Thermo Scientific Dionex DRS 600 Product Manual
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Thermo Scientific Dionex DRS 600 Product Manual

Carbonate suppressor
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Dionex DRS 600 Suppressor
Dionex ERS 500e Suppressor
Dionex ERS 500 Carbonate Suppressor
031956 Revision 13
•
March 2018
For Research Use Only. Not for use in diagnostic procedures.

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  • Page 1 Dionex DRS 600 Suppressor Dionex ERS 500e Suppressor Dionex ERS 500 Carbonate Suppressor 031956 Revision 13 • March 2018 For Research Use Only. Not for use in diagnostic procedures.
  • Page 2 Dionex Anion Electrolytically Regenerated Suppressor 500 for Carbonate Eluents (Dionex AERS 500 Carbonate (4 mm), Item # 085029) (Dionex AERS 500 Carbonate (2 mm), Item # 085028) Thermo Scientific Product Manual for the DRS 600 Suppressor Page 2 of 92 031956-13...
  • Page 3 Revision 11, January 2017, Updated the recommended suppressor hydration procedure. Edited for length and clarity. Added Dionex ERS 500e product. Revision 12, January 2018, Added information to support the release of Dionex DRS 600 and the discontinuance of Dionex ERS 500.
  • Page 4 IMPORTANT test results; or might contain information that is critical for optimal performance of the system. Highlights helpful information that can make a task easier. Thermo Scientific Product Manual for the DRS 600 Suppressor Page 4 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 5: Table Of Contents

    System Requirements ........................20 Electrolytically Regenerated Suppressor Control ................. 22 2.2.1 Dionex Reagent-Free Controller (Dionex RFC) ................. 23 Back Pressure Coils for the Dionex DRS 600, Dionex ERS 500e and Dionex AERS 500 Carbonate ....................... 23 2.3.1 Assembly ............................. 24 Gas Separator Waste Tube for the Dionex ERS 500 ..............
  • Page 6 3.7.3 Pump Trap Column Installation and Regeneration ................57 3.7.4 Neutralization Mode Operation ......................58 Dionex DRS 600, Dionex ERS 500e or Dionex AERS 500 Carbonate Storage ......59 3.8.1 Short-Term Storage (3 to 7 days) ......................59 3.8.2 Long-Term Storage (More than 7 days) ....................59 Example Neutralizer Mode Applications ................
  • Page 7 Low Sample Response (Neutralization Mode Only) ..............85 5.12 Low Neutralization Capacity (Neutralization Mode Only) ............85 Dionex DRS 600, Dionex ERS 500e and Dionex AERS 500 Carbonate Suppressor Cleanup ................... 86 Metal Contaminants or Precipitates ....................86 Organic Contaminants ........................87 Appendix A –...

  • Page 8: Introduction

    2, 3, 4, or 5 mm Ion Chromatography columns and systems. The 2 mm versions of the Dionex DRS 600, Dionex ERS 500e and Dionex AERS 500 Carbonate are specially designed with reduced internal volume to ensure optimum performance with 2 and 3 mm columns and systems.

  • Page 9: Dynamically Regenerated Suppressor

    – Introduction 1.1 Dynamically Regenerated Suppressor The Dionex DRS 600 is an electrolytic suppressor with a new resin formulation that allows the suppressor to be operated in the constant voltage mode. The Dionex DRS 600 continues to use the same clean ion exchange components (screens and membranes) as the Dionex ERS 500 suppressor devices;...

  • Page 10: Suppressor Design

    This orientation ensures complete regeneration of the device. The only difference between the Dionex DRS 600 and Dionex ERS 500e is the composition of the resin in the eluent channel. Electrodes are placed along the length of the regenerant channels to completely cover the eluent channel.
  • Page 11 The function of this is to lower the resistance and aid in the transport of ions in and out of the eluent channel. In the Dionex DRS 600, the eluent channel is filled with ion exchange resin and provides a static capacity which is particularly useful when eluent is pumped into the device with the power off.
  • Page 12 AutoSuppression with the Dionex ADRS 600 Dionex ADRS 600 in AutoSuppression Mode The Dionex DRS 600 (2 mm) suppressor is optimized for MS detection; the suppressor has been designed to have minimal interference for MS applications and is compatible with operation in external water mode.
  • Page 13 O + H + MSA + OH + ½ O + 2 OH ANALYTE IN H TO DETECTOR Thermo Scientific Product Manual for the DRS 600 Suppressor Page 13 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 14: Overview Of Suppression And Neutralization Modes

