Knauer Azura CT 2.1 Instructions Manual
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Knauer Azura CT 2.1 Instructions Manual

Column thermostat
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Column Thermostat CT 2.1
Instructions
HPLC
HPLC
Document no. V6811

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Summary of Contents for Knauer Azura CT 2.1

  • Page 1 Column Thermostat CT 2.1 Instructions HPLC HPLC Document no. V6811...
  • Page 2 KNAUER. Support: Do you have questions about the installation or the operation of your instrument or software? International Support: Contact your local KNAUER partner for support: www.knauer.net/en/Support/Distributors-worldwide Support in Germany (Austria & Switzerland on case-to-case basis): Phone:...

  • Page 3: Table Of Contents

    Table of contents 1. General ................1 About these instructions .
  • Page 4 Table of contents Power supply............12 Computer control.
  • Page 5 Table of contents 10. Disposal ................30 10.1 AVV-Marking Germany .
  • Page 6 AZURA® Column Thermostat 2.1 Instructions, V6811...

  • Page 7: General

    These operating instructions are an integral part of the device. It must be kept in the immediate vicinity of the device and accessible to the user at all times. You can download these and other instructions from the KNAUER web- site: www.knauer.net/library...

  • Page 8: Legal Information

    1.4.3 Warranty conditions For information on warranty please refer to our general terms and condi- tions on the website: www.knauer.net/terms 1.4.4 Declaration of conformity The declaration of conformity is enclosed as a separate document with the product and can be obtained online: www.knauer.net/en/Support/Declarations-of-conformity...

  • Page 9: Basic Safety Instructions

    Operation in potentially explosive areas without special and additio- ƒ nal explosion protection. Contact the KNAUER Customer Support for more information. User qualification The user is qualified to handle the device if all of the following points apply: The user has at least a basic knowledge of liquid chromatography.

  • Page 10: Operator Responsibility

    Basic safety instructions Operator responsibility The operator is any person who operates the device himself/herself or leaves it to a third party for use and who bears the legal product responsi- bility for the protection of the user or third parties during operation. The obligations of the operator are listed below: Know and follow the applicable work safety regulations.

  • Page 11: Working With Solvents

    Basic safety instructions Working with solvents 2.6.1 General requirements The user is trained for handling different solvents. ƒ Note that organic solvents are toxic above a certain concentration. For ƒ handling hazardous solvents see the following section. Mobile phases and samples may contain volatile or combustible sol- ƒ...

  • Page 12: Explosive Environment

    Devices which are shipped without the completed document “Service request form and decontamination report” will not be repaired. If you would like to return a device to KNAUER, make sure to enclose the com- pleted document: www.knauer.net/servicerequest. AZURA® Column Thermostat 2.1 Instructions, V6811...

  • Page 13: Product Information

    3. Product information General The AZURA® Column Thermostat CT 2.1 can be used in the following configurations: Up to 8 columns of dimensions 125 mm x 4.6 mm ID with precolumn ƒ Up to 4 columns of dimensions 300 x 4.6 mm ID ƒ...

  • Page 14: Views

    Product information Views Front view Legend Cartridge for eluent pre-tempering (optional) Door Housing Column holder Temperature sensor Column (not included in the scope of delivery) Leak sensor Fig. 1: Front view Rear view Note: Please note that the RS-232 interface (“service interface”) is solely used for repair and maintenance tasks performed by service technicians.

  • Page 15: Symbols And Signs

    Product information Symbols and signs The following symbols and signs can be found on the device: Symbol Meaning Electric shock hazard. Failure to observe this warning may result in loss of life, serious injury or damage or destruction of the device. Electrostatic discharge hazard.
  • Page 16 Product information Symbol Meaning The device can be used for 15 years according to its intended use before there is a risk that the con- tained substances may escape and thereby pose a risk to the environment and health. AZURA® Column Thermostat 2.1 Instructions, V6811...

  • Page 17: Installation And Initial Startup

    4. Installation and initial startup Before you determine the operation site, read the chapter “Technical Data” (see chapter 11 on page 30). There you will find all device-speci- fic information on power supply, ambient conditions and humidity. Note: The intended use be ensured only if the requirements for ambient conditions of the operating environment are met.

  • Page 18: Space Requirements

    Country-specific plugs: Before switching on the device, check whether ƒ the supplied plug is approved for your country. Overview of the de- vice- and country-specific plug types from KNAUER: www.knauer.net/plugs Power strips: If several devices are connected to one power strip, ƒ...

