Contents Regulatory Notices ....................... 4 Safety Information ......................6 Specifications ........................ 7 Overview of Components ..................... 9 Rear I/O Panel ......................11 UID LED/ BMC Reset Button ..................11 USB 3.2 Gen 1 Type-A Port ..................11 COM RJ45 Port ......................11 GbE RJ45 Port (Optional) &...
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Power Connectors ...................... 28 PSU_PWR1~2: CRPS Power Connectors ..............28 GPU_PWR1~6: 8-Pin GPU Power Connectors ............28 HDD_PWR1~2: 8-Pin HDD BP Power Connectors ..........28 HDD_PWR3: 4-Pin Rear HDD BP Power Connector ..........29 Cooling Connectors ....................30 F2U-1~6: 2U System Fan Connectors..............30 F1U-1~8: 1U System Fan Connectors..............
Chemical Substances Information In compliance with chemical substances regulations, such as the EU REACH Regulation (Regulation EC No. 1907/2006 of the European Parliament and the Council), MSI provides the information of chemical substances in products at: https://csr.msi.com/global/index CE Conformity Hereby, Micro-Star International CO., LTD declares that this device is in compliance with the essential safety requirements and other relevant provisions set out in the European Directive.
Safety Information ∙ Always read the safety instructions carefully. ∙ Keep this User’s Manual for future reference. ∙ Keep this equipment away from humidity. ∙ Lay this equipment on a reliable flat surface before setting it up. ∙ The openings on the enclosure are for air convection hence protects the equipment from overheating.
Specifications Model MS-S3121 Form factor L-shape Dimensions 428mm (16.9”W) x 477mm (18.8”D) Processor Dual AMD EPYC™ 9004 and 9005 series processors, TDP up to 360W Socket 2 x AMD Socket SP5 ∙ 2 x GbE RJ45 ports (optional) Networking - Intel® LAN controller I350-AM2 ∙...
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Model MS-S3121 ∙ 6 x 6-pin chassis hot-swap fan connectors (2U) Cooling ∙ 8 x 8-pin chassis fan connectors (1U) Connectors ∙ 2 x 4-pin CPU PWM fans connectors ∙ 6 x 8-pin GPU power connectors Power ∙ 2 x 8-pin HDD BP power connectors (12V) Connectors ∙...
Rear I/O Panel GbE RJ45 Port USB 3.2 Gen 1 GbE RJ45 Port (Optional) Type-A Port (for mgmt.) VGA Port COM RJ45 Port UID LED/ BMC Reset Button UID LED/ BMC Reset Button In the default setting, this button is configured as a UID button. By using the JUID_SEL1 jumper, users can set it as a BMC Reset Button.
CPU Socket CPU1 CPU0 ⚠ Important Overheating will seriously damage the CPU and system. Always make sure the ∙ cooling fan can work properly to protect the CPU from overheating. Make sure that you apply an even layer of thermal paste (or thermal tape) between the CPU and the heatsink to enhance heat dissipation.
CPU Installation Use appropriate ground straps, gloves and ESD mats to protect yourself from electrostatic discharge (ESD) while installing the processor. ⚠ Important Images are for illustration purposes only; actual parts may vary. 1. Remove the screw on the top of the retention frame. 2.
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4. Pull the external cap upward through the rail guides on the rail frame to remove it. 5. Grip the handle of the carrier frame and slide it downward with the flanges and the rail guides aligned. CPUs are shipped from the factory with pre-assembled carrier frames. ∙...
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7. Push the retention frame downward and use a torque screwdriver to tighten the screw in the middle. Torque Screwdriver Settings Screw Head: Torx T20 Torque: 12.5-15 kgf·cm* *12.5-15 kgf·cm = 122.6~147 N·m = 10.9~13 lbf·in 8. For peak thermal performance, apply proper amount of thermal paste to the bottom center of the heatsink.
Recommended Memory Population D C B D C B CPU1 CPU0 1 CPU Channel Qty. of DDR5 2 CPUs Channel Qty. of DDR5 CPU1 CPU0 CPU1 CPU0 CPU1 CPU0 CPU1 CPU0 CPU1 CPU0 CPU1 CPU0 CPU1 CPU0 CPU1 CPU0 “V” indicates DIMMs are populated with DDR5. ⚠...
Installing Memory Modules 1. Open the side clips to unlock the DIMM slot. 2. Insert the DIMM vertically into the slot, ensuring that the off-center notch at the bottom aligns with the slot. 3. Push the DIMM firmly into the slot until it clicks and the side clips automatically close.
JMCIO1~4: MCIO 4i Connectors These are right-angle 38-pin Mini Cool Edge IO (MCIO) connectors, which support PCIe 4.0 x4 16GT/s and SATA 3.0 6Gb/s interfaces. A JSATA_NVME_SW1 jumper can be used to switch signals between SATA and PCIe NVMe (default). RXP0 TXP0 RXN0...
