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Capintec CAPTUS 2000 Owner's Manual

Thyroid uptake system
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CAPTUS
THYROID UPTAKE SYSTEM
OWNER'S MANUAL
Copyright
®
CAPTUS
is a registered trademark of Capintec, Inc.
ALL RIGHTS RESERVED
Manual Stock No. 9250-0059-A
Capintec, Inc.
Sales and Marketing
and Customer Support
6 Arrow Road
Ramsey, NJ 07446
Phone (800) ASK-4CRC
Fax (201) 825-1336
Capintec, Inc.
Service Center
540 Alpha Drive
Pittsburgh, PA 15238
Phone (800) 227-6832
Fax (412) 963-0610
©
1993 Capintec, Inc.
Rev. J – February 2001
®
2000

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  • Page 1 Service Center 540 Alpha Drive Pittsburgh, PA 15238 Phone (800) 227-6832 Fax (412) 963-0610 © Copyright 1993 Capintec, Inc. ® CAPTUS is a registered trademark of Capintec, Inc. ALL RIGHTS RESERVED Manual Stock No. 9250-0059-A Rev. J – February 2001...

  • Page 3: Table Of Contents

    ® CAPINTEC, INC CAPTUS 2000 TABLE OF CONTENTS SAFETY Symbol Definitions..................1-1 Warning and Caution Labels ............... 1-2 Cautions and Notes ..................1-4 General Safety Tips..................1-5 FUNCTIONAL & TECHNICAL DESCRIPTION General......................2-1 Technical Description .................. 2-1 Detector ................... 2-1 Multichannel Analyzer..............
  • Page 4 ® CAPINTEC, INC CAPTUS 2000 GENERAL OPERATING INSTRUCTIONS Windows Operating Conventions ..............3-1 Common Controls and Technique .............. 3-1 Windows Controls ..................3-1 Trackball Cursor ................3-1 Command Button................3-2 Frame ....................3-3 Radio Button ................ 3-3 Check Box ................3-3 Text Entry Box .................
  • Page 5 ® CAPINTEC, INC CAPTUS 2000 THYROID UPTAKE General Information..................6-1 Defining a Measurement Protocol ............... 6-2 Adding Protocols................6-3 Protocol Name ................. 6-4 Counting Method ................6-5 Multiple Capsule Administration ............6-6 Counting Repetitions, Dose Form, and Predose Measurements ..6-6 Isotope .....................
  • Page 6 ® CAPINTEC, INC CAPTUS 2000 LAB TESTS Schilling Test....................8-2 Setup Counting Parameters ............8-3 Adding Patients ................8-4 Editing Patient Information .............. 8-6 Deleting Patient Information ............8-6 Making Measurements ..............8-8 Test Results ..................8-11 Printing Results ................8-12 ®...
  • Page 7 ® CAPINTEC, INC CAPTUS 2000 MCA (cont) Acquisition and Count Data ................. 10-6 Regions of Interest (ROI)................10-7 Save and Restore Count Data or MCA Settings ......... 10-8 Save MCA Settings................10-8 Recall MCA Settings................ 10-9 Save Spectrum ................10-10 Recall Spectrum ................

  • Page 9: Capintec, Inc

    2000 PREFACE Thank you for purchasing the CAPINTEC line of Thyroid Uptake Measurement Systems. Every effort has been made to insure that the information in this document is complete, accurate, and up-to-date. CAPINTEC assumes no responsibility for the results of errors beyond its control.
  • Page 10 Increase the separation between the equipment and the affected device. • Plug the unit into an outlet on a circuit different from that which the affected device is connected. If this fails to correct the problem, please contact Capintec. IMPORTANT SAFETY INFORMATION ® The CAPTUS 2000 measurement system has been carefully designed to give you years of safe and reliable performance.

  • Page 11: Safety

    ® CAPINTEC, INC CAPTUS 2000 CHAPTER 1 SAFETY ® These warnings and instructions for use form an integral part of the CAPTUS 2000 and must therefore be kept available for consultation at all times. Precise compliance with the warnings and instructions is an essential condition for normal use, correct application and thus safety of patients and user.

  • Page 12: Warning And Caution Labels

    ® CAPINTEC, INC CAPTUS 2000 WARNING AND CAUTION LABELS Located in the center section on both sides of the spring-arm of the floor stand is a warning label, (see Fig. 1-1), concerning the hazard of removing the collimator when the spring-arm is in the wrong position.
  • Page 13 ® CAPINTEC, INC CAPTUS 2000 Figure 1-3 Located on the top of the Isolation Transformer is a label, (see Figure 1-4), providing the system power requirements, the voltage and serial number of the system and the replacement fuse values for both power line voltages.

  • Page 14: Cautions And Notes

    ® CAPINTEC, INC CAPTUS 2000 Located on the left side of the Isolation Transformer is a label, (see Fig. 1-5), with two caution statements pertaining to the main power cord of the Isolation Transformer. The statement, READ INSTRUCTIONS CAREFULLY BEFORE CONNECTING TO OUTLET, directs the user to the owners manual before connecting the power.

  • Page 15: General Safety Tips

    However, there is no guarantee that interference will not occur in a particular installation. CAUTION If any printer other than the model supplied by Capintec is used, the safety of the unit may be compromised or Electromagnetic Interference (EMI) may be introduced into other devices ®...
  • Page 16 ® CAPINTEC, INC CAPTUS 2000 • To avoid damaging the power cord, do not place anything on it or place it where it will be walked on. If the cord becomes damaged, replace it immediately. • Aside from the routine maintenance described in this manual, do not try to service this equipment yourself.

  • Page 17: Functional & Technical Description

    ® CAPINTEC, INC CAPTUS 2000 CHAPTER 2 FUNCTIONAL & TECHNICAL DESCRIPTION GENERAL ® The CAPTUS 2000 Thyroid Uptake / Well Systems is intended to be used by trained Nuclear Medicine Technologists for performing Thyroid Uptake, Thyroid Bioassay, Wipe ® Test, Blood Volume (with Cr-51 or I-125) Test, Shillings (including DICOPAC ) Test and RBC Survival Test.

  • Page 18: Multichannel Analyzer

    ® CAPINTEC, INC CAPTUS 2000 this reason, always handle the detector with care. Avoid scratching the surface with metal objects such as pens. When a gamma or x-ray from a radioactive source reaches the NaI crystal, it collides with the electrons in the crystal matrix and transfers energy, primarily through Compton interaction.

  • Page 19: Technical Specifications

    ® CAPINTEC, INC CAPTUS 2000 TECHNICAL SPECIFICATIONS ® Pentium class computer system including the MS Windows operating system with a multichannel analyzer PC Board, two scintillation detectors, a dual input detector preamplifier/switch PC Board, a trackball pointing device, a color printer, and exceptionally ®...

  • Page 20: Storage

    ® CAPINTEC, INC CAPTUS 2000 Storage The instrument should be stored where the temperature is stable and the range is from +39°F to +115°F (+4°C to +43°C) and the maximum relative humidity is 90% non-condensing to warrant maximum reliability. The instrument should be stored where the barometric pressure is within a range of 15 –...

  • Page 21: Mca Interface Pc Board

    ® CAPINTEC, INC CAPTUS 2000 ® MCA Interface PC Board (Accuspec/NaI Plus Board) 1024 Channels 3 conversion gains: 256, 512, 1024 Maximum Count Rate 100,000 cps ROI's – Automatic or Manual QA automatic-gain adjust, energy calibration, resolution, chi-squared, constancy Automatic efficiency calculation and storage Adjustable Lower Level Discriminator Differential Nonlinearity <2% over the top 98% of channels...

  • Page 22: Regulatory Listings

    ® CAPINTEC, INC CAPTUS 2000 NaI(TI) well type crystal / PM Tube: 5.1 x 5.1 cm (2" x 2") Well diameter: 1.6 cm (0.625") Well depth: 4 cm (1.5") Featuring Monoline construction Pulse Height Resolution – 8.5% or better for Cs137 Lead shielding –...

