Leica ASP300 S Instructions For Use Manual
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Leica ASP300 S Instructions For Use Manual

Leica ASP300 S Instructions For Use Manual

Advanced smart processor vacuum tissue processor
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See also: Operating Manual
Instructions for Use
Leica ASP300 S -
Advanced Smart Processor
Vacuum
Tissue Processor
Leica ASP300 S, English
Order No.: 14 0476 80101 RevJ
Always keep this manual with the instrument.
Read carefully before working with the instrument.

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Aaron
February 18, 2025

I have changed the carbon filter, but the machine keeps on showing a warning to say the carbon has exceeded its life time. How do I reset the carbon filter?

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Mr. Anderson
February 18, 2025

After replacing the carbon filter on a Leica ASP300 S, press the RESET button to reset the filter age to "0".

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Summary of Contents for Leica ASP300 S

  • Page 1 Instructions for Use Leica ASP300 S - Advanced Smart Processor Vacuum Tissue Processor Leica ASP300 S, English Order No.: 14 0476 80101 RevJ Always keep this manual with the instrument. Read carefully before working with the instrument.
  • Page 3 Leica reserves the right to change technical following thorough investigation in this field. specifications as well as manufacturing process- We are under no obligation to update the present es without prior notice.

  • Page 4: Table Of Contents

    Table of Contents Important Information ....................... 6 Symbols and their meanings....................... 6 Qualification of personnel ......................12 Intended use of instrument ....................... 12 Instrument type ........................... 13 Microsoft software license terms.................... 13 Safety ............................14 Safety notes ..........................14 Warnings ............................15 Safety features on the instrument ...................
  • Page 5 7.1.3 Smart clean ..........................81 General cleaning steps ......................82 7.2.1 Daily cleaning and maintenance....................84 7.2.2 Periodic cleaning and maintenance..................86 Checklist for preventive maintenance ..................88 Warranty and Service ......................90 Decontamination Confirmation ..................... 91 Appendix .............................. 92 Leica ASP300 S...

  • Page 6: Important Information

    Important Information 1.1 Symbols and their meanings Leica Biosystems GmbH assumes no liability for consequential loss or damage due to failure to observe the following instructions, particularly in relation to transportation and package han- dling, and failure to observe the instructions for handling the instrument carefully.
  • Page 7 Indicates the date when the medical device was Description: manufactured. Symbol: Title of symbol: CE Compliance The CE marking is the manufacturer's declaration Description: that the medical product meets the requirements of the applicable EC directives. CSA Statement (Canada/USA) Symbol: Title of symbol: Leica ASP300 S...
  • Page 8 Important Information Description: The CSA test mark means that a product has been tested and fulfills the applicable safety and/or perfor- mance standards, including the relevant standards defined or administered by the American National Standards Institute (ANSI), Underwriters Laborato- ries (UL), the Canadian Standards Association (CSA), the National Sanitation Foundation International (NSF) and others.
  • Page 9 Title of symbol: Description: Indicates the manufacturer's catalogue number so that the medical device can be identified. Symbol: Title of symbol: Serial Number Description: Indicates the manufacturer's serial number so that a specific medical device can be identified. Leica ASP300 S...
  • Page 10 Important Information Symbol: Title of symbol: Consult instructions for use Indicates the need for the user to consult the inst- Description: ructions for use. Caution: danger of crushing Symbol: Title of symbol: Symbol: Title of symbol: Inflammable Inflammable reagents, solvents and cleaning agents Description: are marked with this symbol.
  • Page 11 With a pitch of 60° or more, the blue quartz sand flows into the arrow-shaped indica- tor window and sticks there permanently. Improper handling of the shipment is immediately detectable and can be proven definitively. Leica ASP300 S...

  • Page 12: Qualification Of Personnel

    Important Information When delivering the instrument, the recipient must check that the ShockWatch impact indica- tor and tilt indicator are intact. The responsible Leica representative must be notified in the case that one or all indicators have been triggered. 1.2 Qualification of personnel • The Leica ASP300 S may be operated by trained laboratory personnel only.

