Asus ProArt Z490-CREATOR 10G Manual page 12

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When M.2_1 is operating in SATA mode, SATA6G_2 will be disabled.
M.2_2 runs at PCIe 3.0 x2 by default and shares bandwidth with SATA6G_56. When
M.2_2 runs at PCIe 3.0 x4 or is populated by H10, SATA6G_56 will be disabled.
PCIEX16_3 shares bandwidth with Thunderbolt™ 3. Thunderbolt™ 3 will be disabled
if PCIEX16_3 is populated.