  • Page 23: Wipe Test

    ® CAPINTEC, INC CAPTUS 2000 of Interest have been defined for three isotopes, I-131, I-123, or Tc-99m. If normal values have been entered, then results exceeding these values will be flagged. All of the patient information may be printed. The thyroid uptake software has been designed to accommodate a variety of different counting protocols, using either capsules or liquid dosages.

  • Page 24: Lab Tests - Blood

    ® CAPINTEC, INC CAPTUS 2000 The background is the filled area under the peak marked Bkg. The area is given by: × Area PeakChans × BkgChans where Peak Chans is the number of channels in the peak NL is the number of counts below the peak assumed to be background...

  • Page 25: Bioassay

    ® CAPINTEC, INC CAPTUS 2000 RBC Survival Test RBC survival determinations involving radioactive tagging are most frequently used in ® diagnosis of hemolytic anemia. The CAPTUS 2000 software and default counting parameters follow the testing protocol outlined in the Mallinckrodt RBC Survival Instructions which utilize Sodium Chromate Cr51 Injections.

  • Page 27: General Operating Instructions

    ® CAPINTEC, INC CAPTUS 2000 CHAPTER 3 GENERAL OPERATING INSTRUCTIONS WINDOWS OPERATING CONVENTIONS ® ® The CAPTUS 2000 software runs under Microsoft Windows version 3.1 or higher. It conforms to standard Windows interface conventions. If you are familiar with running ®...

  • Page 28: Command Button

    ® CAPINTEC, INC CAPTUS 2000 When the cursor is located within a text box it will change to a thin vertical "I-beam." Note that actually having the ability to input or edit requires that you click the trackball button to cause the edit cursor, a bold blinking vertical line, to appear.

  • Page 29: Frame

    ® CAPINTEC, INC CAPTUS 2000 Activating a command button will cause it to perform the specified function. This may involve additional dialog boxes or various other modes of interaction with the user. Frame A frame groups various controls together into a logical group. Any type of control may be located within a frame.

  • Page 30: Scroll Bars

    ® CAPINTEC, INC CAPTUS 2000 be removed. The contents of the text box can then be edited. The following control keys are active during editing: Delete Deletes the character after the cursor Backspace Deletes the character before the cursor Right Arrow...

  • Page 31: Spin Control

    ® CAPINTEC, INC CAPTUS 2000 Home Moves the slider all the way to the left or down Moves the slider all the way to the right or up Spin Control The spin control is also used to adjust values such as the high voltage on the MCA form.

  • Page 32: Switching To Other Windows Applications

    ® CAPINTEC, INC CAPTUS 2000 Switching to Other Windows Applications Instead of closing down a Windows Application, you can switch to other Windows applications by using certain key sequences. (In previous software versions, exiting the ® CAPTUS 2000 program would shut off the high voltage power supply to the MCA board and the detectors.)

  • Page 33: System Setup

    Your system has been shipped from the factory pre-configured and fully tested. Installation consists of placing the components on the stand and securing them in place as shown in the “CAPTUS 2000 SPRING-ARM STAND UPACKING AND ASSEMBLY INSTRUCTIONS“ (P/N 5432-5061) document.

  • Page 34: Turn On Procedure

    To run the CAPTUS 2000 software, double click on the ® CAPTUS 2000 icon. Figure 4-1, the main menu screen, will appear. Before beginning any measurements, allow the system to warm up at least 30 minutes. It is recommended that the ®...

  • Page 35: General Operational Setup

    ® CAPINTEC, INC CAPTUS 2000 ® Figure 4-1 CAPTUS 2000 Main Menu GENERAL OPERATIONAL SETUP ® The software version installed on your CAPTUS 2000 can be identified by selecting About from the menu bar located at the top of the main menu screen. Information concerning the software version cannot be altered by the user.

  • Page 36: System Parameters

    ® CAPINTEC, INC CAPTUS 2000 SYSTEM PARAMETERS The System Parameters module displays the date, time, system serial number, units of activity, detector configuration, date format and report header. To access information about system parameters, select Systems Parameters... from the drop down list under Setup.
  • Page 37 2000 system is displayed in the serial number view box, Figure 4-4, and cannot be altered by the user. It should be used as a reference together with your software version when contacting the CAPINTEC Service Center for information or assistance.
  • Page 38 ® CAPINTEC, INC CAPTUS 2000 Figure 4-7 ® The date may be entered in either mm/dd/yy or dd/mm/yy format through the CAPTUS 2000 software. To change date format, select the Date Format box, Figure 4-7, use the trackball to position the pointing device over the correct radio button and click, or use the Tab key to select the correct option box and use the up and down arrow keys to move from one radio button in the group to the other.

  • Page 39: Normal Values

    Figure 4-9 NOTE: The normal values shown above are for demonstration purposes only and are not suggested by CAPINTEC for clinical use. To enter normal value ranges, place the arrow over the desired box and click. Then type in the correct value. Note that all percent values must be a number between 1 and 100.

  • Page 40: Reference Standards

    ® CAPINTEC, INC CAPTUS 2000 The Schilling Test normal value range stores values for the percent of Cobalt 57 which has been excreted in a patient’s urine. ® The DICOPAC Test normal value range stores values for the percent of Cobalt 57 and Cobalt 58 which have been excreted in a patient’s urine, and the ratio of Cobalt 57 to Cobalt...
  • Page 41 The information that appears corresponds to the sources used by the Capintec Service Center when setting up and testing your system. You will have to edit the calibration information so that it corresponds to your rod sources. The reference standard information is necessary to measure the efficiency of the source in the Isotope Library.

  • Page 42: Isotope Library

    ® CAPINTEC, INC CAPTUS 2000 ISOTOPE LIBRARY ® The CAPTUS 2000 has an extensive reference library of isotope information which includes the name, half life, major energy peaks, and percent abundance for over 60 isotopes. For those isotopes which exhibit significant sum peak formation in a well geometry, notably Barium 133 and Indium 111, the sum peak has also been added.

  • Page 43: Efficiency Measurements

    Cesium 137 standard reference source. You will need these efficiencies to accurately perform the Constancy Test. The Cs137 efficiencies that are originally listed were measured with the source used at the Capintec Service Center and may not be the same as the efficiencies of your source.
  • Page 44 ® CAPINTEC, INC CAPTUS 2000 Figure 4-12 The isotope drop down list will display all of the sources of the specified isotope that were entered into the reference library data base . If a standard for the desired isotope standard is not listed, select Other from the drop down list.
  • Page 45 ® CAPINTEC, INC CAPTUS 2000 Figure 4-13 Enter the calibrated activity, calibration date, and calibration time for the source. The software will automatically decay correct the source to the current activity. To exit the screen without saving the source information, select CANCEL. To save the source information, select the DONE button.
  • Page 46 ® CAPINTEC, INC CAPTUS 2000 When the background count is completed, DONE will appear in the spectral display area. After the background count has been completed, place the source in the desired position and select the COUNT STANDARD button. Figure 4-15 will appear.
  • Page 47 ® CAPINTEC, INC CAPTUS 2000 Figure 4-16 July 00 SYSTEM SETUP 4-15...
  • Page 48 ® CAPINTEC, INC CAPTUS 2000 4-16 SYSTEM SETUP July 00...

  • Page 49: Archive Files

    ® CAPINTEC, INC CAPTUS 2000 ARCHIVE FILES ® The CAPTUS 2000 software provides the user with an archive file feature to easily save all current data files at one time. The files can be sorted by test group for selective printing.
  • Page 50 ® CAPINTEC, INC CAPTUS 2000 Figure 4-18 To print archived files, select the Print Archive selection for the Archive command list. Figure 4-19 will appear. Figure 4-19 First open the archive file by selecting the correct file name from the listed .dbf files. Select ®...
  • Page 51 ® CAPINTEC, INC CAPTUS 2000 all individual files in the archive file will appear in the viewing area listed in alphabetical order. Select the desired archived file and then select OK. The PRINT ARCHIVE window, Figure 4-20 will appear. Figure 4-20 ®...

