Matrox QuadHead2Go Q2G-DP4K Configuration Manual page 46

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Matrox QuadHead2Go
Most of the QuadHead2Go units will be in 2x2, and as many as
Reason
possible of the 4 outputs on a QuadHead2Go are used.
2x3, 4x3, and 6x configurations.
Exceptions
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Series Configuration Guide
at the bottom left of the video wall array.
If the array has a number of rows that's divisible
by 4, place the final QuadHead2Go unit in 4x1.
Place the final QuadHead2Go unit in 2x1.
Example: