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CRYODRY CD8 User Manual

Freeze dryer
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CD8 Freeze Dryer
User Manual
For Version 5 .0.x
Rev. 2
cryodry.biz

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Summary of Contents for CRYODRY CD8

  • Page 1 CD8 Freeze Dryer User Manual For Version 5 .0.x Rev. 2 cryodry.biz...

  • Page 2: Table Of Contents

    Loading a Preset Program 9.2.5 Starting a Program 9.2.6 Program Vacuum Oven (VO) Extra Drying Power Recovery Manual Control 9.5.1 Defrost Mode System Settings History Screen 9.7.1 History Export 10 Fault Diagnosis 11 Cleaning and Maintenance 11.1 Cleaning 11.2 Maintenance cryodry.biz 2...

  • Page 3: Revision History

    1 Revision History Revision Date Description 24/07/2024 Release 6/08/2024 Image touchups and grammar tweaks cryodry.biz 3...

  • Page 4: Disclaimer, Terms And Conditions

    2 Disclaimer, Terms and Conditions CryoDry Terms and Conditions, 20.12.2012 apply. • The intellectual property rights for this manual belong to CryoDry Pty Ltd (hereinafter referred to as “the • Company”). The Company reserves the right to change product specifications without notice.

  • Page 5: Safety

    DANGER! (may cause serious damage to property and or casualties) 1. No user serviceable parts inside. Service by authorized personnel only. 2. Read this manual prior to operating CD8 and observe and verify that all connections are properly secured. 3. Utility requirements: Ensure that the electrical connections meet the local standards and that the power supply is compatible with CD8 nameplate.
  • Page 6 CD8 before, during, and after freeze drying operation. 2. CD8 must be placed on a suitable surface of at least 77cm x 75cm (DxW), with a weight handling of minimum 100 kg. Allow an additional 20cm space in each dimension for ventilation.

  • Page 7: Panel Warnings

    WARNING – FREEZING CONDITIONS. FROSTBITE HAZARD. Thermal gloves are required for extreme Chamber Wall, Shelves, and Trays temperatures. CAUTION – HOT SURFACE. Shelves and trays can be Shelves and Trays very hot. Thermal gloves are required for extreme temperatures. cryodry.biz 7...

  • Page 8: Lifting And Moving

    Avoid dropping or any severe shock and vibration. Avoid sharp objects. Avoid penetration of the • housing. Two people are required to lift. Lift from each corner of CD8, near the feet. Hold onto the base plate. • cryodry.biz 8...

  • Page 9: Sécurité

    1. Lisez ce manuel avant d’utiliser le CD8. 2. Le CD8 ne doit être ouvert que par le personnel d’entretien autorisé. 3. Ne placez pas d’objets lourds sur le CD8 et ne vous tenez pas debout dessus. 4. N’installez aucun logiciel non autorisé sur le CD8.
  • Page 10 CD8 avant, pendant et après l’opération de lyophilisation. 2. Le CD8 doit être placé sur une surface appropriée d’au moins 77 cm x 75 cm (DxL), avec une capacité de charge d’au moins 100 kg. Prévoyez un espace supplémentaire de 20 cm pour la ventilation.

  • Page 11: Avertissements Du Panneau

    1. R290 - Réfrigérant utilisé dans cet appareil. 2. H220 - Gaz extrêmement inflammable. 3. En cas de fuite de réfrigérant, NE faites PAS fonctionner le CD8. Assurez-vous que le CD8 est débranché de l’alimentation électrique et contactez immédiatement le service d’assistance.

  • Page 12: Levage Et Déplacement

    4.2 Levage et déplacement Pour garantir la sécurité lors du levage ou du déplacement du CD8, veuillez respecter les consignes suivantes : • Ajustez les pieds pour réduire le risque de pincement lors du positionnement du CD8. • Soulevez ou déplacez le CD8 sur la base uniquement.

  • Page 13: Introduction

    5 Introduction Users are advised to carefully read this manual prior to operating CD8 so that they are aware of all precautions outlined, and to ensure operation is in accordance with the instructions contained within this manual. 5.1 After Sales Support If problems are encountered, or technical support is required when installing or operating CD8, contact your local agent or email support@cryodry.biz.

