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Bruker AVANCE User Manual

Bruker AVANCE User Manual

Site planning for avance systems 400-700 mhz with ascend aeon (actively refrigerated) magnets
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Site Planning for AVANCE Systems 400-700 MHz
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with Ascend Aeon (actively refrigerated) Magnets
User Manual
Version 008
NMR
Innovation with Integrity

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Summary of Contents for Bruker AVANCE

  • Page 1 AVANCE Site Planning for AVANCE Systems 400-700 MHz ● with Ascend Aeon (actively refrigerated) Magnets User Manual Version 008 Innovation with Integrity...
  • Page 2 © January 13, 2017 Bruker Corporation Document Number: 10000055449 P/N: H157655 For further technical assistance for this product, please do not hesitate to contact your nearest BRUKER dealer or contact us directly at: Bruker Corporation am Silberstreifen 76287 Rheinstetten Germany Phone: + 49 721 5161 6155 E-mail: nmr-support@bruker.com...

  • Page 3: Table Of Contents

    Contents Contents Introduction............................ 7 Units Used Within This Manual................... 7 Safety.............................. 9 Transport and Rigging Safety ..................... 9 The Magnetic Field ...................... 9 2.2.1 Exclusion Zone ......................... 10 2.2.2 Security Zone........................ 10 2.2.3 The 0.5 mT (5 Gauss) Line .................... 11 2.2.4 Standards on Health and Safety in the Workplace ............ 12 Ventilation ......................... 14 2.3.1 Regular Ventilation...................... 14...
  • Page 4 Measuring Floor Vibrations .................... 46 7.1.4 Bruker NMR Floor Vibration Guidelines................ 46 7.1.5 Floor Vibration Guidelines: Bruker Nano-C and Nano-D .......... 48 7.1.6 Floor Vibration Guidelines: Bruker Nano-C API Damping System ........ 49 Magnetic Environment ...................... 51 7.2.1 Guidelines for Static Objects..................... 51 7.2.2 Guidelines for Moving Objects .................. 51 Electromagnetic Interference .................... 52...
  • Page 5 Contents Fire Detection System and Fire Extinguishers.............. 71 Floor Plan ............................ 73 Magnet Location ....................... 73 Dimensions and Mass of Equipment ................ 74 Floor Load......................... 74 Floor Types ........................ 76 Magnet Pits ........................ 76 Magnet Platform........................ 77 Helium Flex Lines ...................... 77 Maximum Field Strengths for NMR Equipment.............. 78 Cabinet Position........................ 78 9.10 Worktable Position ...................... 78 9.11...
  • Page 6 Contents H157655_1_008...

  • Page 7: Introduction

    For specific questions that may not be addressed in this manual, or for further information on a topic, do not hesitate to contact your local Bruker office. Please also review the Installation Questionaire at the end of the manual.

  • Page 8: Table 1.1: Metric To American Conversion Factors

    Introduction Measure Metric Units American Standard Conversion Factor Units (rounded to nearest hundredth) °F °C C = (F - 32) / 1.8 °C K = C + 273.15 °C C = K - 273.15 °F K = (F + 459.67) / 1.8 °F F = K ×...

  • Page 9: Safety

    Operation of Superconducting Magnets, available from Bruker. Transport and Rigging Safety The following safety notices pertain to the transport and rigging of Avance systems: • The magnet should always be transported gently in an upright position. • The magnets are sensitive to shocks and tilting, thus are fitted with shock and tilt watches during transportation.

  • Page 10: Exclusion Zone

    Safety Figure 2.1: Stronger Stray Fields in Vertical Direction than in Horizontal Direction The magnetic field may affect the operation of electronic medical implants such as pacemakers, if exposed to fields greater than 5 Gauss. Medical implants such as aneurysm clips, surgical clips or prostheses may also be attracted. Further care must be taken around changing fields (e.g.

  • Page 11: The 0.5 Mt (5 Gauss) Line

    We are not aware of other special guidelines for pregnant workers concerning magnetic fields, when compared to other people. Bruker takes a conservative approach and recommends that all pregnant workers should stay outside the 0.5 mT (5 Gauss) line, which is known as a general guideline for public access.

  • Page 12: Standards On Health And Safety In The Workplace

    Safety 2.2.4 Standards on Health and Safety in the Workplace Guidelines on Limits of Exposure to Static Magnetic Fields are introduced by the ICNIRP (International Commission on Non-Ionizing Radiation Protection). They give separate guidance for occupational exposures and exposure of general public. Occupational Exposures It is recommended that occupational exposure of the head and the trunk should not exceed a spatial peak magnetic flux density of 2 mT (20 Gauss) except for the following circumstance:...

