Alesis MultiMix12USB Supplementary Manual page 6

Multimix 8USB users:
1. Turn down the LEVEL, MAIN MIX, and HDPH/CTRL RM knobs.
2. Make sure that the 2 TK TO MIX button is DOWN and the 2 TK TO CTRL
ROOM button in UP, otherwise you'll hear horrible (and LOUD!) feedback
when you turn up the MAIN MIX knob later.
3. Connect the 2 TRACK OUT of the mixer to the 2 TRACK IN with an RCA
cable.
4. Record-Enable a track in Cubase LE and make sure input monitoring is
turned off in the program (if input monitoring is on, you'll hear a delayed
echo of your voice or instrument because of computer latency.)
5. Set each channel's GAIN and LEVEL knobs so that you're getting good
level without lighting the PEAK indicator on the mixer.
The MAIN MIX knob now acts like a master-volume knob for all your mic/line
inputs. Adjust this knob until you're getting good levels into Cubase.
The HDPH/CTRL RM knob now controls the loudness of your headphones
(or studio monitors), but does not affect recording levels in Cubase. You can
set this level to a comfortable setting (or even off) without affecting what gets
recorded into Cubase.
You can now can record into your computer without any latency.