cytiva Chromaflow 50 Operating Instructions Manual
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cytiva Chromaflow 50 Operating Instructions Manual

cytiva Chromaflow 50 Operating Instructions Manual

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Chromaflow Packing Station
50, 100, 200, and 400
Operating Instructions
Original instructions
cytiva.com

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Summary of Contents for cytiva Chromaflow 50

  • Page 1 Chromaflow Packing Station 50, 100, 200, and 400 Operating Instructions Original instructions cytiva.com...

  • Page 2: Table Of Contents

    Table of Contents Table of Contents Introduction ......................4 About this manual ............................5 Important user information ........................6 Associated documentation ........................8 Safety instructions ..................... 9 Safety precautions ............................10 Labels ................................. 16 Emergency procedures ..........................18 System description .................... 22 Chromaflow Packing Station main components ................
  • Page 3 Table of Contents Noise level ................................. 86 Recycling information ..........................87 Regulatory information ..........................88 8.5.1 Contact information ............................ 89 8.5.2 European Union and European Economic Area ................90 8.5.3 Other regulations and standards ......................91 Health and Safety Declaration Form ...................... 92 Further information ............................

  • Page 4: Introduction

    1 Introduction Introduction About this chapter This chapter contains important user information, descriptions of safety notices, regu- latory information, intended use of Chromaflow™ Packing Station, and a list of associ- ated documentation. In this chapter Section See page About this manual Important user information Associated documentation Chromaflow Packing Station 50, 100, 200, and 400 Operating Instructions 29046228 AD...

  • Page 5: About This Manual

    For detailed information about each individual Chromaflow Packing Station refer to the relevant information in the documentation package provided with each product. Contact your local Cytiva representative for more information, if needed. Typographical conventions Software items are identified in the text by bold italic text.

  • Page 6: Important User Information

    1 Introduction 1.2 Important user information Important user information Read this before operating the product All users must read the entire Operating Instructions before installing, oper- ating or maintaining the product. Always keep the Operating Instructions at hand when operating the product. Do not operate the product in any other way than described in the user documenta- tion.
  • Page 7 1 Introduction 1.2 Important user information WARNING WARNING indicates a hazardous situation which, if not avoided, could result in death or serious injury. It is important not to proceed until all stated conditions are met and clearly understood. CAUTION CAUTION indicates a hazardous situation which, if not avoided, could result in minor or moderate injury.

  • Page 8: Associated Documentation

    1 Introduction 1.3 Associated documentation Associated documentation Introduction This section describes the documentation associated with your Chromaflow Packing Station. Product specific documentation In addition to the Operating Instructions manual, the documentation package supplied with each Chromaflow Packing Station also includes detailed specifications and trace- ability documents.

  • Page 9: Safety Instructions

    2 Safety instructions Safety instructions About this chapter This chapter describes safety precautions and emergency shutdown procedures for your Chromaflow Packing Station. The labels on the instrument and information regarding recycling are also described. In this chapter Section See page Safety precautions Labels Emergency procedures...

