Beckman Coulter Multisizer 4 Manuals

Manuals and User Guides for Beckman Coulter Multisizer 4. We have 1 Beckman Coulter Multisizer 4 manual available for free PDF download: User Manual

Beckman Coulter Multisizer 4 User Manual (238 pages)

Particle Analyzer

Brand: Beckman Coulter | Category: Measuring Instruments | Size: 3.09 MB

Table of Contents
3
List of Tables
13
Introduction
15
- Particle Size Determination
  16
- Displaying Multisizer
  17
- Environmental Conditions
  18
- Regulatory Compliance
  19
Before You Start: Warnings and Cautions
19
- Warnings
  19
  - Electrical Warnings
    20
  - Chemical Warnings
    20
  - Mechanical Warnings
    20
  - Fire Warnings
    20
- Cautions
  21
  - Electrical Cautions
    21
  - Chemical Cautions
    21
CHAPTER 1 Analyzer Overview

23
Overview

23
- New Multisizer
  23
- Extended Dynamic Range
  24
- Multisizer
  24
- Multisizer 4 Analyzer Components
  24
  - Power ON/OFF Switch
    25
  - Sample Compartment
    25
  - Control Panel
    25
  - Electrolyte Jar
    25
  - Waste Jar
    26
  - Electrolyte and Waste Jar Fluid Levels
    26
  - Installing and Removing the Electrolyte and Waste Jars
    26
- Installing the Waste Jar
  26
- Control Panel
  27
  - Disabling the Control Panel Buttons
    27
  - Viewing Control Panel Actions in Run Information
    28
  - ON Light
    28
  - Analyzing and Attention Lights
    28
  - Stir on Button
    28
  - Stirrer Direction Controls
    28
  - Stirrer Speed Controls
    29
  - Bar Code Reader
    29
- Sample Compartment
  30
  - Aperture Tube
    30
  - Aperture Tube Knob
    30
  - Sample Platform
    31
- Platform in Loading Position: Beaker Side
  31
  - Reversing the Sample Platform
    32
- Platform in Loading Position: Accuvette® ST Side
  32
  - Platform Release
    33
  - External Electrode
    33
  - Stirrer
    33
- Reversing the Sample Platform
  33
  - Particle Trap
    34
  - Status and Illumination Lights
    34
- Accessories
  35
  - Beakers
    35
  - Accuvette® Sts
    35
  - Calibrators
    35
  - Aperture Tubes
    36
    
    Handling Aperture Tubes
    36
- Cleaning the Aperture Tube, Beakers, and Accuvette® Sts
  37
- Cleaning an Aperture Tube
  38
- Cleaning the Analyzer
  38
- Closed Circuit Filtration System
  39
- Pre-Filtering the Electrolyte and Cleaning Fluid
  39
- Preparing the Analyzer for Sample Runs
  40
- Starting the Analyzer
  40
CHAPTER 2: Software Overview

43
- Opening the Multisizer
  43
- Connecting the Software to the Analyzer
  43
- Multisizer 4 Software Window
  44
- Main Menu
  45
- Main Toolbar Buttons
  47
- Status Panel
  50
- Viewing Area
  52
- Run Menu
  52
- Instrument Toolbar
  53
  - Instrument Toolbar: Run
    53
  - Reset Button
    53
  - Instrument Toolbar: Reset
    54
  - Instrument Toolbar: Fluid Control
    54
- Status Bar
  54
  - Instrument Toolbar: Function
    54
CHAPTER 3: Installing and Calibrating an Aperture

55
Step 9: Measure Noise Level

84
- Step 10: Verify Calibration
  
  85
  - Verify Aperture Calibration
    86
- Step 11: All Done
  
  87
  - Setting Control Sample
    87
CHAPTER 4 : Selecting Analysis Settings: SOM and SOP ,4-1

91
- Definitions: SOM, Preferences, and
  91
  - Using the Create SOM
    91
  - Standard Operating Method
    91
    
    Sop
    91
    
    Som)
    92
    
    Creating Automatically Generated Analysis File
    94
    
    Names
    94
    
    Write-Protecting Saved Analysis
    96
  - Standard Operating Method: Control
    96
  - Standard Operating Method: Run
    98
  - Settings
    98
  - Standard Operating Method: Stirrer
    100
    
    Settings
    100
    
    Copying Manual Stirrer
    101
  - Standard Operating Method: Threshold, Current and
    103
  - Threshold, Current and Gain (Step 5): Entries or
    104
  - Standard Operating Method: Pulse to Size
    105
  - Standard Operating Method: Concentration
    107
  - Information
    107
  - Standard Operating Method: Blockage
    108
  - Detection
    108
  - Saving an SOM to a File
    112
  - Editing SOM Settings
    113
  - The SOM Settings (SOP Loaded)
    115
  - Loading an SOM
    115
- Using a Standard Operating Procedure
  116
  - Creating an SOP
    116
  - Loading an SOP
    118
CHAPTER 5 : Setting View and Print Preferences ,5-1