M2_1~2: M.2 Slots (M Key, PCIe 3.0 x2, 2280) Please install the M.2 solid-state drive (SSD) into the M.2 slot as shown below. Installing M.2 SSD ⚽ Video Demonstration Watch the video to learn how to Install M.2 SSD. 1. Insert your M.2 SSD into the M.2 slot at a 30-degree angle.
Power Connectors PSU_PWR1 PSU_PWR2 GPU_PWR1 HDD_PWR3 GPU_PWR2 GPU_PWR6 GPU_PWR3 GPU_PWR5 GPU_PWR4 HDD_PWR2 HDD_PWR1 PSU_PWR1~2: CRPS Power Connectors These CRPS (Common Redundant Power Supplies) connectors allow you to connect a power supply. To connect the power supply, ensure that the plug is inserted in the proper orientation and that the pins are aligned.
HDD_PWR3: 4-Pin Rear HDD BP Power Connector This connector provides power output to HDDs on rear side. HDD_PWR3 P12V ⚠ Important Make sure that all power connectors are securely connected to the power supply to ensure stable operation of the motherboard. Power Connectors...
Cooling Connectors CPU_FAN1 CPU_FAN2 F2U-1 F2U-2 F2U-3 F2U-4 F2-U5 F2U-6 F1U-1 F1U-2 F1U-3 F1U-4 F1U-5 F1U-6 F1U-7 F1U-8 F2U-1~6: 2U System Fan Connectors The fan power connectors support 2U system cooling fans. P12V F2U-1~6 FAN_TACH FAN_PWM FAN_FAULT F1U-1~8: 1U System Fan Connectors The fan power connectors support 1U system cooling fans.
USB Connectors JUSB1 JUSB2 JUSB1: USB 3.2 Gen 1 Type-A Port The USB (Universal Serial Bus) port is used for connecting USB devices such JUSB1 as keyboards, mice, or other compatible peripherals. It supports data transfer rates up to 5 Gbps and is backward-compatible with USB 2.0 devices. JUSB2: USB 3.2 Gen 1 FPC Connector This port is backward-compatible with USB 2.0 devices and supports data transfer rate up to 5 Gbps.
Other Connectors and Components JCHASSIS1: Chassis Intrusion Header This connector connects to the chassis intrusion switch cable. If the chassis is opened, the chassis intrusion mechanism will be activated. The system will record this status and show a warning message on the screen. To clear the warning, you must enter the BIOS utility and clear the record.
JTPM1: SPI TPM Header This header connects to a TPM (Trusted Platform Module) module (optional). Please refer to the TPM security platform manual for more details. P3V3_AUX SPI_CPU0_3V3_CLK SPI_CPU0_3V3_MISO JTPM1 SPI_CPU0_3V3_MOSI SPI_TPM_CS_N IRQ_TPM_SPI_N P3V3_AUX TPM_RESET_N P3V3_AUX JTPM1 Other Connectors and Components...
JFP_VGA1: Front VGA Header The VGA header is provided for monitors. F_RED F_GRN JFP_VGA1 F_BLU F_VS F_HS F_DDCDAT SEL_FP_N F_DDCCLK F_VGA_5V JFP_VGA1 Other Connectors and Components...
FBP_I2C_1, RBP_I2C_1~2: I2C Headers I2C headers are used to connect to the System Management Bus (SMBus). FBP_I2C_1 is for front HDD backplane, and RBP_I2C_1~2 are for rear HDD backplanes. FBP_I2C_1 I2C_DAT RBP_I2C_1 RBP_I2C_2 I2C_CLK JSGPIO_PCH: Rear Side BP SGPIO Header SGPIO_SATA_CLOCK_RBP JSGPIO_PCH SGPIO_SATA_LOAD_RBP...
BAT1: CMOS Battery If the CMOS battery is out of charge, the time in the BIOS will be reset and the data of system configuration will be lost. In this case, you need to replace the CMOS battery. Replacing CMOS battery 1.
Jumpers ⚠ Important Avoid adjusting jumpers when the system is on; it will damage the motherboard. JUID_SEL1 JRTC_CLR1 JSPI_MUX1 JSEL_BMC1 JSATA_NVME_SW1 Jumper Name Default Setting Description 1-2: BIOS1 & allows BMC to switch (Default) JSPI_MUX1 2-3: BIOS2 (backup only, use when BIOS1 flash crashes) 1-2: BMC1 (Default) JSEL_BMC1 2-3: BMC2...
Onboard LEDs BMC_HB_LED: BMC Heartbeat LED This LED indicates the BMC (Baseboard Management Controller) status. Status Description BMC is not activated BMC is functioning normally Blinking BMC_HB_LED SEG_LED1~4: Port 80 Debug LEDs The Port 80 Debug LEDs display progress and error codes during and after POST (Power-On Self Test).
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