Connection Instructions For Macintosh (Os X Only) - Alesis MultiMix12USB Reference Manual

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Applications
98 Second Edition may require you to insert your Windows disc,
after which the drivers should load correctly.
After the Multimix has been recognized and its drivers have been
installed, open the Control Panel. Select Sounds and Audio
Devices (or Multimedia), go to the Audio tab, and select the "USB
audio codec" as your default sound recording and sound playback
device.
Connection instructions for Macintosh (OS X
only)
After plugging in the Multimix, select "USB Audio CODEC" in
the Sound area of System Preferences. No other action is required.
The Multimix USB is not designed for use with Mac OS9 and
below.
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