  • Page 13: Table 2.1: Bgv B11 Standards For Standard Precautions And Users

    Safety German Regulations In Germany, regulation BGV B11 describes the maximum exposure doses in two basic tables. Table 2.1 applies to situations under the standard precautionary conditions, whereas Table 2.2 applies to systems with field strengths above 5 Tesla and can only be applied to certain subgroups of people, which meet nonstandard precautionary conditions.

  • Page 14: Ventilation

    Safety Ventilation Typical NMR superconducting magnets use liquid cryogens as cooling agents. During normal operation of the magnet system it can be expected that a boil-off will occur: • A normal boil-off of liquids contained in the magnet will occur based on the established boil-off specifications.

  • Page 15: Oxygen Level Sensors

    Safety 2.3.3 Oxygen Level Sensors Oxygen (O ) monitors, or level sensors, are required in the magnet room to detect low levels of O due to cryogenic gases. At a minimum the following sensors must be provided: • One oxygen level sensor must be above the magnet, to detect low oxygen levels caused by high helium gas levels.

  • Page 16: Liquid Helium Refills

    Helium refills are not required during the normal operation given that there is no helium loss. Helium top-offs or refills are to be done by Bruker engineers, these are needed during cryocooler and helium compressor services and in case of power or cooling water failures if no back-up utilities are present.

  • Page 17: Safety From Nearby Construction

    Safety Safety from Nearby Construction In a magnet system hazards come basically from two sources: • Mechanical breakdown of the mounting suspension in the magnet system. • Quench as a result of mechanical movement of the superconductor and as a result the magnet reaching a critical temperature.

  • Page 18: Fire Department Notification

    Safety 2.8.1 Fire Department Notification It is recommended that the magnet operator introduce the fire department and/or local authorities to the magnet site. It is important that these organizations be informed of the potential risks of the magnet system, e.g. that much of the magnetic rescue equipment (oxygen-cylinders, fire extinguishers, axe's etc.) can be hazardous close to the magnet system.

  • Page 19: System Components

    System Components System Components This section describes the types and functions of the various sub-systems that are delivered as part of our AVANCE UltraStabilized NMR systems. These include the following: • Superconducting Magnet Components [} 19]. • Console and Other System Components [} 20].

  • Page 20: Console And Other System Components

    NMR equipment should be placed. Figure 3.1: Spectrometer and Magnet Control The AVANCE console main cabinet, where the actual NMR data acquisition is performed. The probe, which is designed to hold the sample, transmit radio frequency signals which excite the sample and receive the emitted response.

  • Page 21: Cryoprobe System (Optional)

    System Components CryoProbe System (Optional) The Bruker CryoProbe Accessory for the AVANCE NMR spectrometers offers dramatic increases in signal to noise ratio, stability, and ease of use. For site planning details for the CryoProbe accessory, refer to CryoProbe and Other Accessories [} 83].

  • Page 22: Cryoprobe Prodigy System (Optional)

    System Components CryoProbe Prodigy System (Optional) The CryoProbe Prodigy is a new CryoProbe generation designed specifically for AVANCE III spectrometers. Costing significantly less than a conventional CryoProbe, the broadband CryoProbe Prodigy uses nitrogen-cooled RF coils and preamplifiers to deliver a sensitivity...

  • Page 23: Other Optional Components

    NMR sample tube automation. SampleXpress allows automatic measurement of NMR samples with Bruker NMR spectrometers. SampleXpress is controlled by TopSpin or IconNMR, and is equipped with integrated barcode reader registration, which is under control of SampleTrack.
  • Page 24 System Components H157655_1_008...

  • Page 25: Magnet Access And Rigging

    Magnet Access and Rigging Magnet Access and Rigging The magnet is very heavy and fragile, thus requires special consideration during delivery and movement to its final installation point. The other components of the spectrometer system (console, options, etc.) can typically be removed from the trucks with forklifts and are positioned in the NMR lab with a pallet jack.

  • Page 26: Considerations For Transport To The Nmr Laboratory

    Magnet Access and Rigging Considerations for Transport to the NMR laboratory Before delivery the customer must ensure that the system and magnet can be transported to the site. The section on Transport Dimensions and Weights [}  26] in this chapter provides the sizes and weights of the crates in which the system are shipped.

  • Page 27: Magnet Stand Transport Dimensions

    Magnet Access and Rigging Crate Size (m) Magnet Transport Dimensions (m) (for transport to the magnet room) System Width Height Height Uncrated Uncrated w/ Uncrated (MHz/mm) o Pallet with Pallet Jack* Jack** 400/89 Ascend Aeon 1.15 1.35 2.08 0.85 1.53 1.64 500/89 Ascend Aeon 1.15 1.36 2.02...

