page 43: Setting Basket (Apparatus 1) Heights

    Setting Up the 708-DS / 709-DS Figure 21 Accessory Installation Setting Basket (Apparatus 1) Heights 1 Ensure the drive unit is fully raised and the basket shafts are pushed up sufficiently. 2 Clip the basket height gauge provided onto the bottom of the basket shaft.

  • Page 44: Setting Paddle (Apparatus 2) Heights

    Setting Up the 708-DS / 709-DS Figure 22 Tightening the Shaft Locking Collar 7 Raise the drive unit until sufficient clearance is available to move the basket height gauge to the next position. 8 Repeat steps 2 - 7 for all remaining positions.

  • Page 45: Figure 23 Inserting Height Spheres

    Setting Up the 708-DS / 709-DS Figure 23 Inserting Height Spheres 3 Lower the drive unit to its operating position (until it stops). 4 With the shaft locking collars loosened, carefully lower each shaft until the bottom of the paddle blade rests against the height sphere.
  • Page 46 Setting Up the 708-DS / 709-DS This page was intentionally left blank, except for this message. 708-DS / 709-DS Operator’s Manual...

  • Page 47: Operating The 708-Ds / 709-Ds

    708-DS / 709-DS Dissolution Apparatus Operator’s Manual Operating the 708-DS / 709-DS Main Screen - Options Menu Screen - System Menu General 708-DS / 709-DS Conventions Agilent 708-DS / 709-DS Notifications Agilent Technologies...

  • Page 48: Main Screen - Options

    Operating the 708-DS / 709-DS Main Screen - Options The following sections detail the operations available from the 708-DS / 709-DS Main screen. Main Screen - Display Parameters The Main screen displays the system status and is updated once per second.

  • Page 49: Main Screen - Sample Temperatures

    Operating the 708-DS / 709-DS If the apparatus is in idle mode or running a manual method, press the NOT E area over the displayed RPM to quick-set the spindle speed. Upon pressing this area, the numeric data entry screen displays. Enter a valid number to change the RPM and press Ok to return to the Main screen.

  • Page 50: Main Screen - Run

    Probe temperature and "----". This allows you correct an incorrect temperature entry. If the DVH option is installed (709-DS), pressing Bath Probe results in a beep. The Bath temperature remains displayed as "----". Press Printer to print the temperatures. If no printer is installed, the printer icon is not displayed.
  • Page 51 Operating the 708-DS / 709-DS Run - Select Method (Automated) You can enter up to five automated methods through the Select Method screen. In order to select a method to run, press the number of the method. Selecting a method takes you to the Start Options screen. Press Return to return to the Select Start Type screen.

  • Page 52: Table 1 Method - Start Options

    DVH Preheat This option is enabled for the 709-DS Direct Vessel Heating. Each test will require an initial temperature stabilization if accurate temperatures are desired throughout the test. Remove the check from this box if temperature control is not required (709-DS only).
  • Page 53 A screen will appear prompting the user to begin once vessel temperature has stabilized. Without this option, the test will begin immediately after the preheat cycle (709-DS only). Time Delayed Displays the Date and Time screen. The apparatus begins monitoring appropriate temperatures at the entered time and starts when the selected start condition has been reached.
  • Page 54 Operating the 708-DS / 709-DS Run - Manual Operation (708-DS) Parameter Range Resolution Temperature (Bath or Vessel) 25 - 55 ºC 0.1 ºC Spindle Speed 10.0 - 250.0 RPM 0.1 RPM Media Volume 100 to 2000 mL Depends on configuration...
  • Page 55 Operating the 708-DS / 709-DS The Manual Operation screen allows you to run a manual method. Press the rectangular area following the text description to enter parameters. The Data Entry screen displays, allowing you to enter the data. • Press Cancel to return to the Select Start Type screen without saving the test information.
  • Page 56 Operating the 708-DS / 709-DS • The bath temperature is maintained at the set temperature. If the bath is not at the set temperature when the test is started, the bath temperature is displayed in red while it heats or cools. A Bath Temperature Error (“Bath Temperature Error”...