  • Page 13: Instrument Type

    Your instrument is working with an embedded Windows 7 operating system. Terms of the so-called End User License Agreement (EULA) apply. For details, please refer to the language CD where you can find the entire content of this agreement. Leica ASP300 S...

  • Page 14: Safety

    • Be sure to read these notes even if you are already familiar with the operation and use of other Leica products. • The protective devices located on the instrument and the accessories must not be removed or modified. Only qualified service personnel authorized by Leica may repair the instrument and access its internal components. Residual risks • The instrument has been designed and constructed with the latest state-of-the-art technol-...

  • Page 15: Warnings

    Failure to adhere to these instructions may result in an accident, personal injury, damage to the instrument or accessory equipment. Some instrument surfaces become hot during operation. They are marked with this warning label. Touching these surfaces may cause burns. Leica ASP300 S...
  • Page 16 • The installation location must be well-ventilated; there should be no ignition sources there of any kind. The chemicals to be used in the Leica ASP300 S are both flammable and noxious. • Do not operate the instrument in rooms with explosion hazard.
  • Page 17 • Fixing solutions that contain mercury salts, acetic acid, or picric acid can cause corrosion on metal components. • After each paraffin step a retort clean cycle must be run. Leica ASP300 S...
  • Page 18 Safety 2.2 Warnings (continued) Material safety data sheets can be obtained from the supplier of the chemicals. Alternatively, they can be downloaded from the following website: http://www.msdsonline.com Warnings – Handling reagents • Take care when handling solvents! • Always wear rubber gloves and safety goggles when handling the chemicals used in this instrument.

  • Page 19: Safety Features On The Instrument

    Safety 2.3 Safety features on the instrument In the case of power failures or other processing problems the Leica ASP300 S incorporates specimen protection features such as a fluid level sensor and sophisticated software controls which ensure that processing can be completed successfully without damage to the tissue specimens.

  • Page 20: Instrument Components And Specifications

    Instrument Components and Specifications 3.1 Overview – instrument components Fig. 2 Instructions for Use, V 1.9 RevJ – 08/2017...
  • Page 21 13 – Reagent containers (13 units) 14 – Collecting tray 15 – Paraffin drain spout 16 – Remote drain connection 17 – Retort 18 – Wax baths 19 – Cassette basket 20 – Lid for cassette basket 21 – Baffle plate Leica ASP300 S...

  • Page 22: Specific Instrument Options

    3.3 Standard delivery – packing list To prevent damage to the instrument or specimens, only accessories and spare parts authorized by Leica may be used. The standard equipment of the Leica ASP300 S includes the following parts: Part No. Leica ASP300 S basic instrument...
  • Page 23 14 0495 47736 USB memory stick 14 6000 03467 Instructions for Use, printed (German/English, with language CD and ASP300 S 14 0476 80001 demo program 14 0476 80200) The country specific power cord needs to be ordered separately. Please find a list of all power cords available for your device on our website www.LeicaBiosystems.com within the product section.

  • Page 24: Technical Data

    Instrument Components and Specifications 3.4 Technical Data Nominal supply voltages: Two factory-preset voltages (not user-adjustable): 100 to 120 V 230 to 240 V Nominal frequency: 50-60 Hz Main fuses: 2 melting fuses, 20 x 5 mm, UL-approved • for 100 to 120 V F 10 A 250 VAC • for 230 to 240 V F 5 A 250 VAC Nominal power: 1000 VA Dimensions, (L x W x H), in mm:...
  • Page 25 Fluid level sensor: ON/OFF Recirculation (pump in/out): ON/OFF (a) Time before 1st cycle: 16 min (b) Time between cycles: 20 min System setup Password status: Supervisor/Operator Type of password: alphanumeric, freely selectable Reagent Management System: ON/OFF Software interlock: ON/OFF Leica ASP300 S...

  • Page 26: Compatible Reagents

    80, 120 and 140 seconds. • Up to 100 reagent names in memory. 3.5 Compatible reagents Use of the ASP300 S is permitted with the reagents specified in Chap. 3.5 only. These reagents must be validated before use, i.e. tissue processing with patient tissue for diagnostics, by the laboratory itself according to the local or regional accreditation requirements.

