Varian 4000 MS Manuals

Manuals and User Guides for Varian 4000 MS. We have 2 Varian 4000 MS manuals available for free PDF download: Hardware Operation Manual, User Manual

Varian 4000 MS Hardware Operation Manual (161 pages)

Brand: Varian | Category: Laboratory Equipment | Size: 5.31 MB

Table of Contents
35
Introduction
39
Functional Description
41
Overview
41
Transfer Line
43
Analyzer
44
Internal Ionization Configuration
44
External Ionization Configuration
46
Hybrid Configuration
48
Ion Trap
48
Detector
50
Vacuum System
51
Vacuum Manifold
51
Foreline Pump
51
Turbomolecular Vacuum Pump
52
Ion Gauge
52
Thermocouple Gauge
53
Pneumatics
53
Helium Flow
54
Calibration Gas Flow
54
The CI Reagent Gas Flow
54
Electronics
55
Controller
56
Power Board
57
Manifold Electronics
58
RF Generator Assembly
58
Ion Detection Board
59
Ion Amplifier
59
Electronic Flow Control
59
Power Input Subsystem and Turbomolecular Pump Controller
59
Main Power Circuit
60
Periodic Maintenance
61
Procedure Interval
61
Checking Foreline Pump Oil Level and Oil Condition
61
Changing Foreline Pump Oil
61
Flushing the Pump Oil
64
Changing the Oil Mist Cartridge
65
Checking Cooling Fans
66
MS Maintenance Procedures
67
General Recommendations
67
Recommended Tools and Materials
67
Common Procedures
68
Turning off the Mass Spectrometer
68
Turning off the Mass Spectrometer with Nitrogen Purge
70
Moving the Mass Spectrometer Away from the GC
71
Removing the Analyzer Assembly
71
Removing the Source/Ion Trap Assembly
74
Reinstalling the Source/Ion Trap Assembly
75
Reinstalling the Analyzer Assembly
78
Turning on the Mass Spectrometer
80
Checking the Vacuum Status
82
Baking out the Mass Spectrometer
83
Checking Ion Trap Operation
83
Cleaning Procedures
84
Cleaning the External Source
84
Cleaning the Internal Ionization Assembly
94
Cleaning Ion Trap Components
98
Replacing a GC Column
105
Removing the Capillary Column from the System
105
Installing a New Capillary Column in the System
106
Replacing Consumable Components
109
Replacing External Source Filaments
109
Conditioning the Filaments
111
Replacing Internal Source Filaments
111
Replacing the Electron Multiplier
113
Replacing the Damping Gas Getter
115
Replacing the Turbomolecular Pump
115
Filling the Calibration Compound Vial
116
Changing Operational Configuration
117
Changing from Internal to External Configuration
118
Changing from External to Internal Configuration
118
Changing from Internal to Hybrid Configuration
118
Changing from External to Hybrid Configuration
118
Changing from Hybrid Mode to External Configuration
118
Changing from Hybrid Mode to Internal Configuration
118
Switching between External and Internal Sources
118
Changing the Transfer Line Position from External to Internal
119
Changing the Transfer Line Position from Internal to External
121
Installing or Removing the Hybrid Plug
123
Chemical Ionization Options
125
Introduction
125
Internal Configuration CI
125
External Configuration CI
125
Hybrid Configuration CI
126
Installing CI Reagent Gas
126
CI Reagent Gas Requirements
127
Setting up the CI Reagent Gas Supply
127
Checking the Reagent Gas Plumbing for Leaks
130
Setting Flows of CI Reagents in Internal Configuration
131
Internal Mode Default Parameters for CI Reagents
131
External Mode Default Parameters for CI Reagents
131
Ion Intensities for Standard CI Reagents
132
Setting Flows of CI Reagents in External Configuration
132
Setting Flows of CI Reagents in Hybrid Configuration
132
The Liquid CI Inlet Option
133
Filling/Refilling Reservoir Bulb
133
Switching from Liquid to Gaseous CI Reagent Operation
134
Troubleshooting
135
How to Isolate a GC/MS Problem
135
Checking the Data System
135
Checking the GC
135
Checking the Mass Spectrometer
135
Troubleshooting Problems with Spectra
136
No Spectrum Appears
136
Loss of High Mass Peaks
137
Part of the Spectrum Is Missing
137
Poor Resolution with Acceptable Air and Water Levels
138
Troubleshooting High Baseline at High Masses
138
Checking for Leaks
139
Establishing Conditions Required for Leak Checks
139
Fixing a Large Air Leak
140
Fixing a Small-To-Moderate Air Leak
141
Checking GC Connections
141
Troubleshooting Air Leaks Using Leak Detection Gas
141
Fixing High Water Levels
142
GC Troubleshooting
143
Using the COLTEST Sample for Troubleshooting
143
Running the COLTEST Sample
143
Troubleshooting Common Chromatographic Problems
144
Correcting Solvent Tailing or Broadening Problems
144
Correcting Tailing Sample Peaks for Particularly Active Components
145
Correcting Low Response and Severe Tailing with High Boiling Point Compounds
145
Correcting Leading Sample Peaks (Reverse Tailing)
145
Correcting Poor Resolution
145
Lack of Peak Size Reproducibility
146
Correcting Peak Splitting (Particularly for Low Boilers)
146
Correcting Extra, Unexpected Peaks in the Chromatogram
146
Correcting Retention Time Differences between Runs
147
Miscellaneous Procedures and Instructions
149
Other Documents
149
Site Requirements
149
Site Preparation
149
Power
149
Quality of Power
152
Operating Environment
152
Temperature
152
Humidity
153
Exhaust System
153
Gas Requirements
153
Helium - GC Carrier Gas
153
Methane, Isobutane, Ammonia - CI Reagent Gases (with CI Option Only)
154
Cryogenics
154
How to Install the 4000 MS
154
How to Move the 4000 MS
155
Parts and Supplies
156
Electronics
156
Pneumatics
156
Analyzer, Attached to Top Flange
156
Analyzer, Attached to Manifold
158
Chemical Ionization
158
Vacuum
158
O-Rings
159
Miscellaneous/Other
159
Test Samples
160
Varian Service
161

