FTS LYOSTAR 3 Operator's Manual

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YOPHILIZER

PERATOR

ANUAL

FTS S

™ 3

YSTEMS

TAR

& D

/ P

-S

ESEARCH

EVELOPMENT

ILOT

CALE

REEZE

RYER

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Page 1 ’ YOPHILIZER PERATOR ANUAL FTS S ™ 3 YSTEMS & D ESEARCH EVELOPMENT ILOT CALE REEZE RYER...
Page 3 Copyright © 2014 SP Scientific. All marks herein are used under license. All brand or product names mentioned may be trademarks or registered trademarks of their respective companies. Part Number 100004448 Rev 006, 01/14 Original Instructions The U.S. English version of this document is the original instructions. All other languages are a translation of the original instructions.
Page 4: Important Symbols
Important Symbols WARNING! INJURY OR EVEN DEATH MAY RESULT IF RECOMMENDATION CRUSH HAZARD. KEEP HANDS MARKED WITH THIS SYMBOL IS NOT CLEAR WHEN OPERATING DOOR. HEEDED. CORROSIVE CHEMICAL. WEAR ELECTRIC SHOCK DANGER! USE SUITABLE GLOVES, SAFETY APPROPRIATE CAUTION TO AVOID GLASSES, AND PROTECTIVE INJURY OR DEATH.
Page 5: Warranty Information
Please take this opportunity to locate the serial tag on your new FTS Systems LyoStar™ 3 and record the information below for future reference. SP Scientific also recommends that you complete and return your unit’s warranty registration card.
Page 7: Table Of Contents
Contents Important Symbols ............................... ii Freeze Dryer Safety Warnings ..........................ii Warranty Information ............................iii Introduction ......................... 1 Standard Features ............................... 1 Equipment Options .............................. 2 Getting Started ......................3 Initial Inspection ..............................3 Setup Procedure ..............................3 The Freeze-Drying System ..................9 Components and Subsystems ..........................
Page 8 Contents FTS Systems LyoStar™ 3 LyoS™ Control System ............................14 Programmable Logic Controller (PLC) ......................14 Operating your Lyophilizer ..................15 Leak Rate and Function Testing ........................15 Preparation and Pretreatment ..........................15 Product Temperature-Monitoring Probes ...................... 16 Pre-Freezing ..............................17 Stoppers ................................
Page 9 FTS Systems LyoStar™ 3 Contents Guidelines and Performance Expectations ....................52 General Maintenance ....................55 Vacuum System ..............................55 Vacuum Pump ............................... 55 Changing Vacuum Pump Oil ......................... 55 Gas Ballast Valve on the Vacuum Pump ....................... 56 Vacuum Tubing and Gaskets ........................56 Refrigeration System ............................
Page 11: Introduction
Chapter Introduction Introducing the LyoStar™ 3—the pinnacle of freeze dryer engineering. Designed and built like a full-scale production freeze dryer, this pilot-scale lyophilizer offers superior shelf mapping, rapid shelf freezing, a robust 5.5 hp cascade refrigeration system, unmatched process accuracy and reliability, and a sophisticated instrumentation set. In short, the LyoStar™...
Page 12: Equipment Options
Introduction FTS Systems LyoStar™ 3 Equipment Options • Stainless steel product and/or condenser chamber doors. • Water-cooling for enhanced performance. • Stainless steel Bio-seal flange for cleanroom installation. • Liquid nitrogen trap. • Sample Extractor Assembly. Rev 006, 01/14 © SP Scientific 2014...
Page 13: Getting Started
Chapter Getting Started Initial Inspection Your LyoStar™ 3 lyophilizer was carefully packed and thoroughly inspected before leaving the factory. However, in the unlikely event that shipping damage has occurred, retain all packing material and contact your freight carrier immediately. DO NOT ACCEPT DAMAGED SHIPMENTS FROM A CARRIER WITHOUT A SIGNED NOTIFICATION OF DAMAGES.
Page 14 Getting Started FTS Systems LyoStar™ 3 Inspect the inside of the unit for any visible damage. Check refrigeration lines, heat transfer lines and vacuum lines for damage. Check for visible liquid at or near the base of the unit. Open the product and condenser chamber doors. Remove all packing material from chambers.