  • Page 28: Magnet Transport Weights

    Magnet Access and Rigging Accessories Crate Size - including stand if applicable (m) Magnet Stand 400/89 Ascend Aeon F95 950 API 1.32 0.74 1.29 500/89 Ascend Aeon F95 950 API 1.32 0.74 1.29 600/89 Ascend Aeon F95 950 API 1.32 0.74 1.29 700/89 Ascend Aeon F110 950 API...

  • Page 29: Spectrometer And Accessories Transport Dimensions And Weights

    Note: The pallet is now integrated into the crate. Weights include pallets and packing material as required. Weights are for a standard AVANCE configuration, actual weights may increase depending on options selected. * Transport width = width indicated + minimum 1 cm clearance on each side. These are the widths if the console is inserted lengthways through the entrance.

  • Page 30: Table 4.8: Crate Dimensions And Weights For Accessories

    Magnet Access and Rigging Crate Size (m) Weight Accessory (kg) LC-NMR Unit, LC-NMR Control Unit (host n/a* n/a* n/a* 50-250 computer), plus any additional options/ accessories Imaging Cabinet n/a* n/a* n/a* SampleXpress 0.96 0.96 0.52 SampleXpress Lite 0.57 0.69 0.42 SampleJet 1.20 0.80...

  • Page 31: Rigging Equipment

    Magnet Access and Rigging Rigging Equipment Rigging equipment is not included with the NMR system order. The following rigging equipment will be needed for a typical delivery and installation of an NMR magnet system: • Pallet Jack and/or Fork Lift: For transporting system magnet and accessories to the laboratory.
  • Page 32 Magnet Access and Rigging H157655_1_008...

  • Page 33: Ceiling Height Requirements

    Ceiling Height Requirements Ceiling Height Requirements The assembly of the magnet system, the magnet energization, and refills with liquid helium require minimum height clearances. • The ceiling height requirements for the magnet installation and cryogen refills do not need to be met over the entire laboratory. The height requirements need only be met immediately above the magnet, over an area to allow for assembly of the lifting system (if applicable), and over an area to allow for insertion of the helium transfer line.

  • Page 34: Helium Transfer Line

    Ceiling Height Requirements Helium Transfer Line Figure 5.1: Ceiling Height Requirements Ceiling height must allow for insertion of helium transfer lines. Liquid helium dewar. Ceiling height requirements must be met over this area. Magnet. H157655_1_008...

  • Page 35: Figure 5.2: Helium Transfer Lines

    Ceiling Height Requirements Figure 5.2: Helium Transfer Lines Refer to the figure above for the following helium transfer line dimensions. Magnets Part Nr. X (mm) Y (mm) Z (mm) V (mm) W (mm) Remarks Ascend 53962 1455 1508 2060 D3XX 29085 1455 1508 2060...

  • Page 36: Minimum Ceiling Height

    Ceiling Height Requirements Minimum Ceiling Height The minimum ceiling height requirements for operation of each magnet are listed in the following table. Note that the values represent the absolute minimum, an extra 0.3-0.4 m above minimum requirements will make all procedures safer and more convenient. Note: The minimum ceiling height requirements for INSTALLATION may be greater than the values in the table below, depending on the options selected.

  • Page 37: Table 5.2: Minimum Ceiling Height Requirements: Standard Bore 54 Mm

    Ceiling Height Requirements Ceiling Height Requirements The number in the following tables corresponds to a standard magnet configuration using a minimum height stand. The ceiling height can increase up to 250 mm based on the model of the magnet and stand. Refer to the table in Magnet Stand Transport Dimensions for specification on the magnet model and stand.
  • Page 38 Ceiling Height Requirements H157655_1_008...

  • Page 39: Magnetic Stray Fields

    0.5 mT (5 G) line. For further information on acceptable magnetic field limits contact your countries health authorities or your area Bruker office. Various devices are affected by the magnet and must be located outside the limits specified in the following section.

  • Page 40: Horizontal Stray Fields

    Magnetic Stray Fields Please note all measurements in the following tables are in meters! Horizontal Stray Fields Magnet Type 5.0 mT 3.0 mT 1.0 mT 0.5 mT 0.2 mT 0.1 mT 0.05 mT (50 G) (30 G) (10 G) (5 G) (2 G) (1 G) (0.5 G)

  • Page 41: Vertical Stray Fields

    Magnetic Stray Fields Vertical Stray Fields Magnet Type 5.0 mT 3.0 mT 1.0 mT 0.5 mT 0.2 mT 0.1 mT 0.05 mT (50 G) (30 G) (10 G) (5 G) (2 G) (1 G) (0.5 G) 400/54 Ascend Aeon 0.64 0.70 0.87 1.00...