119
- Creating a Preferences File
  119
- Window
  121
  - Printing Sample Information in
    121
  - Selecting Graphs, Statistics, and Data for Printing
    122
    
    Including a Size Distribution Graph in Printed Reports
    122
    
    Including Statistics in Printed Reports
    124
    
    Including Averaged Statistics in Printed Reports
    124
    
    Including a Comparison to Sample Specifications in Printed Reports
    124
    
    Including Overlay Statistics in Printed Reports
    124
    
    Including a Listing in Printed Reports
    125
    
    Including Interpolation Data in Printed Reports
    126
    
    Interpolation Display Data
    127
    
    Including Size Trend Information in Printed Reports
    128
    
    Preferences: Printed Report
    128
    
    Including Size Statistics in Printed Reports
    130
    
    Including Filtration Efficiency in Printed Reports
    130
    
    Including Pulse Data in Printed Reports
    130
    
    Including Blockage Monitor Data in Printed Reports
    132
    
    Setting the Print Order for Reports
    133
  - Preferences: Statistics
    133
  - Statistics Display Preferences
    134
    
    Reports
    134
    
    Using Statistical Category Names
    135
  - Preferences: Averaging and Trend
    135
  - Reports
    135
  - Preferences: Export
    137
  - Reports
    138
  - Preferences: Graph Options
    139
  - Preferences: Fonts and Colors
    139
  - Reports
    140
  - Preferences: View Options
    141
  - Preferences Wizard: Set View
    141
  - Reports
    141
  - Reviewing Your Preferences Settings
    142
- Saving a Preferences File
  143
- Automatically Updating the Default Preferences File
  144
CHAPTER 6 Analyzing a Sample

145
- Analyzer Checklist
  145
- Selecting Analysis Settings
  145
- Loading an SOM
  146
- Loading Preference Settings
  146
- Loading an SOP
  146
- Removing an SOP
  147
- Verifying Preference Settings
  147
- Copy and Print Preference
  147
- Verifying SOM Settings
  148
- Verify SOM Settings
  148
- Entering Sample Information
  149
- Entering Sample Info for Next
  150
- Settings
  150
- Editing Sample Information
  151
- Using Sample Specifications
  151
- Editing Sample Specifications
  153
- Including Sample Specifications in a Printed Report
  153
- Viewing Sample Specifications
  153
- Editing Size Data
  154
- Running an Analysis
  154
- Sample Analysis Variations
  156
  - Running a Multi-Tube Overlap Analysis
    156
  - Determining Particle Concentration Using Time Mode
    157
- Using Blank Runs
  158
CHAPTER 7: Working with Analysis Files

161
- Setting File Preferences
  161
  - Changing Print Settings
    161
- Viewing Analysis Files
  162
  - Changing the Display of an Open File
    162
  - Run Menu Behaviors
    162
    
    Graphs
    162
    
    Listings and Interpolation
    162
  - Viewing Graphs
    162
    
    Graph Menu
    162
    
    Calculate Menu
    163
    
    Display Menu
    163
  - Using Cursors in Graphs
    163
  - Viewing Listings
    164
    
    Listing Menu
    164
    
    Size Column Format
    164
    
    Pulses Column Format
    165
    
    Blockage Monitors Column Format
    166
    
    Calculate Menu
    166
  - Viewing Interpolations
    166
    
    Size Interpolation Data
    167
    
    Changing the Column Display
    168
  - Viewing Statistics
    168
  - Using Cursors in Graphs
    168
  - Comparing Statistics to Sample Specifications
    169
  - Comparing an Analysis to a Standard Run
    169
  - Converting Pulses to Size
    169
  - Converting Pulses to Size between Cursors
    171
  - Converting Pulses to Size for the Widest Distributions
    171
  - Printing Report(S) for One or more Analysis Files
    172
  - Printing a Report of an Open Analysis File
    174
  - Printing with Current Analysis Settings
    175
  - Open Analysis File Print
    175
  - Saving an Analysis File
    176
  - Saving Analysis Data Automatically
    176
  - Saving Analysis Data Manually
    177
  - Opening a Saved Analysis File
    177
  - Importing a File
    178
- Working with Multiple Analysis Files
  179
  - Using Overlay Files
    179
  - Saving an Overlay File
    180
  - Opening a Saved Overlay File
    180
  - Averaging Analysis Files
    180
  - Opening Files for Averaging
    181
  - Adding Data to an Average
    181
  - Saving Averaged Files
    181
  - Opening a Saved List of Averaged Files
    182
  - Creating a Size Trend Analysis
    182
  - Opening Files for a Size Trend
    183
  - Adding a File to a Size Trend
    183
  - Saving a Size Trend
    183
  - Opening a Size Trend
    184
  - Merging Runs
    184
  - Saving a Merged Run
    185
  - Moving between Multiple Files (Cursor Menu and Shortcut)
    185
- Filtration Efficiency
  186
  - Saving a Filtration Efficiency Analysis
    186
  - Including Filtration Efficiency in a Printed Report
    186
CHAPTER 8 Configuring Software and Security