    1.4.1 Mode of Operation Selection The Dionex DRS 600 and Dionex ERS 500e modes of operation depend mainly on the eluent composition, the analysis sensitivity requirements and the sample matrix. The compatibilities are shown in Table 1. For example, eluents containing organic solvents that tend to oxidize easily are not compatible with the AutoSuppression Recycle Mode.
  • Page 15 AERS 500 Carbonate CRS 500 Although the Dionex DRS 600, Dionex ERS 500e and Dionex AERS 500 Carbonate do support Chemical Suppression Mode, the total suppression capacity is reduced. Use of a Chemically Regenerated Suppressor such as the CRS 500 or equivalent is recommended.

  • Page 16: The Autosuppression Recycle Mode

    The AutoSuppression Recycle Mode uses the suppressed conductivity cell effluent as the source of water for the regenerant. This is the preferred method of operation for the Dionex DRS 600 and Dionex AERS 500 Carbonate. The Dionex ERS 500e is also compatible with this mode.

  • Page 17: The Chemical Suppression Mode

    1.4.4 The Chemical Suppression Mode The Dionex DRS 600, Dionex AERS 500 Carbonate and Dionex ERS 500e can be used in the Chemical Suppression Mode; however, the total suppression capacity is reduced compared to a Chemically Regenerated Suppressor. Thermo Scientific recommends the use of a Chemically Regenerated Suppressor such as the Dionex CRS 500 for chemical suppression applications.
  • Page 18 It is important that only low-pressure concentrator columns, such as the Dionex UTAC-XLP2 (Item # 072781) and Dionex TCC-XLP1 (Item # 063889), be used to protect the Dionex DRS 600 from damage. Thermo Scientific Product Manual for the DRS 600 Suppressor...

  • Page 19: Shipment And Storage

    1.5 Shipment and Storage 1.5.1 Shipment The Dionex DRS 600, Dionex ERS 500e, and Dionex AERS 500 Carbonate should not be subjected to temperatures above 50°C for long durations during shipment, storage or operation, or for any duration above 80°C.

  • Page 20: Installation

    Dionex SRS series suppressors (Dionex SRS I, Dionex SRS II, Dionex SRS ULTRA, Dionex SRS ULTRA II and Dionex SRS 300). The Dionex DRS 600 can be used in place of any of these suppressors where recycled eluent mode or external water mode is employed.
  • Page 21 – Installation The Dionex DRS 600, Dionex AERS 500e and Dionex AERS 500 Carbonate suppressors are not designed or validated for use with discrete power supplies (power supplies that deliver current at discreet 50, 100, 300 or 500 mA levels).

  • Page 22: Electrolytically Regenerated Suppressor Control

    – Installation The Dionex DRS 600, Dionex ERS 500e or Dionex AERS 500 Carbonate is installed in the column compartment or detector compartment of the chromatography module immediately after the analytical column and before the conductivity detector cell. All components required for installation of the suppressor are included with the system.

  • Page 23: Dionex Reagent-Free Controller (Dionex Rfc)

    If a DRS Mode or ERS Mode is not available, select the equivalent SRS Mode on the power supply to support the Dionex DRS 600 or Dionex ERS 500e suppressor. The Dionex DRS 600 and Dionex ERS 500e are fully compatible with SRS settings.

  • Page 24: Assembly

    1.0 ft. mL/min The correct amount of back pressure for optimum operation is 40 psi for carbonate eluents. Back pressure over 450 psi after the Dionex DRS 600, Dionex ERS 500e or Dionex AERS 500 Carbonate can cause irreversible damage. CAUTION RFIC hydroxide and MSA applications may be operated with as little as 10 psi of backpressure, or even without any backpressure coils.

  • Page 25: Gas Separator Waste Tube For The Dionex Ers 500

    2.4 Gas Separator Waste Tube for the Dionex ERS 500 The Gas Separator Waste Tube (Item # 045460) is an integral part of the Dionex DRS 600 system. It separates any electrolytic gases generated in the Dionex DRS 600, Dionex ERS 500e or Dionex AERS 500 Carbonate during electrolysis.

