Epson STYLUS PRO 4400 Reference Manual page 66

Note:
When Portrait is selected as the Orientation setting on the Paper
menu, Left or Right binding positions are available. The Top binding
position is supported when Landscape is selected as the
Orientation setting.
4. Specify the width of the binding margin, using the Binding
Margin text box. You can specify any width from 3 to 30 mm.
The specified margin width will be used on both sides of the
fold. For example, if a 10-mm margin is specified, a 20-mm
margin will be inserted. (A margin of 10 mm will be placed
on each side of the fold.)
✽ Folding Edge
✽✽ Margin
5. Click OK to return to the Layout menu, and then click OK to
save your settings.
6. Make sure paper is loaded, and then send a print job from
your application.
7. Instructions for printing the inside pages will be displayed
while the outside pages are output. Follow the on-screen
instructions to reload the paper.
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