Getinge Livit Flex Manuals

Manuals and User Guides for Getinge Livit Flex. We have 1 Getinge Livit Flex manual available for free PDF download: User Manual

Getinge Livit Flex User Manual (358 pages)

Biocontroller for 3 L and 15 L Single-Use Bioreactors

Brand: Getinge | Category: Laboratory Equipment | Size: 52 MB

Table of Contents
2
Safety
11
Safety Symbols
11
Safety Warnings
12
Intended Use
14
EU Declaration of Conformity
15
I Operation
16
General Operation
17
Introduction
17
Sensors and Control Loops
17
Operating the Control Console
18
Authentication
18
Screen Management
18
Bioreactor and System Configuration
18
Icons and Graphical Display Conventions
18
Process Value and Control Loop Presentation
19
Setpoints
19
Reconfiguring the Configured Control Loops
20
Editing the Actuator Settings
21
Trend Chart
22
Tubing Loading for Pumps
23
Livit Links Connection and Devices Installation
25
Connecting and Disconnecting Livit Links
25
Installing and Uninstalling Devices
26
Ph Sensor Calibration
32
General
32
Calibration Routine
32
Calibration Procedure
32
Actuator and Dose Monitor Settings
37
General
37
Dose Monitor
37
Actuator Calibration
40
Bioreactor Preparation
44
General
44
Sensors
45
Single-Use Sensors Preparation
45
Single-Use Ph and Do Sensors Installation
45
Single-Use Ph Sensor Preparation
46
Single-Use Do Sensor Preparation
46
Moving the Reactor to a Biological Safety Cabinet (BSC)
47
Making Hydraulic Connections
48
Mounting the Ph and Do Sensors
50
Filling the Reactor with Medium
50
Preparing Cultivation
51
Installation
51
Control Loops
54
Preset PID Parameter Values
55
Level Control
57
Cultivation
58
Cultivation Steps
58
Start, Stop and Recording Options
59
Polarographic Do
64
Calibration Procedure
64
Sensor Calibration
64
Verification of the Quality of the Do Sensor
69
Inoculation
70
View Process Data
71
Sampling
72
Additions
72
Correction of Measured Ph Value
73
Harvesting, Deactivation, Cleaning
77
Harvesting
77
Deactivation
77
Sensors Cleaning and Storage
78
Ph Sensor
78
Do 2 Sensor
78
System Warnings
79
Emergency Stop During Operation
79
Power Failure During Operation
81
Hardware
83
Control Console
84
Introduction
84
Front View
85
Side View
86
Emergency Stop Button
87
Rear View
88
Lifting the Biocontroller
89
Environmental Conditions
89
Storage Instructions
89
Cleaning Instructions
90
Actuators: Gas Supply Section
91
Valves in Gas Supply Lines
91
Solenoid Valves and Non-Return Valves
91
Flow Control Valves
91
Metering Needle Valves
91
Mass Flow Meters
92
Mass Flow Controllers
92
Electronic Gas Selection Block
93
Specifications for Inlet Gases
94
Rule of Thumb: Gas Flow Rate
94
Tubing Connections
94
Actuators: Heating Blanket
95
Safety
95
Specifications
96
Installation on the Bioreactor and Electrical Connection
97
Actuators: Cold Water Valve and Thermo Circulator
98
Water Connections
98
Thermo Circulator Unit
100
Cold Water Valve Module and Condenser Module
101
Actuators: Pumps and Tubing
102
Safety
102
Pumps
103
Specifications
103
Tubing
103
Available Tubing
103
Actuator Control
104
Digital Actuators Versus Continuous Actuators
104
Actuator for Level/Foam Control
104
Agitation
105
Safety
105
Torque Overview
106
Brushless Stirrer Motors
106
Stepper Stirrer Motor
106
Stirrer Speed Overview
106
Stirrer Motors
107
Stepper Stirrer Motor M02.2
107
Brushless Stirrer Motor M10
107
Brushless Stirrer Motor M20
107
Brushless Stirrer Motor M14
107
Brushless Stirrer Motor M33
107
Motor Cable
108
Motor Adapter
108
Running-In a New Motor with Gearbox
108
Maintenance
109
Reactor Types
110
Appliflex Bioreactors
110
3-Liter Appliflex ST Cell Configuration Bioreactor
110
3-Liter Appliflex ST Microbial Configuration Bioreactor
111