Varian 4000 MS User Manual (39 pages)

Internal Ionization

Brand: Varian | Category: Laboratory Equipment | Size: 0.59 MB

Table of Contents
3
Overview of Internal Configuration
5
Scan Functions Control MS Processes
6
Steps to Create a Mass Spectrum
6
- Sample Introduction
  6
- Ionization
  6
- Fragmentation
  7
- Ion Storage
  7
- Ion Preparation
  7
- Ion Analysis
  7
About Internal Electron Ionization
7
About Internal Chemical Ionization
9
Selectivity Considerations
11
- Type of Matrix
  11
- Using EI and PCI to Get more Information
  11
Conversion from External to Internal Configuration
12
- Checklist
  12
Conversion from Hybrid to Internal Configuration
12
- Outline
  12
- Effects of Hardware Configuration Changes
  12
Starting the Instrument
13
- Initial Pump down
  13
- Check the Vacuum Status
  13
- Diagnostic Tests
  14
- Setting System Temperatures
  15
  - Analysis Temperatures
    15
  - System Bakeout
    15
- Startup and Shutdown
  16
  - Starting the System
    16
  - Shutting down the System
    16
Adjustment and Tuning of the MS
16
- Checks and Adjustments
  16
  - RF Tune
    16
  - Adjusting the RF Ramp
    17
  - Adjusting the Calibration Gas
    17
  - CI Gas Adjustment
    18
  - Air/Water Check
    18
Setting up CI Reagents
18
- Installing a Liquid Reagent
  19
- Installing a Gaseous Reagent
  20
- Auto Tune
  20
  - Integrator Zero
    20
  - Set Electron Multiplier
    20
  - Electron Lens Tuning
    20
  - Ion Lens Tuning
    21
  - RF Full Scale Adjust
    21
  - Mass Calibration
    21
  - Trap Frequency Calibration
    21
  - Trap DC Offset Voltage
    21
Preparing an MS Method for Data Acquisition
22
- Building a New MS Method
  22
- Edit the 4000 MS Method Segments
  25
- Viewing Method Parameters in Manual Control
  31
  - Activating a Method
    31
  - Displaying Ions
    32
  - Viewing Method Parameters
    33
  - Editing a Method in Manual Control
    33
  - Saving a Method
    35
Acquiring Data
35
- Acquisition
  35
  - Status and Control
    36
- Activating a Method
  37
- Injecting a Single Sample
  37
- Injecting Using a Samplelist
  38
- Monitoring the Status of Runs
  39

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