Page 15 FTS Systems LyoStar™ 3 Getting Started Clearance. Twenty-four (24) inches (61 cm) of obtainable clearance is recommended on all sides of the unit for serviceability and efficient operation. If multiple machines are being operated in a single area, position them so that the hot exhaust from one does not blow into the intake of another.
Page 16 Getting Started FTS Systems LyoStar™ 3 Vacuum Pump Exhaust. If applicable, check your facilities vacuum pump exhaust piping. SP Scientific recommends an adequate vacuum pump exhaust system be installed, as pump vapors can be unpleasant in the lab and are not typically permitted in a clean room environment. SP Scientific suggests vacuum pump exhaust piping travel horizontally from the pump across to a “T”...
Page 17 FTS Systems LyoStar™ 3 Getting Started Inert Gas for Systems with Praxair’s ControLyo™ Nucleation On- Demand Technology. LyoStar™3 lyophilizers equipped with ControLyo™ Nucleation On-Demand Technology require an inert gas source for system pressurization. Argon (preferred), nitrogen or other suitable inert gas should be supplied with the gas pressure capable of delivering 4 scfm when regulated between 50 and 60 psig.
Page 19: The Freeze-Drying System
Chapter The Freeze-Drying System PRACTICAL OPERATING TIP. REFER TO YOUR CONTROL SYSTEM OPERATOR’S MANUAL FOR SPECIFIC DETAILS REGARDING THE OPERATION OF YOUR UNIT. Components and Subsystems Before operating your LyoStar™ 3 for the first time, take a few moments to familiarize yourself with the lyophilizer’s components and subsystems.
Page 20: Product Drying Chamber
The Freeze-Drying System FTS Systems LyoStar™ 3 Product Drying Chamber Standard Chamber The standard product-drying chamber is a horizontally mounted square vessel manufactured from grade 316L stainless steel. The chamber is designed for and provided with reinforcement capable of withstanding full vacuum. It is insulated to limit energy loss and includes all ports and connections required for connecting the lyophilizer’s necessary sub-systems and components.
Page 21: Product Shelves
FTS Systems LyoStar™ 3 The Freeze-Drying System Product Shelves The LyoStar™ 3 lyophilizer is offered with up to four usable shelves and one radiant heat shelf. The radiant heat shelf is mounted above the top product shelf to provide uniform heating to product located on the uppermost useable product shelf. All shelves are manufactured from grade 316L stainless steel.
Page 22: Shelf Heat-Transfer System
The Freeze-Drying System FTS Systems LyoStar™ 3 Shelf Heat-Transfer System The shelves are hollow to allow heat transfer fluid to circulate through them, and connected in parallel with inlet and outlet manifolds by stainless steel corrugated tubes. Both the inlet and outlet manifolds are located within the chamber.
Page 23: Condenser System
FTS Systems LyoStar™ 3 The Freeze-Drying System Condenser System The external ice condenser consists of a continuous, multiple loop coil located inside a horizontally mounted, cylindrical vessel manufactured from grade 316L stainless steel. The condenser chamber, which is designed for and provided with reinforcement capable of withstanding full vacuum, is located below the product-drying chamber.
Page 24: Aeration And Vacuum Level Control
The Freeze-Drying System FTS Systems LyoStar™ 3 Aeration and Vacuum Level Control You may ‘break’ vacuum in the product and condenser chambers by aeration using nitrogen, room air or other suitable gas. A single inert gas port, which is located on the freeze dryer’s rear panel, is provided for vacuum release, vacuum level control and...
Page 25: Operating Your Lyophilizer
Chapter Operating your Lyophilizer PRACTICAL OPERATING TIP. YOUR LYOPHILIZER IS SUPPLIED WITH A SOPHISTICATED CONTROL SYSTEM. REVIEW YOUR CONTROL SYSTEM OPERATOR’S MANUAL BEFORE OPERATING YOUR FREEZE DRYER. WHEN IN OPERATION, ALWAYS ASSUME THE LYOPHILIZER CHAMBERS ARE UNDER VACUUM. ALL GLASSWARE UNDER VACUUM REPRESENTS A SIGNIFICANT IMPLOSION HAZARD.
Page 26: Product Temperature-Monitoring Probes
Operating your Lyophilizer FTS Systems LyoStar™ 3 Product Temperature-Monitoring Probes LyoStar™ 3 lyophilizers are equipped with ANSI Type T temperature-monitoring thermocouple probes, allowing you to monitor product temperature throughout the lyophilization process. The probe ends may be inserted directly into your product samples prior to freezing.
Page 27: Pre-Freezing