  • Page 57: Main Screen - Stop

    Operating the 708-DS / 709-DS Main Screen - Stop When the system is running, the Stop button is displayed. When you press Stop, the Pause Method screen displays: When this screen displays, the currently running method or manual test continues to run until you select an option. You have the option of pausing or stopping the test, or canceling this dialog and returning to the 708-DS / 709-DS Operator’s Manual...
  • Page 58 Operating the 708-DS / 709-DS active method. The Pause Method button allows for media change during a dissolution test. If you select Pause Method, the Method Paused screen displays: When a method is paused, the system takes the following actions: •...

  • Page 59: Main Screen - Drive Unit Up / Down

    Operating the 708-DS / 709-DS A corresponding message is also printed for documentation. Clearing the Pause Alarm returns you to the Method Paused screen where you can complete the following tasks. • If installed, the main drive may be raised or lowered.

  • Page 60: Manual Drive Unit Up / Down

    Operating the 708-DS / 709-DS Manual Drive Unit Up / Down The manual lift is controlled by a knob on the right side of the instrument. To adjust the position of the drive unit, loosen the knob and raise or lower to the desired position. Tighten the knob to secure the drive unit in position.

  • Page 61: Manual Sampling

    Operating the 708-DS / 709-DS Manual Sampling If your Agilent 708-DS / 709-DS is not equipped with the Auto Sampling option for unattended sample collection, you will have to retrieve the samples manually. The evaporation cover design provides easy access to the appropriate dissolution sampling zone with the traditional manual sampling cannula.

  • Page 62: Main Screen - Manifold Up / Down

    Operating the 708-DS / 709-DS The various ports of the standard evaporation cover of the Agilent 708-DS / 709-DS are described in the following figure: Figure 27 Agilent 708-DS / 709-DS Standard Evaporation Cover Main Screen - Manifold Up / Down Press Manifold to raise the manifold to its highest position.

  • Page 63: Main Screen - Lock

    Operating the 708-DS / 709-DS Main Screen - Lock In order to lock the instrument, press . The Lock the instrument screen displays. Enter the access code, confirm it, and press Ok. The instrument returns to the Main screen and the Instrument Locked icon is displayed. Further changes to the instrument are prohibited until the instrument is unlocked or the power is cycled.

  • Page 64: Main Screen - Unlock

    Operating the 708-DS / 709-DS Main Screen - Unlock icon indicates that the instrument is currently locked. In order to unlock the instrument, press . The Unlock the instrument screen displays requesting an access code: Enter the access code and press Ok. The instrument returns to the Main screen and displays indicating that the system is unlocked.

  • Page 65: Main Screen - Remote Control

    Operating the 708-DS / 709-DS Main Screen - Remote Control When the unit is being controlled remotely, the words Remote Control flash on the bottom of the screen, the Run / Stop button is not displayed, and the screen is locked. Although all other buttons are displayed, they are disabled.

  • Page 66: Main Screen - Maintenance Due Icon

    Operating the 708-DS / 709-DS When the Timer Alarm duration elapses, an Alarm screen displays to notify the user and an alarm briefly sounds. The screen displays until you press Ok. See “Alarm Time Expired” on page 106 The Timer Alarm is provided as a convenience and does not affect the NOT E running of a manual test or an automated method.

  • Page 67: Menu Screen - System Menu

    Operating the 708-DS / 709-DS Menu Screen - System Menu Press Menu from the Main screen to access the System Menu. The System Menu provides an entry point for setting various system parameters. Each of the different functions available through this screen...

  • Page 68: Menu Screen - Method Editor

    Operating the 708-DS / 709-DS Menu Screen - Method Editor The Method Editor allows you to create a new method, enter new method parameters, or modify an existing method. Forty slots are allocated for storage of methods in system memory. In order to create a new method, select an empty memory slot, which is indicated by dashes in the name field.

  • Page 69: Table 2 Method Properties Screen

    Operating the 708-DS / 709-DS Method Properties Screen 1 Table 2 Method Properties Screen 1 Option Function Name 32-character alphanumeric name used to describe the method. Duration The minimum time the method will take to run. The actual duration will be the value of this field or the sum of the final timepoint and final spin duration, whichever is greater.