  • Page 26: Manually Setting The Voltage

    Instrument Method  The DRS Voltage is set back to the default voltage setting on the Chromeleon ePanel or commanded from an Instrument Method Thermo Scientific Product Manual for the DRS 600 Suppressor Page 26 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.
  • Page 27 Figure 5 Instrument Method Wizard Figure 6 Setting a User set Voltage in the Instrument Method Wizard Thermo Scientific Product Manual for the DRS 600 Suppressor Page 27 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 28: Suppressor Current Setting

    2.6.1 Calculating the Optimum Current Setting If using a Dionex DRS 600 in Legacy Mode, a Dionex ERS 500e or Dionex AERS 500 Carbonate suppressor, the optimum current setting depends on the eluent concentration, sample counterion concentration, flow rate, and mode of operation. If the sample counterion concentration exceeds the eluent concentration, use the sample counterion concentration in the calculation discussed below.
  • Page 29 50, 100, 300 or 500 mA. A lower flow rate requires a lower current. A 2 mm Dionex DRS 600 or Dionex ERS 500e should NEVER be operated at a current above 150 mA. A 2 mm Dionex AERS 500 Carbonate should NEVER be operated at a current above 30 mA.

  • Page 30: Operating Drs 600 Suppressor With Chromeleon

    Dionex Integrion HPIC System, you should ensure that you are using Chromeleon (CM) version 7.2.7 or later. If you don’t have this, your suppressor will operate exactly like the previous Thermo Scientific™ Dionex™ ERS 500 suppressor. Firmware and Software Requirements for Thermo Scientific™ Dionex™ ICS 6000™...

  • Page 31: Programming The Drs 600 Suppressor With Chromeleon

    2.7.2 Programming the DRS 600 Suppressor with Chromeleon The default power mode of operation for a Dionex DRS 600 suppressor is the Dynamic Mode or Constant Voltage. DRS can be operated under constant current power mode (CC) as well. To achieve this, change power mode from Dynamic (CV) to Legacy mode (CC).
  • Page 32 – Installation Figure 7 Changing Mode in the ePanel Thermo Scientific Product Manual for the DRS 600 Suppressor Page 32 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.
  • Page 33 Legacy Power Mode Setting). The current can be set from the System wizard or from the Instrument Method. For setting the optimum current setting for the suppressor, please refer to Section 2.6. Thermo Scientific Product Manual for the DRS 600 Suppressor Page 33 of 92 031956-13 For Research Use Only.
  • Page 34 – Installation Figure 9 Accessing Chromeleon Settings Figure 10 View as Expert Setting Thermo Scientific Product Manual for the DRS 600 Suppressor Page 34 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.
  • Page 35 Next view or choose the power mode. To change the mode select “Constant Current” or “Constant Voltage” Note that by default, the power mode is set to Constant Voltage or CV. Thermo Scientific Product Manual for the DRS 600 Suppressor Page 35 of 92 031956-13 For Research Use Only.
  • Page 36 Figure 12 Accessing Chromeleon settings in the Expert view Figure 13 Choosing the Electrolytics Tab in Integrion System Thermo Scientific Product Manual for the DRS 600 Suppressor Page 36 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.
  • Page 37 – Installation Figure 14 Choosing the Suppressor Tab Thermo Scientific Product Manual for the DRS 600 Suppressor Page 37 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 38: Operating The Drs 600 With A New Method With Integrion And Ics 6000

    Operating the DRS 600 with ICS 6000 with the Legacy Instrument Method DRS 600 suppressor operates in the Dynamic mode as a default with CV as the power mode. Thermo Scientific Product Manual for the DRS 600 Suppressor Page 38 of 92 031956-13 For Research Use Only.
  • Page 39 The CC commands are ignored and the recommended voltage is applied since the mode is Dynamic. The audit trail will capture the applied voltage information. Also, note that the method captures the mode of operation. Thermo Scientific Product Manual for the DRS 600 Suppressor Page 39 of 92 031956-13 For Research Use Only.

  • Page 40: Operating The Drs 600 With Integrion With The Legacy Instrument Method

    Legacy instrument method (Figure 17) e) Save the method. The Legacy Instrument method will operate in the Constant Voltage mode. The audit trail will capture the Voltage information. Thermo Scientific Product Manual for the DRS 600 Suppressor Page 40 of 92 031956-13...
  • Page 41 – Installation Figure 16 Deleting a command line in the Script while using Legacy Instrument Method in CC mode Thermo Scientific Product Manual for the DRS 600 Suppressor Page 41 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.
  • Page 42 No additional script changes are required. The Power mode can be Constant Voltage or Constant Current. Thermo Scientific Product Manual for the DRS 600 Suppressor Page 42 of 92 031956-13 For Research Use Only.