FTS Systems LyoStar™ 3 Operating your Lyophilizer Thermocouple Connection Once thermocouples are properly placed, the product may be loaded into the chamber. When connecting the thermocouple wire connector to the corresponding outlet on the product chamber jack panel, make sure that you achieve a copper-to- copper connection.
Page 28: Freezing / Thermal Treatment
Operating your Lyophilizer FTS Systems LyoStar™ 3 Freezing / Thermal Treatment Product samples must be frozen before the start of the drying process. Freezing can be accomplished directly in the product chamber as part of an automated cycle, or in a shell bath or laboratory freezer.
Page 29: Drying Step 17
FTS Systems LyoStar™ 3 Operating your Lyophilizer Drying Step 17 Some products may require an additional drying step even when they appear dry. It is during this phase that any remaining unfrozen water is removed from the product. Using the lyophilizer’s control system, the temperature is typically increased during this step to remove bound water until the residual water content falls to the range required for optimum product stability.
Page 31: Liquid Nitrogen Trap
Chapter Liquid Nitrogen Trap The optional auto-fill Liquid Nitrogen (N ) Trap is designed to protect the vacuum 2(liq) pump from the corrosive properties of acid and alkaline vapors, as well as the low temperatures and organic solvents associated with the freeze-drying process. A liquid level controller with a thermistor-type level sensor is provided with the Liquid Nitrogen Trap.
Page 32: Operation
Liquid Nitrogen Trap FTS Systems LyoStar™ 3 Operation Before you begin operating the Liquid Nitrogen Trap, read the Liquid Level Controller manual and familiarize all personnel with the safe handling and storage of liquefied gases. Ensure that all three reservoir cover latches have been closed and the reservoir cover is secure.
Page 33 FTS Systems LyoStar™ 3 Liquid Nitrogen Trap To activate the liquid nitrogen trap, open the inlet and outlet valves. Ensure that the bypass valve is closed. When the liquid nitrogen trap is in use, all valves should be parallel as shown below.
Page 34: Cleaning
Liquid Nitrogen Trap FTS Systems LyoStar™ 3 Cleaning The accumulation of condensed vapors may result in a loss of vacuum, which typically indicates that defrosting is required. Check the trap by isolating the trap (i.e., closing the inlet and outlet valves) and breaking vacuum to the trap, which is accomplished by removing the drain plug from the drain hose located under the stainless steel vessel.
Page 35 FTS Systems LyoStar™ 3 Liquid Nitrogen Trap When possible, remove the inner reservoir. Rinse off and clean any remaining condensate. Drain the condensate using the drain line and wipe the outer reservoir clean. Loosen the thumbscrews again and lower the lid.
Page 37: Sample Extractor Assemblies
Chapter Sample Extractor Assemblies The optional Sample Extractor Assemblies for LyoStar™ 3 lyophilizers allows you to select and remove a serum bottle or vial from the product chamber at any time during a freeze-dry run. The selection and removal process is accomplished with virtually no interruption to the drying process.
Page 38: Sample Extractor
Sample Extractor Assemblies FTS Systems LyoStar™ 3 Sample Extractor Installation Standard Door Removal Before installing the Sample Extractor Assembly, the standard acrylic door must be removed from the freeze-dryer. Ensure that the unit is not in operation and that the product chamber is not under vacuum.
Page 39: Sample Extractor Operation
FTS Systems LyoStar™ 3 Sample Extractor Assemblies Align the Sample Extractor Assembly door with the hinge brackets and reinstall the quick release pins. Sample Extractor Assembly Door Without Front Antechamber Cover And Selector Arm. Reinstall the front antechamber plate with the selector arm using the thumbscrews.
Page 40 Sample Extractor Assemblies FTS Systems LyoStar™ 3 Manipulate the selector arm to select and extract a vial(s). To extract a vial(s), push the button on the end of the selector arm to open the spring-loaded jaws. Place the open jaws around the top of the selected vial and release the button to close the jaws and secure the vial.
Page 41 FTS Systems LyoStar™ 3 Sample Extractor Assemblies Slide the isolation door closed and lower the handle to lock it into position. Remove the plastic shroud from the stoppering ram. Plastic Shroud removed from stoppering ram Isolation Door Handle lowered to lock isolation door into position.