  • Page 42: Stray Field Plots

    Magnetic Stray Fields Stray Field Plots Figure 6.1: Example of a Stray Field Plot H157655_1_008...

  • Page 43: Environment And Site Survey Measurement

    • Measuring the extent of vibrations at the magnet location is a relatively simple matter; if you suspect a problem you should contact your local Bruker office. The following thresholds represent the maximum velocities and accelerations that could be tolerated on the floor of the laboratory where the magnet is going to be located.

  • Page 44: Integrated Isolator Options

    7.1.1 Integrated Isolator Options All Bruker magnets are delivered standard with integrated isolators as follows: • EMI (Elastomeric Isolators) – Standard for 300-500 MHz magnets. • ADI (Air Spring and Damped Isolators) – Standard for 600 MHz magnets, optional for 300-500 MHz magnets.

  • Page 45: Table 7.1: Application And Interpretation Of The Generic Vibration Criterion (Vc) Curves

    Environment and Site Survey Measurement Criterion Amplitude µm/s Description of Use Curve (11µi/s) Barely perceptible vibration. Appropriate to sleep areas in most instances. Usually adequate for computer equipment, hospital recovery rooms. Residential day 200 (8 000) semiconductor probe test equipment, and (ISO) microscopes less than 40x.

  • Page 46: Measuring Floor Vibrations

    7.1.3 Measuring Floor Vibrations Bruker offers a service for measuring floor vibrations using specialized hardware and software. We recommend measurements to be done over a period of at least 1 hour (ideally much longer) to try capturing both steady state conditions and transient events.

  • Page 47: Figure 7.3: Example Of The Bruker Tolerance Level For Elastomer Dampers. Resolution <0.125

    Environment and Site Survey Measurement Figure 7.3: Example of the Bruker Tolerance Level for Elastomer Dampers. Resolution <0.125 Hz, 1… 200 Hz, > 30 min, Average Measurement 1 (displayed in velocity) Figure 7.4: Elastomer Dampers H157655_1_008...

  • Page 48: Floor Vibration Guidelines: Bruker Nano-C And Nano-D

    3…12 µm/s 1.6…6.4 µms >20 Hz 12 µm/s 6.4 µm/s Table 7.3: ADI Damping System (Elastomeric Isolators) Figure 7.5: Example of the Bruker Tolerance Level for ADI Dampers. Resolution <0.125 Hz, 1…200 Hz, > 30 min, Average Measurement 1 (displayed in velocity) H157655_1_008...

  • Page 49: Floor Vibration Guidelines: Bruker Nano-C Api Damping System

    Environment and Site Survey Measurement Figure 7.6: ADI Dampers 7.1.6 Floor Vibration Guidelines: Bruker Nano-C API Damping System API Damping System Figure 7.7: Tolerance Level Nano-C for API Dampers H157655_1_008...

  • Page 50: Figure 7.8: Example Of The Bruker Tolerance Level For Api Dampers. Resolution <0.125 Hz

    According to VDI 2038 (2013) Bruker is following the threshold values of sensitive laboratory equipment. Bruker implemented a Nano-C limit which is less critical as Nano-D. The only big difference in observing these data is to use a higher resolution as only 1/3 octave. We recommend to measure with a resolution of <...

  • Page 51: Magnetic Environment

    It must be emphasized however, that such recommendations represent a situation that may not be achievable. Please consult with Bruker for possible solutions if one or more of these recommendations cannot be satisfied.

  • Page 52: Electromagnetic Interference

    If you suspect that you have a source of interference located near the proposed magnet site then you should contact Bruker BioSpin for a site survey. Bruker offers a service for measuring EMF interferences using specialized hardware and software. We recommend measurements to be done over a period of at least one hour (ideally much longer) to try capturing both steady state conditions and transient events.

  • Page 53: Measuring Dc Fluctuating Fields

    Bruker office for further clarification. 7.3.2.3 Reducing DC Interference Two Bruker technologies help to suppress the DC field perturbations: • Modern magnets with EDS technology (External Disturbance Suppression) efficiently suppress interferences by a factor ~25-1000, depending on the model and disturbance frequency.

  • Page 54: Ac Emf Interference

    Environment and Site Survey Measurement 7.3.3 AC EMF Interference In high resolution NMR AC disturbances in the frequency range of 1Hz to several 100 Hz cause modulation sidebands in NMR spectra, as long as the disturbance frequency is equal to or larger than the line width. As long as these sidebands are small in amplitude they disappear in the noise floor.

