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ADInstruments NIBP ML125 Series Owner's Manual

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ADInstruments NIBP ML125 Series Owner's Manual

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Summary of Contents for ADInstruments NIBP ML125 Series

  • Page 1 Artisan Technology Group is your source for quality new and certified-used/pre-owned equipment SERVICE CENTER REPAIRS WE BUY USED EQUIPMENT • FAST SHIPPING AND DELIVERY Experienced engineers and technicians on staff Sell your excess, underutilized, and idle used equipment at our full-service, in-house repair center We also offer credit for buy-backs and trade-ins •...
  • Page 2 NIBP Controller Owner’s Guide Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com...
  • Page 3 MacLab are registered trademarks of ADInstruments Pty Ltd. The names of specific recording units, such as PowerLab 8/30, are trademarks of ADInstruments Pty Ltd. LabTutor Server, Chart and Scope (application programs) and LabTutor Online are trademarks of ADInstruments Pty Ltd.

  • Page 4: Table Of Contents

    Optional Trigger Controls ....... . .18 Connecting to Other ADInstruments Front-ends ....19 Power-up Test .
  • Page 5 A Technical Details How it Works ......... . 26 Circuit Principles .

  • Page 6: Safety Notes

    ADInstruments products are NOT intended to be used as medical devices or in medical environments. That is, no product supplied by ADInstruments is intended to be used to diagnose, treat or monitor a subject. Furthermore no product is intended for the prevention, curing or alleviation of disease, injury or handicap.
  • Page 7 Safety Symbols Devices manufactured by ADInstruments that are designed for direct connection to humans are tested to IEC 601-1:1998 (including amendments 1 and 2) and 60601-1-2, and carry one or more of the safety symbols below. These symbols appear next to those inputs and output connectors that can be directly connected to human subjects.
  • Page 8 • All Bio Amp front-ends (except for the ML138 Octal Bio Amp) and PowerLab units with a built-in Bio Amp are supplied with a 3-lead or 5- lead Bio Amp subject cable and lead wire system. The ML138 Octal Bio Amp is supplied with unshielded lead wires (1.8 m).
  • Page 9 Therefore, under no circumstances should any other transformer be used with the Stimulus Isolator. For a replacement transformer plug pack please contact your nearest ADInstruments representative. General Safety Instructions To achieve the optimal degree of subject and operator safety, consideration...
  • Page 10 While it is not possible to cover all arrangements of equipment in a system, some general guidelines for safe use of the equipment are presented below: • Any electrical equipment which is located within the SUBJECT AREA should be approved to IEC60601-1. •...
  • Page 11 Cleaning and Sterilization ADInstruments products may be wiped down with a lint free cloth moistened with industrial methylated spirit. Refer to the manufacturer’s guidelines or the Data Card supplied with transducers and accessories for specific cleaning and sterilizing instructions.
  • Page 12 Environment Electronic components are susceptible to corrosive substances and atmospheres, and must be kept away from laboratory chemicals. Storage Conditions • Temperature in the range 0–40 °C • Non-condensing humidity in the range 0–95%. Operating Conditions • Temperature in the range 5–35 °C •...
  • Page 13 NIBP Controller Owner’s Guide Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com...

  • Page 14: Overview

    Overview The ADInstruments ML125 NIBP (Non-Invasive Blood Pressure) Controller performs non-invasive blood pressure measurement on rats and mice using specialised tail cuffs. This Owner’s Guide covers the features of the NIBP Controller and its ® operation with your ADInstruments PowerLab and LabChart software.

  • Page 15: Checking The Nibp Controller

    1. Check there are no obvious signs of damage to the outside casing. 2. Check there are no obvious signs of internal damage (like rattling). If you find a problem, please contact your ADInstruments distributor immediately. The Front Panel Figure 1–1...

  • Page 16: Pulse Input Connector

    Trigger Output C Input and Output Sockets The NIBP Controller is designed to receive power and control signals from an ADInstruments PowerLab. These are supplied by an ‘I C Bus’ (a ‘bus’ is simply information-transmission circuitry such as cables and connectors).

  • Page 17: Pressure Signal Output

    Output socket of the NIBP Controller allows connection of further ADInstruments front-ends to the system, in series (the input of the next connects to the output of the previous). Pressure Signal Output Connect this output to a PowerLab input channel to record pressure. This signal is proportional to the cuff pressure and is precalibrated to produce 1 V per 300 mmHg.

  • Page 18: Using The Controller

    Using the Controller This chapter guides you through connecting your NIBP Controller to your PowerLab and performing a power-up test to make sure there are no problems. This chapter also covers setting up the NIBP Controller in a typical system, and calibrating the pressure signals. IMPORTANT: Always make sure that the PowerLab is turned off before you connect or disconnect the NIBP Controller.

  • Page 19: Connecting The Nibp Controller

    PowerLab is on. Connect the I C Output of the PowerLab to the I C Input of the NIBP Controller. Additional ADInstruments front-ends may be connected to the system by connecting to the I C Output of the NIBP Controller. Figure 2–1...