  • Page 19: Computer Control

    Installation and initial startup Computer control Note: HPLC devices from KNAUER only work with IP addresses, which have been assigned by IPv4. IPv6 is not supported. This chapter describes how to set up a chromatography system in a local area network (LAN) and how a network administrator can integrate this LAN into your company network.

  • Page 20: Connecting Devices With Lan

    Set the router properties (see section 4.4.4). 4.4.4 Configuring the router The router is preset at the factory. Information about address, user na- me and password is noted in the router manual: www.knauer.net/en/ Support/Library/PC-hardware AZURA® Column Thermostat 2.1 Instructions, V6811...

  • Page 21: Integrating Lan Into The Company Network

    Installation and initial startup Process Procedure 1. To open the router configuration, start your Internet browser and enter the IP address (does not apply for all routers). 2. Enter user name and password. 3. Configure the router as DHCP server. 4.

  • Page 22: Setting Ip Addresses Via Software

    Installation and initial startup Setting IP addresses via software Note: Check the IT security standards for your lab before intervening in the LAN settings. PurityChrom® Static IP addresses are required to run certain chromatography software, e.g. Purity Chrom®. For a comprehensive overview on how to set static IP addresses for PurityChrom®, refer to the document ”PurityChrom®...

  • Page 23: Mobile Control: Setting A Dynamic Ip Address Via Device Name

    Installation and initial startup 4.5.2 Mobile Control: Setting a dynamic IP address via device name Prerequisites The device is switched on. ƒ Mobile Control is installed and running. ƒ The connection between Mobile Control and the device has been ƒ established.

  • Page 24: Firmware Wizard: Setting A Static Ip Address

    Installation and initial startup Fig. 6: Reset device to default settings 4.5.4 Firmware Wizard: Setting a static IP address Note: More information about LAN settings can be found in the Mobile Control Software Instructions in the chapter ”Firmware Wizard” (docu- ment no.

  • Page 25: Firmware Wizard: Setting A Dynamic Ip Address

    Installation and initial startup Process 6. Click <Reset Conn. Settings> to accept changes. 7. Restart the device (recommended). Result The device is now accessible via the static IP address. 4.5.5 Firmware Wizard: Setting a dynamic IP address Prerequisites The device is switched on. ƒ...

  • Page 26: Installing Cartridge For Eluent Pre-Tempering

    Installation and initial startup Installing cartridge for eluent pre-tempering A cartridge can be purchased as an option for the eluent pre-temper. The cartridge allows you to control the eluent tempering to the temperature of the thermostat before entering the column. This prevents a tempera- ture gradient on the column and thus increases the reproducibility and separation efficiency.

  • Page 27: Capillary Guide

    Installation and initial startup Capillary guide If a capillary is led up and out of the thermostat interior, make sure to use the provided cut-out. This is particularly to be observed with an installed cartridge for eluent pre-tempering. The cut-out ensures that the capillary is not bent and damaged when closing the door.

  • Page 28: Operation

    If the device is part of a HPLC system, you should note the following: The network connection to the router is established ƒ The chromatography software has been installed by KNAUER or a ƒ company authorized by KNAUER. Switching on Prerequisites The installation has been completed.

  • Page 29: Functionality Tests

    Installation Qualification (IQ) The customer may request the Installation Qualification, which is free of charge. In case of a request, the technical support of KNAUER or a pro- vider authorized by KNAUER performs this functionality test during the installation.

  • Page 30: Troubleshooting

    7. Troubleshooting Measures: Compare errors with error list “7.2 Possible problems and solutions” on ƒ page 25. Contact the Technical Support. ƒ Go through the following steps, in case no connection between the computer and the devices can be established. Check after each step if the problem is solved.

  • Page 31: Possible Problems And Solutions

    Troubleshooting Possible problems and solutions Error Solution Device cannot be Inspect the power cable to ensure that it is switched on plugged into the power supply. The alarm does not Check leak sensor settings. trigger in case of leakage The alarm is triggered, The leak sensor sensitivity is set too high.

  • Page 32: Replacing Fuses

    Troubleshooting Replacing fuses The device has a fuse holder on the rear of the device. It is located be- tween the power on/off switch and socket for the power supply cable. The fuse holder contains a fuse for the operation and a spare fuse. Burns Inserting an inappropriate fuse can pose a fire hazard.