  • Page 43: Operation

    – Operation 3. Operation This section provides instructions for the start-up and operation of the Dionex DRS 600, Dionex ERS 500e and Dionex AERS 500 Carbonate suppressors, including the selection process and suppression modes of operation. 3.1 Chemical Purity Requirements Precise and accurate results require eluents free of ionic impurities;...

  • Page 44: Start-Up

    – Operation 3.2 Start-up The Dionex DRS 600, Dionex ERS 500e or Dionex AERS 500 Carbonate is installed in the column or detector chamber of the chromatography module right after the analytical column and before the conductivity detector cell. On the Dionex ICS-6000, the suppressor mounts on the conductivity detector module in the DC.

  • Page 45: Hydration

    NOTE Thermo Scientific Product Manual for the DRS 600 Suppressor Page 45 of 92 031956-13 For Research Use Only.

  • Page 46: Back Pressure Coil Pressure Test

    If it is less than 30 psi (carbonate eluents) or 10 psi (other eluents), then add more tubing to achieve 30 – 40 psi (carbonate eluents) or 10 – 40 psi (other eluents). Thermo Scientific Product Manual for the DRS 600 Suppressor Page 46 of 92 031956-13 For Research Use Only.

  • Page 47: Quick Back Pressure Check

    3.3 Plumbing for the AutoSuppression Recycle Mode Operation Figure 18 The Auto Suppression Recycle Mode Plumbing Diagram Thermo Scientific Product Manual for the DRS 600 Suppressor Page 47 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 48: Eluent Flow Path Connections In The Autosuppression Recycle Mode

    0.010” i.d. PEEK tubing (black) with 10-32 ferrule/bolt fittings on 4 mm systems. Avoid adding dead volume to the system by keeping all eluent lines as short as possible. A. Install the Dionex DRS 600, Dionex ERS 500e or Dionex AERS 500 Carbonate inside the Dionex ICS Module.

  • Page 49: Installation In Thermal Chamber

    20° C is ideal. NOTE If using a Dionex DRS 600 in Legacy Mode, a Dionex ERS 500e or Dionex AERS 500 Carbonate, set the required current based on your specific application requirements for column flow rate and temperature in addition to eluent concentration. If using Chromeleon software, the Wizards can greatly assist you in determining the correct requirements.

  • Page 50: Plumbing For The Autosuppression External Water Mode Operation

    NOTE destructive detection technique such as PCR-UV/Vis or Mass Spec is employed. Thermo Scientific Product Manual for the DRS 600 Suppressor Page 50 of 92 031956-13 For Research Use Only.

  • Page 51: Eluent Flow Path Connections For The Autosuppression External Water Mode

    4 mm systems. Avoid adding dead volume to the system by keeping all eluent lines as short as possible. A. Install the Dionex DRS 600, Dionex ERS 500e or Dionex AERS 500 Carbonate in the first slot inside the Chromatography Module.

  • Page 52: Regenerant Flow Path Connections In The Autosuppression External Water Mode With Peristaltic Pump

    ® Peristaltic Pump Quick Start Guide” (Item # 065203). For the Dionex DRS 600, Dionex ERS 500e or Dionex AERS 500 Carbonate plumbing refer to Figure 19, The AutoSuppression External Water Mode Plumbing Diagram and pump the Deionized water into the “Regen in” port of the suppressor using the peristaltic pump at the same flow rate as the eluent flow rate.

  • Page 53: Installation In Thermal Chamber

    3.5 Plumbing for Chemical Suppression Mode Operation The Dionex DRS 600, Dionex ERS 500e and Dionex AERS 500 Carbonate can be used in the Chemical Suppression Mode; however, the total suppression reduced compared to a Chemically Regenerated Suppressor.

  • Page 54: Regenerant Flow Path Connections In Mpic Suppression Mode Using Pressurized Water Delivery System

    The Dionex Suppressor Installation Kit (Item # 038018) contains all of the components needed to install and operate a Dionex DRS 600 or Dionex ERS 500e with a pressurized regenerant reservoir. The kit contains the Suppressor Installation Parts Kit (Item # 039055), a 25-psi regulator (Item # 038201), and a 4-liter regenerant reservoir (Item # 039164).
  • Page 55 Organic eluent solvents levels should be kept NOTE below 40%. Thermo Scientific Product Manual for the DRS 600 Suppressor Page 55 of 92 031956-13...