  • Page 27: Recommended Reagent Handling

    • The recommended temperature for cleaning reagents in the cleaning cycle is 65 °C. • Only zinc formalin based on zinc sulfates may be used in the ASP200 S/ASP300 S. If zinc formalin is used, the cleaning program must include an additional cleaning water step.

  • Page 28: Cycle For Changing Reagents

    Instrument Components and Specifications 3.6.1 Cycle for changing reagents Reagent Week 1 Week 2 Week 3 Week 4 At least 3 times a At least 3 times a At least 3 times a At least 3 times a Formalin week week week week...

  • Page 29: Initial Operation

    • The chemicals to be used in the Leica ASP300 S are both flammable and noxious. • The installation site for the Leica ASP300 S must be well ventilated, and there must be no ignition sources of any kind in the area.

  • Page 30: Electrical Connection

    Initial Operation 4.2 Electrical connection Severe damage may occur if the instrument is connected to a power Notice! supply voltage other than that to which Observe the following instructions it was originally set. carefully to prevent damage to the in- The power supply voltage for the strument (refer also to Chap.

  • Page 31: Connecting An Uninterruptible Power Supply (Ups)

    • Switch the instrument on at the main switch. • Start the UPS. Fig. 4a Fig. 4a is provided as an example only and shows the correct connection of the ASP300 S to an uninterruptible power supply (UPS). Leica ASP300 S...

  • Page 32: Installing Accessories

    Initial Operation 4.3 Installing accessories • Move the instrument to its final setup location. Active carbon filter • Unpack the active carbon filter (13) and insert it (see Fig. When doing so, make sure that the filter is inserted with the correct side up. Note the direction of the label (29) on the front of the filter –...
  • Page 33 The magnetic stirrer must be inserted such that the outer curvature (32) of the two stir- rer blades (31) faces downwards! (Fig. Do not insert them the other way around, as then there will be no effective stirring. Fig. 7 Leica ASP300 S...

  • Page 34: Making The Data Connections

    Initial Operation 4.4 Making the data connections For data transfer and storage, the instrument console is equipped with an USB port (11). An USB memory stick is part of the standard deliv- ery. For information on alarm connections, see Chap. 3.1. Fig.

  • Page 35: Anti-Reflection Clip - Function

    Fig. and pry the clip out from the inside. Once bent, clips may no longer be used and must be disposed of. In this case, install a new clip from the standard scope of delivery. Fig. 11 Leica ASP300 S...

  • Page 36: Alarm Functions

    Initial Operation 4.6 Alarm functions Local alarm This alarm is external to the Leica ASP300 S, e.g. The Leica ASP300 S is equipped with 3 different in the office of the instrument operator. alarm functions: The local alarm is used when the instrument...

  • Page 37: Switching The Instrument On

    4.7 Switching the instrument on The instrument MUST be connected to a grounded power socket. For additional electrical fuse protection, we recommend connecting the Leica ASP300 S to a socket with a residual current circuit breaker. • C onnect the power cable to the power socket. If applicable, switch on the switch for the power socket.
  • Page 38 Initial Operation SYSTEM DIAGNOSTICS menu If TOUCH HERE ... is touched dur- ing initialization (Fig. 13) and the password for supervisor mode is en- tered, the SYSTEM DIAGNOSTICS menu (Fig. 15) opens. This menu provides access to basic instrument settings. Notice! Only experienced operators may adjust the settings, since incorrect...

  • Page 39: Touchscreen Functions

    HELP button. Fig. 17 Button symbols Pressing a button on the Leica ASP300 S activates the corresponding in- strument function. All buttons have a uniform design for easy identification. The buttons may contain text labels or graphical icons.

  • Page 40: Checklist For Initial Operation

    Initial Operation 4.9 Checklist for initial operation When the instrument is prepared to the point where it can be switched on, the menus listed below have to be opened and the corresponding parameters configured. → Screen display Press button Parameter selection Set warning values for the age of the carbon →...