  • Page 10: Safety Precautions

    WARNING Use only approved parts. Only spare parts and accessories that are approved or supplied by Cytiva may be used for maintaining or servicing the product. Chromaflow Packing Station 50, 100, 200, and 400 Operating Instructions 29046228 AD...
  • Page 11 2 Safety instructions 2.1 Safety precautions Flammable liquids and explosive environment WARNING Flammable liquids. This product is not approved for handling liquids under flammable conditions. Make sure to use liquids only under conditions where they are not flammable. Refer to local and/or national classifications of flammable liquids.
  • Page 12 2 Safety instructions 2.1 Safety precautions CAUTION Use ear protection whenever working close to the system in opera- tion. Installing and moving WARNING Heavy object. Because of the significant weight of Chromaflow Packing Station, care must be taken not to cause squeezing or crushing injuries during movement.
  • Page 13 2 Safety instructions 2.1 Safety precautions CAUTION Do not turn on the air supply before all connections have been made and checked. NOTICE The system is not fitted with lifting eye bolts or other equipment for lifting with telphers or similar equipment. The system should only be lifted using the lower part of the frame.
  • Page 14 2 Safety instructions 2.1 Safety precautions WARNING Use columns that withstand expected pressures. Always use appropriate pressure alarms, pressure vents or rupture discs, and safety equipment. If not, the columns might rupture, resulting in injury. CAUTION Reduce the pump setting prior to using the START/RESET button, to avoid an immediate high pressure increase in the system when it is reactivated.
  • Page 15 2 Safety instructions 2.1 Safety precautions WARNING Do not perform any type of service while Chromaflow Packing Station is connected to an air supply. WARNING Decontaminate before maintenance. To avoid personnel being exposed to potentially hazardous substances, make sure that the column is properly decontaminated and sanitized before mainte- nance or service.

  • Page 16: Labels

    2 Safety instructions 2.2 Labels Labels Introduction This section describes the labels and symbols on your Chromaflow Packing Station. System label The system label is located on the back of the equipment. The system label identifies the equipment and shows electrical data, regulatory compliance, and warning symbols.
  • Page 17 2 Safety instructions 2.2 Labels Symbol/text Description Warning! Read the user documentation before using the system. Do not open any covers or replace parts unless specifically stated in the user documentation. EMERGENCY STOP label, yellow with black text. (EMER- GENCY STOP button is red). Section 2.3 Emergency procedures, on page 18 further information regarding the emergency stop.

  • Page 18: Emergency Procedures

    2 Safety instructions 2.3 Emergency procedures Emergency procedures Introduction This section describes how to perform an emergency shutdown and the procedure for restarting Chromaflow Packing Station following an emergency shutdown. Precautions WARNING Pressure may remain in the column and tubing for an extended period after shutdown.
  • Page 19 Depressurize the lines and vessels that are under pressure. This is done by opening valves and disconnecting hoses carefully. Diagnose and remedy the root cause of the problem. Contact Cytiva if the problem cannot be solved. Restart after emergency shutdown Follow the instruction below to restart a Chromaflow Packing Station after emergency shutdown.
  • Page 20 2 Safety instructions 2.3 Emergency procedures Step Action Make sure that the condition that caused the emergency stop is corrected. Reset the EMERGENCY STOP button by turning it clockwise. Chromaflow Packing Station 50, 100, 200, and 400 Operating Instructions 29046228 AD...
  • Page 21 2 Safety instructions 2.3 Emergency procedures Step Action Reduce the pump setting and press the START/RESET button on the lower control panel. WARNING Reduce the pump setting prior to using the START/ RESET button, to avoid an immediate high pressure increase in the system when it is reactivated.

  • Page 22: System Description

    3 System description System description About this chapter This chapter provides a description of the Chromaflow Packing Station. In this chapter Section See page Chromaflow Packing Station main components Control panels Flowchart Chromaflow Packing Station 50, 100, 200, and 400 Operating Instructions 29046228 AD...

  • Page 23: Chromaflow Packing Station Main Components

    3 System description 3.1 Chromaflow Packing Station main components Chromaflow Packing Station main components Introduction This section describes important features of Chromaflow Packing Station. Overview The Chromaflow Packing Station is a semi-automatic packing station designed to be used with Chromaflow columns. Using a Chromaflow Packing Station together with a Chromaflow column reduces operator time and simplifies column priming, packing and unpacking.
  • Page 24 3 System description 3.1 Chromaflow Packing Station main components Chromaflow Packing Station 50, 100, 200, and 400 Operating Instructions 29046228 AD...
  • Page 25 3 System description 3.1 Chromaflow Packing Station main components Important features and connection points The following illustration shows a schematic overview of a Chromaflow Packing Statio n and indicates the locations of important features and connection points. Part Function Upper control Allows the operator to control flow paths and displays panel information about air pressure and flow of buffer and...
  • Page 26 3 System description 3.1 Chromaflow Packing Station main components Part Function Connects to column SIB. Slurry inlet bottom (SIB) Connects to column SOB. Slurry outlet bottom (SOB) Inlet C Connects to slurry tank. (The slurry tank is denoted SLURRY on the upper control panel.) Outlet D Connects to waste collection tank.