Page 42 Sample Extractor Assemblies FTS Systems LyoStar™ 3 Press down on the stoppering ram to manually stopper the vial. Stoppering Ram Stopper Vial Sample Before the sample can be removed from the antechamber, the antechamber pressure must be returned to atmospheric pressure. If you connected an inert gas source for backfilling, remove it now.
Page 43: Asme-Coded Stainless Steel Sample Extractor Assembly
FTS Systems LyoStar™ 3 Sample Extractor Assemblies Remove the vial(s). Vial Sample Close the front plate to reseal the antechamber. ASME-Coded Stainless Steel Sample Extractor Assembly Sample Extractor Assembly Components The ASME-Coded Stainless Steel Sample Extractor is comprised of a stainless steel...
Page 44: Sample Extractor Operation
Sample Extractor Assemblies FTS Systems LyoStar™ 3 Sample Extractor Operation To operate the Sample Extractor Assembly: Ensure that the auxiliary vacuum pump is connected to vacuum pump inlet. Vacuum Pump Inlet Activate the auxiliary vacuum pump and open the antechamber vacuum valve (by turning it to the right) to pull vacuum in the antechamber.
Page 45 FTS Systems LyoStar™ 3 Sample Extractor Assemblies From the LyoS™ control system, ensure that the lyophilizer’s parameters are stable before proceeding. Ensure that the flashlight is securely fitted to the sample extractor assembly then press the black button on the back of the flashlight to illuminate the chamber.
Page 46 Sample Extractor Assemblies FTS Systems LyoStar™ 3 Once the vial is directly beneath the stoppering ram, press down on the stoppering ram to manually stopper the vial. Once stoppered, use the selector arm to pick up the vial and bring it directly over the antechamber.
Page 47: Shelf Spacing
FTS Systems LyoStar™ 3 Sample Extractor Assemblies Shelf Spacing Certain applications of the Sample Extractor Assemblies may require shelf spacing adjustments. Latching one (1) shelf up will position the other shelves so that a 20 ml vial may be used. It also increases the accessible shelf area to 240 in (0.15 m...
Page 49: Stoppering
Chapter Stoppering The LyoStar™ 3’s stoppering system provides bottom-up shelf collapse allowing you to fully seat partially inserted stoppers into product vials at the end of a freeze dry cycle. A compact hydraulic power unit, mounted below the product chamber, is used to create the required stoppering pressure.
Page 50: Stoppering
Stoppering FTS Systems LyoStar™ 3 Stoppering The hydraulic stoppering mechanism may be operated under vacuum or after backfilling the chamber with inert gas. Operation of the stoppering system while the unit is at low temperatures is not recommended (i.e., below -5° C).
Page 51: Inert Gas Backfill
FTS Systems LyoStar™ 3 Stoppering Inert Gas Backfill Some processes benefit from an oxygen-free atmosphere within product vials. This can be accomplished by backfilling with an inert gas prior to stoppering. To backfill your product chamber with an inert gas: From a gaseous nitrogen source, attach rubber tubing to the port labeled “INERT GAS”.
Page 53: Shelf-Latching
Chapter Shelf-Latching The product shelf assembly used in the manufacture LyoStar™ 3 lyophilizers is designed with a moveable shelf stack, which is primarily used to facilitate the stoppering of product vials. However, the ability of the shelf stack to move up and down also serves a second purpose.
Page 54 Shelf-Latching FTS Systems LyoStar™ 3 Loosen the wing nuts. Obtain the shelf-latching plates. Shelf-Latching Plate Slide the shelf-latching plates on either side of the shelf stack between the shelf fluid hoses and the shelf assembly so that the lip of the plate rests on top of the shelf assembly.
Page 55 FTS Systems LyoStar™ 3 Shelf-Latching Secure wing nuts. Operate the stoppering system and return the shelves to their full down position (only the usable shelves will travel). The shelves are then available for loading. See examples. Three-Shelf Unit Converted To Two Three-Shelf Unit Converted To Single Usable Shelves Using Shelf-Latching Kit.
Page 57: Praxair's Controlyo™ Nucleation On-Demand Technology
