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Summary of Contents for Astrea Evolve 600
- Page 1 Refresh Kit: Guide to Replacing the Wetted Flow Path Evolve ® 600 mm Process Column...
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Page 2: Table Of Contents
Table of Contents Replacing the Wetted Flow Path ............... 4 General Guidelines ..................5 Stage 1– Refresh the Adjuster Assembly of the Evolve ® 600 mm Process Column .... 7 Disassembly of Adjuster Assembly ..............7 Reassemble and Refresh the Adjuster Assembly ........... 10 Stage 2 –... - Page 3 Table of Figures Figure 1: List of Refresh Kit components and Column schematic. Parts shown in red are the wetted flow path components..............4 ® Figure 2: Photograph of Evolve 600 mm Process Column showing alignment indicators..6 Figure 3: Photograph of Evolve ®...
- Page 4 Figure 25: Fixed Assembly Evolve ® 600 mm Process Column ........19 Figure 26: Displaced bottom flow cell during disassembly ......... 19 Figure 27 (a-c): Reassembly of Column Bottom Flow Cell and base ....... 20 Figure 28 (a-c): Reassembly of Column ..............21 Figure 29 (a-c): Location of Adjuster Assembly completing Column Refresh Procedure ..
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Page 5: Replacing The Wetted Flow Path
Replacing the Wetted Flow Path This manual describes the procedures necessary to replace the wetted flow path components in the Evolve ® 600 Process Column using the Column Refresh Kit. KIT COMPONENTS KIT COMPONENTS Flow Tube Adaptor 15 mm Bore Fixed cell seal Adjuster Flow Tube 15 mm Bore Fixed bed support seal... -
Page 6: General Guidelines
General Guidelines There are four stages to refreshing the column by replacing the wetted flow path. The first three stages are based on the disassembly and reassembling each column sub assembly with new components, before the final stage of rebuilding and testing the complete column. STAGE 1 –... - Page 7 The following tool kit is provided with the original column. Tool Where used Allen Key Set Various locations Allen key 14 mm Adaptor & Torque Tie Bar fixing Bolts Wrench 3/8" Drive Spanner 22 mm/24 mm Flow tube adaptor, Adjuster Flow tube, Column Feet Spanner 19 mm/24 mm Flanges bolts Adjuster, Fixed and locking flow cell nut Adjustable Spanner...
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Page 8: Stage 1- Refresh The Adjuster Assembly Of The Evolve
Stage 1– Refresh the Adjuster Assembly of the Evolve 600 mm Process Column ® Disassembly of Adjuster Assembly 1. Detach any pipework from the top sanitary clamp adapter. 2. Remove flange fixing bolts from the top column tube flange. Retain bolts, nuts and washers. -
Page 9: Figure 4: Adjuster Assembly Evolve ® 600 Column
8. Identify the parts as shown in the schematic and photograph below. Figure 4: Adjuster Assembly Evolve ® 600 column. Figure 5 (a-c): Disassembly stages of the Adjuster Assembly 9. Remove the seal actuation nut and spacer (Figure 5a) 10. Slowly, using the hoist, lift the adjuster flange. Pause the lift when the adjuster is approx. -
Page 10: Figure 6 (A-C): Removal Of Seal Adjust Tube
Figure 6 (a-c): Removal of Seal Adjust Tube 14. Undo the locking nut on the flow cell inlet (Figure 6a) and move it towards the flow cell (Figure 6b). 15. Using “flats” and adjustable spanner, undo the seal setting tube and slide it upwards and retain (Figure 6c) Figure 7a, 7b: Removal of Flow Tube 16. -
Page 11: Reassemble And Refresh The Adjuster Assembly
Reassemble and Refresh the Adjuster Assembly At the start of the procedure, the adjuster assembly is partly assembled and consists of adjuster flange, seal actuation handles, threaded central seal height adjust tube and seal setting ring. The adjuster flow cell is supplied as an assembled unit which simplifies adjuster assembly protocols. -
Page 12: Figure 10: Location Of Bed Support Retaining Ring Onto The Adjuster Flow Cell
4. Fit the bed support retaining ring and bed support to the adjuster flow cell. Working around the retaining ring click it into position by locating the outer edge into the groove on the outside of the flow cell. Bed Support Retaining Ring Adjuster... -
Page 13: Figure 12 (A-D): Assembly Stages Of The Adjuster Assembly - Connection To Back Of Adjuster
Figure 12 (a-d): Assembly stages of the Adjuster Assembly – Connection to back of Adjuster Flow cell 8. Slide the stainless steel seal setting tube over the flow tube and connect to the flow cell inlet. Ensure that the tube is fully engaged, and no manual rotation can be achieved. Tighten using adjustable spanner (Figure 12b). -
Page 14: Figure 14: Reassembly Of Adjuster Assembly - Fitting Seal Adjust Handle