  • Page 27: Control Panels

    3 System description 3.2 Control panels Control panels Introduction This section describes the control panels that operate your Chromaflow Packing Station. The upper control panel provides a view of the flow scheme and has a gauge showing the packing pump air pressure. It also provides the ability to toggle the flow path between inlets B and C, and between column SIT and SIB.
  • Page 28 3 System description 3.2 Control panels Part Function Packing buffer flow path Indicates that the flow pathway from the PACKING BUFFER tank to the packing pump indicator is open. Three way valve control Turn this switch to choose buffer, slurry or switch shut-off.
  • Page 29 3 System description 3.2 Control panels Part Function Slurry outlet bottom Slurry outlet top PACKING BUFFER Buffer/water tank PACKING PUMP Pumps fluids towards the column UNPACKING PUMP Pumps fluids from the column Lower control panel - sizes 50, 100 and 200 The table below describes the lower control panel functions.
  • Page 30 3 System description 3.2 Control panels Part Function EMERGENCY Press to stop operation immediately in an emergency STOP situation. For more information see Section 2.3 Emer- gency procedures, on page FINE ADJUST- Used to make fine-scale adjustments to the packing MENT PACKING pump air pressure.
  • Page 31 3 System description 3.2 Control panels Lower control panel - size 400 The table below describes the lower control panel functions. Part Function AIR SUPPLY 0 (off) or I (on) switch for activation or deactivation of PACKING PUMP air supply to the packing pump. START/RESET Press to restart after an emergency stop or after loss of pneumatic feed.
  • Page 32 3 System description 3.2 Control panels Part Function TOP NOZZLE Used to move the top nozzle to the following posi- tions: • Run (set the switch to RUN) • Pack (set the switch to PACK) • Unpack (set the switch to UNPACK) Note: Only applicable for automatic nozzles.

  • Page 33: Flowchart

    3 System description 3.3 Flowchart Flowchart Introduction This section explains how your Chromaflow Packing Station connects buffer, slurry and waste collection tanks to a column to perform priming, packing and unpacking opera- tions. Configuration flowchart - all sizes PACKING BUFFER XV-022A XV-021A COLUMN...
  • Page 34 3 System description 3.3 Flowchart NOTICE The pressure safety equipment indicated in red in the diagram above is not provided as part of the Chromaflow Packing Station delivery. The diagram indicates the recommended placement of suitable pressure safety equipment when connecting a Chromaflow Packing Station to a column to perform chromatog- raphy resin packing, unpacking or cleaning.
  • Page 35 3 System description 3.3 Flowchart Part Function UNPACKING PUMP Pumps fluids from the column (P-202) XV-021A PACKING BUFFER valve XV-021C SLURRY valve XV-022A SIT valve XV-022C SIB valve Chromaflow Packing Station 50, 100, 200, and 400 Operating Instructions 29046228 AD...

  • Page 36: Installation

    4 Installation Installation About this chapter This chapter provides required information to enable users and service personnel to unpack, install, move and transport Chromaflow Packing Station. In this chapter Section See page Site requirements Transport in crate Unpack from the crate Transport when unpacked Setup Precautions...
  • Page 37 4 Installation WARNING Only personnel with appropriate training may move and unpack the delivery crates. All movement and unpacking must be performed in adherence with local regulations. Even if the instructions in the user documentation and instruction manuals are followed, it is the customers' responsibility to guar- antee the safety of the personnel working with the product.