  • Page 53: Quality Assurance

    ® CAPINTEC, INC CAPTUS 2000 CHAPTER 5 QUALITY ASSURANCE WARM UP If your system will be used in a single location we recommend that you leave the computer powered at all times. This will minimize warm up problems and will provide the lowest wear and tear on the system.

  • Page 54: Energy Calibration

    ® CAPINTEC, INC CAPTUS 2000 Figure 5-1 Energy Calibration The first step in the Autocalibrate Sequence is measurement of the Cs137 standard. This function uses the 662 keV peak and the 32 keV peak of Cs137 to automatically adjust the high voltage, coarse gain, fine gain, and zero offset to provide a calibration of approximately 2.0 keV per channel in the MCA.
  • Page 55 ® CAPINTEC, INC CAPTUS 2000 Figure 5-2 Place the Cs137 rod source in the well of a drilled well detector, or against the surface of the flat field detector. For an easy way to insure reproducible source placement for the uptake probe, turn the uptake probe so that the collimator opening is facing up towards the ceiling.
  • Page 56 ® CAPINTEC, INC CAPTUS 2000 Note that during the autocalibration procedure with Cesium 137, a parameter labeled “strength” appears in the results display area. The ratio of the strength values is used to confirm that both Cesium 137 peaks are within the MCA viewing area for proper calibration.

  • Page 57: Constancy

    ® CAPINTEC, INC CAPTUS 2000 Figure 5-4 Select Yes to omit the Eu152 calibration, and No to return to Figure 5-3. Constancy The third step in the daily test and calibration process is a Constancy Test. Before performing the Constancy Test, the standard source calibration information must be entered through Setup Tests and the efficiency must be entered through the Isotope Library.
  • Page 58 ® CAPINTEC, INC CAPTUS 2000 setup information and return to the main autocalibration screen, or CANCEL to exit without saving and return to the main autocalibration screen. The Constancy Test uses this calibration information to decay correct the Cs137 rod source.

  • Page 59: Quarterly Tests

    ® CAPINTEC, INC CAPTUS 2000 QUARTERLY TESTS Chi-Squared Test Upon acceptance testing and at least quarterly, a chi-squared and detector resolution test should be performed. A chi-squared test is a very sensitive check of the overall counting performance of the system. One of the counts during the measurement process will also be used to automatically calculate detector resolution, which is a measure of the ability of a system to distinguish between two peaks close in energy.

  • Page 60: Detector Resolution

    ® CAPINTEC, INC CAPTUS 2000 ® (physical and radioactive) in the area around the CAPTUS 2000 is unchanging. To stop the counting process, select ABORT at any time during acquisition. You will return to the main autocalibration screen. When the process is complete "DONE" appears in the MCA display area.
  • Page 61 ® CAPINTEC, INC CAPTUS 2000 unexpected changes in background rate or temperature during the testing process. Make sure that the source is securely positioned so that is does not move. If the Chi-squared value is consistently out of range, it may indicate a problem with the counter/timer mechanism of the system or the detector itself.

  • Page 62: Printing Test Results

    ® CAPINTEC, INC CAPTUS 2000 PRINTING TEST RESULTS To print autocalibration and quality assurance test results, select the PRINT button from the main autocalibration screen. The autocalibration history screen as seen in Figure 5-8 will appear. Figure 5-8 The software has three printing options. Immediate test results, complete history summary, or a selected section of the displayed results.
  • Page 63 ® CAPINTEC, INC CAPTUS 2000 Figure 5-9 July 00 QUALITY ASSURANCE 5-11...
  • Page 64 ® CAPINTEC, INC CAPTUS 2000 To print only the calibration history in a summary form, select the CALIBRATION HISTORY from the Print Option box. The history reports a one line summary listing date/time, voltage, gain, constancy, FWHM, and chi-squared results for each calibration. Use the scroll bar on the side of the display area to view all of the results.
  • Page 65 ® CAPINTEC, INC CAPTUS 2000 To print only a selected portion of the data, first place the trackball arrow indicator in the display box. Click once and drag the arrow over the area to be printed. The data selected will be highlighted. Once the data has been selected, choose the PRINT SELECTION button.

  • Page 67: Thyroid Uptake

    ® CAPINTEC, INC CAPTUS 2000 CHAPTER 6 THYROID UPTAKE GENERAL INFORMATION Thyroid uptake is a measurement of the ratio of the amount of radioactive material concentrated in the thyroid gland to the amount of radioactive material administered to the patient. Thyroid uptake measurements are generally used to determine conditions of hyperthyroidism.

  • Page 68: Defining A Measurement Protocol

    ® CAPINTEC, INC CAPTUS 2000 Figure 6-1 All thyroid uptake features are accessed from the main THYROID UPTAKE screen. Before beginning an uptake measurement, at least one measurement protocol must be added to the list of protocols. Also, the isotope regions of interest, counting time, and probe distance defaults should be defined.

  • Page 69: Adding Protocols

    ® CAPINTEC, INC CAPTUS 2000 Figure 6-2 The Protocols window contains a drop down list which contains all protocols entered into the database. From this window, you can add new protocols, view, edit, or delete existing protocols, and restore deleted protocols. To exit from the Protocols window and return to the main THYROID UPTAKE screen, select the DONE command button.

  • Page 70: Protocol Name

    ® CAPINTEC, INC CAPTUS 2000 Figure 6-3 Protocol Name Figure 6-4 Select a name for the protocol by clicking on the white text box as it appears in Figure 6-4. You may use up to 16 characters including spaces. No two protocols can have the same name.

  • Page 71: Counting Method

    ® CAPINTEC, INC CAPTUS 2000 Counting Method First review the counting method box, Figure 6-5. Choose either Decay Correct Administered Dose or Measure Same Reference Dose Before Each Uptake. Figure 6-5 When Decay Correct Administered Dose is selected, the capsule must first be measured before it is administered.

  • Page 72: Multiple Capsule Administration

    ® CAPINTEC, INC CAPTUS 2000 Multiple Capsule Administration Figure 6-6 When more than one capsule or dosage is given to any one patient, three methods of measurement are available, as shown in Figure 6-6. When all capsules are counted at the same time, choose Dose Measured is Dose Administered.

  • Page 73: Isotope

    ® CAPINTEC, INC CAPTUS 2000 return you to the previous screen without saving any count data. Note that when the room background is measured after the capsule count, it is always only measured once. Choose the correct type of dose, either capsule or liquid from the Dose Form box. Selecting Capsule will result in the word capsule count on the results report.
  • Page 74 ® CAPINTEC, INC CAPTUS 2000 VIEWING, EDITING, DELETING, AND RESTORING PROTOCOLS Once a list of protocols has been created, you can view each protocol. From the Protocols window as seen in Figure 6-2, select the protocol from the drop down list and then select the VIEW command button.

  • Page 75: Regions Of Interest

    ® CAPINTEC, INC CAPTUS 2000 Figure 6-10 Once a protocol has been deleted, it can be restored. From the Protocols window as seen in Figure 6-2, select RESTORE command button. If there are no deleted protocols, a message appear to tell you. If there are deleted protocols, a Restore Protocol window will appear as seen in Figure 6-11.
  • Page 76 ® CAPINTEC, INC CAPTUS 2000 Figure 6-12 Regions of Interest (ROI’s) are defined for the thyroid uptake isotopes based upon percent of the primary peak. The ROI’s should be sufficiently wide so that the entire peak is within the measurement window. Do not set ROI limits on the slope of a peak. The default settings listed in Figure 6-12 provide an adequate window for good measurement results.