13. Fit the spacer and seal adjuster handle - bit may be necessary to remove the slings to enable easy access. The seal adjust handle should be set so that the top of the handle is level with the top of the seal adjust tube; see Figure 14 Figure 14: Reassembly of Adjuster Assembly –... -
Page 15: Stage 2 - Refresh The Tube Assembly Of The Evolve ® 600 Mm Process Column
Stage 2 – Refresh the Tube Assembly of the Evolve ® 600 mm Process Column Disassembly of the Tube unit. Tube Unit Assembly Wetted Flow Path components DISCARD Non-wetted components RETAIN Tube (complete with scale label, Id labels) Top column flange Buffer seals Tie bars and bolts Flange Shield Ring &... -
Page 16: Figure 18: Maintenance Block Position To Support The Column Tube Unit
3. Using appropriate lifting slings or equipment attach the hoist to the eye bolts. 4. Using the correct spanners, remove and retain the column tube bottom flange bolts, washers and bolts. 5. Place the maintenance blocks on the floor. These should be spaced to support the bottom flange and equally spaced;... -
Page 17: Figure 20A, 20B: Disassembly Of Tube Unit
9. Loosen the column top tie bar bolts using the socket adjuster. Remove and retain the tie bar fixing bolts from the top flange and remove the top flange (Figure 20a) Figure 20a, 20b: Disassembly of tube unit 10. Loosen the column bottom tie bar bolts using the socket adjuster. Remove tie bars by manually twisting the bars (Figure 20b). -
Page 18: Reassemble And Refresh The Tube Unit
Reassemble and Refresh the Tube Unit In the column refresh kit, the tube is supplied ready for assembly with scale label, Evolve ® label and rating plate and buffer seals on the tube wall. The flange shield ring and tube seal are required to complete this reassembly. -
Page 19: Figure 24 (A-C): Reassembly Of Column Tube Unit
7. Lift and locate the acrylic tube. Ensure it is located centrally and evenly within the shield ring (Figure 24a). This is a two-person operation. 8. Locate and secure tie bars on the bottom flange using the bottom fixing bolts. Initially hand tighten the bolts, working diametrically opposite. -
Page 20: Stage 3 - Refresh The Fixed Assembly Of The Evolve ® 600 Mm Process Column
Stage 3 – Refresh the Fixed Assembly of the Evolve 600 mm Process Column ® Disassembly of the Fixed End Assembly. 1. To assist it is recommended that column feet are lowered to provide a stable base. 2. Identify the components on the schematic shown in Figure 25. Figure 25: Fixed Assembly Evolve ®... -
Page 21: Reassemble And Refresh Of The Fixed Assembly
Reassemble and Refresh of the Fixed Assembly The bottom flow cell is supplied complete with the flow tube adaptor and gasket in place. 1. Move the column base (Figure 27a) under the overhead hoist and lower column feet to provide a stable base. Place the bottom flow cell on the backing plate using the alignment indicators to ensure flow cell is in the correct orientation. -
Page 22: Stage 4 - Rebuild And Test The Evolve ® 600 Mm Process Column
Stage 4 - Rebuild and Test the Evolve ® mm Process Column Reassembly of the column is the reverse of disassembly and starts from column bottom upwards. Each sub assembly is reassembled before attached to the column. Assemble Tube Unit onto the Column Base and Bottom Flow Cell 1. -
Page 23: Figure 29 (A-C): Location Of Adjuster Assembly Completing Column Refresh Procedure
CAUTION 9. Move the assembly over the column unit, using alignment indicators to line up the adjuster. Slowly position the adjuster unit into the column tube (See Figure 28c). Alignment pins located in the top flange are provided to assist positioning (See Figure 29a). -
Page 24: Preparing For Column Use: Hydrostatic Leak Test
Preparing for Column Use: Hydrostatic Leak Test The purpose of this test is to check that there are no leaks from the column and the column is ready to use. Due to the materials of fabrication, when the column is initially exposed to pressure the column components will flex. -
Page 25: Contact Us
Contact Us To view our Evolve ® Column User guides please visit: https://www.astreabioseparations.com/resources/hardware-user-guides For further enquires please contact: sales@astrea-bio.com Refresh Kit: Guide to Replacing the Wetted Flowpath - Evolve ® 600 mm Process Column... -
Page 26: Revision History
Revision History Revision Comments Date Released Jan 2022 Further Disassembly/assembly Guidance provide May 2023 Rebranding Apr 2024 Manual Revision Date April 2024 Refresh Kit: Guide to Replacing the Wetted Flowpath - Evolve ® 600 mm Process Column... - Page 27 This product is covered by or for use under one or more patents: https://www.astreabioseparations.com/legal/patents/ All trademarks, trade names, trade dress, product names and logos are the property of Astrea UK Services Ltd. Copyright © 2023 Astrea Bioseparations Ltd. All rights reserved.
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