  • Page 38: Site Requirements

    4 Installation 4.1 Site requirements Site requirements Space and floor load For space and floor requirement, see external dimensions and weights in Section 8.1 Specifications, on page • Make sure that the floor can handle the weight of the Chromaflow Packing Station. Note that for the weight to be equally distributed over all wheels, the floor must be level and without irregularities.

  • Page 39: Transport In Crate

    4 Installation 4.2 Transport in crate Transport in crate Precautions WARNING Heavy object. Because of the significant weight of Chromaflow Packing Station, care must be taken not to cause squeezing or crushing injuries during movement. Instructions • Use a pallet jack or forklift with a minimum capacity to match the empty weight of the equipment plus the transport box.

  • Page 40: Unpack From The Crate

    • Check that the equipment for any apparent damage. Document any found damage carefully. If any equipment is missing or damage is found, contact your Cytiva representative. Unpacking instructions Follow the instructions below to unpack the Chromaflow Packing Station from the transport crate.
  • Page 41 4 Installation 4.3 Unpack from the crate Step Action Use the 10 mm wrench or power tool to unscrew all of the bolts encircled with black paint (indicated by circles in the image) around the lid of the crate. Lift and remove the top lid. Locate the three top support beams and unscrew the marked bolts fastening the beams on the outside of the crate (indicated by arrows in the image).
  • Page 42 4 Installation 4.3 Unpack from the crate Step Action Unscrew the marked bolts from the bottom front support beam (indicated by arrows in the image) holding the Chromaflow Packing Station in place. Chromaflow Packing Station 50, 100, 200, and 400 Operating Instructions 29046228 AD...
  • Page 43 4 Installation 4.3 Unpack from the crate Step Action Use a forklift to remove Chromaflow Packing Station from the transport crate. Insert the forks as shown in the following illustration. NOTICE Place a soft material between the forks of the forklift and the Chromaflow Packing Station frame during lifting operations to help prevent damage to the surfaces.
  • Page 44 4 Installation 4.3 Unpack from the crate Step Action NOTICE The system is not fitted with lifting eye bolts or other equipment for lifting with telphers or similar equipment. Lift by placing lifting equipment under the lower part of the frame. Place the Chromaflow Packing Station on a level surface.

  • Page 45: Transport When Unpacked

    4 Installation 4.4 Transport when unpacked Transport when unpacked Precautions WARNING Heavy object. Because of the significant weight of Chromaflow Packing Station, care must be taken not to cause squeezing or crushing injuries during movement. Instructions • Your Chromaflow Packing Station can be rolled by hand on hard and level surface with the wheel brakes released.

  • Page 46: Setup

    4 Installation 4.5 Setup Setup Introduction This section describes the steps that need to be taken to set up a Chromaflow Packing Station before use. In this section Section See page 4.5.1 Set up your Chromaflow Packing Station 4.5.2 Connect compressed air supply 4.5.3 Guidelines for connections 4.5.4...

  • Page 47: Set Up Your Chromaflow Packing Station

    4 Installation 4.5 Setup 4.5.1 Set up your Chromaflow Packing Station 4.5.1 Set up your Chromaflow Packing Station Introduction This section describes the steps that need to be performed prior to operating your Chromaflow Packing Station. Physical installation Each Chromaflow Packing Station is delivered fully assembled. The Chromaflow Packing Station is equipped with wheels that allow it to be easily rolled to its desig- nated location of use.

  • Page 48: Connect Compressed Air Supply

    4 Installation 4.5 Setup 4.5.2 Connect compressed air supply 4.5.2 Connect compressed air supply Introduction This section describes how to connect the compressed air supply. For air supply requirements refer to Section 8.1 Specifications, on page Connect compressed air supply to the Chromaflow Packing Station Step Action...

  • Page 49: Guidelines For Connections

    4 Installation 4.5 Setup 4.5.3 Guidelines for connections 4.5.3 Guidelines for connections Introduction This section provides guidelines for the connection of process components to the Chromaflow Packing Station. General guidelines for connections • Use non-collapsible piping or tubing that has an internal diameter sufficient for the flow rate specified.