  • Page 77: Counting Time And Probe Distance

    ® CAPINTEC, INC CAPTUS 2000 COUNTING TIME AND PROBE DISTANCE From the main THYROID UPTAKE screen as seen in Figure 6-1, select the Setup command from the menu bar at the top left. Select the Defaults listing that appears in the drop down list.
  • Page 78 ® CAPINTEC, INC CAPTUS 2000 Figure 6-15 If there is only one counting protocol, the name will appear. If more than one protocol exists, select the desired protocol from the drop down list and then select the CONFIRM command button. A PROTOCOL window like the one seen in Figure 6-3 will appear with all the protocol’s information and a Protocol Confirmation box as seen in Figure 6-16.

  • Page 79: Editing Patient Information

    ® CAPINTEC, INC CAPTUS 2000 Next, enter your Dosage Data. The isotope associated with the selected protocol will appear automatically. The counting time and probe distance will appear from the Default Settings window, Figure 6-14. These default settings may be changed for any patient. Enter the lot number, calibration date, time, and activity of the isotope.

  • Page 80: Administer Dose

    ® CAPINTEC, INC CAPTUS 2000 delete the patient, and re-enter under the correct ID. After the desired changes have been made, select the DONE button to save the changed information. CANCEL will exit the screen without saving changes made to the patient library screen. Since each ID must be unique to insure that results are always stored in the correct file, to save different uptake studies on the same patient requires an ID extension.

  • Page 81: Deleting Information

    ® CAPINTEC, INC CAPTUS 2000 Figure 6-17 Note that it is important to correctly enter the administered date and time when using the decay correct method. In both the decay correct and the two capsule method, the software will use the administered time to calculate the elapsed hours for the thyroid uptake measurement.

  • Page 82: Making Measurements

    ® CAPINTEC, INC CAPTUS 2000 Figure 6-18 To delete all patients and data in the patient library, select the Delete All Patients listing from the menu bar located at the top of the main THYROID UPTAKE screen. Then select the Delete All listing that appears in the drop down list.
  • Page 83 ® CAPINTEC, INC CAPTUS 2000 Figure 6-19 To exit at any time choose the EXIT button. To begin counting, choose START PROCEDURE button. A sequence of pop up screens will appear as defined in your protocol setup and prompt you through the correct measurement process. As the measurement process begins and counts are acquired, the live spectra will be displayed on the screen.

  • Page 84: Predose Measurements

    ® CAPINTEC, INC CAPTUS 2000 Predose Measurements If the protocol being used has predose measurements enabled, then Figure 6-20 will appear. Figure 6-20 Predose measurements permit the measurement and correction for previously administered residual isotopes in the patient. The predose measurement must be made before administering the thyroid uptake radiopharmaceutical to the patient.
  • Page 85 ® CAPINTEC, INC CAPTUS 2000 After the measurement has been completed, you will be given the opportunity to reject the count. Figure 6-22 will appear and require you to validate and accept the count data before it is permanently saved to the patient result file.

  • Page 86: Capsule Count Measurement

    ® CAPINTEC, INC CAPTUS 2000 6-24 will appear and no correction will be made for the residual activity. Select OK to confirm receipt of the message. Figure 6-24 The predose measurement results will appear in the thyroid uptake patient result area as shown in the main THYROID UPTAKE screen, Figure 6-1.
  • Page 87 ® CAPINTEC, INC CAPTUS 2000 Figure 6-26 This is an opportunity to reject an incorrect count. To accept the data, select the YES button. To reject the data select the NO button. You will then return to the previous step in the count sequence.

  • Page 88: Room Background Measurement

    ® CAPINTEC, INC CAPTUS 2000 Figure 6-27 Select Yes to use the previous room background and capsule counts. Select No to count the capsule. This option will save you from having to measure a capsule of the same activity for several patients on the same day. These values are saved in memory and will not be ®...

  • Page 89: Patient Background Count

    ® CAPINTEC, INC CAPTUS 2000 Figure 6-29 Select Yes to use the previous room background counts or No to count the room background. Note that the window will display which isotope is being used. If the ROI is changed for a particular isotope, the room background counts corresponding to that isotope will also be affected.

  • Page 90: Patient Neck Count

    ® CAPINTEC, INC CAPTUS 2000 Patient Neck Count After the patient background is measured and saved, Figure 6-31 will appear and the patient’s neck must be counted to determine the activity of isotope concentrated in the thyroid gland. Figure 6-31 To measure the patient’s neck, select the Yes button.

  • Page 91: Results

    ® CAPINTEC, INC CAPTUS 2000 To eliminate a subsequent capsule count and decay correct from the original capsule count, select OK. Select Cancel to return to the Capsule Count window, Figure 6-25. RESULTS All of the count data and calculated results appear in the Thyroid Uptake Results box on the main THYROID UPTAKE screen, Figure 6-1.
  • Page 92 ® CAPINTEC, INC CAPTUS 2000 To print a report which contains the patient demographic data, counting protocol, count data, and calculated results for a specific patient, choose the Selected Patient option. A large amount of information that appeared as comments entered in the comment free text section will appear as a second page addendum to the patient result report.
  • Page 93 ® CAPINTEC, INC CAPTUS 2000 Figure 6-35 shows a typical report in which three capsules are measured for two repetitions each. Note that the average value is used for the uptake calculation. Figure 6-35 July 00 THYROID UPTAKE 6-27...
  • Page 94 ® CAPINTEC, INC CAPTUS 2000 To print all of the patients in the patient library, select Patient List option. Select the PRINT button to print the desired option. Figure 6-36 represents a typical patient list report. To exit without printing, select the CANCEL button.

  • Page 95: Wipe Tests

    ® CAPINTEC, INC CAPTUS 2000 CHAPTER 7 WIPE TESTS ® To access the wipe test functions, select the WIPE TESTS button from the CAPTUS 2000 Main Menu Screen. After selecting WIPE TESTS from the Main Menu screen, the Wipe Location Directory screen appears, as shown in Figure 7-1.

  • Page 96: Adding Wipe Locations

    ® CAPINTEC, INC CAPTUS 2000 ADDING WIPE LOCATIONS Before beginning any wipe tests, you must first define wipe test locations, counting times, and trigger limits. To add a wipe test, choose the ADD button from the Wipe Location screen shown in Figure 7-1. Figure 7-2 will appear.

  • Page 97: Isotope Efficiency

    ® CAPINTEC, INC CAPTUS 2000 You may exit the add wipe test screen at any time by selecting the SAVE button. Any information which has been entered will be saved to the appropriate wipe test data file. If you do not wish to save the information, choose the CANCEL button. The software will return to the original wipe test location screen without saving any information.

  • Page 98: Edit Information

    ® CAPINTEC, INC CAPTUS 2000 peak finding program to better determine the activity of an isotope when multiple peaks or isotopes are present. For this reason, the efficiency recorded in the isotope library will always be lower than the full spectrum efficiency.

  • Page 99: Making Measurements

    ® CAPINTEC, INC CAPTUS 2000 Yes to delete all of the previously entered wipe test location and setup information. Select No to undo the delete command and return to the previous screen. Figure 7-4 If you select Yes, a second similar window will appear with the message, “Deleting all the test data CANNOT be undone.

  • Page 100: Background Measurement

    ® CAPINTEC, INC CAPTUS 2000 Figure 7-5 Background Measurement ® Before measuring a wipe, the CAPTUS 2000 requires a background measurement. Choose the COUNT BACKGROUND button. Figure 7-6 will appear. Select the OK button to proceed with the background count, or the Cancel button to return to the previous screen.

  • Page 101: Wipe Measurement

    ® CAPINTEC, INC CAPTUS 2000 The software will measure the background, and store the count data for each channel of the MCA in memory. As the measurement begins and counts are acquired, the live spectra will be displayed on the screen, and COUNTING BACKGROUND will flash in red at the top of the screen.