  • Page 56: Plumbing For Neutralization Mode Operation

    B. Connect the eluent line from the Sample Injection Valve to the ELUENT IN port of the Dionex DRS 600. C. Connect the ELUENT OUT port of the Dionex DRS 600 to Port 5 of the Injection Valve in the analytical system.

  • Page 57: Pump Trap Column Installation And Regeneration

    Using a coupler (Item # 039056) and a 1/8” OD piece of tubing (Item # 035728) from the AutoNeutralization Ship Kit, connect one end of this line to the REGEN OUT port of the Dionex DRS 600 and then connect the other end of the line to the Gas Separator Waste Tube.

  • Page 58: Neutralization Mode Operation

    D. Common bases or acids that have been diluted fourfold or more can be completely neutralized after one pass through the Dionex DRS 600 at flow rates ≤ 0.5 mL/min. E. After complete neutralization, the sample is delivered to the injection valve of the Dionex...

  • Page 59: Dionex Drs 600, Dionex Ers 500E Or Dionex Aers 500 Carbonate Storage

    3.8 Dionex DRS 600, Dionex ERS 500e or Dionex AERS 500 Carbonate Storage The Dionex DRS 600, Dionex ERS 500e and Dionex AERS 500 Carbonate are shipped with deionized water as the storage solution. If the suppressor will not be used for more than three days, prepare it for storage.

  • Page 60: Example Neutralizer Mode Applications

    Dionex IonPac TCC-XLP1 (Item # 063889) should be used to concentrate the trace anions or cations in the sample neutralized by the Dionex DRS 600. The use of other concentrators may result in excessive back pressure to the Dionex DRS 600, thus damaging the suppressor.

  • Page 61: Cation System Blank

    Dionex CDRS 600. To reduce the amine blank, follow the Dionex DRS 600 start-up procedure in Section 3.2, “Start- up Procedure for the Dionex Dynamically Regenerated Suppressor (Dionex DRS 600).” The amine blank is normally reduced to a constant level after 24 hours of operation.

  • Page 62: System Calibration

    The addition of a complexing agent such as pyridine- 2,6-dicarboxylic acid (PDCA, Item # 039671) to the CS12A eluent is required to selectively remove transition metals from the eluent via the suppression system. Detection Limits of Dionex DRS 600 Sample Pretreatment and Subsequent Ion Chromatography Anion ppb*...

  • Page 63: Anion Example Applications

    0.5-5.0 mM NaOH in 3.5 min 5.0-38.25 mM NaOH in 12 min 18.0 The steps for sample neutralization can be performed while the Thermo Scientific Dionex IonPac AS11 is equilibrating with the starting eluent (90% E1/10% E2). NOTE Seven minutes are required at the beginning of the above program for equilibration of the Dionex IonPac AS11 with E1 prior to injecting the next sample.

  • Page 64: Dionex Ionpac As11 Gradient Analysis Of 10% Sodium Hydroxide

    With Guard: 1,850 psi (12.75 MPa) Figure 21 Dionex IonPac AS11 Gradient Analysis of Blank, Standard, 10% NaOH Sample and Spiked 10% NaOH Sample Thermo Scientific Product Manual for the DRS 600 Suppressor Page 64 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.
  • Page 65 0.072 2.072 2.303 ND = None Detected The following examples demonstrates sample neutralization can be performed with the Thermo Scientific Dionex IonPac AS12A column using the ADRS 600 suppressor Thermo Scientific Product Manual for the DRS 600 Suppressor Page 65 of 92 031956-13 For Research Use Only.

