MSI 845E Neo-V User Manual page 74

Here it provides the Karaoke function which will automatically remove human
voice (lyrics) and leave melody for you to sing the song. Note that this function
applies only for 2-channel audio operation.
Just check the Voice Cancellation box and then click OK to activate the
Karaoke function.
Using 2-, 4- or 6-Channel Audio Function
A-5