  • Page 70: Table 3 Method Properties Screen

    Operating the 708-DS / 709-DS From the Method Properties screen: • Press Clear > Yes to return all method parameters to default values and return to the Select Method screen. • Press Cancel to exit the routine without saving the values and return to the Select Method screen.
  • Page 71 Operating the 708-DS / 709-DS Table 3 Method Properties Screen 2 Option Function DDM Increment This is the time, in seconds, between successive tablet drops. Tablets are dropped starting with position one and continuing through the highest position installed (6 or 8).
  • Page 72 Operating the 708-DS / 709-DS Method Properties Screen 3 Table 4 Method Properties Screen 2 Option Function Enable Manifold Enabling this option activates the optionally installed sampling manifold. The manifold lowers the sampling probes into the solution, allowing automated sample collection as well as the temperature probes for automated temperature measurement.
  • Page 73 Operating the 708-DS / 709-DS Table 4 Method Properties Screen 2 Option Function Enable Sample Enabling this option activates the sample notification dialog as well as Point Alarm activating the audible and visual alarms. This alarm draws the operator to the machine at the timepoint for manual sampling scenarios.
  • Page 74 Operating the 708-DS / 709-DS Method Properties Screen 4 Using this Method Properties screen, you can specify up to twelve time points per test. These points specify when changes in spindle speed, collection of samples, and recording of data occur.
  • Page 75 Operating the 708-DS / 709-DS All time points are relative to the start of the test. A time point of 000:10:00 allows for a sample to be taken 10 minutes after the start of the test. If a second time point is entered as 000:25:00, the next sample point is programmed 25 minutes into the test.
  • Page 76 Operating the 708-DS / 709-DS Method Cancel Dialog The Are you sure? screen displays when Cancel is pressed from one of the Method Properties screens. This option allows you to return to the Method Editor if Cancel is pressed inadvertently.

  • Page 77: Menu Screen - Reports

    Operating the 708-DS / 709-DS Menu Screen - Reports If a printer is installed, check Enable Printer to enable all printer functions. Un-check the box to disable printing. • To print results from the last completed test, press Last Run Results.
  • Page 78 Operating the 708-DS / 709-DS • To print the contents of a method, press Print Method. The Select Method screen displays prompting you to select a method to print: Available methods have a name associated with them. Methods that have not yet been configured have a series of dashes in the name field indicating available memory.
  • Page 79 Operating the 708-DS / 709-DS Press Print Instrument Settings to print all of the instrument configuration parameters and their current values. Press Ok to return to the Menu screen. 708-DS / 709-DS Operator’s Manual...

  • Page 80: Menu Screen - Alarms

    Operating the 708-DS / 709-DS Menu Screen - Alarms Two different alarms are available through the Alarms screen: Table 5 Menu Screen - Alarms Alarm Function Timer This alarm functions as a countdown timer. Enter the duration as HH:MM:SS. Press Ok to start the timer. When the alarm duration expires, the Alarm Time Expired warning displays (“Alarm Time...
  • Page 81 Operating the 708-DS / 709-DS From the Alarms screen: • Press Ok to enable the Timer Alarm and return to the Menu screen. • Press Cancel to discard any changes and return to the Menu screen. 708-DS / 709-DS Operator’s Manual...

  • Page 82: Menu Screen - Instrument

    Operating the 708-DS / 709-DS Menu Screen - Instrument Menu Screen - Instrument Settings Screen 1 Table 6 Menu Screen - Instrument Settings Screen 1 Option Function Tester ID A twelve-character field that helps identify the instrument. The Tester ID is printed out with the other system information during a test.
  • Page 83 Operating the 708-DS / 709-DS Table 6 Menu Screen - Instrument Settings Screen 1 Option Function Date / Time Allows you to set the current date and time as well as set the desired format. Press the date format button to advance the date format to the next available format.
  • Page 84 Operating the 708-DS / 709-DS Menu Screen - Instrument Settings Screen 2 Table 7 Menu Screen - Instrument Settings Screen 2 Option Function Temperature Allowable temperature variation from the set point. When alarms are Tolerances enabled in Instrument Settings, deviations greater than this will cause an alarm but not stop the method.
  • Page 85 Operating the 708-DS / 709-DS From the Instrument Settings screen: • Press Back to return to the previous Instrument Settings screen. • Press Finish to save all settings and return to the Menu screen. • Press Next to advance to the next Instrument Settings screen.
  • Page 86 Operating the 708-DS / 709-DS Menu Screen - Instrument Settings Screen 4 Table 9 Menu Screen - Instrument Settings Screen 3 Option Function Bath Heating Enable this option to program the power-save feature for the Energy Save heater/circulator (708-DS only). Heater/circulator on and off times can be specified to conserve energy and reduce stress on the components of the unit.

