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XCell ATF4
REPLIGEN XCell ATF4 Manuals
Manuals and User Guides for REPLIGEN XCell ATF4. We have
2
REPLIGEN XCell ATF4 manuals available for free PDF download: User Manual
REPLIGEN XCell ATF4 User Manual (126 pages)
With C410:V4B Controller
Brand:
REPLIGEN
| Category:
Laboratory Equipment
| Size: 4 MB
Table of Contents
Table of Contents
3
1 Description of the Xcell™ ATF (Alternating Tangential Flow) System and Process
5
Xcell TM ATF System Pump Cycle
7
Xcell™ ATF System Control Scope and Objectives
9
2 Utility Requirements
9
3 Dimensions and Weight
10
4 Xcell™ ATF Pump Housing Assemblies
11
See Appendix 7 for List of Spares and Accessories
16
5 Xcell TM C410V4B Controller Layout
21
General Layout
21
Filtration Assembly (Stainless Steel)
22
Pneumatics Box (P-Box) Components
22
Electrical Box (E-Box)
22
Power Box (Power Separation) Components
24
Primary Pneumatic Services
24
Primary Electric Services
25
Signal
25
6 C410V4B Controller Process and Control
26
Control Overview
26
Control Functional Algorithms
28
Interface and Screens
29
Startup
54
Examples
56
7 Xcell™ ATF Hollow Fiber Module and Diaphragm Replacement
58
Separating the Filtration Assembly from the Bioreactor
58
HFM Removal
58
HFM Insertion
59
Screen Module Replacement
60
Diaphragm Replacement
60
Assembly
61
Use
61
8 Sterilization
62
Preparation of Filtration Assembly for Autoclaving
62
Autoclave Cycle
63
Sterilization of Filtrate / Harvest Line
64
9 Connection to Bioreactor (ATF-To-Bioreactor)
65
Hard Connection
65
10 Maintenance
66
Diaphragm
66
Pump Air Inlet Filter
66
O" Rings, Gaskets and Quick Connects
66
Appendix 1: Cycle Time Vs. Flow Rate
67
Appendix 2: Access Levels to the C410V4B Controller
68
Appendix 3: Controller Lists: Alarm, Warning, Inputs & Outputs
75
Appendix 4: Profinet Communication
77
Appendix 5: Profibus Communication
79
Appendix 6: Delta V Example Configuration
100
Appendix 7: OPC Communication
107
Appendix 8: Audit Trail (if Equipped)
117
Appendix 9: EU Declaration of Conformity
120
Appendix 10: UL Listing
123
Appendix 11: Spares List
124
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REPLIGEN XCell ATF4 User Manual (25 pages)
Stainless Steel Housings
Brand:
REPLIGEN
| Category:
Water Filtration Systems
| Size: 1 MB
Table of Contents
Table of Contents
3
Table 1. Explanation of User Attention Phrases
8
Table 2. Explanation of Symbols
8
Figure 1. Pressure and Exhaust Strokes
8
Table 3. Dimensions
9
Table 4. Suggested Scale of Operation
9
Installing the Diaphragm
10
Figure 2. Xcell® ATF 2 Stainless Steel Housing
10
Xcell® ATF 2 Stainless Steel Housing Hollow Fiber Filter Installation
11
Figure 3. Orientation of Silicone Diaphragm in Xcell® ATF 2 Stainless Steel Housing
11
Figure 4. Xcell® ATF 2 Stainless Steel Housing Installation of HFM
11
Filter Wetting
12
Integrity Testing Pre-Autoclaving
12
Autoclaving
12
Integrity Testing Post-Autoclaving
12
Xcell® ATF 2 Stainless Steel Tubing Set Kits and Accessories
13
Table 5. Headplate Fitting Part Numbers
13
Table 6. Xcell® ATF 2 Tubing Set Kit Options
13
Table 7. Xcell® ATF 2 Required Accessories
13
Tubing Set Kit for Xcell® ATF 2 Stainless Steel Housing Connected to Glass Bioreactor
14
Figure 5. Xcell® ATF 2 Stainless Steel Housing Connection to Glass Bioreactor (Tri-Clamp)
14
Figure 6. Xcell® ATF 2 Stainless Steel Housing Connection to Glass Bioreactor
14
Removing the Housing from the Bioreactor
15
HFF Removal
15
Decontaminating the HFF for Disposal
15
Pump Air Inlet Filter, O-Rings, Gaskets, and Quick Connects
15
Installing the Diaphragm
16
Figure 7. Xcell® ATF 4 Stainless Steel Housing
16
Xcell® ATF 4 Stainless Steel Housing Hollow Fiber Filter Installation
17
Figure 8. Orientation of Silicone Diaphragm in Xcell® ATF 4 Stainless Steel Housing
17
Filter Wetting
18
Integrity Testing Pre-Autoclaving
18
Autoclaving
18
Integrity Testing Post-Autoclaving
18
Xcell® ATF 4 Stainless Steel Housing Tubing Set Kits and Accessories
19
Table 8. Headplate Fitting Part Numbers
19
Table 9. Xcell® ATF 4 Tubing Set Kit Options
19
Table 10. Xcell® ATF 4 Required Accessories
19
Tubing Set Kit for Xcell® ATF 4 Stainless Steel Housing Connected to Glass Bioreactor
20
Figure 9. Xcell® ATF 4 Stainless Steel Housing Connection to Glass Bioreactor (Tri-Clamp)
20
Figure 10. Xcell® ATF 4 Stainless Steel Housing Connection to Glass Bioreactor (Aseptiquik®)
20
Removing the Housing from the Bioreactor
21
HFF Removal
21
EU Declaration of Conformity
22
Tube Set Kits
23
Table 11. Xcell® ATF 2 Spare Parts
23
Table 12. Xcell® ATF 4 Spare Parts
24
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