  • Page 55: Reducing Ac Emf Interference

    Figure 7.10: Specification Framework with the Magnetic Field Represented as 0 to Peak Values 7.3.3.3 Reducing AC EMF Interference Two Bruker technologies help to suppress the DC field perturbations: • Modern magnets with EDS technology (External Disturbance Suppression) efficiently suppress AC interferences by a factor ~25-10000, depending on the model and disturbance frequency.

  • Page 56: Most Commonly Studied Nuclei

    Furthermore, the advanced BSMS digital lock system - included with all Bruker AVANCE spectrometers - allows a shift in the 2H lock frequency with certain limits. This may allow enough variation in the absolute magnet field strength to shift the NMR signal away from that of local broadcasting frequencies.

  • Page 57: Utility Requirements

    AVANCE cabinet. Other Power Requirement Considerations • For installation of the AVANCE system a 230V / 16A outlet is needed for the turbo-pumps, as well as an additional 230V / 16A outlet for the magnet power supply (during installation and service).

  • Page 58: Table 8.1: Requirements Of Basic System (2 Channels)

    BCU-II must come from (BCU-II) separate outlet). UPS for CCU UPS requirements: At least 5 kW for the AVANCE and CCU. UPS for AVANCE UPS requirements: At least 2.6 kW for the spectrometer cabinet Spectrometer (depends on configuration). The battery time must be selected Cabinet according to the maximum duration anticipated for a power failure.

  • Page 59: Telecommunication

    • 600-800 MHz: Nitrogen gas with >96% purity. Notes: • A nitrogen separator (offered by Bruker as an option) can be built into the AVANCE cabinet as an available solution. This will produce the nitrogen gas required for VT work.

  • Page 60: Other Specifications

    Operating Pressure Recommended Average Flow* AVANCE + VT Unit 6-8 bar (80-120 psi) 43 l/min. (~1.52 cfm) AVANCE + VT + Sample 6-8 bar (80-120 psi) 55 l/min. (~1.95 cfm)** Changer AVANCE + MAS 6-8 bar (80-120 psi) 300 l/min. (~11 cfm) * This is the actual consumption and minimum needed at the instrument input after the N2 supply (either a bulk tank, or a N2 separator).

  • Page 61: Compressed Air System

    Utility Requirements 8.3.4 Compressed Air System When designing a suitable compressed air system the following points must be taken into consideration: • To prevent magnetic impurities from entering the magnet use only copper or stainless steel lines. Do not use iron or steel pipes. Plastic piping is unsuitable where very low dew points are required.

  • Page 62: Air Compressors

    The plastic tubing used to carry the supply from the final gate valve to the console has an outside diameter of 8 mm and is supplied by Bruker. • Some types of dryers, e.g., absorption dryers can use up to 25% of the air flow to regenerate the drying material.

  • Page 63: Dryers

    Utility Requirements 8.3.4.2 Dryers Refrigeration Dryers This type of dryer removes moisture from gas by cooling to within a few degrees of the freezing point of water. The condensed moisture is removed in a separator and drain trap mechanism located immediately downstream of the dryer. This drain should be valve switched automatically.

  • Page 64: Filters

    10 kW of dissipated heat. Bruker recommends the installation of a dedicated cooling water loop serving the helium compressor. This may be achieved by using either a refrigerated indoor or outdoor chiller, or a water-water heat exchanger depending on the specific conditions and utilities available at the customer site.

  • Page 65: Lighting

    (air-return) closer to the NMR spectrometer equipment (AVANCE console, UPS, CryoCooling unit, BCU-I) that releases most of the heat output into the space. This would help with removing the heat closer to its sources and ultimately help with the overall temperature stability in the room.

  • Page 66: Table 8.4: Maximum Humidity In The Nmr Laboratory

    Utility Requirements The maximum humidity in the lab depends on the room temperature. There are parts on or near the NMR spectrometer and the magnet system (like the nitrogen heat exchangers) which have temperatures of 14…16°C. When the room temperature is 25°C, with a humidity of 80 %, the dew point of this air is at 21.3°C.

  • Page 67: Heat Dissipation Into The Room

    He Compressor BNL - inside water-cooled 2.0 kW He Compressor BNL - outside air-cooled 2.2 kW Table 8.5: Heat Dissipation into the Room by Typical AVANCE Systems 8.6.2 System Stability Air Temperature The heat dissipation of the magnet system is constant over time. It is essential to minimize or avoid short term oscillations of the HVAC system, and provide a continuous slow flow of air that in turn reduces the speed of any temperature changes.

