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User guide
Read this user guide carefully before you use your NovoPen® 6 for
insulin delivery the first time
Find a quick guide at the back of this manual
8-4260-01-001-5.indd 4
8-4260-01-001-5.indd 4
3/03/2025 4:54:21
3/03/2025 4:54:21

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Summary of Contents for Novo Nordisk NovoPen 6

  • Page 1 User guide Read this user guide carefully before you use your NovoPen® 6 for insulin delivery the first time Find a quick guide at the back of this manual 8-4260-01-001-5.indd 4 8-4260-01-001-5.indd 4 3/03/2025 4:54:21 3/03/2025 4:54:21...
  • Page 2: Table Of Contents

    Contents Overview of pen parts ������������ Inside cover If you need more insulin than what is left in the cartridge ���������������������������������������� 22 Introduction ����������������������������� Inside cover How to replace a used insulin Important notes ���������������������������������������� 1 cartridge �������������������������������������������������� 24 Prepare the pen for an injection Error/display messages ���������������������������...
  • Page 3 Piston rod Dose LOT number Dose Insulin (on reverse side) head pointer button window Pen cap Insulin Cartridge Piston Dose Pen ID Dose scale holder counter memory Dose memory Number of units last injected Time passed since last injection (hh:mm:ss) Single-use needle (example) Insulin cartridge (Penfill®...
  • Page 4 – even if you have used NovoPen® The pen is durable, which means that you can reuse 6 or similar Novo Nordisk delivery systems before. It it. When you have used all the insulin in a cartridge, will tell you all you need to know about your pen and you simply replace it with a new one.
  • Page 5: Important Notes

    4mm single-use disposable needles. • Always read the leaflet that comes with the • Novo Nordisk is not responsible for harm Penfill® cartridge package for information due to using NovoPen® 6 with products other related to the insulin.
  • Page 6: Insert An Insulin Cartridge

    Insert an insulin cartridge • Pull off the pen cap. • Twist off the cartridge holder. Put it to one side for later use. • The piston rod may stick out of your pen. If so, push it completely in until it stops. The piston rod and the piston rod head may be loose and move on their own.
  • Page 7 • Take a new insulin cartridge. Hold the cartridge holder and let the cartridge slide in with the threaded end first as illustrated. The colour of your cartridge may differ from the one shown in the illustration. It depends on the type of insulin you use. Check the name and colour of the cartridge to make sure that it contains the type of insulin you need.
  • Page 8 • Twist the cartridge holder back on, as illustrated, until you hear or feel a click� 8-4260-01-001-5.indd 4 8-4260-01-001-5.indd 4 3/03/2025 4:54:23 3/03/2025 4:54:23...
  • Page 9: If You Use White And Cloudy Insulin

    If you use white and cloudy insulin If you use an insulin cartridge with cloudy-looking insulin (white insulin suspension), always resuspend this right before injection� See the Penfill® cartridge 3 ml leaflet on how to resuspend your type of insulin. Make sure there is enough space in the cartridge before you resuspend the insulin: The piston must be above the white line on the cartridge holder...
  • Page 10: Attach A New Needle

    Attach a new needle • Take a new needle, and tear off the paper tab. • Push the needle straight onto the pen. Turn until it is on tight� • Pull off the outer needle cap and save it. You will need it after the injection, to safely remove the needle from the pen.
  • Page 11 • Pull off the inner needle cap and throw it away. A drop of insulin may appear at the needle tip. This is normal, but you must still test the insulin flow� The needle is covered by two caps. You must remove both caps. If you forget to remove both caps you will not inject any insulin and your blood sugar level may get too high.
  • Page 12: Always Test The Insulin Flow Before You Inject

    ALWAYS test the insulin flow before you inject ALWAYS test the flow before you inject� Keep testing until insulin squirts from the needle tip. This makes sure that any gap and air bubbles are removed and that insulin is getting through the needle. •...
  • Page 13 • Press the dose button until the dose counter shows “0”. The “0” must line up with the dose pointer. • Check that insulin squirts from the needle tip. If no insulin appears, repeat steps 1-3 until insulin squirts from the needle tip.
  • Page 14: Select Your Dose

    Select your dose • Pull out the dose button, if it is not already out. • Make sure the dose counter shows “0” before you start� The “0” must line up with the dose pointer. • Turn the dose button to select the dose you need� You can turn the dose button forward or backward to adjust the dose.
  • Page 15 Always look through the insulin window to make sure that the insulin in your pen looks the way it should� The Penfill® cartridge 3 ml leaflet will tell you how your type of insulin should look. Always use the dose counter and the dose pointer to see how many units you select�...
  • Page 16: Inject Your Dose