  • Page 87: Menu Screen - Calibration

    Operating the 708-DS / 709-DS Menu Screen - Calibration Menu Screen - Calibration Screen 1 The Calibration screen allows you to fine-tune the height of the manifold for Apparatus 1 (Baskets) and Apparatus 2 (Paddles). The volumes shown change based on the installed vessel size set in Instrument Setting Screen 2 (“Menu Screen - Instrument Settings...
  • Page 88 Operating the 708-DS / 709-DS Each of the gray boxes contains a numeric value. The value is the sampling location of the manifold as measured from its home position. These values range from 0 at home to 999 at the manifold's lowest position.
  • Page 89 Operating the 708-DS / 709-DS Menu Screen - Calibration Screen 2 Calibration and Preventative Maintenance due dates may be entered on the Regulatory Calibration Date screen. A reminder displays over the Main screen to indicate that calibration or maintenance is required. You must develop your own Calibration and Preventative Maintenance schedules.

  • Page 90: Menu Screen - Diagnostics

    Operating the 708-DS / 709-DS Menu Screen - Diagnostics Menu Screen - Diagnostics Screen 1 Table 10 Menu Screen - Diagnostics Screen 1 Option Function Spindle Allows control of the spindle. Press the block next to Run and enter the desired RPM.
  • Page 91 Operating the 708-DS / 709-DS Table 10 Menu Screen - Diagnostics Screen 1 Option Function Manifold Control The manifold may be ejected for cleaning and maintenance. Before ejecting, raise the head, disconnect the two thermistor cables, remove the tubing from the tubing clamps, and remove the evaporation covers.
  • Page 92 Operating the 708-DS / 709-DS Menu Screen - Diagnostics Screen 2 Table 11 Menu Screen - Diagnostics Screen 2 Option Function Print Test Sheet Sends a test message to the printer. A printer is required for this option. Opens a new window with the operational parameters of the Direct Vessel Heating module.

  • Page 93: Table 12 Diagnostics - Dvh Diagnostics Screen 1

    Operating the 708-DS / 709-DS Diagnostics - DVH Diagnostics Screen 1 When a self test is requested, a green check mark displays as each vessel passes the self test. If a self test fails, a red X displays. On systems with less than 8 vessels installed, the extra positions remain blank.
  • Page 94 Operating the 708-DS / 709-DS Diagnostics - DVH Diagnostics Screen 2 The DVH screen displays a button for each vessel position. If Test Single Vessel Lower heater was selected on the previous screen, press a button to turn on the lower heater for a vessel. If Test Single Vessel Both heaters was selected on the previous screen, press a button to turn on both heaters.

  • Page 95: Menu Screen - User Access

    Operating the 708-DS / 709-DS Menu Screen - User Access You can use user levels to restrict changes to specific instrument settings and method parameters. Three levels of access are provided: • Administrator • Advanced User • User You can customize each user access level, but changes can only be made NOT E when the instrument is in Administrator mode.

  • Page 96: General 708-Ds / 709-Ds Conventions

    Operating the 708-DS / 709-DS General 708-DS / 709-DS Conventions Alphanumeric Data Entry The Data Entry screen acts as on-screen keyboard for the instrument. The left arrow functions as a backspace key. Spaces, periods, and dashes are provided as usable characters.

  • Page 97: Numeric And Time / Date Entry

    Operating the 708-DS / 709-DS Numeric and Time / Date Entry This screen is a specialized subset of the alphanumeric data entry screen. It has been optimized for numeric, date, and time data entry. As keys are pressed, they display in the upper box of the display. The valid data entry range and the previous data entry will be shown just below the display.