  • Page 68: Emergency Ventilation During Installation And Quenches

    Utility Requirements Emergency Ventilation During Installation and Quenches Due to the large amount of liquid helium contained in the magnet, an emergency exhaust system may be required to prevent O depletion during a magnet quench. Likewise, during the installation, refilling and cooling of superconducting magnets, large volumes of nitrogen or helium gases may be generated under certain conditions.

  • Page 69: Emergency Exhaust Solutions

    • Insulation of exhaust piping should also be provided to prevent cold burns and O condensation during a quench. Please contact Bruker if the implementation of quench pipes is planned! H157655_1_008...

  • Page 70: Figure 8.2: Emergency Quench Pipes

    The air conditioning system could, for example, be connected to an oxygen level sensor. Please contact Bruker for further information on exhaust solutions. H157655_1_008...

  • Page 71: Fire Detection System And Fire Extinguishers

    Utility Requirements Fire Detection System and Fire Extinguishers Rooms containing NMR magnets should be equipped with temperature sensors for fire detection. These must respond only to a sudden rise of temperature, and not be triggered by a quench (sudden drop of temperature). Optical smoke detectors cannot discriminate between smoke from a fire and fog from either a helium refill or caused by a quench, so these may not be used.
  • Page 72 Utility Requirements H157655_1_008...

  • Page 73: Floor Plan

    Floor Plan Floor Plan Magnet Location When locating the magnet, certain considerations must be made with regards to the laboratory environment: • To increase magnet homogeneity, the magnet should be located away from permanent iron structures such as support beams in walls and floors. Reference: Electromagnetic Interference [} 52].

  • Page 74: Dimensions And Mass Of Equipment

    (filled with cryogens and including stand). The assembly of the magnet system, the magnet energization and refills with liquid helium require additional ceiling height. Component Width (m) Depth (m) Height (m) Weight (kg) AVANCE TwoBay 1.31 0.83 1.55 AVANCE OneBay 0.69 0.83 1.29...

  • Page 75: Figure 9.2: Magnet Dimensions

    Floor Plan Magnet Dimensions and Mass The values in the following table correspond to the following figure: Figure 9.2: Magnet Dimensions Maximum magnet diameter Magnet height from the floor, including stand. Overall footprint diameter Refer to the Magnet Dimensions and Total Weights table for the values of A, B, and C. Magnet Type Total Magnet Weight incl.

  • Page 76: Floor Types

    HVAC (Heating Ventilation Air Conditioning) [} 65] Emergency Ventilation During Installation and Quenches [} 68]). • Magnet refills and access for transport dewars. • Cable lengths. • Siting the BCU-I or BCU-II cooling unit. • Siting the CryoPlatform Consult your local Bruker Installation Engineer for details. H157655_1_008...

  • Page 77: Magnet Platform

    The platform must be constructed of wood or other non-magnetic material. It must accommodate the magnet and provide safe access for sample insertion and cryogen fills. Consult you Bruker office for further guidelines when using a magnet platform. Figure 9.3: Example of a Simple Magnet Platform...

  • Page 78: Maximum Field Strengths For Nmr Equipment

    ** Use wooden furniture if access during critical measurements is required. Table 9.4: Maximum Field Strength for NMR Equipment Cabinet Position The various units within the AVANCE cabinet, especially the acquisition computer, must be kept at a minimum distance from the magnet. Protection of the acquisition computer and digital electronics from the magnet’s stray field is best achieved by positioning the cabinet so...

  • Page 79: Service Access Requirements

    • Ventilation: A minimum of 30 cm must left between the back of the cabinet and any wall to ensure proper ventilation. • Service access - AVANCE: Sufficient space (~ 60 cm) must be left in front of the AVANCE so the cabinet may be pulled away from the wall for service. Service access to the sides is not required.

  • Page 80: Layout Examples

    Floor Plan 9.12 Layout Examples The following layout examples of some NMR systems include the equipment and utilities. A description of each of the NMR system components is presented in the chapter System Components [} 19], while the details regarding the utility requirements are presented in the chapter Utility Requirements [} 57].

  • Page 81: Figure 9.5: Top View Of The Ascend 400 Magnet

    Floor Plan Figure 9.5: Top View of the Ascend 400 Magnet 1 AVANCE Console 7 Preamplifier 2 Temperature Control Unit BCU I 8 Sample Changer 3 Magnet System 9 Damping Post for CryoProbe Transfer Line 4 0.5 mT (5 Gauss) Line 10 He Gas Cylinder 6.0 for CryoPlatform...
  • Page 82 Floor Plan H157655_1_008...

