Thermo Scientific 163960 Manuals

Manuals and User Guides for Thermo Scientific 163960. We have 1 Thermo Scientific 163960 manual available for free PDF download: Installation Qualification/Operational Qualification Protocols And Instructions

Thermo Scientific 163960 Installation Qualification/Operational Qualification Protocols And Instructions

Thermo Scientific 163960 Installation Qualification/Operational Qualification Protocols And Instructions (60 pages)

Capillary- and Nano HPLC Systems

Brand: Thermo Scientific | Category: Laboratory Equipment | Size: 1 MB

Table of Contents

Warnings
3
Safety Precautions
3
Table of Contents
5
Introduction
7
The Purpose of OQ/PQ
7
Defining the Limits
7
General Notes and Recommendations
8
How this Manual Is Structured
8
For Additional Information
8
Requirements for a Successful OQ/PQ
9
Overview
9
Checks and Acceptance Limits
10
Process
13
Required Materials
13
Preparations
15
CHROMELEON® Setup
15
System Setup
18
Performing the Checks
21
Evaluating the Tests
22
Repeating Tests
22
Test Procedures
23
Overview
23
Lamp Intensity of the UV Detector
24
Performing the Lamp Intensity Test
24
Wavelength Check
25
Performing the Test
25
Flow Cell Check
26
Performing the Intensity Test of the Flow Cell
26
Ultimate Fluid Path Test
27
Performing the Test
27
Baseline Noise and Drift Test of the UV Detector and Oven Test
28
Drift and Noise
28
Theory of the Noise and Drift Calculation of CHROMELEON
29
Oven Accuracy
29
Performing the UV Detector Drift and Noise Test and the Oven Test
30
Linearity of the UV Detector
31
Performing the UV Detector Linearity Test
32
Reproducibility of the Injection Volume
33
Performing the Test
33
Linearity of the Injection
34
Performing the Test
34
Gradient Accuracy
35
4.10.1 Performing the Test
37
Switchos Fluid Path Check
38
4.11.1 Performing the Test
38
Switchos Flow Rate and Pressure Stability Test
39
4.12.1 Performing the Test
39
Switchos Valve Position Check
40
4.13.1 Performing the Test
40
Completing and Printing the OQ/PQ Report
41
4.14.1 Result of the Gradient Accuracy Test
41
4.14.2 Completing the Cover Page and Printing
42
Troubleshooting
43
Overview
43
Sample and Mobile Phase Considerations
43
Probable Causes and Solutions
44
CHROMELEON ® Listings
45
Overview
45
Wavelength Check (NAN Configuration)
46
Noise and Drift Test (NAN Configuration)
47
UV Linearity (NAN Configuration)
49
Autosampler Reproducibility (NAN Configuration)
51
Autosampler Injection Linearity (NAN Configuration)
53
Gradient Accuracy Test (NAN Configuration)
55
Switchos Pump Test (NAN Configuration)
57
Stop Flow
59

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