    Inject your dose ALWAYS test the flow before you inject. • Check the name and colour of the cartridge to make sure that it contains the type of insulin you need. If you take a wrong type of insulin, your blood sugar level may get too high or too low. •...
  • Page 17 • Remove the needle from your skin� • After injection, information about your dose is stored in the dose memory. See pages 16-17. Always inject by pressing the dose button� Do not turn it� If you turn the dose button, you will not inject insulin. Always watch the dose counter to know how many units you inject�...
  • Page 18: After Your Injection

    After your injection • Remove the needle right away by screwing it into a sharps container� • If you do not have a sharps container, follow a one-handed needle recapping method. Lead the needle tip into the outer needle cap on a flat surface without touching the needle. •...
  • Page 19 • Hold the black cartridge holder and unscrew the needle. Throw it away carefully as your doctor or nurse has instructed you. • Put the pen cap on your pen after each use to protect the insulin from light. • Store your pen carefully. The pen should be out of sight and reach of others, especially children, see page 29 on how to store the pen.
  • Page 20: How To Check Your Last Dose

    How to check your last dose • Make sure the dose counter shows “0“ before you start. The “0” must line up with the dose pointer. • Pull out the dose button and push it back in. Do not twist the dose button. The dose memory display will now show the details of your last dose�...
  • Page 21: What Does The Dose Memory Display Show

    What does the dose memory display show? • Number of units last injected. • Time passed since last injection (hours:minutes:seconds). Three examples are shown at the right. 5 units injected The display only shows the details of your last injection or 3 hours, insulin flow test�...
  • Page 22: How To Keep A Personal Injection Log

    If your device does not have a compatible app or other software, locate and download one or contact Novo Nordisk for information. Please visit novonordisk.com/novopenapps for a list of apps which can connect with NovoPen® 6� Check your app or other software to see: •...
  • Page 23 Transfer your injection history to your device� • Find the NFC spot on your device. • Hold the dose memory of the pen straight against the NFC spot on your device and ensure the pen stays in contact with the NFC spot.
  • Page 24: How To Check How Much Insulin Is Left

    How to check how much insulin is left The dose counter can show exactly how much insulin is left in the cartridge, when there is less than 60 units left. • Turn the dose button until it stops. • Check the dose counter: –...
  • Page 25 • Use the insulin scale to see approximately how much insulin is left in the insulin cartridge. Insulin scale shows approx� much insulin is left If you need more insulin than what is left in the cartridge, take your full dose from a new cartridge, see page 22. 8-4260-01-001-5.indd 21 8-4260-01-001-5.indd 21 3/03/2025 4:54:26...
  • Page 26: If You Need More Insulin Than What Is Left

    If you need more insulin than what is left in the cartridge If you need more insulin than what is left in the cartridge, take your full dose from a new cartridge� • Remove the needle. Twist off the cartridge holder and throw away the used cartridge.
  • Page 27 Only if advised by your doctor or nurse, you may split your dose between two cartridges. If you become distracted, make a miscalculation or forget to test the flow, you may get a single under- or overdose which may lead to too high or too low blood sugar levels. If you feel unwell after splitting the dose, check your blood sugar and/or contact your doctor or nurse.
  • Page 28: How To Replace A Used Insulin

    How to replace a used insulin cartridge • Remove and throw away the needle from your pen if the needle is still on, see pages 14-15. • Twist off the cartridge holder. When you twist off the cartridge holder, the piston rod sticks out of your pen.
  • Page 29 • Tilt the cartridge holder and let the cartridge slide out� Throw it away as your doctor or nurse has instructed you. • Push the piston rod back in. Then insert a new cartridge and twist the cartridge holder back on. Attach a new needle and test the insulin flow, see pages 6-9.
  • Page 30: Error/Display Messages

    Error/display messages Error message Last injection not recorded to dose memory If you see this message, you have received the insulin you last injected, but the dose memory did not register the injection. What to do? The pen still works to deliver insulin. If you cannot remember how much and how long ago you injected, check your blood sugar level repeatedly before you take more insulin.
  • Page 31: End Message

    End message Blank display Pen approaching end of life Dose memory inactive or battery dead The battery is running low, and the dose The dose memory has not been activated or the memory is approaching end of life. battery is dead. What to do? What to do? Contact your healthcare professional to get...
  • Page 32: How To Care For Your Pen

    How to care for your pen Care Cleaning • Only use your NovoPen® 6 as described in • Only clean your pen with a mild detergent on a moistened cloth. this user guide. • Do not drop your pen or knock it against •...
  • Page 33: Storage

