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This is not harmful for the pedal but may cause high spikes to the speakers. It’s however suggested to connect the EXP/CV jack with pedal powered off. If reset happens when V-Uno is connected to software it is necessary to do a software DISCONNECT...
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These knobs can be assigned to any effect parameter via software USB and jack DC connectors USB port is used to upload effects to V-Uno and handle all the dedicated functions. It can be used to power V-Uno too. USB can be connected to a PC, either a Windows device or Mac, as well an Android device equipped with USB OTG (check your mobile device manual to make sure it supports USB on-the- go).
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If USB and jack connector are connected at same time V-Uno will get power from DC jack and draw almost all the current from jack PSU.