  • Page 98: Parameter Limits / Ranges

    Operating the 708-DS / 709-DS Parameter Limits / Ranges Table 14 Parameter Limits / Ranges Parameter Range Resolution Configured Spindle Speed 10.0 - 250.0 RPM 0.1 RPM “Main Screen - Display Parameters” on page 48 “Run - Manual Operation (708-DS)”...

  • Page 99: Table 4. Method Properties Screen

    Operating the 708-DS / 709-DS Table 14 Parameter Limits / Ranges Parameter Range Resolution Configured Manifold Lead 000:00:00 to 1 second “Method Properties Screen 3” on page 72 Time 000:01:00 Sample Point 000:00:05 to 1 second “Method Properties Screen 3”...

  • Page 100: Agilent 708-Ds / 709-Ds Notifications

    Operating the 708-DS / 709-DS Agilent 708-DS / 709-DS Notifications Main Screen - Error Conditions Tolerance limit monitoring is enabled when the spindle starts moving and the bath starts heating. Any fluctuations beyond the tolerance limits cause the corresponding displayed value to turn from blue to red and a dialog box with the corresponding error message to be displayed.
  • Page 101 Operating the 708-DS / 709-DS If an error occurs during a test, you must clear the error screen manually. Clearing the error screen also clears the audible alarm. If a printer is installed and alarms are enabled in the Instrument Settings, the error condition is printed for record keeping.

  • Page 102: Dialog Screens (Green / Blue)

    Operating the 708-DS / 709-DS Dialog Screens (Green / Blue) Table 15 Dialog Screens (Green / Blue) Delayed Start Dialog The Delayed Start screen displays when a delayed start time has been entered (“Method - Start Options” on page 52). The date and time when the method starts is displayed on the screen.
  • Page 103 Operating the 708-DS / 709-DS Table 15 Dialog Screens (Green / Blue) Staggered Manual Drops The Staggered Manual Drops screen provides a visual indication of when to drop tablets for manual introduction. Preheat Complete Displays when the preheat process has completed.

  • Page 104: Warning Screens (Yellow)

    Operating the 708-DS / 709-DS Warning Screens (Yellow) Table 16 Warning Screens (Yellow) Instrument Calibration Due This Service Due warning displays when the instrument is due for calibration (“Menu Screen - Calibration Screen 1” on page 87). Press Ok to clear the warning.
  • Page 105 Operating the 708-DS / 709-DS Table 16 Warning Screens (Yellow) Load Dosage Prompt This first warning displays when Apparatus 2 (paddle) or Apparatus 5 (paddle over disk) are being used. It indicates that it is time to lower the samples into the vessels. Press Ok to clear the dialog and continue the run.
  • Page 106 Operating the 708-DS / 709-DS Table 16 Warning Screens (Yellow) Instantaneous Spindle Speed Jump If the spindle speed varies by more than 2% over a 40-msec interval, the Spindle Speed Warning screen displays. Caution (Stop): The most common cause of this error is a shaft being held while performing diagnostics.
  • Page 107 Operating the 708-DS / 709-DS Table 16 Warning Screens (Yellow) Out of Paper Notification This warning is applicable to systems with a printer installed. This warning does not interrupt a running method. If the printer runs out of paper during a run (“Printer Maintenance”...
  • Page 108 Operating the 708-DS / 709-DS Table 16 Warning Screens (Yellow) Lower Drive Unit Notification Displays on systems with manual drive units. It indicates that the drive unit must be fully lowered before any testing may proceed (“Manual Drive Unit Up / Down”...

  • Page 109: Error Screens (Red)