    Storage Disposal • With an insulin cartridge inserted, please see • Do not throw the pen out with your the storage instructions in the Penfill® household waste. cartridge 3 ml leaflet that comes with the • Throw away your pen as instructed by Penfill®...
  • Page 34: Additional Information

    Additional Information Technical information If you find that your NovoPen® 6 is faulty, please Novo Nordisk A/S, hereby declares that the radio contact your healthcare professional to get equipment type NovoPen® 6 is in compliance a replacement. Additionally, please contact the with Directive 2014/53/EU.
  • Page 35 – 2 indicates protection against vertically falling water drops when enclosure tilted up to 15°. NovoPen 6 is not waterproof� The Ingress Protection rating IP52 means that the device is water resistant only in certain circumstances and it is therefore advised to keep it away from water and other liquids.
  • Page 36 Date of issue: 2025/02 © 2025 novonordisk.com Manufactured by: Novo Nordisk (China) Pharmaceuticals Co. Ltd. 99 Nanhai Road, TEDA 300457 Tianjin, P.R.China Novo Nordisk A/S Novo Allé DK-2880 Bagsværd, Denmark 8-4260-01-001-5 8-4260-01-001-5.indd 3 8-4260-01-001-5.indd 3 3/03/2025 4:54:20 3/03/2025 4:54:20...
  • Page 37 Quick guide Important: Read the complete user guide before you use your pen for insulin delivery the first time How to check your last dose • The dose counter must show “0”. • Pull out the dose button and push it back in.
  • Page 38: Error Message

    What does the dose memory display show? • Number of units last injected. Time passed since last injection (hours:minutes:seconds) 5 units last injected 3 hours, 45 minutes and 10 seconds since last injection See pages 16-17 in the user guide for more information. Error message If you see this message, you have received the insulin you last injected, but the dose memory did not register the...
  • Page 39: Attach A New Needle

    Insert an insulin Attach a new cartridge needle • Pull off the pen cap. • Take a new insulin cartridge • Take a new needle, and tear and check that: off the paper tab. • Twist off the cartridge holder. –...
  • Page 40: Inject Your Dose

    ALWAYS test the Select your dose Inject your dose insulin flow Wait and count slowly 1-2-3-4-5-6 ALWAYS test the flow • Pull out the dose button, if it • Insert the needle into your before you inject� Keep is not already out. skin and press the dose testing until insulin squirts from button until the dose counter...
  • Page 41 User guide Read this user guide carefully before you use your NovoPen Echo® Plus for insulin delivery the first time Find a quick guide at the back of this manual 8-4261-01-001-5.indd 4 8-4261-01-001-5.indd 4 11/02/2025 7:34:57 11/02/2025 7:34:57...
  • Page 42: Quick Guide Is Found At The Back

    Contents If you need more insulin than Overview of pen parts ..Inside cover what is left in the cartridge ..22 Introduction ....Inside cover How to replace a used insulin Important notes ......1 cartridge ........24 Prepare the pen for an injection Error/display messages ....
  • Page 43 Insulin Piston rod Dose Dose LOT number window head pointer button (on reverse side) Pen cap Insulin Cartridge Piston Dose Pen ID Dose scale counter memory holder Dose memory Number of units last injected Time passed since last injection (hours: minutes: seconds) Single-use needle Insulin cartridge (example)
  • Page 44: Introduction

    The pen injector uses Pay special attention to these notes as they are Penfill® 3 ml cartridges of Novo Nordisk insulin and important for safe use of the pen. If you do not single-use disposable needles (supplied separately).
  • Page 45: Important Notes

    Healthcare Professional how to avoid 4mm single-use disposable needles. mix ups. • Novo Nordisk is not responsible for harm due • Always read the leaflet that comes with the to using NovoPen Echo® Plus with products Penfill® cartridge package, for information other than these.
  • Page 46: Insert An Insulin Cartridge

    Insert an insulin cartridge • Pull off the pen cap. • Twist off the cartridge holder. Put it to one side for later use. • The piston rod may stick out of your pen. If so, push it completely in until it stops. The piston rod and the piston rod head may be loose and move on their own.
  • Page 47 • Take a new insulin cartridge. Hold the cartridge holder and let the cartridge slide in with the threaded end first as illustrated. The colour of your cartridge may differ from the one shown in the illustration. It depends on the type of insulin you use. Check the name and colour of the cartridge to make sure that it contains the type of insulin you need.
  • Page 48 • Twist the cartridge holder back on, as illustrated, until you hear or feel a click. 8-4261-01-001-5.indd 4 8-4261-01-001-5.indd 4 11/02/2025 7:34:59 11/02/2025 7:34:59...
  • Page 49: If You Use White And Cloudy Insulin