  • Page 66: Dionex Ionpac As12A Isocratic Analysis Of 25% Sodium Hydroxide

    See Table 10 Figure 22 Dionex IonPac AS12A Isocratic Analysis of Blank, Standard, 25% NaOH Sample and Spiked 25% NaOH Sample Thermo Scientific Product Manual for the DRS 600 Suppressor Page 66 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.
  • Page 67 0.100 0.134 + 0.028 0.234 0.238 + 0.022 Based on 8 runs ND = None Detected Thermo Scientific Product Manual for the DRS 600 Suppressor Page 67 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 68: Dionex Ionpac As12A Isocratic Analysis Of 20% Ammonium Hydroxide

    5. Nitrate 7. Sulfate 8. Oxalate Figure 23 Dionex IonPac AS12A Analysis of 20% Ammonium Hydroxide Thermo Scientific Product Manual for the DRS 600 Suppressor Page 68 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 69: Dionex Ionpac As12A Isocratic Analysis Of 25% Tetramethylammonium Hydroxide

    Analyte 1. Chloride 7. Sulfate 8. Oxalate Figure 24 IonPac AS12A Analysis of 25% Tetramethylammonium Hydroxide Thermo Scientific Product Manual for the DRS 600 Suppressor Page 69 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 70: Ionpac As12A Isocratic Analysis Of 25% Tetrabutylammonium Hydroxide

    3. Nitrate 7. Sulfate 8. Oxalate Figure 25 Dionex IonPac AS12A Analysis of 25% Tetrabutylammonium Hydroxide Thermo Scientific Product Manual for the DRS 600 Suppressor Page 70 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 71: Cation Example Applications

    – Example Applications 4.5 Cation Example Applications The following examples demonstrates sample neutralization can be performed with the Thermo Scientific Dionex IonPac CS12A column using the CDRS 600 suppressor 4.5.1 Dionex IonPac CS12A Blank and Standard Analysis Sample: 100 µL of Standard or Blank neutralized in the Dionex CDRS 600 Concentrator Column: Low Pressure Trace Cation Concentrator (i.e.

  • Page 72: Dionex Ionpac Cs12A Analysis Of 24% Sulfuric Acid

    10.6 + 0.1 30.6 33 + 1 Based on 8 runs ND = None Detected, B = Blank Thermo Scientific Product Manual for the DRS 600 Suppressor Page 72 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 73: Dionex Ionpac Cs12A Analysis Of 25% Acetic Acid

    5. Trimethylamine 6. Magnesium 7. Calcium 133.0 Figure 28 Dionex IonPac CS12A Analysis of 25% Acetic Acid Thermo Scientific Product Manual for the DRS 600 Suppressor Page 73 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 74: Dionex Ionpac Cs12A Analysis Of 10% Hydrofluoric Acid

    7. Magnesium 15.3 8. Calcium 59.6 Figure 29 Dionex IonPac CS12A Analysis of 10% Hydrofluoric Acid Thermo Scientific Product Manual for the DRS 600 Suppressor Page 74 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 75: Dionex Ionpac Cs12A Analysis Of 22% Phosphoric Acid

    6. Magnesium 22.4 7. Calcium 144.1 Figure 30 Dionex IonPac CS12A Analysis of 22% Phosphoric Acid Thermo Scientific Product Manual for the DRS 600 Suppressor Page 75 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 76: Troubleshooting Guide

    The purpose of the Troubleshooting Guide is to help you solve operating problems that may arise while using the Dionex DRS 600, Dionex ERS 500e or Dionex AERS 500 Carbonate. For more information on problems that originate with the Ion Chromatograph System or the specific exchange column set in use, refer to the Troubleshooting Guide in the appropriate Product Manual.

  • Page 77: Small Or Increasing Analyte Peak Areas

    – Troubleshooting Guide 5.2 Small or Increasing Analyte Peak Areas This problem is caused by running eluent through the Dionex DRS 600, Dionex ERS 500e, or Dionex AERS 500 Carbonate with the power off while using the AutoSuppression Recycle Mode or the AutoSuppression External Water Mode.

  • Page 78: Suppressor Electrolytic Regeneration Steps

    5.2.2 Suppressor Electrolytic Regeneration Steps A. The Dionex DRS 600, Dionex ERS 500e and Dionex AERS 500 Carbonate are unique that they can be regenerated electrolytically. Although this is slower than Chemical Regeneration, it does not require the suppressor to be disconnected or the use of any reagents.
  • Page 79 NOTE Do not use the Analytical pump for regeneration purpose as this would contaminate the pump NOTE Thermo Scientific Product Manual for the DRS 600 Suppressor Page 79 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 80: High Background Conductivity

    A. Run the “Optimizing the default voltage to a target application” procedure to optimize the Dionex DRS 600 default voltage. B. Check the Dionex DRS 600 (Legacy Mode only), Dionex ERS 500e or Dionex AERS 500 Carbonate current settings. Refer to the suppressor current settings; see Section 2.6.