  • Page 83: Cryoprobe And Other Accessories

    CryoProbe and Other Accessories 10 CryoProbe and Other Accessories ™ The CryoProbe accessory for the AVANCE Series NMR Spectrometers offers dramatic increases in signal to noise ratio (S/N) by reducing the operating temperature of the NMR coil assembly and the preamplifier.

  • Page 84: Figure 10.1: Cryoprobe System Overview

    CryoProbe and Other Accessories Figure 10.1: CryoProbe System Overview Refer to the layout examples for more information. H157655_1_008...

  • Page 85: Cryocooling Unit

    (7.5 kW average, 8.5 kW peak), it must be cooled to prevent overheating. Bruker offers both water cooled and air cooled helium compressors. In either case, placing the compressor in a remote room (allowing He gas flex lines up to 20 m to reach the CryoCooling unit) or an enclosure will keep the noise of the unit out of your laboratory.

  • Page 86: Helium Compressor - Indoor Water Cooled

    CryoProbe and Other Accessories 10.2.1.1 Helium Compressor - Indoor Water Cooled • Requires chilled water source (supplied by customer) with a flow and temperature within the specified admissible ranges shown in the plots below. It is important that not only the temperature stays below the maximum temperature threshold but also the flow is not greater than the upper threshold shown.

  • Page 87: Figure 10.4: Helium Compressor - Indoor Water Cooled

    CryoProbe and Other Accessories Inlet Temperature Range [°C] (°F) [4.0 ~ 28.0] (39.2 ~ 82.4) Inlet Pressure Range [MPa] (psig) [0.10 ~ 0.69] (14.5 ~ 100) Flow Rate [liter/min.] (gallon/min.) [4.0 ~ 10.0] (1.1 ~2.6) Characteristics Pressure Drop [MPa] (psig) [0.025 ~ 0.085] (3.55 ~ 12.1) Heat Output [kW ] (BTU/Hr) into <Steady State>...

  • Page 88: Helium Compressor - Indoor Air Cooled

    CryoProbe and Other Accessories 10.2.1.2 Helium Compressor - Indoor Air Cooled • The room air handling system must be able to dissipate 7.5 kW of heat. • Siting this helium compressor in the same room as the NMR is not recommended. •...

  • Page 89: Space Requirements And Specifications

    CryoProbe and Other Accessories 10.2.2 Space Requirements and Specifications 10.2.2.1 Indoor Helium Compressors The indoor helium compressors (air or water cooled) have space requirements to allow for airflow and servicing the unit. The minimum room space needed is 1.25 m (width) x 0.8 m (depth) x 0.7 m (height).

  • Page 90: Outdoor Helium Compressors

    CryoProbe and Other Accessories 10.2.2.2 Outdoor Helium Compressors The outdoor helium compressor has an outdoor and an indoor unit. Each component has space requirements for airflow and servicing. The indoor component requires a space of 0.5 m (width) x 1.3 m (depth) x 1 m (height). The outdoor component requires a space of 1.4 m (width) x 1.7 m (depth) x 1.25 m (height), and should be sited on a concrete slab.

  • Page 91: Helium Cylinders

    5 Gauss line in a serviceable location (i.e. changing the bottle should not interfere with nearby magnets). The helium regulator and a special He gas hose are supplied by Bruker. Two lengths for the He gas hose line are available (10 m and 20 m).
  • Page 92 CryoProbe and Other Accessories Helium Transfer line from CryoCooling Unit to CryoProbe • A standard length transfer line, determined by the magnet, is delivered with each CryoPlatform. Longer transfer lines may be ordered if necessary to accommodate the CryoCooling unit in your laboratory. If a longer transfer line is required a special review of your site will be required.

  • Page 93: Cryoprobe Prodigy System (Optional)

    CryoProbe and Other Accessories 10.5 CryoProbe Prodigy System (Optional) The CryoProbe Prodigy uses nitrogen-cooled RF coils and preamplifiers to deliver a sensitivity enhancement over room temperature probes of a factor of 2 to 3. The Prodigy package is comprised of: •...
  • Page 94 • Sample protection option: Add 40 l/min. (1.4 cfm) to above values. Case 2: Use an N gas separator to generate the required gas on site (as specified in Case 1). Bruker Compressed air with dew point < offers a N Separator (P/N 46540). Requirements -25°C available.

  • Page 95: Cryofit

    CryoProbe and Other Accessories 10.6 CryoFit This section describes the requirements for the site planning for the CryoFit. 10.6.1 Introduction A CryoFit converts a standard CryoProbe into a flow probe within a few minutes. The CryoFit is a long metal pole with a flow cell. The flow cell is positioned inside the CryoFit during storage and installation.
  • Page 96 CryoProbe and Other Accessories H157655_1_008...