  • Page 50: Grounding Connection

    4 Installation 4.5 Setup 4.5.4 Grounding connection 4.5.4 Grounding connection Grounding point Use a grounding wire connected from the plant grounding network to the Chromaflow Packing Station grounding point. The grounding point is located on one outer corner of the skid, as shown in the following illustration. The location of the grounding point is also indicated on the skid by a grounding label.

  • Page 51: Connect A Column

    If there is any question about safety concerning the intended setup, please contact your Cytiva representative for clarification. Chromaflow Packing Station 50, 100, 200, and 400 Operating Instructions 29046228 AD...
  • Page 52 4 Installation 4.5 Setup 4.5.5 Connect a column Connect a column Follow the diagram and instructions below to connect a column to a Chromaflow Packing Station. PACKING BUFFER XV-022A XV-021A COLUMN SLURRY PACKING PUMP P-201 XV-022C XV-021C UNPACKING PUMP P-202 COLLECTION EXTENT OF PACKING STATION Note:...
  • Page 53 4 Installation 4.5 Setup 4.5.5 Connect a column Step Action Connect outlet SIT on the Chromaflow Packing Station to the column SIT. Connect outlet SIB on the Chromaflow Packing Station to the column SIB. Connect outlet SOB on the Chromaflow Packing Station to the column SOB. Note: Check the inner diameter of the tubing connected to the column and the Chromaflow Packing Station.
  • Page 54 4 Installation 4.5 Setup 4.5.5 Connect a column COLUMN NOTICE The pressure safety equipment indicated in blue in the diagram above is not provided as part of the Chromaflow Packing Station delivery. The diagram indicates the recommended placement of suitable pressure safety equipment when connecting a column to a system to perform chromatography applications, or to perform sanitization-in-place.
  • Page 55 4 Installation 4.5 Setup 4.5.5 Connect a column PSV-371 XV-022A COLUMN PACKING PUMP P-201 XV-022C UNPACKING PUMP P-202 EXTENT OF PACKING STATION NOTICE The pressure safety equipment indicated in blue in the diagram above is not provided as part of the Chromaflow Packing Station delivery.

  • Page 56: Operation

    These particular steps are part of a general procedure suggested by Cytiva, although modifications can be made to these instructions that do not need a pressure gauge. To order a pressure gauge, contact your Cytiva representative. In this chapter...
  • Page 57 5 Operation WARNING Never exceed the operating limits stated in this document and on the system label. Operation of the product outside these limits can damage equipment and cause personal injury or death. WARNING Only personnel with appropriate training may move and unpack the delivery crates.

  • Page 58: Prepare Your Chromaflow Packing Station

    5 Operation 5.1 Prepare your Chromaflow Packing Station Prepare your Chromaflow Packing Station Introduction This section describes the steps that should be performed to prepare your Chromaflow Packing Station for operation. Prerequisites Before your Chromaflow Packing Station is taken into operation, make sure that all procedures in the following chapters and sections have been performed: •...

  • Page 59: Final Actions Before Operating

    5 Operation 5.1 Prepare your Chromaflow Packing Station 5.1.1 Final actions before operating 5.1.1 Final actions before operating Introduction This section outlines important actions that should be performed before starting your Chromaflow Packing Station. Protection from high pressure Protection of the column from overpressure can be accomplished, for example, by adding a relief valve or burst disc before the column.

  • Page 60: Priming

    Various procedures are available for priming your Chromaflow Packing Station and the connected column. For more information about column priming, refer to the user documentation for your column. If further instructions are needed, please contact your local Cytiva representative. Chromaflow Packing Station 50, 100, 200, and 400 Operating Instructions 29046228 AD...

  • Page 61: Pack A Column

    Chromaflow columns can be packed via the bottom (upflow) or top (downflow) nozzle. For detailed information about column packing, refer to the user documentation for your column. If further instructions are needed, please contact your local Cytiva repre- sentative. Precautions WARNING Use columns that withstand expected pressures.