  • Page 102: Adding Text Comments

    ® CAPINTEC, INC CAPTUS 2000 wipes in the isotope library, then the software will also provide the isotope identification. For those isotopes which have an efficiency stored in memory, the count rate will be converted to an activity result. Figure 7-8 In addition, for the full spectrum, total cpm, background cpm, net cpm, and the activity will be displayed.

  • Page 103: Counting The Next Wipe

    ® CAPINTEC, INC CAPTUS 2000 To add comments to the printed report, select the COMMENTS button which only appears on the Wipe Data Acquisition screen, Figure 7-8. Figure 7-9 will appear. Figure 7-9 The flashing cursor will appear in the text box area. Type in the desired text. The comments section will accommodate up to 8,000 characters.

  • Page 104: Printing Results

    ® CAPINTEC, INC CAPTUS 2000 PRINTING RESULTS Detailed Analysis Report ® The CAPTUS 2000 software has several printing options for convenient reporting formats. To print a detailed analysis of an individual wipe, you must select the PRINT button immediately after the wipe has been counted and the results appear on the screen, as shown in Figure 7-8.
  • Page 105 ® CAPINTEC, INC CAPTUS 2000 Figure 7-10 July 00 WIPE TESTS 7-11...

  • Page 106: Text Comments For The Summary Wipe History Report

    ® CAPINTEC, INC CAPTUS 2000 Figure 7-11 Once the desired data has been selected and sorted, all of the displayed data can be printed, or only a selected portion of the data can be printed. To print all of the displayed data, select the PRINT button after sorting.
  • Page 107 ® CAPINTEC, INC CAPTUS 2000 which appears on Wipe History Report screen, Figure 7-10. Figure 7-9 will be displayed and the flashing cursor will appear in the text box area. Type in the desired text. The comment section will accommodate up to 8,000 characters. To save the text, select the DONE button.

  • Page 108: Deleting Wipe Test History

    ® CAPINTEC, INC CAPTUS 2000 Deleting Wipe Test History ® The CAPTUS 2000 WIPE HISTORY will store 300 wipe tests. Upon attempting to count wipe test number 301, a message will appear prompting you to print, archive, and delete the history.

  • Page 109: Lab Tests

    ® CAPINTEC, INC CAPTUS 2000 CHAPTER 8 LAB TESTS ® By selecting the LAB TESTS button from the CAPTUS 2000 Main Menu Screen, Figure 8-1 will appear. LAB TESTS accesses all of the urine and blood in vitro testing modules, which ®...

  • Page 110: Schilling Test

    ® CAPINTEC, INC CAPTUS 2000 each screen. Once you become familiar with one module, you should easily be able to operate any of the other modules. The count acquisition screen also operates in an identical manner in each module. SCHILLING TEST To perform a Schilling Test, select the SCHILLING TEST button from the LAB TESTS Main screen.

  • Page 111: Setup Counting Parameters

    ® CAPINTEC, INC CAPTUS 2000 Figure 8-2 Setup Counting Parameters From the menu bar located at the top of the screen, a Setup command is available. This allows the user to enter counting parameters which will appear as default settings each time a patient is entered into the Schilling Test Library.

  • Page 112: Adding Patients

    ® CAPINTEC, INC CAPTUS 2000 Figure 8-3 Enter the Standard dilution. Generally the activity of the standard solution is too high to measure in a well counter without dilution. A 1 to 100 dilution means that 1 part of standard solution is mixed with 99 parts of non radioactive solution for a diluted solution of 1%.
  • Page 113 ® CAPINTEC, INC CAPTUS 2000 Figure 8-4 Use the trackball indicator or the Tab key to move from one text box to another and enter the requested information. Patient demographic data includes Last Name, First Name, Middle Initial, Date of Birth, ID, and Physician. Middle Initial and Date of Birth fields are optional and do not need to be completed.

  • Page 114: Editing Patient Information

    ® CAPINTEC, INC CAPTUS 2000 A comment section is available for free text input of up to 8,000 characters. Any information entered into the comment section will appear on the printed report. The INSERT COMMENTS FILE button enables the user to copy a previously stored .txt file. A .txt file is ®...
  • Page 115 ® CAPINTEC, INC CAPTUS 2000 Figure 8-5 To delete all patients and data in the patient library, select Delete All from the menu bar located at the top of the Main Thyroid Uptake screen. Figure 8-6 will appear and require confirmation to proceed with the delete command.

  • Page 116: Making Measurements

    ® CAPINTEC, INC CAPTUS 2000 then delete all data from the Schilling Test library. Alternatively, if you do not need to archive patient results, at the end of each quarter, print a hard copy report for each patient and then delete all non active patients.
  • Page 117 ® CAPINTEC, INC CAPTUS 2000 the ABORT ACQUISITION button, which appears during live acquisition, and the count will not be saved. To stop the count and save the counting data before the preset live time has elapsed, choose STOP & SAVE. When you are finished counting, select the EXIT command.
  • Page 118 ® CAPINTEC, INC CAPTUS 2000 Figure 8-11 To cancel the counting procedure select OK, and the software will return to Figure 8-8. However, only the EXIT button will then be activated. PROCEDURE ABORTED will appear in blue beneath the spectral display area. At this point, the only option is to select EXIT and return to the main Schilling Test Library screen.

  • Page 119: Test Results

    ® CAPINTEC, INC CAPTUS 2000 Figure 8-13 To proceed with the standard count, place the standard sample in the well counter and select the OK button. To cancel the procedure, select the Cancel button, and Figure 8-11 will appear. After the count is completed, Figure 8-10 will appear and require confirmation of the data.

  • Page 120: Printing Results

    ® CAPINTEC, INC CAPTUS 2000 × × Excretion × where U = Urine sample count rate B = Background (either room or patient blank) S = standard count rate V = total urine volume A = urine aliquot D = dilution of the standard Printing Results To print an individual patient report, first select the desired patient from the patient library list.
  • Page 121 ® CAPINTEC, INC CAPTUS 2000 To exit the print selection screen without printing and return to the previous screen, select the CANCEL button. Figure 8-16 shows a typical Schilling Test report. Figure 8-16 July 00 LAB TESTS 8-13...

  • Page 122: Dicopac ® Test

    ® CAPINTEC, INC CAPTUS 2000 ® DICOPAC TEST ® ® DICOPAC is a trademark of Medi-Physics, Inc. The software in the CAPTUS 2000 follows the Medi-Physics DICOPAC Kit format. For this reason, you must also follow the DICOPAC Kit instructions exactly. To perform a DICOPAC Test, select the DICOPAC button from the Lab Test Main screen.

  • Page 123: Adding Patients

    ® CAPINTEC, INC CAPTUS 2000 both Co57 and Co58 excretion, and a 57/58 ratio of about 1. Patients with pernicious anemia have decreased Co58 excretion, low normal to normal Co57 excretion, and an increased 57/58 ratio which generally exceeds 1.4.

  • Page 124: Editing Patient Information

    ® CAPINTEC, INC CAPTUS 2000 Once the patient demographic information has been entered, the testing information must be entered under the Dose Data column. Enter the lot number and activity of the Co57 and Co58 labeled Vitamin B-12 capsules to be given to the patient. Next enter the total volume of the urine collected over the test period.

  • Page 125: Deleting Patient Information

    ® CAPINTEC, INC CAPTUS 2000 example 123456) 123456A for the first study, 123456B for the second study, 123456C for the third study and so on. Deleting Patient Information The patients will remain in an alphabetical order in the Patient Directory until deleted. Note that only the most recent test data and results are stored for each patient.