15-Liter Appliflex ST Cell Configuration Bioreactor
113
Auxiliaries
114
Reactors Inserts
114
Off-Gas Line Configuration (Filter Heating)
115
Integrated Single-Use Sample System
116
Sensors and Livit Links
117
Smart Sensors
117
Ph and Do
117
Livit Links
118
Dual Level/Temperature
118
Analog I/O
119
Balance
121
Livit Links Holders
124
Article Numbers
125
Start-Up Kits
127
Start-Up Kits for the 3 and 15 L Appliflex Reactors
127
Software
128
General
129
Home Screen
129
Icons
130
Graphical Display Conventions
131
Keypad and Keyboard
133
Update Software Version
135
Authentication
139
Login Levels
139
Login Procedure
139
Authorization Table
141
User Management
142
Create New User
143
Change Password
145
Delete User
146
Edit Automatic Logout Interval
147
Screen Management
148
Add
148
Dashboard
149
Overview
150
Chart
153
Remove
161
Move
162
Clear All
164
Configuring a Bioreactor
165
Creating Widgets
165
Moving, Resizing and Deleting Widgets
169
Configuring Widgets
170
Configuring Control Loops
173
Sequential Control
175
Sensors
180
Settings Options
180
Trend Chart
181
Calibrate
182
Limits
183
Control
186
Actuators
190
General
191
Advanced
192
Available Sensors
193
Ph Smart Sensor
193
Polarographic Do Smart Sensor
194
Optical Do Lumisens Sensor
202
Point Calibration
202
Temperature Sensor
209
Level/Foam Sensor
210
Pressure Switch
213
Balance
215
Bluesens Bluevary Sensor
217
Bluesens BCP Sensor
219
Mettler Ph Sensor
222
Mettler Polarographic Do Sensor
225
Mettler Optical Do Sensor
228
Mettler CO Sensor
231
Hamilton Ph Sensor
234
Hamilton Do
237
Sensor
237
Hamilton Redox Sensor
240
Hamilton Dencytee Biomass Sensor
243
Presens Optical Ph Single-Use Sensor
246
Presens Optical Do Single-Use Sensor
248
Aber Futura Biomass Sensor
250
Analog Input
253
Actuators
255
Settings Options
255
Trend Chart
256
Calibrate
257
Limits
258
General
260
Dose Monitor
261
Advanced
262
Available Actuators
263
Pump
263
Heating Blanket
265
Cooling Valve
267
Thermo Circulator Unit (TCU)
269
Filter Heater
271
Gas
273
Stirrer
277
Analog out
278
System Options
281
Bioreactor Configuration
281
Bioreactors
281
Control Loops
285
Dose Monitors
287
Data Management
289
Instrument Configuration
297
System Configuration
303
Network
303
OPC UA Setup
308
Instrument Setup
312
Instrument Info
312
Instrument Operations
314
Interface Settings
318
Interface Operations
318
Screen Settings
319
Screen Cleaning
323
Alarms
324
Alarm History
324
Icons
326
Export Alarm Data
326
Filters
327
Acknowledge Alarms
330
Clear Alarm Data
331
Copyright Notices and Disclaimers
332
Exprtk Lib
332
Open62541 & Open62541 C++ Classes
332
Qcustomplot
332
Qt Xlsx Writer
333
Simplecrypt
333
Qsortfilterproxymodel
333
Breakpad
333
Appendix Pid Control
335
Introduction
336
Different Types of Control
336
PID Control Loop
336
Control Algorithm
337
Control Variables and Parameters
338
Control Variables
338
PV: Process Value
338
SP: Setpoint
338
CO: Controller Output
338
Control Parameters
339
P: Proportional Gain
339
I: Integral Time
340
D: Derivative Time
340
DB: Dead Band
341
Actuators Variables and Parameters
342
Actuator Variables
342
AO: Actuator Output
342
Actuator Parameters
343
Actuator Output Interval Time
343
Actuator Output Limits
343
PID in Applikon Controllers
346
Actuator Configuration
346
Sequential Control
347
Gas Actuators with Constant Stirrer Speed
347
Controlled Stirrer Speed
349
Low-Limit Value for Air Supply (MFC)
352
Parameters and Actuators in Bioreactor Control
353
Temperature Control
353
Ph Control
354
Do Control
354
Level Control
355
Optimizing PID Parameters
355
Proportional Gain
355
Integral Time
356
Derivative Time
356
Default PID Control Settings
356
Acronyms
357

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