    If you use white and cloudy insulin If you use an insulin cartridge with cloudy-looking insulin (white insulin suspension), always resuspend this right before injection. See the Penfill® cartridge 3 ml leaflet on how to resuspend your type of insulin. Make sure there is enough space in the cartridge before you resuspend the insulin: The piston must be above the white line on the cartridge...
  • Page 50: Attach A New Needle

    Attach a new needle • Take a new needle, and tear off the paper tab. • Push the needle straight onto the pen. Turn until it is on tight. • Pull off the outer needle cap and save it. You will need it after the injection, to safely remove the needle from the pen.
  • Page 51 • Pull off the inner needle cap and throw it away. A drop of insulin may appear at the needle tip. This is normal, but you must still test the insulin flow. The needle is covered by two caps. You must remove both caps.
  • Page 52: Always Test The Insulin Flow Before You Inject

    ALWAYS test the insulin flow before you inject ALWAYS test the flow before you inject. Keep testing until insulin squirts from the needle tip. This makes sure that any gap and air bubbles are removed and that insulin is getting through the needle. •...
  • Page 53 • Press the dose button until the dose counter shows “0”. The “0” must line up with the dose pointer. • Check that insulin squirts from the needle tip. If no insulin appears, repeat steps 1-3 until insulin squirts from the needle tip. If no insulin appears after several attempts, check the insulin window to see if there is a gap between the black piston rod head and the piston, see illustrations 3A and 3B.
  • Page 54: Select Your Dose

    Select your dose • Pull out the dose button, if it is not already out. • Make sure the dose counter shows “0” before you start. The “0” must line up with the dose pointer. • Turn the dose button to select the dose you need. You can turn the dose button forward or backward to adjust the dose.
  • Page 55 If you need more than 30 units, you may choose to use another Novo Nordisk insulin delivery device with a higher maximum dose. The dose button should turn easily. Do not force it to turn.
  • Page 56: Inject Your Dose

    Inject your dose ALWAYS test the flow before you inject. • Check the name and colour of the cartridge to make sure that it contains the type of insulin you need. If you take a wrong type of insulin, your blood sugar level may get too high or too low.
  • Page 57 • Remove the needle from your skin. • After injection, information about your dose is stored in the dose memory. See pages 16-17. Always inject by pressing the dose button. Do not turn it. If you turn the dose button, you will not inject insulin. Always watch the dose counter to know how many units you inject.
  • Page 58: After Your Injection

    After your injection • Remove the needle right away by screwing it into a sharps container. • If you do not have a sharps container, follow a one-handed needle recapping method. Lead the needle tip into the outer needle cap on a flat surface without touching the needle.
  • Page 59 • Hold the black cartridge holder and unscrew the needle. Throw it away carefully as your doctor or nurse has instructed you. • Put the pen cap on your pen after each use to protect the insulin from light. • Store your pen carefully. The pen should be out of sight and reach of others, especially children, see page 29 on how to store the pen.
  • Page 60: How To Check Your Last Dose

    How to check your last dose • Make sure the dose counter shows “0“ before you start. The “0” must line up with the dose pointer. • Pull out the dose button and push it back in. Do not twist the dose button. The dose memory display will now show the details of your last dose.
  • Page 61: What Does The Dose Memory Display Show

    What does the dose memory display show? • Number of units last injected. • Time passed since last injection (hours:minutes:seconds). 5.5 units Three examples are shown to the right. injected • The display only shows the details of your last injection 3 hours, or insulin flow test.
  • Page 62: How To Keep A Personal Injection Log

    Check if your device has a compatible app or other software to read your injection details. If your device does not have a compatible app or other software, locate and download one or contact Novo Nordisk for information. Please visit novonordisk.com/novopenapps for a list of apps which can connect with NovoPen Echo®...
  • Page 63 Transfer your injection history to your device. • Find the NFC spot on your device. • Hold the dose memory of the pen straight against the NFC spot on your device and ensure the pen stays in contact with the NFC spot. •...
  • Page 64: How To Check How Much Insulin Is Left

    How to check how much insulin is left The dose counter can show exactly how much insulin is left in the cartridge, when there is less than 30 units left. • Turn the dose button until it stops. • Check the dose counter: –...
  • Page 65 • Use the insulin scale to see approximately how much insulin Insulin scale is left in the insulin cartridge. shows approx. how much insulin is left If you need more insulin than what is left in the cartridge, take your full dose from a new cartridge, see page 22. 8-4261-01-001-5.indd 21 8-4261-01-001-5.indd 21 11/02/2025 7:35:03...
  • Page 66: If You Need More Insulin Than What Is Left In The Cartridge

