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Summary of Contents for Agilent Technologies Enhancer Cell
- Page 1 Agilent Enhancer Cell Operator’s Manual...
- Page 2 Copyright editions. Further, to the maximum extent A CAUTION notice denotes a permitted by applicable law, Agilent © Agilent Technologies, Inc. 2020 hazard. It calls attention to an disclaims all warranties, either express or operating procedure, practice, or implied, with regard to this manual and...
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Page 3: Table Of Contents
Content Introduction Assembly Components Unpacking Your Enhancer Cell Assembly Operation Membrane Selection Information for the Enhancer Cell Ideal Characteristics for a Membrane Examples of Membranes Used for In Vitro Release Tests Enhancer Cell Operator’s Manual... - Page 4 Content This page was intentionally left blank, except for this message. Enhancer Cell Operator’s Manual...
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Page 5: Introduction
Introduction Assembly Components 8 Unpacking Your Enhancer Cell Assembly 9 Enhancer Cell Operator’s Manual... - Page 6 The adjustment tool is universal and fits all sizes. Both the alignment tool and the adjustment tool are required and must be ordered separately. The Enhancer Cell Assembly does not include the vessel, paddle, or membrane / skin.
- Page 7 Introduction 0.5 cm² 2 cm² 4 cm² Figure 2. Enhancer Cell Assembly Surface Areas Figure 3. Paddle over Enhancer Cell Enhancer Cell Operator’s Manual...
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Page 8: Assembly Components
• Cell body – provides a variable depth reservoir for the sample (semisolid, solution, suspension, or emulsion) being tested. Two additional tools are required to properly use the Enhancer Cell Assembly and must be ordered separately: • Adjustment tool – to move the adjustment plate. -
Page 9: Unpacking Your Enhancer Cell Assembly
Introduction Unpacking Your Enhancer Cell Assembly 1 Carefully remove the Enhancer Cell Assembly. 2 Ensure all of the following items were shipped with your Enhancer Cell: • Enhancer Cell Assembly Operator’s Manual • Retaining ring • Washer • Adjustment plate with O-ring •... - Page 10 Introduction This page was intentionally left blank, except for this message. Enhancer Cell Operator’s Manual...
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Page 11: Operation
Operation Membrane Selection Information for the Enhancer Cell 14 Enhancer Cell Operator’s Manual... - Page 12 Enhancer Cell Assembly. The PTFE parts are delicate and could be damaged by extreme force. 1 Using empty dissolution vessels and empty Enhancer Cell Assemblies, set the appropriate paddle height. The recommended distance from the top of the cell to the bottom of the paddle is 25 mm.
- Page 13 Operation 10 Carefully place the completed assembly into the bottom of the dissolution vessel, with the membrane facing up. Add the appropriate preheated medium and begin the test. Enhancer Cell Operator’s Manual...
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Page 14: Membrane Selection Information For The Enhancer Cell
Tests • Regenerated cellulose (Dialysis membrane) • Silastic membrane - polydimethyl siloxane • Fluoropore FHLP hydrophobic membrane • Ethylene vinyl acetate (Cotrans 9702) • Skin (human, rat, rabbit, porcine, mouse) • Cuprophan • Carbosil • Polysulfone Enhancer Cell Operator’s Manual... - Page 15 In This Book • Chapter 1 Introduction • Chapter 2 Operation www.agilent.com © Agilent Technologies, Inc. 2020 70-9072 Rev B February 2020...