Chapter Praxair’s ControLyo™ Nucleation On-Demand Technology THE FOLLOWING SECTION IS INTENDED FOR LYOSTAR™ 3 LYOPHILIZERS CONFIGURED WITH PRAXAIR'S CONTROLYO™ NUCLEATION ON-DEMAND TECHNOLOGY. FOR ADDITIONAL INFORMATION, REFER TO YOUR CONTROL SYSTEM OPERATOR’S MANUAL. ControLyo™ Nucleation On-Demand Technology is a new technology developed by Praxair, Inc., which utilizes a series of pressurization and depressurization events within the product-drying chamber using a gas to enable controllable instantaneous and homogeneous nucleation of the freezing event for all product containers in the...
Page 58: The Praxair Controlyo™ Nucleation On-Demand Technology Process
Praxair’s ControLyo™ Nucleation On-Demand FTS Systems LyoStar™ 3 Technology The Praxair ControLyo™ Nucleation On-Demand Technology Process Pressurization The pressurization process for controlled nucleation involves the introduction of a sterile filtered inert gas into the lyophilizer product chamber. The control of the pressurization process is based on a pressurization setpoint and the measured product chamber pressure.
Page 59: Importance Of Controlled Nucleation
FTS Systems LyoStar™ 3 Praxair’s ControLyo™ Nucleation On-Demand Technology Importance of Controlled Nucleation “Nucleation” denotes the onset of ice crystallization as the formulation is cooled during the Freezing / Thermal Treatment phase of the lyophilization cycle. The temperature at which nucleation occurs plays a key role in the outcome of the lyophilization process.
Page 60: Key Steps
Praxair’s ControLyo™ Nucleation On-Demand FTS Systems LyoStar™ 3 Technology Key Steps Key steps for utilizing Praxair’s ControLyo™ Nucleation On-Demand Technology are outlined below: Load product containers into the lyophilizer and securely latch the chamber doors. Connect the supply gas source to the compressed gas inlet of the lyophilizer.
Page 61 FTS Systems LyoStar™ 3 Praxair’s ControLyo™ Nucleation On-Demand Technology Cool product containers to the target nucleation temperature (e.g., 1 to 2 °C below the thermodynamic freezing point of your product). The shelf temperature should be set at a temperature such that the product is maintained below the target nucleation temperature during depressurization.
Page 62: Mechanism
Praxair’s ControLyo™ Nucleation On-Demand FTS Systems LyoStar™ 3 Technology Mechanism The exact mechanism by which Praxair’s ControLyo™ Nucleation On-Demand Technology induces nucleation is not fully understood, but there are hypotheses as to what may give rise to nucleation. The gas in the product chamber undergoing expansion during depressurization will cool, and the cold gas contacting the surface of the metastable liquid in the vial might induce nucleation.
Page 63 FTS Systems LyoStar™ 3 Praxair’s ControLyo™ Nucleation On-Demand Technology The ControLyo™ technology has been designed for SP Scientific’s LyoStar™ 3 lyophilizers to provide robust nucleation control capabilities. It is anticipated that the ControLyo™ technology should be able to achieve the following in a LyoStar™ 3 lyophilizer: •...
Page 64 Praxair’s ControLyo™ Nucleation On-Demand FTS Systems LyoStar™ 3 Technology Rev 006, 01/14 © SP Scientific 2014...
Page 65: General Maintenance
Chapter General Maintenance Proper routine maintenance is the key to an efficiently operating lyophilizer with minimal downtime, and will likely extend the life of your equipment, sub-systems and components. Maintenance should be performed a minimum of four times a year. Because system use and application varies from one facility to another, system maintenance may need to be performed more frequently.
Page 66: Gas Ballast Valve On The Vacuum Pump
General Maintenance FTS Systems LyoStar™ 3 Scheduling Oil Changes After clean oil is loaded into the vacuum pump and all necessary connections have been made between the vacuum pump and the freeze dryer, perform a full capacity test cycle. Have a qualified technician check the oil after the test cycle. If the oil appears dirty, you may need to change the oil after every use.
Page 67: Refrigeration System
FTS Systems LyoStar™ 3 General Maintenance Refrigeration System The LyoStar™ 3 is designed for installation and operation in a room with a controlled temperature of between 19 and 25 °C. If the ambient temperature is routinely higher than the equipment specifications, the amount of refrigerant gas being condensed as it passes through the condenser will be less.
Page 68: Acrylic Parts
General Maintenance FTS Systems LyoStar™ 3 Acrylic Parts Clean acrylic parts with a mild detergent. Use a soft cloth or Kimwipes® to avoid scratching the acrylic. CAUTION! DO NOT USE ORGANIC SOLVENTS OR ABRASIVE CLEANERS. mical Resistance Chart Chemical Code...