187
- Configuration Overview
  187
  - Configuration Options
    187
- Security Modes and Configuration
  187
- Customizing Main Menus
  189
- Names
  189
- Customizing Run Menus
  191
- Customizing Toolbars
  193
- Customizing the Status Panel
  194
- Panel
  195
- Customizing Sample Info Names
  196
- Customizing Recent File and Folder Lists
  197
  - Selecting a New Folder from the Recent Folder List
    198
  - Adding a Folder to the Recent Folders List
    198
- Customizing the Save Preferences Default Setting
  199
- Choosing a Language
  199
- Multisizer 4 Configuration Options
  200
- Bar Code Reader Configuration Options
  201
- Customizing Security Settings
  202
  - Logging in
    204
  - Logging out
    204
  - Changing Your Password
    204
- Administrator Menu Options
  205
  - Customizing User Privileges
    206
CHAPTER 9 Troubleshooting

207
- Resolving Common Problems
  207
  - Reducing Noise
    207
  - Measuring the Noise Level
    208
  - Purging the Metering Pump
    208
  - Adjusting the Metering Pump
    209
  - Setting the Vacuum Regulator
    209
  - Measuring Gain Stage Offsets
    209
    
    Setting Custom Measurement Intervals
    210
    
    System Error: Unable to Measure Gain Stage Offsets
    210
  - Resolving Error Messages on Software Startup
    211
- Viewing Advanced Multisizer Settings
  212
  - Waste Tank Settings
    212
    
    Calibrating Waste Tank Sensors
    212
  - Vacuum Settings
    213
    
    Flow Rate Error Messages
    214
    
    Adjusting Volumetric Flow Settings
    214
  - Fill, Flush, and Drain Settings
    215
    
    Viewing System Flush Time
    215
    
    Draining the System
    217
    
    Aperture Resistance Settings
    218
  - Calibrating the Electrolyte and Waste Jars
    219
- Working with Field Service
  221
  - Requesting Service and Technical Support
    221
  - Identifying the Instrument
    221
  - Updating Firmware and FPGA Software
    222
  - Viewing the Instrument Schematic
    223
  - Viewing the Error Log
    224
  - Opening Service Mode
    224
CHAPTER 10: Regulatory Compliance

225
- Regulatory Compliance
  225
  - Electronic Signatures (21 CFR Part 11)
    225
    
    Electronic Records
    225
    
    FDA Requirements
    225
  - Security Controls
    226
    
    Electronic Controls
    226
    
    System Validation
    226
    
    Audit Trail
    227
- File History and Audit Trail
  227
  - Accessing File History
    227
  - Setting Audit Trail Options
    228
- Maintaining Electronic Signatures
  229
  - Generating Electronic Signatures
    229
  - Applying Electronic Signatures
    230
- Additional Security Features
  231
  - Starting the Multisizer 4 with Security Enabled
    231

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Beckman Coulter Multisizer 4 Manuals

Beckman Coulter Multisizer 4 User Manual (238 pages)

Table of Contents

CHAPTER 1 Analyzer Overview

Overview

CHAPTER 2: Software Overview

CHAPTER 3: Installing and Calibrating an Aperture

Step 1: Select the New Aperture Tube

Step 2: Remove the Currently Installed Aperture Tube

Step 3: Install the New Aperture Tube

Step 4: Place a Beaker of Clean Electrolyte on the Platform

Step 6: Fill the System

Step 7: Adjust the Metering Pump

Step 8: Set Current and Gain

Step 9: Measure Noise Level

Step 10: Verify Calibration

Step 11: All Done

CHAPTER 4 : Selecting Analysis Settings: SOM and SOP ,4-1

CHAPTER 5 : Setting View and Print Preferences ,5-1

CHAPTER 6 Analyzing a Sample

CHAPTER 7: Working with Analysis Files

CHAPTER 8 Configuring Software and Security

CHAPTER 9 Troubleshooting

CHAPTER 10: Regulatory Compliance

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