  • Page 126: Making Measurements

    ® CAPINTEC, INC CAPTUS 2000 Figure 8-21 Choose Yes to delete all DICOPAC data and No to cancel the delete command and return to the previous screen. The system will continue to accumulate patient data indefinitely. This will eventually result in a very long library list to sort. A recommended procedure is to periodically (monthly or quarterly) archive the patient data for reference, and then delete all data from the DICOPAC Test library.
  • Page 127 ® CAPINTEC, INC CAPTUS 2000 Figure 8-22 If two repetitions have been selected in the counting protocol, each of the subsequent count screens will appear twice and two measurements for each count will be recorded. The two counts will be averaged. Both the raw count data and the calculated values will appear in the result view box as shown in Figure 8-17, DICOPAC Test Library screen.
  • Page 128 ® CAPINTEC, INC CAPTUS 2000 Select OK to proceed with the background measurement. During the counting process, COUNTING BACKGROUND will flash in red above the spectral display. Once the measurement has been completed, Figure 8-24 will appear and require data validation.
  • Page 129 ® CAPINTEC, INC CAPTUS 2000 Figure 8-26 The patient blank count is an optional background measurement step. The patient blank is a urine sample collected from the patient before the administration of the DICOPAC Test capsules. It will be subtracted from the patient urine sample instead of the room background count to yield net patient counts.
  • Page 130 ® CAPINTEC, INC CAPTUS 2000 Figure 8-28 To proceed with the Co58 standard count, place the Co58 standard sample in the well counter and select the OK button. To cancel the procedure, select the Cancel button, and Figure 8-25 will appear. Once the count is completed, Figure 8-24 will appear and require confirmation of the data.

  • Page 131: Test Results

    ® CAPINTEC, INC CAPTUS 2000 Test Results After completion of the measurement process, all of the raw count data and calculated test results will appear in the appropriately labeled boxes in the patient data screen. The results are calculated as follows: ×...
  • Page 132 ® CAPINTEC, INC CAPTUS 2000 Figure 8-30 Choose the Selected Patient Option as shown. Then choose the PRINT button as shown in Figure 8-30. The individual patient report will include all of the demographic data, sample and standard information, raw count data, test data and time, and calculated results. If normal values have been entered through SETUP/Normal Values, these ranges will also appear on the printed report.
  • Page 133 ® CAPINTEC, INC CAPTUS 2000 Figure 8-31 July 00 LAB TESTS 8-25...

  • Page 134: Blood Volume Test

    ® CAPINTEC, INC CAPTUS 2000 BLOOD VOLUME TEST Blood Volume determinations involving radioactive tagging are most frequently used in specific disease conditions when the hematocrit may not accurately estimate true blood volume. Such conditions include extensive trauma or burn patients, certain types of anemia, and polycythemia.
  • Page 135 ® CAPINTEC, INC CAPTUS 2000 Figure 8-33 Use the trackball indicator or the Tab key to move from one text box to another and enter the requested information. Patient demographic data includes Last Name, First Name, Middle Initial, Date of Birth, ID, Height, Weight, and Physician. Middle Initial, Date of Birth, Height and Weight fields are optional and do not need to be completed.
  • Page 136 ® CAPINTEC, INC CAPTUS 2000 Administered Administered to Standard Sample Size Volume Activity Ratio Cr51 I 125 1000 Note that Cr51 procedure uses the administered to Standard Activity Ratio (or standard dilution) and administered volume parameters only, while I 125 procedures utilizes administered to standard activity ratio (or standard dilution) and sample size parameter only.

  • Page 137: Editing Patients

    ® CAPINTEC, INC CAPTUS 2000 Editing Patients If you wish to review or edit any information which has already been entered on a patient, first select the desired patient from the Patient Directory list on the main Blood Volume Test screen, then choose the EDIT button.

  • Page 138: Making Measurements

    ® CAPINTEC, INC CAPTUS 2000 Figure 8-35 Choose Yes to delete and No to cancel the delete command and return to the previous screen. If Yes is selected, the software will again request confirmation of the delete command. Figure 8-36 will appear.
  • Page 139 ® CAPINTEC, INC CAPTUS 2000 Figure 8-37 Note the Go To MCA command located at the top of the Blood Volume Data Acquisition screen. This features provides a direct link to the complete MCA program without exiting from the Blood Volume module. Use this feature to check the isotope identification of a source, verify a region of interest, check a patient for previously administered isotopes, or any other MCA use.
  • Page 140 ® CAPINTEC, INC CAPTUS 2000 calculated values will appear in the result view box as shown in Figure 8-32, Blood Volume Test Library screen. The first measurement in the counting sequence is a background measurement. After selecting the START PROCEDURE button, Figure 8-38 will appear.
  • Page 141 ® CAPINTEC, INC CAPTUS 2000 Figure 8-40 To cancel the counting procedure select OK, and the software will return to Figure 8-37. However, only the EXIT button will then be active. PROCEDURE ABORTED will appear in blue beneath the spectral display area. At this point, the only option is to select EXIT and return to the main Blood Volume Library screen.
  • Page 142 ® CAPINTEC, INC CAPTUS 2000 Figure 8-42 To proceed with the plasma standard count, place the plasma standard sample in the well counter and select the OK button. To cancel the procedure, select the Cancel button, and Figure 8-40 will appear. Once the count is completed, Figure 8-39 will appear and require confirmation of the data.

  • Page 143: Test Results

    ® CAPINTEC, INC CAPTUS 2000 Figure 8-44 To proceed with the patient’s plasma sample count, place the plasma sample in the well counter and select the OK button. To cancel the procedure, select the Cancel button, and Figure 8-40 will appear. After the count is completed, Figure 8-39 will appear and require confirmation of the data.

  • Page 144: Printing Test Results

    ® CAPINTEC, INC CAPTUS 2000 When using the I-125 test protocol, results are calculated as follows: × × Plasma Volume × × Whole Blood Volume Cell Volume Whole Blood Volume Plasma Volume Cell Volume Radioactiv Hematocrit Whole Blood Volume where W = Net standard count rate...
  • Page 145 ® CAPINTEC, INC CAPTUS 2000 Figure 8-46 July 00 LAB TESTS 8-37...

  • Page 146: Rbc Survival Test

    ® CAPINTEC, INC CAPTUS 2000 To print the patient library list, select the Patient List Option shown in Figure 8-45. The last name, first name, ID, and physician will be printed for each patient in memory. The patients are stored in alphanumeric order until deleted. However, only the most recent set of test data is stored for each patient.

  • Page 147: Adding Patients

    ® CAPINTEC, INC CAPTUS 2000 Figure 8-47 Adding Patients Before beginning an RBC Survival Test, first enter patient demographic data into the patient library. Select the ADD button from the bottom of the RBC Survival main screen. Figure 8- 48 will appear.
  • Page 148 ® CAPINTEC, INC CAPTUS 2000 Figure 8-48 Use the trackball indicator or the Tab key to move from one text box to another and enter the requested information. Patient demographic data includes Last Name, First Name, Middle Initial, Date of Birth, ID, and Physician. Middle Initial and Date of Birth fields are optional and do not need to be completed.

  • Page 149: Editing Patient Information

    ® CAPINTEC, INC CAPTUS 2000 ® A sample volume of 4 ml is a good volume for the well detector provided with the CAPTUS 2000 system. The sample volume must remain the same for all of the samples counted throughout the RBC survival study.
  • Page 150 ® CAPINTEC, INC CAPTUS 2000 Figure 8-49 To delete all patients and data in the patient library, select Delete All from the menu bar located at the top of the Main RBC Survival screen. Figure 8-50 will appear and require confirmation to proceed with the delete command.

