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Analgesy-Meter
Cat.
3 7 2 1 5 / 3 7 2 1 6
1
GENERAL
The 37215 is the up to date version of the classical 7200 which, since 1965, is helping to
perform a rapid precise screening of analgesic drugs in a number of academic and indus-
trial
laboratories,
BIBLIOGRAPHY.
The 37215 features a weight displacing screw driven by a low voltage geared motor, to
increase safety, and an optical switch to measure the start/stop time-lag (hence the force
at which the animal struggles).
2
INSTRUMENT DESCRIPTION
2.1
The Method
The Basile Analgesy-Meter has been designed to perform rapid precise screening of an-
algesic drugs on the normal and inflamed rat paw, according to the Randall-Selitto test.
The instrument is basically a device which exerts a force increasing at a constant rate (a
certain number of grams per second). This force is continuously monitored by a pointer
moving along a linear scale.
The force is applied to the animal's paw, which is placed on a small plinth under a cone-
shaped pusher with a rounded tip. The plinth is made of TEFLON, which is biologically
inert and has a very low friction coefficient. Thus, if the animal suddenly withdraws its
paw, it slips out easily without being injured.
The operator depresses a pedal-switch to start the mechanism which exerts the force.
When the rat struggles, the operator releases the pedal and reads off the scale the force
at which the animal felt pain.
2.2
The Force Exerting Mechanism
The pusher (1), see figure 1 & 2, is mounted on a bracket (2) fixed to an arm (3), which
pivots on a fulcrum.
The paw is placed between plinth (4) and pusher (see the colour picture on the leaflet).
When the pedal is depressed, the geared motor (5) starts, thereby rotating the screw (6),
which moves the slide (7) along the scale (8).
according
to
the
Randall-Selitto
test,
37215 Instruction Manual (Rev. 4)
see
paragraph
Page 1
7.4-
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