    Operating the 708-DS / 709-DS Error Screens (Red) Table 17 Error Screens (Red) Parameter Out of Range The Parameter Out of Range error displays when a parameter has been entered that is outside the valid range. The range minimum and range maximum are displayed.
  • Page 110 Operating the 708-DS / 709-DS Table 17 Error Screens (Red) Timepoint Overlap Error The Timepoint Overlap error screen displays when the time point start times entered do not provide sufficient time for all operations to perform before the next time point is due. This error typically occurs when the manifold lead time plus the manifold down time exceeds the time point interval.
  • Page 111 Operating the 708-DS / 709-DS Table 17 Error Screens (Red) Bath Heater Error The Bath Error - Heater Disabled screen shows all of the possible errors associated with the bath heater and the bath probe. A red X displays before the current error condition. If a bath heater error is encountered, the current running method is not stopped and you are given the option of correcting the error and continuing the test.
  • Page 112 Operating the 708-DS / 709-DS Table 17 Error Screens (Red) Spindle Speed Error This Spindle Error screen displays when the spindle speed has exceeded the allowable tolerance range (“Menu Screen - Instrument Settings Screen 2” on page 84). Press Ok to resume the test and send a message to the printer, if installed.
  • Page 113 Operating the 708-DS / 709-DS Table 17 Error Screens (Red) DVH Communications Error (709-DS) DVH communication is tested at the beginning of each method or manual test start (“Main Screen - Run” on page 50). A DVH Communication Error displays when a communications error has been detected.
  • Page 114 Operating the 708-DS / 709-DS This page was intentionally left blank, except for this message. 708-DS / 709-DS Operator’s Manual...

  • Page 115: Maintenance And Troubleshooting

    708-DS / 709-DS Dissolution Apparatus Operator’s Manual Maintenance and Troubleshooting Preventive Maintenance Sample Line / Paddle / Basket Care Vessels and Evaporation Covers Water Bath and Temperature Probes (708-DS) Manifold Maintenance Accessing the Top Cover Printer Maintenance Agilent Technologies...

  • Page 116: Preventive Maintenance

    A small dusting of belt material may be found on the motor plate. This NOT E is normal and not a cause for concern. 3 Check that the spring-loaded belt tensioner is maintaining pressure on the belt and is not loose. 708-DS / 709-DS Operator’s Manual...

  • Page 117: Sample Line / Paddle / Basket Care

    • Use care when removing vessels from the apparatus while the paddles or basket shafts are installed so that you do not bump them. • When attaching or removing baskets, do not bend the clips excessively. 708-DS / 709-DS Operator’s Manual...

  • Page 118: Baskets

    • Use caution when handling baskets. It is important that they retain their cylindrical shape, so take care not to kink or bend the mesh. Check frequently to ensure that the mesh is completely open and that there are no rips or tears. 708-DS / 709-DS Operator’s Manual...

  • Page 119: Rinsing Sample Lines

    2 Activate the pumping mechanism to properly flush the tubing lines. Rinse Tray 1 Raise the drive unit of the 708-DS / 709-DS to its maximum height. 2 Push each shaft up to provide clearance for the rinse tray. Do not rotate the shafts with the shafts pushed up. This could cause NOT E damage to the cannulas / probes on the sampling manifold.

  • Page 120: Rinse Cups (Optional)

    Maintenance and Troubleshooting 6 Carefully lower the drive unit of the 708-DS / 709-DS until each sample cannula is submerged in the cleaning solution of the rinse tray. 7 Activate the pump configured with the system until the tubing is sufficiently cleansed.
  • Page 121 3 Activate the pump configured with the system until the tubing loop is sufficiently cleansed. 4 Finally, detach the rinse cups, place them in their transport tray, dispose of the waste, and rinse the cups to be ready for their next use. 708-DS / 709-DS Operator’s Manual...

  • Page 122: Vessels And Evaporation Covers

    DVH vessel should it become accidentally broken or damaged during use. The vessel utilizes a Noryl collar and a PVC coating to properly align the vessel within the 709-DS as well as protect the electronic components. Although these materials have excellent thermal, electrical and chemical resistance;...

  • Page 123: Water Bath And Temperature Probes (708-Ds)

    7 Reinstall and tighten the bulkhead fitting to the bath and / or screw in the elbow or T-fitting, depending on whether it’s an inlet or outlet. 8 Fill the bath with water and inspect for leaks. If it’s still leaking, contact Technical Service. 708-DS / 709-DS Operator’s Manual...
  • Page 124 Temperatures between the values listed may be interpolated. 4 Probes are interchangeable and manufactured with a tolerance of +/- 0.1 °C. Probes found to be outside of the tolerance of +/- 0.1 °C should be replaced. 708-DS / 709-DS Operator’s Manual...

  • Page 125: Figure 29 Resistance Value Of Temperature Probe

    Maintenance and Troubleshooting Figure 29 Resistance Value of Temperature Probe 708-DS / 709-DS Operator’s Manual...