  • Page 62: Unpack A Column

    For more information about column unpacking, refer to the user documentation for your column. If further instructions are needed, please contact your local Cytiva repre- sentative. Chromaflow Packing Station 50, 100, 200, and 400 Operating Instructions 29046228 AD...

  • Page 63: Disconnection After Use

    5 Operation 5.4 Disconnection after use Disconnection after use Introduction This section describes how to disconnect your Chromaflow Packing Station from the column after column priming, packing or unpacking. After use Your Chromaflow Packing Station should be flushed and rinsed carefully and directly after use to make sure that no adsorbent remains.

  • Page 64: Maintenance

    Each Chromaflow Packing Station is designed to require a minimum of service and maintenance. The operator is only permitted to perform the maintenance procedures as described in this chapter. For other maintenance work, contact your local Cytiva representative. For information about ordering spare parts, contact your local Cytiva representative.
  • Page 65 6 Maintenance WARNING For continued protection against injury risks due to fluid jets or burst pipes, the piping system must be tested for leakage at maximum pressure when the following situations apply: • After assembly or maintenance • Before operation or Cleaning-In-Place (CIP) WARNING LOCK OUT / TAG OUT (LOTO)! Before any maintenance or decommissioning work is performed on the system, make sure...

  • Page 66: User Maintenance Schedule

    Chromaflow Packing Station. It is however recommended that trained and certified personnel perform a preventive maintenance test procedure annually on all instruments, pumps and valves. Contact your local Cytiva representative for more information about available preventive maintenance agreements.
  • Page 67 6 Maintenance 6.1 User maintenance schedule Component Action Connections and Check for leakage. Replace seals if needed. Carry out a seals leakage test at maximum operating pressure. Maintenance annually or as needed The table below lists maintenance actions that are required annually or as needed. Component Action Pump...

  • Page 68: Cleaning

    For more information about cleaning the connected column, refer to the user docu- mentation for your column. If further instructions are needed, contact your local Cytiva representative. Precautions...
  • Page 69 6 Maintenance 6.2 Cleaning WARNING Hazardous substances and biological agents. When using hazardous chemical and biological agents, take all suitable protec- tive measures, such as wearing protective clothing, glasses and gloves resistant to the substances used. Follow local and/or national regulations for safe operation and maintenance of this product.

  • Page 70: Cleaning A Chromaflow Packing Station Without A Connected Column

    6 Maintenance 6.2 Cleaning 6.2.1 Cleaning a Chromaflow Packing Station without a connected column 6.2.1 Cleaning a Chromaflow Packing Station without a connected column Introduction The instructions in this section describe how to clean a Chromaflow Packing Station without a connected column. In this procedure, the PACKING BUFFER tank is denoted vessel B, and the SLURRY tank is denoted vessel C.
  • Page 71 6 Maintenance 6.2 Cleaning 6.2.1 Cleaning a Chromaflow Packing Station without a connected column Flushing the flow path Note: The arrows in the illustration show both possible flow paths used during rinsing. The illustration shows flow from vessel C to SIT, shown by the green indicators.
  • Page 72 6 Maintenance 6.2 Cleaning 6.2.1 Cleaning a Chromaflow Packing Station without a connected column Sanitization Note: The arrows in the illustration show all possible flow paths used during sani- tization. The illustration shows flow from vessel B to SIT, shown by the green indicators.
  • Page 73 6 Maintenance 6.2 Cleaning 6.2.1 Cleaning a Chromaflow Packing Station without a connected column Final rinsing Note: The arrows in the illustration show all possible flow paths used during rinsing. The illustration shows flow from vessel C to SIT, shown by the green indicators.
  • Page 74 6 Maintenance 6.2 Cleaning 6.2.1 Cleaning a Chromaflow Packing Station without a connected column Preparation for storage Note: The arrows in the illustration show all possible flow paths used during storage preparation. The illustration shows flow from vessel C to SIT, shown by the green indicators.