Page 69: Routine Maintenance Schedules
FTS Systems LyoStar™ 3 General Maintenance Routine Maintenance Schedules The typical lyophilizer is a sophisticated instrument used for processing pharmaceutical and/or biotechnology products. Each lyophilizer includes, as a minimum, a refrigeration system, vacuum system, shelf system, condenser system, electrical system, control system and a heat transfer system, as well as optional systems.
Page 70: Recommended Monthly Maintenance Schedule
General Maintenance FTS Systems LyoStar™ 3 Recommended Monthly Maintenance Schedule SP Scientific recommends performing the following maintenance tasks monthly. If additional assistance is required, please contact SP Scientific Service. Recommended Monthly Maintenance Task Level Inspect the product chamber and condenser door gaskets and ensure that they are clean and free of defects (cuts, cracks, tears).
Page 71: Recommended Annual Maintenance Schedule
FTS Systems LyoStar™ 3 General Maintenance Recommended Annual Maintenance Schedule SP Scientific recommends performing the following maintenance tasks annually. If additional assistance is required, please contact SP Scientific Service. Recommended Annual Maintenance Task Level Complete all items outlined in the Recommended Monthly and Quarterly Level 1 Maintenance Schedules.
Page 72: Recommended Five-Year Maintenance Schedule
General Maintenance FTS Systems LyoStar™ 3 Recommended Five-Year Maintenance Schedule SP Scientific recommends performing the following maintenance tasks every five years. If additional assistance is required, please contact SP Scientific Service. Recommended Five-Year Maintenance Task Level Level 1, Complete all items outlined in the Recommended Monthly, Quarterly and Annual Level 2, Maintenance Schedules.
Page 73: Appendix A: Sample Recipe
Appendix Appendix A: Sample Recipe The sample recipe is provided as a general reference only. The format is based on the Recipe screen of the LyoS™ control system. The following recipe parameters are intended for use with one (1) liter of water. Before you begin, fill one bulk-processing tray with water, place it on one of the product shelves in the chamber and close the door.
Page 75: Appendix B: Troubleshooting
Appendix Appendix B: Troubleshooting Troubleshooting Chart Condition Possible Cause Recommended Corrective Action Check the voltage and amperage Freeze-dryer starts hard (i.e., difficulty supplied to the unit against the freeze- or rough starting). Makes chugging Low voltage supply. dryer’s serial tag. If supply is low, contact noises at startup.
Page 76 Appendix B: Troubleshooting FTS Systems LyoStar™ 3 Condition Possible Cause Recommended Corrective Action Verify that power is connected and refrigeration switch is on. No power to compressor. Check for power on compressor wires in Compressor does not start. electrical panel (See schematic drawing).
Page 77: Additional Troubleshooting: Vacuum System
FTS Systems LyoStar™ 3 Appendix B: Troubleshooting Additional Troubleshooting: Vacuum System If a vacuum leak is suspected in your freeze-dryer, perform a preliminary vacuum leak check of your system. The following steps will guide you through troubleshooting your vacuum system.
Page 78: Product Chamber And Condenser Vacuum Leak Check
Appendix B: Troubleshooting FTS Systems LyoStar™ 3 Product Chamber and Condenser Vacuum Leak Check To check the product and condenser chambers, and related vacuum connections: Open the product chamber door and visually inspect the shelf assembly for liquid leaks. Use a flashlight if necessary. If a liquid leak is observed, call SP Scientific Service immediately.
Page 79: Appendix C: Stainless Steel Cleaners
Appendix Appendix C: Stainless Steel Cleaners Cleaning Required Cleaning Agent Application Method Effect on Finish Use in direction of polish lines May scratch No. 2 (mill- Penny-Brite or Copper-Brite on No. 4 (polished) finish. rolled) and Nos. 7 and 8 Wipe with dry cloth.
Page 82 SP Scientific 3538 Main Street Stone Ridge, NY 12484 USA (800) 251-1531 (845) 687-0071 935 Mearns Road Warminster, PA 18974 USA (800) 523-2327 (215) 672-7800 815 State Route 208 Gardiner, NY 12525 USA (800) 431-8232 (845) 255-5000 www.SPScientific.com...

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