  • Page 97: 11 Installation

    The spectrometer system will arrive at the site in crates. The crates should only be opened by the Bruker BioSpin service engineer. The commissioning of the magnet involves several stages as outlined in the table below. The installation time line given below is an approximation;...

  • Page 98: Installation Requirements Checklist

    Installation 11.3 Installation Requirements Checklist For the installation the customer must provide the following: Lifting equipment and minimum ceiling height as outlined in the table in Charging the Magnet [} 99]. Pallet jack and/or fork lift for transporting system accessories. A cylinder of N gas 50l/200 bar (~2 cu.ft, 3000 psi, 4.6 grade) with reducing regulator valves to deliver pressure of 0.5 bar (~8 psi), as specified in Other...

  • Page 99: Magnet Evacuation And Flushing With Nitrogen Gas

    Installation 11.4.2 Magnet Evacuation and Flushing with Nitrogen Gas Once the magnet has been assembled and placed in the magnet room, rough pumping of the cryostat can begin. At the same time the cryostat is flushed through with dry nitrogen gas. The customer must provide a 50l (4.6 grade)/200 bar (~2 cu.ft, 3000 psi) cylinder of dry nitrogen gas (99.996% purity).
  • Page 100 Installation Magnet Transport Weights Magnet Type Magnet Magnet LHe After Weight Weight Needed Needed Empty Filled for Cool- Training with with Precool down Quench Magnet Magnet Stand Stand Charging (kg)* (kg) 400/54 Ascend Aeon 500/54 Ascend Aeon 600/54 Ascend Aeon 1010 1060 700/54 Ascend Aeon...

  • Page 101: 12 Contact

    NMR Hotlines Contact our NMR service centers. Bruker BioSpin NMR provides dedicated hotlines and service centers, so that our specialists can respond as quickly as possible to all your service requests, applications questions, software or technical needs. Please select the NMR service center or hotline you wish to contact from our list available at: https://www.bruker.com/service/information-communication/helpdesk.html...
  • Page 102 Contact H157655_1_008...

  • Page 103: List Of Figures

    Hz, 1…200 Hz, > 30 min, Average Measurement 1 (displayed in velocity)....Figure 7.4: Elastomer Dampers ...................... Figure 7.5: Example of the Bruker Tolerance Level for ADI Dampers. Resolution <0.125 Hz, 1… 200 Hz, > 30 min, Average Measurement 1 (displayed in velocity)......Figure 7.6: ADI Dampers ........................
  • Page 104 List of Figures H157655_1_008...

  • Page 105: List Of Tables

    VT Nitrogen Gas Quality (500 MHz and above) ..............Table 8.4: Maximum Humidity in the NMR Laboratory ............... Table 8.5: Heat Dissipation into the Room by Typical AVANCE Systems ......... Table 8.6: Total Gas Volume and Maximum He Gas Flow: Standard Bore 54 mm ......Table 8.7: Total Gas Volume and Maximum He Gas Flow: Wide Bore 89 mm ........
  • Page 106 List of Tables Table 10.2: Cooling Water Specifications ..................... Table 10.3: Technical Data for Indoor Compressors ................Table 10.4: Technical Data for Outdoor Compressors ................. Table 10.5: Prodigy System Equipment Dimensions................Table 10.6: Prodigy System Electrical Requirements................Table 10.7: Prodigy System N2 Gas Requirements ................Table 10.8: Prodigy System Ventilation Requirements ................

  • Page 107: Index

    External Disturbance Suppression .... 55 Fans .............. 43 Faraday cage ........... 56 Air conditioning .......... 52 Ferromagnetic materials........ 51 Airplanes ............ 43 Ferromagnetic objects ........ 10 Automobiles............ 43 Fire extinguishers ........ 18, 71 AVANCE Cabinet Floor Types Dimensions and weight ....... 74 PVC ............. 76 Vinyl............. 76 Wood ............ 76 Fluxgate magnetometer ........ 53 Fork Lift............. 31 B-CU-I Dimensions and weight ....... 74...
  • Page 108 Index Subways ............ 52 Sunlight ............ 73 nitrogen separator .......... 59 Support beams .......... 73 Oil Content: ............ 60 Television broadcasts........ 55 Optical smoke detectors ........ 71 Television stations .......... 52 overall floor load .......... 74 temperature sensors ........ 71 Oxygen level sensors ........ 68 Trains ............... 43 Oxygen-cylinders.......... 18 Trams ............... 52 Transformers ............ 52 Pacemakers ............. 10 Pallet Jack ............ 31 UPS .............. 57...
  • Page 109 H157655_1_008...
  • Page 110 ● Bruker Corporation info@bruker.com www.bruker.com Order No: H157655...

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