Lexus RX400h2006 Owner's Manual page 309

AIR CONDITIONING
1. Open the glove box. Remove the 2 pins installed on the
upper part of the glove box and lower the glove box.
2. Remove the filter case from the filter outlet as shown in
the illustration.
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3. Remove the filter from the filter case.
4. Inspect the filter on the surface.
If it is the just moderately dusty, it may be cleaned by blowing
compressed air from the reverse surface. Do not wash or oil
the filter.
If it is dirty, it should be replaced.
When installing the filter in the filter case, keep the arrow
pointing up.