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Summary of Contents for Pall Cadence ILC
- Page 1 User Guide USD 2841c Cadence Inline Concentrator ™ with Delta and Omega Membranes ™ Care and Use Procedures...
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Page 2: Table Of Contents
5.1 Preparation: Equipment and Materials ....................9 5.2 Part 1 — Pre-Use Conditioning ......................10 Procedure A — Connect the Cadence ILC Module to the Tubing ............10 Procedure B — Flush the Cadence ILC Module with Purified Water ..........10 Procedure C — Sanitize the Cadence ILC Module ................11 Procedure D —... -
Page 3: Important Information
Sicherheitsrichtlinien lesen. Die doornemen. Sicherheitsrichtlinien in dieser Sprache Veiligheids instructies in het erhalten Sie von Pall. Nederlands zijn bij Pall verkrijgbaar. Avvertenza importante Prima dell’uso leggere le istruzioni per la sicurezza. Le istruzioni per la sicurezza in Italiano possono essere richieste a Pall. -
Page 4: Application Of The Care And Use Procedures
This guide describes the care and use of Cadence Inline Concentrator (ILC) modules with Delta and Omega 10 kDa and 30 kDa membranes. Do not apply these procedures to Pall’s conventional tangential flow filtration (TFF) cassettes or Cadence single-pass TFF (SPTFF) standard modules. -
Page 5: Locating Safety Information
Support Services — The Pall Biotech customer support team can answer technical questions and provide replacement parts. Pall operates a technical service to assist in the application of our products. This service is readily available to you and welcome your questions so that we can help. In addition, an extensive network of technical representatives is available throughout the world. -
Page 6: Learning About The Cadence Inline Concentrator Module
• Total membrane area Cadence ILC Module Port Locations Cadence ILC modules have feed, retentate, and two permeate ports. Ports on the Cadence T01 and T02 modules use female Luer lock connectors. The ports on the Cadence T12 modules use female MPC quick disconnect connectors. A label located next to each port identifies the port’s function. -
Page 7: Application Of Single-Pass Tangential Flow Filtration
The Four Parts of a Single-Pass TFF Process The SPTFF process can be divided into four parts: • Part 1 — The first part involves connecting the Cadence ILC module and preparing it for use. This part (called pre-use conditioning) involves several sequential steps. - Page 8 • Part 3 — The third part (called post-use conditioning) includes cleaning, testing and storage of the Cadence ILC module. This part is optional and is applicable only when the module is reused. • Part 4 — The fourth part includes proper disposal of the Cadence ILC module.
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Page 9: Using The Cadence Ilc Module
1 pressure sensor. Typically, end-users also have retentate and/or permeate flowmeters (or scales) to monitor their process. • Appropriate tubing set. Pall can provide tubing sets for your application, please contact your Pall representative for more details •... -
Page 10: Part 1 - Pre-Use Conditioning
Exceeding 4.1 barg (60 psig) of feed pressure can permanently damage the Cadence ILC module or lead to product leakage. Do not exceed a feed pressure of 1.5 barg (22 psig) when the permeates are fully closed. Additionally, do not exceed the pressure rating of the tubing during operation or integrity testing. -
Page 11: Procedure C - Sanitize The Cadence Ilc Module
Procedure D — Flush the Cadence ILC Module with Purified Water Flush the sanitization solution from the Cadence ILC module with purified water following these steps: 1. Connect the feed line to a supply of purified water. -
Page 12: Procedure E - Determine Cadence Ilc Module Normalized Water Permeability (Nwp)
Procedure E — Determine Cadence ILC Module Normalized Water Permeability (NWP) If a new or previously used and stored Cadence ILC module is used, the user will need to measure the permeability of the module before use. Later, after using and cleaning the module, the NWP of the module should be measured again. -
Page 13: Procedure F - Determine The Hold-Up Volume Of The Cadence Setup And Module
Table 2 Temperature correction factors (TCF ) for Cadence ILC module permeability 20 °C T °C T °C 20 °C 20 °C 1.57 0.83 1.52 0.81 1.47 0.80 1.43 0.78 1.39 0.76 1.35 0.75 1.31 0.73 1.27 0.72 1.24 0.70 1.20... -
Page 14: Procedure G - Test The Integrity Of The Cadence Ilc Module
CAUTION! Do not exceed the pressure rating of the tubing during operation or integrity testing. Tubing that is rated to at least 4.1 bar (60 psi) should be used. 4. Measure the air flow out of the permeate port using the Pall Flowstar integrity tester or other integrity test equipment. -
Page 15: Procedure H - Flush With Buffer
Procedure I — Process Product Before initiating the processing step, review the recommended operating parameters below. Follow these steps to process feed material with the Cadence ILC module: 1. Connect the feed line to the feed solution. 2. Place the retentate and permeate lines into separate collection vessels. -
Page 16: Part 3 - Post-Use Conditioning
If product must be flushed from the module with purified water or buffer before beginning the cleaning step, follow Procedure B (Flush the Cadence ILC module). Then go to the Cleaning Steps below. -
Page 17: Procedure L - Flush The Cadence Ilc Module With Purified Water
Procedure G — Test the Integrity of the Cadence Set-Up and ILC Module. Procedure O — Add Storage Solution to the Cadence ILC Module The objective for proper storage of the Cadence ILC module is to ensure the module remains wet and to prevent microbial growth during storage. -
Page 18: Part 4 - Post-Use Disposal
6. Stop the feed pump after 10 L/m of storage solution passes through the module. 7. Disconnect the module from the set-up and cap the ports while keeping Cadence ILC module full of storage solution. 8. Place the module in a sealed plastic bag.
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