  • Page 41: Switching Off The Instrument

    ON/OFF switch on the rear panel of the instrument (item 42 in Fig. Notice! The ASP300 S is allowed to be switched off completely in this way only. Otherwise, severe damage to the instrument's hardware and loss of data can occur. Leica ASP300 S...

  • Page 42: Operation

    Operation 5.1 Setting up the instrument parameters From the start screen, press MENU to switch to the MENU FUNCTIONS → window, and press the MORE button there. Fig. 22 Fig. 21 In the 5.1.1 System setup MORE MENU FUNCTIONS press SYSTEM SETUP SYSTEM SETUP is divided into five areas:...
  • Page 43 Press the buttons to access the entry windows where settings or correc- tions can be made, if necessary. Date and time setup screen Fig. 25 Fig. 26 Leica ASP300 S...
  • Page 44 Operation DISPLAY/BUZZER: • The number next to DISPLAY OFF indicates the remaining time (in min) until the screen saver (after the last user action) is activated. • The BUZZER VOLUME can be set between 1 and 10. INSTRUMENT Press PARAFFIN BATH SET TEMP. to open the input screen (Fig.

  • Page 45: Access Levels

    A password is required for supervisor level access to the instrument. Enabling SUPERVISOR MODE already requires entering the password. 5.1.2 Access levels The Leica ASP300 S may be configured to allow two levels of user access. "Operator" symbol Operator access level: • Operators may run programs and view results. On this level, the OPERATOR symbol is displayed in the upper right corner of the touchscreen;...
  • Page 46 Operation Enabled or Disabled LOCK MODE: In the Leica ASP300 S, there is a lock mode to protect against operation by unauthorized per- sons. Enabled: The lock mode has to be activated in the System Setup. A password is required for the activation and deactivation.

  • Page 47: Installation Menu

    Enter a name (20 characters maximum) for the in the selected language. Press YES to restart the instrument. instrument and display the user interface in the The instrument name is also displayed on the newly selected language. FAVORITES screen. Leica ASP300 S...
  • Page 48 New versions of the operating software are distributed on hard disk drives. For any upgrade or update of the software the hard disk drive needs to be replaced. This procedure needs to be performed by Leica Technical Ser- vice, and must never be done by customers.
  • Page 49 → knowledge the dialog box by clicking Yes. Successful completion of data transfer will be indicated by an according dialog box. Data will be saved in "\ Leica\Data\". More Functions Menu Eject the USB-Device To avoid data loss, in the...

  • Page 50: Editing The Reagent List

    Operation 5.1.4 Editing the reagent list Adding new reagents 1. Enter the reagent name and allocate the new reagent to the reagent group it belongs to. 2. Determine how many stations (bottles) work with the new reagent. 3. Fill the stations (bottles) according to the reagent list. Entering reagent names Takes place via the REAGENTS menu option.
  • Page 51 If a reagent is renamed, all stations and programs linked to that reagent need to be reedited as well! • Highlight the reagent the name or group of which you wish to change. • Press the corresponding button symbol in the headline. • In the entry window (or via the keyboard), enter the new reagent group allocation / the new reagent name. • Press OK to save the new reagent group / reagent name. Fig. 41 Leica ASP300 S...
  • Page 52 Operation Deleting reagents • Highlight the reagent to be deleted in the SET UP REAGENTS AND WARNING THRESHOLDS screen. • Press CLEAR. ↓ • Press YES in the screen to confirm the reagent is deleted. Please remember that a reagent which is already used in a program cannot be deleted. Fig.

  • Page 53: Viewing The Program List

    Operation 5.1.5 Viewing the program list This list (Fig. 43) shows all programs defined in the ASP300 S. → You can create: • Up to 15 infiltration programs • 3 retort cleaning programs • 1 paraffin cleaning program At supervisor access level: • The program names for the infil- tration programs can be edited. • New infiltration programs can be added and existing ones can be deleted.