  • Page 20: Connecting To Other Adinstruments Front-Ends

    Connecting to Other ADInstruments Front-ends The NIBP Controller is designed to be used with other ADInstruments front- ends. The NIBP Controller can be used anywhere in the series of I connections, as long as there are enough analog inputs on your PowerLab to support the required number of signals of the front-ends.

  • Page 21: Connecting Pulse Transducers

    Figure 2–2 The NIBP Controller and PowerLab set up for use with tail cuff, pulse transducer and animal restraint cage Animal restraint cage Tail cuff 5. Click the Start button in LabChart to begin recording. 6. Push the Start/Stop button on the front of the NIBP Controller to begin a measurement cycle.

  • Page 22: Indirect Blood Pressure Measurements In Small Animals Using Tail Cuffs

    Figure 2–3 Typical recording using LabChart showing the pulse and pressure signals Cuff Inflation Cuff Deflation Indirect Blood Pressure Measurements in Small Animals using Tail Cuffs Background Information This technique has been used routinely for the non-invasive measurement of blood pressure in rats, and more recently in mice. The technique provides a good estimate of actual systolic pressure.

  • Page 23: Protocol Development Guidelines

    Users are presented with all the information that is typically recorded by NIBP systems and can implement their own algorithms. The following guidelines are provided to assist in the development of protocols and reliable algorithms for the non-invasive measurement of blood pressure in small animals.
  • Page 24 8. Measured signals: The basic signals recorded by the ML125 NIBP system are the cuff pressure and the caudal artery pulse. Cuff pressure is an accurate high level signal with noise of less than +/– 0.1 mmHg and absolute error of less than +/– 2 mmHg (after calibration). This data is used in association with the reappearance of the caudal artery pulse to determine the systolic pressure.
  • Page 25 offline measurement of cycle height. This is particularly useful when the pulse amplitude is modulated by a respiratory artefact. c. Ratemeter: The Cyclic Measurements ‘Rate’ function can be set up to accurately measure and display the tail pulse rate, and to directly indicate the position of the systolic blood pressure point (as shown in Figure 2–4).

  • Page 26: A Technical Details

    A P P E N D I X Technical Details This appendix describes some important technical aspects of the NIBP Controller operation. You do not need to know this material to use the NIBP Controller. It is likely to be of interest to the technically-minded and is not intended in any way as a service guide.

  • Page 27: How It Works

    How it Works The NIBP Controller is a microprocessor controlled pump, designed to perform the cuff inflation and deflation sequence required for non-invasive blood pressure measurement. Internal amplifiers and filters are provided to allow monitoring of the cuff pressure and the subject’s pulse so that systolic and diastolic pressure can be determined.

  • Page 28: Pump Control

    Pump Control Control over the cuff inflation and deflation sequence is achieved using an internal microprocessor. The microprocessor waits until it detects a start signal either from the front Start/Stop button or from the external trigger input. It then turns on the internal pump and starts to fill the cuff. While pumping, it continuously monitors the cuff pressure and compares it to the maximum cuff pressure set on the back panel switch (either 200 mmHg or 280 mmHg).

  • Page 29: The Pulse Input Connector

    The Pulse Input Connector This connector has provision for two types of analog input: a differential high-gain signal, or a single-ended low-gain signal. The differential input is used for small signals typically obtained from pulse transducers connected to rats and mice. The single-ended low gain input can be used for other pulse transducers that provide a larger signal.

  • Page 30: B Specifications

    A P P E N D I X Specifications Cycle Operation Max Inflation Pressure: 200 or 280 mmHg (switch-selectable) Measurement Cycle Time: 40–150 BPM (large animals): 44 s (for 200 mmHg) 87 s (for 280 mmHg). 90–420 BPM (rats): 22 s (for 200 mmHg) 41 s (for 280 mmHg).

  • Page 31: Manual Start/Stop Input

    Manual Start/Stop Input Operation: Contact the closure input for starting or stopping measurement cycle. Shorting the input signal results in a start or stop operation. Minimum Contact Closure: 1 ms Remote Trigger Input Operation: Voltage level input for starting or stopping NIBP cycle.

  • Page 32: Operating Requirements

    65 mm 200 mm 275 mm × × (2.56" 7.9" 10.8") Weight: 1.7 kg ADInstruments reserves the right to alter these specifications at any time. Appendix B Specifications Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com...
  • Page 33 NIBP Controller Owner’s Guide Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com...

  • Page 34: Index

    Index back panel 15 Power indicator 14 block diagram 26 power up testing 19 PowerLab connection 18 pressure and pulse monitoring 27 circuit principles 26 pressure output connection 16 cleaning 10 Pulse Input connector 15, 28 connecting pulse input gain adjustment 16 pulse transducers 20 pulse output connection 15, 16 to other front-ends 19...
  • Page 35 NIBP Controller Owner’s Guide Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com...
  • Page 36 Artisan Technology Group is your source for quality new and certified-used/pre-owned equipment SERVICE CENTER REPAIRS WE BUY USED EQUIPMENT • FAST SHIPPING AND DELIVERY Experienced engineers and technicians on staff Sell your excess, underutilized, and idle used equipment at our full-service, in-house repair center We also offer credit for buy-backs and trade-ins •...

This manual is also suitable for:

Nibp ml125mNibp ml125r

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