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10.1
Operation Sequence
1. Sequence 1: Enter main page (See Fig 17).
2. Sequence 2: Manage parameters (see 11.6).
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3. Sequence 3: Lyophilization
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4. Sequence 4: Shelf pre-cooling is an option for constant temperature regulation.
5. Sequence 5: Pre-cooling
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6. Sequence 6: Coils Cooling
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7. Sequence 7: Establish Chamber Vacuum
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8. Sequence 8: Primary drying
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Note: The temperature is controllable using the dialogue window. Additionally the silicon
oil inlet may be adjusted to control the temperature value.
9. Sequence 9: Pressure rise test as an option
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10. Sequence 10: Secondary drying
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Note:
During the process, the rate of heat transfer will become very slow due to the reduction of
the water content in the product. Additionally, the low pressure vacuum environment of the
Version 1.0
Click each parameter to set proper value.
Lyophilizer automatically runs the process according to the
parameters that have been set in sequence 2.
Step 5.1: Start circulation pump.
Step 5.2: Start compressor.
Step 5.3: Open shelves cooling valve until the temperature of the
silicon oil inlet (already set-in parameter manage) is lower than or
equal to set value.
Step 5.4: To ensure the product is completely frozen, make sure that
the time condition at the specified temperature is met.
Open the coils cooling valve, close the shelves cooling valve to cool
the condenser until the temperature of condenser (already set in Para.
manage) is lower than or equal to the set value. The value is usually
set around –40℃.
Start the vacuum pump and then open the pump isolation valve to
achieve the chamber vacuum required (the value is already set). The
temperature of condenser should be approximately –40℃.
Step 8.1: When the pressure of chamber is lower than the value (as
set in Recipe), start the electric heater to begin primary drying.
Step 8.2: The rate of heating of the product should be in accordance
to the process recommendations. It is important to ensure the product
is not allowed to thaw during the process (the temperature is less than
the product eutectic temperature).
If the pressure rise is distinctly slower than required for the primary
drying process (based on set value), go to the next test. If this test
fails, restart the last stage of primary drying again or else forcibly go to
next step.
It is identical to primary drying only at a higher temperature.
User Manual
43
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