  • Page 81: Noisy Baseline

    In the above figure, a bubble is released from ELUENT IN line by loosening and tightening the fitting at 56.6 minutes into the run. Noise: ~2.5 nS before < 0.5 nS after Thermo Scientific Product Manual for the DRS 600 Suppressor Page 81 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

  • Page 82: Decreased Sensitivity

    A. Check for leaks throughout the system. If a fitting is leaking, tighten it carefully until the leak stops. Do not over tighten. If the Dionex DRS 600, Dionex ERS 500e or Dionex AERS 500 Carbonate is observed to be leaking from the center or bottom seam, see Section 5.8, “Liquid Leaks.”...

  • Page 83: System Back Pressure Increases Over Time

    ERS 500 into the housing and check the back pressure after the suppressor. B. If there is liquid coming out of any of the four ports of the Dionex DRS 600, Dionex ERS 500e or Dionex AERS 500 Carbonate, carefully tighten the fittings in the leaking port –...

  • Page 84: Poor Or Unstable Recovery Of Certain Peaks

    (See Section 6.1, “Metal Contaminants or Precipitates”). 5.10 Peaks and spikes in the absence of an injection A. Excessive current applied to the Dionex DRS 600 (Legacy Mode only), Dionex ERS 500e or Dionex AERS 500 Carbonate: Recalculate the optimum current and apply; never apply more than 10% above the optimum current except when executing the Electrolytic Regeneration Steps.

  • Page 85: Low Sample Response (Neutralization Mode Only)

    5.11 Low Sample Response (Neutralization Mode Only) A. If the Dionex DRS 600 is observed to be leaking, see Section 5.8. “Liquid Leaks.” B. Ensure the Sample Injection Valve and Recycle Valve are operating correctly. Refer to the valve manuals that accompany the valves.

  • Page 86: Dionex Drs 600, Dionex Ers 500E And Dionex Aers 500 Carbonate Suppressor Cleanup

    NOTE 031841-02 “Removal of Iron Contamination from Electrolytic Suppressors.” For the Dionex DRS 600 in Legacy Mode, as well as the Dionex ERS 500e and Dionex AERS 500 Carbonate, the suppressor voltage is a good indicator of the resistance across the suppressor.

  • Page 87: Organic Contaminants

    G. Reinstall the analytical (and guard) column(s). Begin pumping eluent through the system at the flow rate required for your analysis and equilibrate the system and resume normal operation. Thermo Scientific Product Manual for the DRS 600 Suppressor Page 87 of 92 031956-13 For Research Use Only.

  • Page 88: Appendix A - Current Settings

    Optimum Current Settings for Common Eluents; Dionex AERS 500 (4 and 2 mm) Legacy Mode, and Dionex AERS 500e (4 and 2 mm) The Dionex DRS 600, when operated in Dynamic Mode, does not require the setting of the electrical current.
  • Page 89 (50, 100, 300 and 500 mA) current settings. For optimum performance, it is recommended to use a Dionex RFC-10 or Dionex RFC-30 power supply to provide fine current control with the optimum setting. Thermo Scientific Product Manual for the DRS 600 Suppressor Page 89 of 92 031956-13 For Research Use Only.

  • Page 90: Optimum Current Settings For Common Eluents; Dionex Aers 500 Carbonate (4 And 2 Mm)

    External Water Mode is the mode used if organic solvents (up to 40%) are present in the eluent. It eliminates the potential for buildup of contaminating ions resulting from the oxidation of solvents. Thermo Scientific Product Manual for the DRS 600 Suppressor Page 90 of 92 031956-13 For Research Use Only.

  • Page 91: Optimum Current Settings For Common Eluents; Dionex Cers 500 (4 Mm And 2 Mm) And Dionex Cers 500E (4 Mm And 2 Mm)

    Optimum Current Settings for Common Eluents; Dionex CERS 500 (4 mm and 2 mm) and Dionex CERS 500e (4 mm and 2 mm) The Dionex DRS 600, when operated in Dynamic Mode, does not require the setting of the electrical current.
  • Page 92 2 mL/min (2 mm suppressors) Maximum External Water Flow Rate 5 mL/min (4 mm suppressors) Measured with power ON using a graduated cylinder Thermo Scientific Product Manual for the DRS 600 Suppressor Page 92 of 92 031956-13 For Research Use Only. Not for Use in Diagnostic Procedures.

This manual is also suitable for:

Dionex ers 500eDionex ers 500

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