  • Page 75: Cleaning A Chromaflow Packing Station And A Connected Column

    6 Maintenance 6.2 Cleaning 6.2.2 Cleaning a Chromaflow Packing Station and a connected column 6.2.2 Cleaning a Chromaflow Packing Station and a connected column Cleaning procedure The following illustration shows the flow path used to clean inlet B and outlet SIB of a Chromaflow Packing Station together with the connected column.

  • Page 76: Storage

    This section describes how to store a Chromaflow Packing Station for both short-term (up to one month) and for long-term storage. Long-term storage and other special storage conditions may require other solutions than 20°C ethanol. For additional advice on storage, contact your Cytiva service repre- sentative. Precautions...
  • Page 77 6 Maintenance 6.3 Storage Long-term storage The procedure for long term storage is described below. This procedure is applicable for storage durations longer than one month. Step Action Perform the actions described for Short-term storage, on page 76, above. Place Chromaflow Packing Station in a dust free environment with well- controlled climate.

  • Page 78: Troubleshooting

    Chromaflow Packing Station. If the suggested actions in this guide do not solve the problem or if the problem is not covered by this guide, contact your Cytiva representative for advice. Pumps This section outlines troubleshooting for pump related issues.
  • Page 79 7 Troubleshooting Problem Possible cause/corrective action Too high • Check that connected outlet is actually used. outlet pres- • Outlet containers are placed too high relative to the pump. Make sure sure that the outlet containers are placed as close to Chromaflow Packing Station as possible and on the same floor of the building.

  • Page 80: Reference Information

    8 Reference information Reference information About this chapter This chapter provides reference information that may be useful when installing, oper- ating, maintaining and troubleshooting Chromaflow Packing Station. Information about how to obtain support training, service and spare parts is also described. In this chapter Section See page...

  • Page 81: Specifications

    8 Reference information 8.1 Specifications Specifications Introduction This section contains technical data pertaining to Chromaflow Packing Station and its components. For complete technical data, refer to the System Documentation Binder in the product documentation package. General technical data The table below gives general technical data for Chromaflow Packing Station. Chromaflow Packing station Parameter Flammable...
  • Page 82 8 Reference information 8.1 Specifications Chromaflow Packing station Parameter Crate weight [kg] 110 kg 110 kg 125 kg 150 kg (approximate) Approximate crate dimen- 1030 x 1200 x 1030 x 1200 x 1150 x 1200 x 1500 x 1500 x sions [mm] 1340 mm 1340 mm...
  • Page 83 8 Reference information 8.1 Specifications Parameter Chromaflow Packing Station Piping Material 316L Wetted part Frame Material Wetted part Wheels Material Polyurethane coated Wetted part Interface connection dimensions The values presented in this table represent the interface connection dimensions of Chromaflow Packing Station. Chromaflow Packing Station Parameter Inlet B...
  • Page 84 8 Reference information 8.1 Specifications Dead volume The table below provides information that is useful for preparing buffers and resin slurry in the correct volumes. Section Volume, Volume, Volume, Volume, Inlet B to SIT 0.72 L 1.7 L 3.7 L 10.8 L (Including packing pump)

  • Page 85: Chemical Resistance

    8 Reference information 8.2 Chemical resistance Chemical resistance Introduction This list covers chemical resistance for Chromaflow Packing Station. It should be noted that the effects of a chemical will be more severe at higher tempera- tures and pressures and that combined effects have not been taken into consideration. In general, the use of the following chemicals should be avoided: •...

  • Page 86: Noise Level

    8 Reference information 8.3 Noise level Noise level Introduction This section describes the noise levels for the Chromaflow Packing Station. Noise level Maximum measured noise level for Chromaflow Packing Station is 85 dB (A). Note: The maximum noise level of individual units may vary slightly. CAUTION Use ear protection whenever working close to the system in opera- tion.