  • Page 54: Adding And/Or Modifying Programs

    Operation 5.1.6 Adding and/or modifying programs Creating a new program • Make sure you are logged on at supervisor level. • In the VIEW/EDIT PROGRAMS screen (Fig. 43) highlight a program as similar as possible to the program you wish to create. (This minimizes the number of operating steps). • Press COPY to copy the selected program. The new program will have the same name as the program copied, however, the figure "(2)"...
  • Page 55 Operation Editing program steps • To edit a step, highlight the corresponding line and press the respective headline. • In the entry windows that pop up, enter / select the program step settings. ↓ ↓ ↓ ↓ ↓ Fig. 45 Leica ASP300 S...
  • Page 56 Operation Editing program steps (continued) Setting a delay step A delay step is a step that is extended to ensure that a program will finish at a specified time. • Highlight the program step you wish to define as delay step. • Touch the DELAY button. The delay symbol is moved to the selected step, thus defining the step as delay step.

  • Page 57: Favorites

    Operation 5.1.7 Favorites Up to five favorites can be configured in the ASP300 S. Favorites can be programmed so that they: • end "as soon as possible" (NOW) or • end at a predefined time. ↓ Fig. 46 Adding/modifying a Favorite • Select the program line to be modified. ↓ • Touch the PROGRAMS button. • Select the program you want and press OK to confirm.
  • Page 58 Operation Assigning a day for the end time If an end time has been assigned to a Favorite program, a specific weekday can also be set on which the program is to end. ↓ • Press the DAY button. • Select the desired day from the list and confirm with OK. Assigning a symbol to a "Favorite" A corresponding symbol is displayed, which helps the operator recognize Fig.

  • Page 59: Configuring The Stations

    • Station 12 can only be assigned a cleaning • The SELECT REAGENT field appears. alcohol. Only those reagents that are compat- • Stations 13 and 13-ext. can only be assigned ible with the selected station will be cleaning water/detergents. offered for selection. • Wax baths may only be used for paraffin. • Highlight the reagent you want and confirm your selection with OK. Leica ASP300 S...

  • Page 60: Reagent Groups

    Operation 5.1.9 Reagent groups In this window (Fig. 51), the colors used in the graphical → → program display for each reagent group are displayed. ↓ Fig. 51 Changing the color of a reagent group • Highlight the line containing the reagent to be modified. • Press the COLOR button in the table header; the SELECT COLOR window appears.

  • Page 61: Reagent Handling

    • Finally, pressurized air is used to clear the hose after each fill / drain so that no dirt remains. • The hose should therefore not be removed from the bulk container until this cleaning step is complete. Leica ASP300 S...
  • Page 62 Operation Filling/draining reagents → From the FAVORITES screen, press MENU. In the MENU FUNCTIONS window, tap the SMART SCREEN button. The SMART SCREEN (Fig. 53) pops up. The smart screen is the initial screen for manual operation of the instrument. The following steps should only be carried out by trained laboratory personnel, experienced in handling...

  • Page 63: Replacing The Paraffin

    From FAVORITES, call up the SMART SCREEN → screen. (see previous chapter) • Select the paraffin reservoir to be emptied and the receptacle (External, Fig. 56). Then, press STATION DRAIN..→ • This is followed by multiple security prompts that you have to confirm individually in order Fig. 56 to continue. Leica ASP300 S...
  • Page 64 Software control • After refilling with paraffin pellets, the ASP300 S does not allow you to run any pro- grams until the paraffin is completely melted. The software calculates the amount of time required for melting the paraffin and does not...
  • Page 65 Change the delay time only if you are absolutely sure that the entered time is correct. If the instrument attempts to run a paraffin step with paraffin that is not completely melted, substantial faults and malfunctions may result. Leica ASP300 S...

  • Page 66: Running Programs

    Fig. 61 Fig. 62 Up to five favorites can be configured in the In the Start screen, press the ALL ASP300 S. PROGRAMS button. This window displays all of the A "Favorite" is an infiltration program that is used infiltration programs defined in the frequently and thus has been assigned to the instrument.

