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Hardware Overview
Ion Sources
Ion Sources
Electrospray Ionization (Dual ESI) source
Electrospray relies in part on chemistry to generate analyte ions in solution
before the analyte reaches the mass spectrometer. The LC eluent is sprayed
(nebulized) into a chamber at atmospheric pressure in the presence of a strong
electrostatic field and heated drying gas.
The electrostatic field causes further dissociation of the analyte molecules. The
heated drying gas causes the solvent in the droplets to evaporate. As the droplets
shrink, the charge concentration in the droplets increases. Eventually, the
repulsive force between ions with like charges exceeds the cohesive forces and
the ions are ejected (desorbed) into the gas phase. These ions are attracted to
and pass through a capillary sampling orifice into the mass analyzer.
Figure 5. ESI source with cover
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Agilent Revident LC/Q-TOF System User Guide
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