    If you need more insulin than what is left in the cartridge If you need more insulin than what is left in the cartridge, take your full dose from a new cartridge. • Remove the needle. Twist off the cartridge holder and throw away the used cartridge.
  • Page 67 Only if advised by your doctor or nurse, you may split your dose between two cartridges. If you become distracted, make a miscalculation or forget to test the flow, you may get a single under- or overdose which may lead to too high or too low blood sugar levels. If you feel unwell after splitting the dose, check your blood sugar and/or contact your doctor or nurse.
  • Page 68: How To Replace A Used Insulin Cartridge

    How to replace a used insulin cartridge • Remove and throw away the needle from your pen if the needle is still on, see pages 14-15. • Twist off the cartridge holder. When you twist off the cartridge holder, the piston rod sticks out of your pen.
  • Page 69 • Tilt the cartridge holder and let the cartridge slide out. Throw it away as your doctor or nurse has instructed you. • Push the piston rod back in. Then insert a new cartridge and twist the cartridge holder back on. Attach a new needle and test the insulin flow, see pages 6-9.
  • Page 70: Error/Display Messages

    Error/display messages Error message Last injection not recorded to dose memory If you see this message, you have received the insulin you last injected, but the dose memory did not register the injection. What to do? The pen still works to deliver insulin. If you cannot remember how much and how long ago you injected, check your blood sugar level repeatedly before you take more insulin.
  • Page 71: End Message

    End message Pen approaching Blank display end of life Dose memory inactive or battery dead The battery is running low, and the dose memory is approaching end of life. The dose memory has not been activated or the battery is dead. What to do? What to do? Contact your healthcare professional to get a...
  • Page 72: How To Care For Your Pen

    How to care for your pen Care Cleaning • Only use your NovoPen Echo® Plus as • Only clean your pen with a mild detergent described in this user guide. on a moistened cloth. • Do not drop your pen or knock it against •...
  • Page 73: Storage

    Storage Disposal • Do not throw the pen out with your • With an insulin cartridge inserted, please see the storage instructions in the Penfill® household waste. cartridge 3 ml leaflet that comes with the • Throw away your pen as instructed by Penfill®...
  • Page 74: Additional Information

    Additional Information Technical information Novo Nordisk A/S, hereby declares that the radio If you find that your NovoPen Echo® Plus is equipment type NovoPen Echo® Plus is in faulty, please contact your Healthcare compliance with Directive 2014/53/EU. The full Professional to get a replacement.Additionally,...
  • Page 75 Protection against ingress NovoPen Echo® Plus is classified according to the Ingress Protection rating as IP52, where: – 5 indicates protection against harmful amounts of dust. – 2 indicates protection against vertically falling water drops when enclosure tilted up to 15°. NovoPen Echo®...
  • Page 76 Date of issue: 2025/02 © 2025 novonordisk.com Manufactured by: Novo Nordisk (China) Pharmaceuticals Co. Ltd. 99 Nanhai Road, TEDA 300457 Tianjin, P.R.China Novo Nordisk A/S Novo Allé DK-2880 Bagsværd, Denmark 8-4261-01-001-5 8-4261-01-001-5.indd 3 8-4261-01-001-5.indd 3 11/02/2025 7:34:56 11/02/2025 7:34:56...
  • Page 77 Quick guide Important: Read the complete user guide before you use your pen for insulin delivery the first time How to check your last dose • The dose counter must show “0”. • Pull out the dose button and push it back in.
  • Page 78 What does the dose memory display show? • Number of units last injected. • Time passed since last injection (hours:minutes:seconds) 5.5 units last injected 3 hours, 45 minutes and 10 seconds since last injection See pages 16-17 in the user guide for more information. Error message If you see this message, you have received the insulin you last injected, but the dose memory did not register the...
  • Page 79 Insert an insulin Attach a new cartridge needle • Pull off the pen cap. • Take a new insulin cartridge • Take a new needle, and tear and check that: off the paper tab. • Twist off the cartridge holder. •...
  • Page 80 ALWAYS test the Select your dose Inject your dose insulin flow Wait and count slowly 1-2-3-4-5-6 ALWAYS test the flow • Pull out the dose button, if it • Insert the needle into your before you inject. Keep is not already out. skin and press the dose testing until insulin squirts from button until the dose...

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