  • Page 67: Editing A Program That Has Been Called Up

    • Press OK to confirm. Programs can be started up to 6 days in advance. So that the program is ended at the defined date/time, the delay step is lengthened accordingly. Fig. 64 Leica ASP300 S...
  • Page 68 Operation The RUN OPTIONS function displays the options with which the current program is started. • LEVEL TEST enabled: The lower level sensor in the retort is acti- ↓ vated. The program is stopped with an error message if the level is not reached. • WAVE MOTION activated: During each infiltration step, the reagent is periodically pumped from the bottle to the re-...

  • Page 69: Starting A Program

    CONTINUE restarts the program. The end time of a running program can be changed only if the delay step has not yet been completed. • You can switch from the graphical to the table display by touching the → TABLE, and back again with GRAPHICAL. Leica ASP300 S...

  • Page 70: Opening The Retort

    Operation 5.3.3 Opening the retort The signal tone and the 10-second waiting time occur each time the retort is unlocked! For this reason, we recommend only locking the retort before starting a program or before cleaning in order to prevent unnecessary waiting times. • To unlock, turn the lever for the retort's locking/unlocking mechanism (Fig.
  • Page 71 4) and the samples can be removed Approx. 45° and secured. The instrument can no longer be operated after the retort has been unlocked using the mechanical emergency unlock. Notify a responsible Leica service technician! Fig. 74 Leica ASP300 S...

  • Page 72: Reagent Status

    Operation 5.4 Reagent status This window (Fig. 64) is used to display and update the current reagent → status of the stations. In addition, reagent stations can be marked as full or empty here. The following is displayed: • The current age of each reagent • The current status of each station • Criteria that trigger warning mes- sages (Fields colored in red)

  • Page 73: System Monitor

    5.5 System monitor The SYSTEM MONITOR function provides important infor- → → mation about the status of the Leica ASP300 S. PUMP AGE: Indication of the operating hours of the pressure/ vacuum pump. The configured warning value determines the triggering of a warning message.

  • Page 74: The Online Help

    Operation 5.6 The online help The Leica ASP300 S has an online help that can be started from every main window. It contains a reference to the Instruction for Use. The online help can be accessed from any screen by pressing the HELP button.

  • Page 75: Troubleshooting

    • If, on account of a power failure, the paraffin temperature is reduced to the point that the paraffin is no longer suitable for continuing the ongo- ing program, the Leica ASP300 S builds in a delay time sufficient to bring the paraffin back to a suitable operating temperature before the paraffin step.

  • Page 76: Troubleshooting

    Troubleshooting 6.3 Troubleshooting If a problem occurs in the Leica ASP300 S, take the following steps to diag- nose the problem: • Check for error messages indicating the nature of the problem. • Check the Run Log for any messages that indicate the nature of the fail- ure. If the failure occurred during a program run, check the Run Log for an indication of whether the failure occurred during the fill, processing →...

  • Page 77: Typical Fill Or Drain Problems

    (consistent with the type of reagents/solvents used in the clean program). If you cannot eliminate the problem by carrying out the above listed steps, call Leica Technical Service before attempting to run any further programs. Leica ASP300 S...

  • Page 78: Cleaning And Maintenance

    → → respective line and press EDIT. Three retort cleaning programs and a paraffin cleaning program are defined in the ASP300 S. Clean programs cannot be copied or deleted. Replacement schedule for cleaning reagents: The cleaning reagents (cleaning xylene and cleaning alcohol) must be replaced weekly...
  • Page 79 "13-ext" at the required point in time during the cleaning program, then to remove it once it is no longer used. The station 13-ext can be assigned exclusively to reagents from the cleaning water group. It may only be used for cleaning programs. Leica ASP300 S...

  • Page 80: Paraffin Cleaning

    Cleaning and maintenance 7.1.2 Paraffin cleaning It is possible to clean used paraffin of solvent residues (xylene) in the Leica ASP300 S. To do so, select the paraffin bath for which the paraffin should be cleaned in the CLEANING ↓...

  • Page 81: Smart Clean

    Cleaning and Maintenance 7.1.3 Smart clean The smart cleaning prepares the ASP300 S for transport. During a smart clean, a series of air cleaning steps will be applied which will remove any excess liquid (condensate) from all internal tubing. Before starting a smart cleaning, a complete retort cleaning program must be carried out in the ASP300 S.