  • Page 33: Maintenance And Care

    Switch off the device. Pull the power plug. Maintenance contract The device may only be opened by the Technical Support of KNAUER or any company authorized by KNAUER. This maintenance work is covered by a separate maintenance contract. Cleaning and caring for the device Device defect Intruding liquids can cause damage to the device.

  • Page 34: Testing The Leak Sensor

    Open the door between the two tests for a few minutes to evapo- rate the methanol of the first test. Correction of If this test does not bring the desired results, please contact the KNAUER the leak sensor Customer Support.

  • Page 35: Transport And Storage

    Do not hold onto front cover or leak tray, as these parts are loosely attached to the device. Transporting the device Documents: If you want to return your device to KNAUER for repairs, ƒ enclose the Service Request Form and Decontamination Report which can be downloaded from our website: www.knauer.net/servicerequest...

  • Page 36: Disposal

    160214. 10.2 WEEE registration number KNAUER as a company is registered by the WEEE number DE 34642789 in the German "Elektroaltgeräteregister" (EAR). The number classifies to category 8 and 9, which, among others, comprises laboratory equipment.

  • Page 37: Technical Data

    11. Technical data 11.1 Main features Thermostat Temperature control Microprocessor-controlled Peltier element for heating and cooling, fan-supported two-way air circulation Temperature range 5-85 °C Heating/cooling rate 2 °C/min Temperature accuracy ± 0.2°C Temperature stability ± 0.1 °C Column compartment Mobile phase Passive temperature control with optional pre-tempering cartridge Number of columns...

  • Page 38: Repeat Orders

    Use the included packing list for repeat orders of spare parts. If there are any questions concerning repeat orders, contact the Technical Support. Further information Further information on spare parts and accessories can be found online: www.knauer.net. 12.1 Device Name Order number AZURA®...

  • Page 39: Index

    13. Index Accessories 32 Old devices 30 Optional 7 Operating Environment 32 Ambient conditions 11, 29 Operation 22 Ambient temperature 11 Operation Qualification (OQ) 23 AVV-marking 30 Operation site 11 Original packaging 29 Column compartment 31 Company network 15, 24 Power supply 12, 32 Control Precolumn tempering...
  • Page 40 Appendix: Installation Qualification (IQ)
  • Page 41 Installation Qualification (IQ) for a Device Customer approval Prior to installation at the customer site, the customer has reviewed the OQ document and agrees with the design and scope Company name: Name Function Reviewed & approved Date Signature VIQ-Installation-Qualification-Device, Version 3.1 Date: Signature: Revision:...
  • Page 42 KNAUER Wissenschaftliche Geräte GmbH. Scope The customer can request the Installation Qualification. In case of a request, the technical support of KNAUER or a provider authorized by KNAUER performs this functionality test during the installation. The IQ is a standardized document and includes the following: ƒ...
  • Page 43 Installation Qualification (IQ) for a Device Installation Qualification Tests Test Description Specification Passed Failed Comment /LOR No. Identify the device. The name on the device matches the name on the delivery order. Check the device for No transport damage is transport damage.
  • Page 44 Installation Qualification (IQ) for a Device List of rectifications (LOR) Type of Description of Persons LOR No. Test No. Action plan Due date Date/signature deviation* the deviation responsible * Type of deviation: A = acceptable (e.g. not a GMP-critical deviation) N = not acceptable Continuation of qualification activities into the next qualification phase is only possible when deviation is rectified.
  • Page 45 Installation Qualification (IQ) for a Device List of changes to the document Revision no. Description of change Additional information Date/signature VIQ-Installation-Qualification-Device, Version 3.1 Date: Signature: Revision:...
  • Page 46 Installation Qualification (IQ) for a Device 10. Certificate and appoval A KNAUER employee or an employee authorized by KNAUER has checked the device and performed all tests described in the IQ. The IQ form has to be signed by an authorized person. The scope of the IQ meets the customer‘s requirements.
  • Page 47 Installation Qualification (IQ) for a Device Appendix: List of supporting documents Test no. Description VIQ-Installation-Qualification-Device, Version 3.1 Date: Signature: Revision:...
  • Page 48 Latest KNAUER instructions online: www.knauer.net/library KNAUER Phone: +49 30 809727-0 Wissenschaftliche Geräte GmbH Fax: +49 30 8015010 Hegauer Weg 38 E-mail: info@knauer.net 14163 Berlin Internet: www.knauer.net © KNAUER 2023...

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