  • Page 14: Technical Specifications

    10°C to 30°C 10% to 80%, non-condensing Area of Operation Indoors only Overvoltage Category Category II Voltages and Frequencies For North America with UL mark AC120V 50/60Hz For the rest of the world AC100-120V, 50/60Hz AC220-240V, 50/60Hz Pollution Degree cryodry.biz 14...

  • Page 15: Precautions

    Ensure the door seal ring and the chamber door remain clean. Only clean with soapy water and avoid using solvents or other cleaning agents. • Do not rapidly power on/off CD8. Wait for at least a minute after powering off CD8 to power it on again. •...

  • Page 16: Components Overview

    8 Components Overview Touchscreen Vacuum Pump Chamber Door Connector Seal KF25 Chamber Door Vent Door Lock Vacuum Pump Supply Output USB-A Port USB-B Port CD8 Power Power Switch Socket Fuse (250VAC F15AL) Vent Drain Valve cryodry.biz 16...
  • Page 17 Fuse (250VAC F15AL) CD8 Power Socket Vacuum Pump Supply Output AC 120V, 12A, 50/60Hz AC120V, 50/60Hz, Max 2.8A AC 220-240V, 8A, 50/60Hz (Not for UL-mark) AC220-240V, 50/60Hz, Max 1.6A (Not for UL-mark) Drain Valve Closed Drain Valve Open cryodry.biz 17...

  • Page 18: Software Operation

    9 Software Operation Immediately after powering on CD8, the Home screen is shown (Figure 1). Figure 1 To go back to the Home screen, tap the “Home” icon that is present on most screens (Figure 2). Figure 2 cryodry.biz 18...

  • Page 19: Autodry

    Figure 3 Figure 4 shows the AutoDry Start screen. Tap on “Start” to begin the freeze-drying process. Figure 4 If in operation (i.e. Program or Defrost is running), Figure 5 shows an error message with the “Start” button blocked. cryodry.biz 19...
  • Page 20 Figure 5 To proceed, stop Defrosting or the Program by navigating onto the respective screen, and tap on “Stop” or “Cancel”. cryodry.biz 20...

  • Page 21: Autodry Process

    ”Estimated Running Time” is displayed at the bottom of the screen. This time is based on the average runtime of previous successful AutoDry runs. Therefore, CD8 first needs to almost complete a run before the displayed time is self-corrected. Adjusting any of the AutoDry parameters will reset this timer.
  • Page 22 Figure 7 shows the Evacuation stage. Figure 7 Figure 8 shows the Drying stage. Figure 8 cryodry.biz 22...
  • Page 23 Figure 9 shows the Storage stage. Figure 9 cryodry.biz 23...

  • Page 24: Editing Autodry Parameters

    Figure 10 Figure 11 shows the Parameter Editor screen. This screen provides significant control over the behavior of the AutoDry algorithm. Only 3 of the 4 stages can be modified with AutoDry: Freezing, Drying, and Storage. Figure 11 cryodry.biz 24...
  • Page 25 Higher temperatures and lower sensitivity will achieve shorter drying times but may have negative impacts on product quality. Reducing drying temperatures and sensitivity will likely produce better quality results. Figure 13 cryodry.biz 25...
  • Page 26 The Storage stage (Figure 14) specifies CD8 operation at the conclusion of a run. We recommend storage above ambient temperature, to prevent rehydration. Figure 14 To restore to the default parameters for AutoDry, tap on “Reset”. The following popup will display (Figure...

  • Page 27: Program

    9.2 Program CD8 has up to 12 customisable programs available, each with 16 steps. From the Home screen, tap on “Program” (Figure 16) to access a list of available programs (Figure 17). Figure 16 To review the remaining 6 available programs, tap on the right arrow (Figure 17).
  • Page 28 Figure 18 shows the remaining 6 programs. To go back, tap on the left arrow. Figure 18 cryodry.biz 28...
  • Page 29 To edit one of these programs, tap on one of the programs (Figure 19) to enter the program editor. This will be explored in the later chapters. Figure 19 cryodry.biz 29...