  • Page 87: Recycling Information

    8 Reference information 8.4 Recycling information Recycling information Introduction This section contains information about decommissioning a Chromaflow Packing Station. Decontamination Chromaflow Packing Station shall be decontaminated before decommissioning and all local regulations shall be followed with regard to scrapping of the equipment. Disposal, general instructions When taking a Chromaflow Packing Station out of service, the different materials must be separated and recycled according to national and local environmental regulations.

  • Page 88: Regulatory Information

    8 Reference information 8.5 Regulatory information Regulatory information Introduction This section lists the regulations and standards that apply to the product. In this section Section See page 8.5.1 Contact information 8.5.2 European Union and European Economic Area 8.5.3 Other regulations and standards Chromaflow Packing Station 50, 100, 200, and 400 Operating Instructions 29046228 AD...

  • Page 89: Contact Information

    Manufacturing information The table below summarizes the required manufacturing information. Requirement Information Name and address of manufacturer Cytiva Sweden AB Björkgatan 30 SE 751 84 Uppsala Sweden Telephone number of manufacturer + 46 771 400 600 Chromaflow Packing Station 50, 100, 200, and 400 Operating Instructions 29046228 AD...

  • Page 90: European Union And European Economic Area

    8 Reference information 8.5 Regulatory information 8.5.2 European Union and European Economic Area 8.5.2 European Union and European Economic Area Introduction This section describes regulatory information for the European Union and European Economic Area that applies to the equipment. Conformity with EU Directives See the EU Declaration of Conformity for the directives and regulations that apply for the CE marking.

  • Page 91: Other Regulations And Standards

    8 Reference information 8.5 Regulatory information 8.5.3 Other regulations and standards 8.5.3 Other regulations and standards Introduction This section describes the standards that apply to the product. Biological and chemical compatibility The Wetted parts of the product meet the material requirements of the following standards and regulations: Requirement Description...

  • Page 92: Health And Safety Declaration Form

    Service Ticket #: To make the mutual protection and safety of Cytiva service personnel and our customers, all equipment and work areas must be clean and free of any hazardous contaminants before a Service Engineer starts a repair. To avoid delays in the servicing of your equipment, complete this checklist and present it to the Service Engineer upon arrival.
  • Page 93 To make sure the mutual protection and safety of Cytiva personnel, our customers, transportation personnel and our environment, all equipment must be clean and free of any hazardous contaminants before shipping to Cytiva. To avoid delays in the processing of your equipment, complete this checklist and include it with your return.

  • Page 94: Further Information

    For a complete list of wetted materials, refer to the information in the Material conformity document in the product documentation package. Spare parts and accessories Your local Cytiva representative will be able to suggest recommended spare parts and accessories. Remaining aspects Contact your local Cytiva representative for advice regarding: •...

  • Page 95: Index

    Index Index Maintenance schedule, 66 Manufacturing information, 89 Accessories, 94 Method optimization, 94 Air supply, 48, 59 MPB, 28, 34 MPT, 28, 34 CE, 90 conformity, 90 Notes and tips, 7 marking, 90 Nozzle control, 26 Chemical resistance, 85 Cleaning, 68 Compressed air supply, 48 Configuration, 23 On site service, 92...
  • Page 96 Index SIT, 28, 34 SOB, 29, 34 SOT, 29, 34 Space and floor load, 38 Spare parts, 94 Storage, 76, 77 long-term, 77 short-term, 76 System description, 22 Training, 94 Transport, 39, 45 in the crate, 39 unpacked, 45 Troubleshooting, 78 Typographical conventions, 5 Upper control panel, 27 Wetted materials, 94...
  • Page 97 Page intentionally left blank...
  • Page 98 © 2020 Cytiva All goods and services are sold subject to the terms and conditions of sale of the supplying company operating within the Cytiva business. A copy of those terms and conditions is available on request. Contact your local Cytiva representative for the most current information.

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