Spectradyne nCS1 Quick Start Manual
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Spectradyne nCS1
Quick Start Guide
© Spectradyne LLC
www.NanoparticleAnalyzer.com

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Summary of Contents for Spectradyne nCS1

  • Page 1 Spectradyne nCS1 Quick Start Guide © Spectradyne LLC www.NanoparticleAnalyzer.com...
  • Page 2: Table Of Contents

    Contents Purpose of the Quick Start Guide ..........................3 The nCS1 Instrument: Overview & Specifications ....................3 Specifications ................................3 Running the nCS1 ................................4 Workflow Process ............................... 4 Startup Instrument and Software ........................ 4 Prime the Instrument ............................4 Load the Sample ..............................
  • Page 3: Purpose Of The Quick Start Guide

    The nCS1 is a powerful tool for obtaining detailed size and concentration information about particle distributions in liquids. The core technology utilized in the nCS1 is called Resistive Pulse Sensing (RPS). A clean disposable cartridge targets a specific size range of particles for each analysis, eliminating concerns of contamination between samples.
  • Page 4: Running The Ncs1

    ❖ Make sure the cartridge calibration file is up-to-date, please contact support@spectradynellc.com for the latest version. ➢ NOTE: The instrument should be turned on before running the nCS1 software. If the instrument is powered off, the software will need to be restarted before next use. 2. Prime the Instrument This sequence should be performed to prepare the instrument for running the first cartridge on startup.
  • Page 5: Load The Sample

    ❖ Gently tap the cartridge on a flat surface to shift/remove any bubbles if necessary. Figure 3. Any air bubbles in the analyte must not occlude the bottom of the reservoir. © Spectradyne LLC, All rights reserved Version 2.5.0 Revision 1, July 2020...
  • Page 6: Load The Cartridge Into The Ncs1

    (Utilities frame, Figure 2). ❖ Click on “About this instrument…” under Manual Utilities frame, see Figure 5. ➢ Load the cartridge into the socket in the front of the nCS1 following the specific hardware version instructions below. Figure 5. Manual Utilities frame ©...
  • Page 7 ➢ The middle indicator light (blue), and the button ring light (blue) on the front panel of the instrument must be illuminated before proceeding. ➢ Press the cartridge engage button on the front of the nCS1 to raise the cartridge into the instrument. The top indicator light (white) will illuminate to indicate that the stage has reached the top of its range of motion and that the cartridge is ready for priming.
  • Page 8: Acquire Data

    ➢ When the routine is complete, the Acquisition frame (Figure 9) will be activated and data acquisition will begin automatically. Figure 8. Run Control frame and fill monitors status. © Spectradyne LLC, All rights reserved Version 2.5.0 Revision 1, July 2020...
  • Page 9 (Figure 12) using the Live CSD feature of the Auto-analysis Engine (Figure 11). Figure 10. Exemplary raw data: Smooth baseline with particle detection events appearing as downward spikes. © Spectradyne LLC, All rights reserved Version 2.5.0 Revision 1, July 2020...
  • Page 10 Figure 11. Auto-analysis Engine Interface. Figure 12. An example of the Live CSD plot. © Spectradyne LLC, All rights reserved Version 2.5.0 Revision 1, July 2020...
  • Page 11: End The Measurement Run

    ➢ Follow the next prompt to remove the cleaning cartridge and store it in a safe place for re-use. ➢ Power off the instrument during long periods of inactivity (e.g., overnight). ➢ IMPORTANT: Refrigerate buffer bottles and DI water bottles after use © Spectradyne LLC, All rights reserved Version 2.5.0 Revision 1, July 2020...
  • Page 12: Data Analysis

    Refer to the Operation Manual for Viewer software features and data analysis. Cartridge Size and Concentration Coverage A more up-to-date cartridge size coverage can be found on our website. © Spectradyne LLC, All rights reserved Version 2.5.0 Revision 1, July 2020...
  • Page 13: More Information And Technical Support

    More Information and Technical Support More detailed information on the operation of the nCS1 and its software can be obtained by sending email to support@spectradynellc.com. At Spectradyne we are eager to help with your particle analysis. Please contact us for help with specific measurement challenges and for help with the analysis of specific particle populations.

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