  • Page 30: Autodry/Program Stages

    9.2.1 AutoDry/Program Stages CD8 Programs and AutoDry are broken down into 4 stages. Chronologically, they are as follows: Freezing, Evacuation, Drying, and Storage. See section “9.2.2 Writing a Program & Parameters Explained” for more details on each of the parameters, and how they control each stage.
  • Page 31 Duration” specifies how long the shelves must stay under the specified temperature before proceeding to the Evacuation stage. Figure 21 9.2.2.2 Evacuation Stage The Evacuation stage (Figure 22) is controlled by Step 1’s pressure. Once the specified pressure is reached, CD8 will proceed to the next stage. Figure 22 cryodry.biz 31...
  • Page 32 The Evacuation stage will only run for up to 15 minutes. If the run has exceeded that time and the pressure is more than 0.5 mbar above from the setpoint, CD8 will abort the run and enable the compressor in the manual page. The below message will appear, indicating that the Evacuation stage has failed (Figure 23).
  • Page 33 Drying stage. When all steps have this option checked, the total process time equals the sum of all drying steps (independent from how long it takes CD8 to ‘ramp’ from step to step). When the checkbox is unchecked, the timer will only start once the shelves reach the temperature setpoint.
  • Page 34 9.2.2.4 Storage stage CD8 will maintain a specified temperature and pressure that the product will be left at once the run has finished (Figure 26). Specify a pressure such as 1 mbar to avoid additional drying whilst in Storage and specify a temperature between 25-40C to prevent the product from absorbing moisture when it is reintroduced to the atmosphere.

  • Page 35: Renaming A Program

    9.2.3 Renaming a Program CD8 provides functionality to rename programs. On either the first or second Program Editor screen, tap on the program’s name to prompt the keyboard function (Figure 27). Figure 27 Type in a name, and then tap “Enter” to confirm the input. The name will update. The program name will be displayed on the Program Selection, Program Progress, and System Idle screens.

  • Page 36: Loading A Preset Program

    9.2.4 Loading a Preset Program CD8 comes with 4 preset programs as examples. To load a program, first select a program to load a preset program from the Program Selector screen. The button to load programs is located on the top-right of the Program Editor (Figure 28).
  • Page 37 Botanical example programs are available. Tapping on one of them will show a popup with product preparation instructions. Figure 30 Tap on “SafeDry”. Figure 31 is the popup that appears. Tapping on “Load” will close the popup and write the SafeDry program onto the selected program. Figure 31 cryodry.biz 37...

  • Page 38: Starting A Program

    • Chamber door contact surface is clear of ice, and the door is closed. It is important to defrost CD8 before conducting a run. In addition, occasionally opening the ballast valve on the pump to release moisture buildup is recommended.
  • Page 39 Figure 34 You will need to stop the other mode (such as Defrost) to start a program. If no other mode is running, and it has successfully initialized, you may tap on “Start” to begin the program (Figure 35). cryodry.biz 39...
  • Page 40 Figure 35 Verify the program is running by the sound of the compressor starting and the Program Progress screen appearing (Figure 36). cryodry.biz 40...
  • Page 41 Note: Most timers don’t start unless the preconditions are met. For example, if the “Incl. Ramp Time” is unchecked, the drying step timer starts once the shelf temperatures are reached. This is indicated with a message under the “Cancel” button. cryodry.biz 41...
  • Page 42 (Figure 36), “Evacuating” (Figure 37), “Drying” (Figure 38) and “Storage” (Figure 39). Figure 37 Note: If the pressure isn’t reached within a certain amount of time, the evacuation stage is aborted. This is explored in “9.2.2.2 Evacuation Stage”. Figure 38 cryodry.biz 42...
  • Page 43 Figure 39 When the Stage/Drying step displays “Storage” (Figure 39), the Program is finished, and will maintain temperatures and pressure based on the storage parameters. Stopping a program is explored in “9.3 Extra Drying”. cryodry.biz 43...

  • Page 44: Program Vacuum Oven (Vo)

    9.2.6 Program Vacuum Oven (VO) Vacuum Oven (VO) provides the ability for CD8 to serve as a vacuum oven. Enabling VO skips the Freezing stage, and the compressor remains off throughout the run. VO is enabled on the Program Editor’s first screen, by checking the VO box on the top left (Figure 40).