  • Page 82: General Cleaning Steps

    Cleaning and maintenance 7.2 General cleaning steps Paraffin reservoirs Work carefully! Be careful as the walls of the paraffin reservoirs are very hot and may cause burns! • Wipe the paraffin reservoirs and lids clean. The lid can be removed for cleaning purposes. • If they are dirty, remove the wax strainers from the paraffin reservoirs. Clean, dry, and reinsert them. • Ensure that the air vent hole at the top rear right hand corner is unob- structed.
  • Page 83 Filter label side up, as specified on the label on the front side of the filter. The arrow must point upwards. Do not operate without having an ac- tive carbon filter installed. Leica ASP300 S...

  • Page 84: Daily Cleaning And Maintenance

    Cleaning and maintenance 7.2.1 Daily cleaning and maintenance Cleaning the retort lid • Remove wax from the inside of the retort lid with the plastic scraper provided. Thoroughly remove all wax deposits from around the lid seal. • For convenience, the lid may be removed during cleaning. Lift the lid to a vertical position, release the hinge lock and pull the lid toward you. Only use the plastic scraper provided when cleaning the retort lid and seal to avoid damage to the retort lid seal and to the PTFE coat- ing on the retort lid.
  • Page 85 This procedure is particularly important with bottles containing chloroform. O-rings that have not been lubricated swell when ex- posed to chloroform. The reagent containers can then become very difficult to remove. Checking the retort lid seal • Regularly check the retort lid seal for damage. If the seal is damaged, it must replaced without delay. Leica ASP300 S...

  • Page 86: Periodic Cleaning And Maintenance

    Cleaning and maintenance 7.2.2 Periodic cleaning and maintenance Cleaning the reagent containers • Empty and clean the reagent containers. Using a bottle brush and a laboratory detergent in warm water. Never clean reagent containers in an automatic dishwasher. The reagent containers are NOT dishwasher-proof! • Refill and reconnect the bottles once cleaned. Make sure the bottle lids are tight and the bottles are properly seated in their home position at the rear of the reagent module.
  • Page 87 ASP6025, the smaller (Fig. 85, 47) is for use with the ASP200 S / ASP300 S. To prevent damage to the sensors, NEVER use the larger spoon for cleaning the sensors in the ASP200 S / ASP300 S.

  • Page 88: Checklist For Preventive Maintenance

    Cleaning and maintenance 7.3 Checklist for preventive maintenance Step Daily Weekly Monthly every 3 months √ √ Lubricate the O-rings of the reagent * During container and check them for damage. remote filling and draining √ After exiting the retort cleaning program, wipe the retort and cover dry.
  • Page 89 Clean the reagent containers from the inside if necessary. √ Make sure that the shutter caps of the reagent containers and the O-rings fit correctly and are tight. √ Check that the reagent containers are fitted securely in the ports. Leica ASP300 S...

  • Page 90: Warranty And Service

    Leica Biosystems Nussloch GmbH guarantees that the contractual product delivered has been subjected to a comprehensive quality control proce- dure based on the Leica in-house testing standards, and that the product is faultless and complies with all technical specifications and/or agreed characteristics warranted.

  • Page 91: Decontamination Confirmation

    Decontamination Confirmation Every product that is returned to Leica Biosystems or that requires on-site maintenance must be properly cleaned and decontaminated. You can find the dedicated template of the decontamination confirmation on our website www.LeicaBiosystems.com within the product menu. This template has to be used for gathering all required data.

  • Page 92: Appendix

    • Using sponges to affix small tissue samples for processing or packing them in filter paper. • Packing small biopsies into Leica CellSafe biopsy capsules, biopsy sponges or biopsy bags. Insufficiently prepared specimens can lead to the intrusion of artifacts into important instrument components and thus cause damage.
  • Page 94 Leica Biosystems Nussloch GmbH Heidelberger Straße 17-19 D- 69226 Nussloch Phone: +49 6224 - 143 0 Fax: +49 6224 - 143 268 Web: www.LeicaBiosystems.com...

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