  • Page 126: Removing Or Adjusting Cannulas / Probes

    / probe accordingly. Manifold Maintenance Removing the Manifold The manifold of the Agilent 708-DS / 709-DS is installed and removed with the touch of a button. The initial installation procedure is described “Sample Manifold Installation”...

  • Page 127: Accessing The Top Cover

    2 Press the cover down into place, aligning the front holes with the respective dosage delivery module (DDM) openings, and slipping over the left-hand power switch. 3 Re-fasten the cover screws. 708-DS / 709-DS Operator’s Manual...

  • Page 128: Printer Maintenance

    Replacement is recommended when the red line is visible. If the paper roll is not changed and the paper supply is exhausted, the 708-DS / 709-DS gets an out-of-paper signal from the printer, and displays an error on the screen.

  • Page 129: Figure 31 Accessing The Printer Handle

    1 Place fingers underneath the light-colored handle and pull forward to pop out the front of the printer. Figure 31 Accessing the Printer Handle Opening the chamber reveals the paper roll or empty core inside. Figure 32 Open Printer Chamber 708-DS / 709-DS Operator’s Manual...

  • Page 130: Inserting A Thermal Paper Roll (5095-0307)

    2 Internal side levers hold the roll in place. Since it is empty or nearly empty, use your fingers to pull out the small roll or core. The empty core is disposable. Each new roll includes a cardboard core. NOT E Figure 33 Removing the Thermal Paper Roll 708-DS / 709-DS Operator’s Manual...

  • Page 131: Figure 34 Inserting A Thermal New Paper Roll

    Figure 34 Inserting a Thermal New Paper Roll 2 Lead the paper out for a few inches and close the top lid of the chamber. 708-DS / 709-DS Operator’s Manual...

  • Page 132: Figure 35 Leading Paper And Closing The Lid

    4 To verify that the paper is not skewed or jammed, press the upper-right hand button on the printer to feed some paper. If paper does not feed, re-open the chamber and re-center the paper. 708-DS / 709-DS Operator’s Manual...

  • Page 133: Figure 37 Feeding Paper

    Maintenance and Troubleshooting Figure 37 Feeding Paper 708-DS / 709-DS Operator’s Manual...

  • Page 134: Thermal Printer Test

    Maintenance and Troubleshooting Thermal Printer Test In the second Diagnostics screen, press Print Test Sheet to print sample text and verify the printer is functioning properly. Figure 38 Printer Test 708-DS / 709-DS Operator’s Manual...

  • Page 135: Obtaining Warranty And Other Services

    To place a service order (warranty or other services), please contact your local Customer Care Center. Contact information can be found at www.agilent.com under your country using the Contact Us link. Place your service request using the displayed phone number or E-mail address. 708-DS / 709-DS Operator’s Manual...
  • Page 136 Maintenance and Troubleshooting 708-DS / 709-DS Operator’s Manual...

  • Page 137: Index

    EVT Probe Paddle, Installation, Sample Line, Water Bath, Clearance, Conventions, 17, Data Entry Alphanumeric, Dialog Delayed Start, Delayed Start Date / Time, Method Completion, Time Point Approaching, Dialog Screens, Entry Numeric and Time / Date, Equipment, 708-DS / 709-DS Operator’s Manual...
  • Page 138 Stop, Removing the Apparatus, Screen 1, Unlock, Removing the Paper Roll, Screen 3, Resistance Value of Temperature Screen 4, Probe, Rinse Cup, Shaft Locking Collars, Taking a Manual Sample, Notifications, Tightening the Shaft Locking Collar, 708-DS / 709-DS Operator’s Manual...
  • Page 139 Temperature Probe Open, (Apparatus I), Temperature Sampling Setting Paddle Heights Notification, (Apparatus II), Water Bath Setup, Filling, Water Bath Setup, Temperature Probe Installation, Temperature Probes, Top Cover Accessing, Removing, Replacing, Tubing, Unpacking Procedure, Vessel Installation, 708-DS / 709-DS Operator’s Manual...
  • Page 140 Index This page was intentionally left blank, except for this message. 708-DS / 709-DS Operator’s Manual...

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