  • Page 151: Making Measurements

    ® CAPINTEC, INC CAPTUS 2000 Choose Yes to delete all RBC Survival Test data and No to cancel the delete command and return to the previous screen. The system will continue to accumulate patient data indefinitely. This will eventually result in a very long library list to sort. A recommended procedure is to periodically (annually or semiannually) archive the patient data for reference, and then delete all data from the RBC Survival Test library.
  • Page 152 ® CAPINTEC, INC CAPTUS 2000 Figure 8-52 To abort the count, select the ABORT ACQUISITION button, which appears during live acquisition, and the count will not be saved. To stop the count and save the counting data before the preset live time has elapsed, choose STOP & SAVE. When you are finished counting, select the EXIT command.
  • Page 153 ® CAPINTEC, INC CAPTUS 2000 Figure 8-53 Select OK to proceed with the background measurement. Insure that no sources of radiation are near the well during the background measurement. During the counting process, COUNTING BACKGROUND will flash in red above the spectral display. Once the measurement has been completed, Figure 8-54 will appear and require data validation.
  • Page 154 ® CAPINTEC, INC CAPTUS 2000 Figure 8-55 To proceed with the initial sample count, place the sample in the well counter and select the OK button. To cancel the procedure, select the Cancel button, and Figure 8-52 will appear, with only the EXIT button active. During the live acquisition, COUNTING SAMPLE will appear and flash in red at the top of the screen.

  • Page 155: Test Results

    ® CAPINTEC, INC CAPTUS 2000 Figure 8-57 Select OK to return to Figure 8-56 and enter the hematocrit value for the sample. If you select Cancel from Figure 8-57, you will return to Figure 8-52, the Data Acquisition screen, and only the EXIT button will be active. Both the background count and sample count data will also be lost.
  • Page 156 ® CAPINTEC, INC CAPTUS 2000 Figure 8-58 Choose the Selected Patient Option as shown. Then choose the PRINT button as shown in Figure 8-58. The individual patient report will include all of the demographic data, raw count data, test date and time, and calculated results, and graph with best straight line fit of data points.
  • Page 157 ® CAPINTEC, INC CAPTUS 2000 Figure 8-59 July 00 LAB TESTS 8-49...

  • Page 159: Bioassay

    ® CAPINTEC, INC CAPTUS 2000 CHAPTER 9 BIOASSAY ® When the BIOASSAY button from the CAPTUS 2000 Main Menu Screen is selected, Figure 9-1 appears. The Bioassay module permits the user to measure and calculate the system efficiency for I 125, I 131, and I 123, and measure, calculate, and archive thyroid burden of staff personnel.

  • Page 160: Bioassay Setup

    ® CAPINTEC, INC CAPTUS 2000 Note that the Edit, Delete, Add, Count, Print, and Done buttons are arranged in an identical manner to the Thyroid Uptake and Lab Test screens, and function in an identical manner. BIOASSAY SETUP A Setup command is available from the menu bar located at the top of the screen. This allows the user to measure or enter efficiencies, counting time, spillover ratios and save into Bioassay Library.

  • Page 161: Efficiency Measurements

    ® CAPINTEC, INC CAPTUS 2000 To exit the screen without saving any setup data, select the CANCEL button. To save data input into the Setup screen, exit by selecting the DONE button. To input a value, use the Tab key or trackball indicator to move to the desired text box, and type in the desired value.
  • Page 162 ® CAPINTEC, INC CAPTUS 2000 while peak counts will appear in the left hand corner of the screen. To abort the count, select the ABORT ACQUISITION button, which appears during live acquisition, and the count will not be saved. To stop the count and save the counting data before the preset live time has elapsed, choose STOP &...
  • Page 163 ® CAPINTEC, INC CAPTUS 2000 Figure 9-4 Insure that all sources of radiation have been removed. Select OK to proceed with the background measurement. To exit the background measurement screen without saving any data select CANCEL. Figure 9-3 will appear again with only the EXIT button active. The only option at this time is to select EXIT and return to the Main Bioassay screen.

  • Page 164: Printing Efficiency Results

    ® CAPINTEC, INC CAPTUS 2000 Figure 9-3 will appear again with only the EXIT button active. During acquisition, COUNTING STANDARD will flash in red at the top of the screen. Upon completion of the standard count, the Figure 9-5 will appear again and require data validation.
  • Page 165 ® CAPINTEC, INC CAPTUS 2000 Figure 9-7 July 00 BIOASSAY...

  • Page 166: Adding Staff

    ® CAPINTEC, INC CAPTUS 2000 ADDING STAFF Before performing a Bioassay measurement, first enter staff demographic data into the bioassay library. Select the ADD button from the bottom of the main Bioassay Test screen. Figure 9-8 will appear. Figure 9-8 Use the trackball indicator or the Tab key to move from one text box to another and enter the requested information.

  • Page 167: Editing Staff Information

    ® CAPINTEC, INC CAPTUS 2000 Once all of the required information has been entered, exit the screen by selecting the DONE button. The information which has been entered will be saved to the Bioassay database file. Note that the software requires the entry of all non optional fields before exiting through the DONE button.

  • Page 168: Making Measurements

    ® CAPINTEC, INC CAPTUS 2000 Figure 9-10 Choose Yes to delete and No to cancel the delete command and return to the previous screen. If Yes is selected, the software will again request confirmation of the delete command. Figure 9-11 will appear.
  • Page 169 ® CAPINTEC, INC CAPTUS 2000 Figure 9-12 To exit the Data Acquisition screen at any time choose the EXIT button. If you exit before the entire counting process has been completed, all data will be lost. To begin counting, choose the START PROCEDURE button. Note the Go To MCA command located at the top of the Data Acquisition screen.
  • Page 170 ® CAPINTEC, INC CAPTUS 2000 Figure 9-13 Note that all bioassay measurements must be performed in a low background area to insure adequate detection of low activity. Select OK to proceed with the background measurement. During the counting process, COUNTING BACKGROUND will flash in red above the spectral display. Once the measurement has been completed, Figure 9-14 will appear and require data validation.

  • Page 171: Results

    ® CAPINTEC, INC CAPTUS 2000 Figure 9-15 Once the person is properly positioned, select OK to proceed with the neck count. COUNTING NECK will flash in red at the top of the acquisition screen. Upon completion of the counting process, Figure 9-14 will appear and require validation of the data before saving.
  • Page 172 ® CAPINTEC, INC CAPTUS 2000 Figure 9-16 To exit from the print option screen, select the CANCEL button, and you will return to the Main Bioassay Test screen. 9-14 BIOASSAY July 00...
  • Page 173 ® CAPINTEC, INC CAPTUS 2000 Figure 9-17 July 00 BIOASSAY 9-15...

  • Page 175: Mca

    ® CAPINTEC, INC CAPTUS 2000 CHAPTER 10 ® The CAPTUS 2000 has a fully functional 1024 multichannel analyzer (MCA) board. All parameters are software controlled. Up to ten Regions of Interest (ROI) can be defined at one time. Presets enable live time, real time, or total peak counts to be set. Spectral images can be overlapped, filtered, or subtracted.

  • Page 176: Setup Menu

    ® CAPINTEC, INC CAPTUS 2000 The gain and voltage settings determined in Autocalibration are saved in memory. When the MCA is selected these settings are automatically transferred, so that the 1024 channels are calibrated at about 2 keV/channel. To switch detectors, place the trackball indicator on the correct option in the detector option box, Figure 10-2, and click.

  • Page 177: High Voltage/Amplifier Adjustment

    ® CAPINTEC, INC CAPTUS 2000 A maximum peak count of 999999999 counts may be entered. Enter the number of peak counts in numerical characters without any commas. Type in the desired values in the appropriate box. Move from box to box by using the trackball pointer or the Tab key. Whenever multiple limits are set, the acquisition will stop whenever the first preset limit is reached.

  • Page 178: Adc/Zero Adjustments

    ® CAPINTEC, INC CAPTUS 2000 The voltage from the single power supply is applied concurrently to both detectors in a two detector system. The detector switch controls the signal input to the MCA board. You can turn the high voltage on or off by clicking on the appropriate option box with your trackball indicator or using the Tab key.

  • Page 179: Quick Calibration Restore

    ® CAPINTEC, INC CAPTUS 2000 Figure 10-6 The Zero Offset, which sets the channel location of zero keV, ranges from a value of 0 to 255. To increase the Zero offset value, select the right arrow key from the arrow bar located beneath the Zero Offset value.