  • Page 45: Extra Drying

    “Cancel” will close the popup and re-enable the opening of the vacuum control valve. To start the extra drying, tap on “No”, and the following popup will appear (Figure 43): Figure 43 cryodry.biz 45...
  • Page 46 “More Drying Time” respectively, while for Program, the parameters will be based on the last step for the Program. After tapping on “Confirm”, the popup will disappear, and “Extra Drying” will be visible on the Drying Stage section of the Program Progress screen (Figure 45). Figure 45 cryodry.biz 46...

  • Page 47: Power Recovery

    If a transient power outage occurs during a Program or AutoDry run, CD8 will automatically recover back to the last state before CD8 lost power. A popup will appear as soon as power is restored to CD8 (Figure 46). Figure 46 This is designed to be completely autonomous.

  • Page 48: Manual Control

    9.5 Manual Control To enter the Manual Control screen, tap on the “Manual” button (Figure 47). Figure 47 Figure 48 shows the Manual Control screen. Figure 48 cryodry.biz 48...
  • Page 49 On the right-hand side (Figure 49), temperature and pressure setpoints can be specified for CD8 to maintain (if enabled). Figure 49 The left-hand side provides relay control of CD8. They are as follows: Compressor • • Vacuum Valve • Vacuum Pump •...
  • Page 50 Note: For CD8 to maintain the pressure setpoint, enable both the Vacuum Pump and Vacuum Valve. The Vacuum Valve will not open if the pump isn’t enabled, and a warning will display (Figure 51). This is to prevent suck-back contamination from the pump.

  • Page 51: Defrost Mode

    9.5.1 Defrost Mode While CD8 is in an idle state, tap on “Defrost” from the Home screen to enter the Defrost screen (Figure 52). Figure 52 Figure 53: The Defrost screen prior to starting. Figure 53 cryodry.biz 51...
  • Page 52 • Chamber door is closed. Set the Defrost Temperature and Defrost Time as desired (Figure 54). A 50 C defrost temperature and 2 hours hold time are generally adequate. Figure 54 Tap on “Start” (Figure 55). Figure 55 cryodry.biz 52...
  • Page 53 The “Defrosting” icon will appear (Figure 56). Figure 56 The System Defrost screen will display the real-time values for the lower and upper shelf temperature and chamber temperature. Tap “Cancel” to stop the defrosting process (Figure 57). Figure 57 cryodry.biz 53...

  • Page 54: System Settings

    Tap “Settings” on the Home screen (Figure 58). Figure 58 (Figure 59). Rebooting the display is not the same as power cycling CD8. After updating, perform a power cycle using the main power switch located under the display. Figure 59 cryodry.biz 54...
  • Page 55 The screen timeout specifies the time it takes to display the System State since the last touch interaction. Setting it to 0 minutes will disable it. The System State screen (Figure 60) shows a general overview of the current state of CD8. Figure 60...

  • Page 56: History Screen

    9.7 History Screen The History screen shows data from CD8 over time, in 15 second intervals. To access this screen, tap on “History” from the Home screen (Figure 61). Figure 61 Figure 62 is the History screen. Tap on “Page Up” and “Page Down” to navigate through the history of the temperature/pressure sensors with the associated time stamps.

  • Page 57: History Export

    9.7.1 History Export To export the History of CD8, insert a USB formatted as FAT32 into the USB-A port of CD8. After inserting the USB, navigate to the History screen and tap on “Export” (Figure 63). 17:02:51 2023/06/21 16.6 16.3 16.5...

  • Page 58: Fault Diagnosis

    Verify that the ballast valve is in a closed position on the pump (if fitted). Verify that CD8 is defrosted, and that the inner door ring contacts a clean surface. Check that the compressor is enabled and has been running for at least 1 hour.

  • Page 59: Cleaning And Maintenance

    If an oil vacuum pump is used, check the vacuum oil after every 100 hours of operation, and replace the • vacuum pump oil if the level is low or if the oil is dirty. • If a dry pump is used, refer to its User’s Manual. Clean instrument vents regularly to prevent dust build up. • cryodry.biz 59...
  • Page 60 CryoDry Pty Ltd Unit 31, 1 Talavera Road, Macquarie Park NSW 2113 Australia Email: support@cryodry.biz Website: https://cryodry.biz @cryodry @cryodry /company/cryodry @cryodry @cryodryau...

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