Alesis MultiMix12USB Supplementary Manual page 7

Multimix 12/16USB:
1. Turn down the HDPH/CTRL RM knob along with the LEVEL and MAIN
MIX faders.
2. Make sure that the 2 TK TO HDPH/CTRL RM and MIX TO HDPH/CTRL
RM buttons are DOWN.
3. Record-Enable a track in Cubase LE and make sure input monitoring is
turned off in the program (if input monitoring is on, you'll hear a delayed
echo of your voice or instrument because of computer latency.)
4. Set each channel's GAIN knob and FADER so that you're getting good
level without lighting the CLIP indicator on the mixer.
The MAIN MIX fader on the lower right now acts like a master-volume control
for all your mic/line inputs. Adjust this fader until you're getting good levels
into Cubase.
The HDPH/CTRL RM knob controls the levels of your headphones (or studio
monitors), but does not affect recording levels in Cubase. You can set this
level to a comfortable setting (or even off) without affecting what gets
recorded into Cubase.
You can now can record into your computer without any latency.