  • Page 180: Acquisition And Count Data

    ® CAPINTEC, INC CAPTUS 2000 Figure 10-7 The settings determined during Autocalibration will appear in blue for the selected detector. These values cannot be changed in the MCA mode. To restore these settings for an energy calibration of 2 keV/channel, select the RESTORE CALIBRATED SETTINGS button. To exit the screen without restoring the automatic calibration settings, select the CANCEL button.

  • Page 181: Regions Of Interest (Roi)

    ® CAPINTEC, INC CAPTUS 2000 Figure 10-8 Figure 10-9 Both scale controls operate in the same manner. Select the up arrow with the trackball indicator to increase the scale value. Select the down arrow with the trackball indicator to decrease the scale value. When the displayed spectrum is erased by the CLEAR A button, the automatic scale feature is restored for the subsequent count.

  • Page 182: Save And Restore Count Data Or Mca Settings

    ® CAPINTEC, INC CAPTUS 2000 To define a second ROI, click on the up arrow beside the ROI number box until 2 appears, and repeat the procedure outlined above to define the beginning and ending channels. Continue this process for a maximum of 16 ROI’s.

  • Page 183: Recall Mca Settings

    ® CAPINTEC, INC CAPTUS 2000 Figure 10-11 Recall MCA Settings To retrieve a stored MCA file, from the main menu bar choose File, then Load MCA settings... Figure 10-12 will appear. If the files have been stored to a floppy disk, select the correct disk drive first.

  • Page 184: Save Spectrum

    ® CAPINTEC, INC CAPTUS 2000 Save Spectrum After acquisition has been stopped, choose the File option located on the upper menu bar. To save the count data from the currently displayed spectrum, select the Save Spectrum... choice. Figure 10-13 will appear.

  • Page 185: Manipulation Of Acquired Spectrum

    ® CAPINTEC, INC CAPTUS 2000 Figure 10-14 MANIPULATION OF ACQUIRED SPECTRUM Moving the Displayed Spectrum A and B ® The CAPTUS 2000 can display two spectra simultaneously, overlap or subtract one spectrum from another, and apply various shape smoothing filters to the displayed spectrum.

  • Page 186: Applying Spectral Filters

    ® CAPINTEC, INC CAPTUS 2000 Figure 10-16 All manipulation of displayed spectrum occurs through the use of the Operations command selection located on the Main Menu bar across the top of the MCA screen. Selecting Operations provides the following choices: 1 – Copy A to B, 2 – Copy B to A, 3 – A=A-B, and Convolutions….
  • Page 187 ® CAPINTEC, INC CAPTUS 2000 Figure 10-17 The filters will be applied only to the spectrum stored in location A. To apply a filter, choose the desired filter from the option list. Then select the Apply Filter button. The filtered spectrum data will be stored in Spectrum B.

  • Page 188: Quadratic Smooth

    ® CAPINTEC, INC CAPTUS 2000 Figure 10-18 The calculations and references for the MCA filters are as follows: Quadratic Smooth Calculates the quadratic/cubic smoothing from the following equation (Savitzky and Golay, Anal. Chem. Vol 36, p1627 (1964)): ∑ spec coef −...

  • Page 189: Printing Mca Data

    ® CAPINTEC, INC CAPTUS 2000 PRINTING MCA DATA To print an MCA spectral report, select the PRINT button located at the left of the MCA display area. The printout will contain the spectrum or spectra shown in the display area.
  • Page 190 ® CAPINTEC, INC CAPTUS 2000 Figure 10-19 10-16 July 00...

  • Page 191: Time Activity Analysis

    ® CAPINTEC, INC CAPTUS 2000 TIME ACTIVITY ANALYSIS Setup Information ® The CAPTUS 2000 also has a special module which permits the user to make repeated measurements at timed intervals. The resulting count data can be displayed either in a graph or tabular form, printed, and saved to disk.
  • Page 192 ® CAPINTEC, INC CAPTUS 2000 Before beginning acquisition, first define the required counting parameters. Choose Setup Tests from the upper menu bar, and then select the Setup Tests option. Figure 10-21 will appear. Figure 10-21 Enter the length of time for each count in seconds, from 1 to 31999. The software will automatically count the time as live time to compensate for any changes in count rate throughout the counting sequence.

  • Page 193: Making Measurements

    ® CAPINTEC, INC CAPTUS 2000 reports. To return to the main Time Activity screen without saving information, select the CANCEL button. For counting sequences which involve a long time period and a short lived isotope, Setup Tests also has a Decay Correction command available. Figure 10-22 will appear.

  • Page 194: Displaying Results

    ® CAPINTEC, INC CAPTUS 2000 Figure 10-23 To begin the data acquisition, select the OK button. To cancel data acquisition, select the Cancel button. You may stop the counting sequence at any time by selecting the ABORT button which appears during all acquisition. The data for any counts which have been completed will be displayed in the results box.
  • Page 195 ® CAPINTEC, INC CAPTUS 2000 Figure 10-26 The software will automatically provide a suitable vertical and horizontal scale to accommodate the measured count rates for display in graph form. Decay corrected data will appear labeled with a ∇ symbol, while raw data will appear labeled with a short  mark.

  • Page 196: Save Time Activity Results

    ® CAPINTEC, INC CAPTUS 2000 Save Time Activity Results Results may be saved to hard or floppy disk, and recalled. After the entire counting sequence has been completed, choose the File command from the main menu bar. Select the Save Results option, and Figure 10-28 will appear.

  • Page 197: Printing Results

    ® CAPINTEC, INC CAPTUS 2000 Figure 10-29 PRINTING RESULTS To print results, complete the entire counting sequence and select the desired result display format. The results will be shown in the Time vs. Activity Analysis display box. Next select the PRINT button. The date and time of the report, any ID information, counting sequence setup, decay correction if defined, date and time of each measurement, and displayed results data will be printed.
  • Page 198 ® CAPINTEC, INC CAPTUS 2000 Figure 10-30 10-24 July 00...

  • Page 199: Cleaning And Maintenance

    It is recommended that periodic (every five years) re-calibration of the CAPTUS 2000 readout unit and detectors be performed by Capintec to guarantee optimum operation of the instrument. Contact the Capintec factory in Pittsburgh for servicing or re-calibration at 1-800- 227-6832.

  • Page 200: Pointer Assembly

    ® CAPINTEC, INC CAPTUS 2000 • POINTER ASSEMBLY: Use a soft cloth that is dampened with propanol alcohol to sterilize or clean the black pointer and assembly. • KEYBOARD: Use a can of compressed air with a narrow, straw-like extension to blow away any trapped particles from under the keys.

  • Page 201: Preventive Maintenance

    If the unit fails to pass Autocalibration Test or any other test, the user should not attempt to perform any adjustments to the system. In this event, please contact Capintec for further assistance. The Quality Assurance tests should be immediately performed if: •...

  • Page 202: Fuse Servicing

    ® CAPINTEC, INC CAPTUS 2000 FUSE SERVICING CAUTION FOR CONTINUED PROTECTION, REPLACE ONLY WITH SAME TYPE AND RATING OF FUSE (S) Power Line Fuses The power line fuses are located on the front side of the Isolation Transformer Unit directly below the main power cord connector.

  • Page 203: Computer, Monitor And Printer Fuses

    ACCESSORIES AND REPLACEMENT PARTS The following accessories and replacement parts are available form Capintec. Call Capintec at 1-800-227-6832 for answers to your questions or to place an order. •...
  • Page 204 ® CAPINTEC, INC CAPTUS 2000 Figure 11-2 11-6 CLEANING AND MAINTENANCE July 00...
  • Page 205 NEW PRODUCT WARRANTY Conditions and Limitations CAPINTEC warrants its products to be free from defects in material and workmanship for a period of 12 months after delivery to the original purchaser. During the warranty period, our liability is limited to the repair of...

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