Table of Contents
Summary of Contents for Severn LS40/60
- Page 1 L S 4 0 / 6 0 F R E E Z E D R Y E R LS40/60 Freeze Dryer Instruction Manual Severn Science Limited 4 Short Way Thornbury Bristol BS35 3UL Info@severnscience.co.uk Tel: 01454 414723 Fax: 01454 281680...
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Page 2: Table Of Contents
L S 4 0 / 6 0 F R E E Z E D R Y E R CONTENTS INTRODUCTION Scope General safety General description 1.3.1 Freeze Drying – Basic Principles 1.3.2 The Condenser Unit 1.3.3 The Drying Chamber 1.3.4 Control System TECHNICAL DATA INSTALLATION... - Page 3 L S 4 0 / 6 0 F R E E Z E D R Y E R Running a Freeze Drying Cycle 4.6.1 Run a program Now 4.6.2 Run a program from a Point 4.6.3 Scheduling a Program 4.6.4 End of Program Sequence (EPS) Program Monitoring 4.7.1...
- Page 4 L S 4 0 / 6 0 F R E E Z E D R Y E R ALARMS Alarm Acknowledgment Alarm History Alarm Note Alarm History Archive MAINTENANCE Maintenance Plan Vacuum pump Oil level Oil Mist Filter Element Oil Drain Kit Change Vacuum Pump Oil Vacuum Pump Service Door Seals...
- Page 5 Thornbury, Bristol BS35 3UL England Model / Serial No: Date of Issue: Severn Science Limited hereby declares that the above product conforms with the essential protection requirements Low Voltage Directive 73/23/EEC amended by 93/68/EEC. EMC Directive 89/336/EEC as amended by 92/31/EEC.
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Page 6: Introduction
L S 4 0 / 6 0 F R E E Z E D R Y E R 1.0 INTRODUCTION 1.1 SCOPE This manual provides installation and operation instructions for the LYOSCIENCE LS40 and LS60 freeze dryers. The manual and all accompanying documentation must be read before operating the equipment. -
Page 7: General Safety
Standard LS40 and LS60 freeze dryers are not suitable for use with Sodium Azide. Please contact Severn Science if you wish to use Sodium Azide; the equipment can be modified by the manufacturer for safe operation with Sodium Azide if required. -
Page 8: The Condenser Unit
L S 4 0 / 6 0 F R E E Z E D R Y E R 1.3.2 THE CONDENSER UNIT The condenser unit consist of a cylindrical chamber (290 X 620 mm) with an inlet port situated near the front of the chamber and a 25 mm outlet port positioned at the rear of the chamber. -
Page 9: Control System
Temperatures measured on shelves. LS40 (to –40 220 minutes LS60 (to –55 130 minutes LS60 (to –60 160 minutes Maximum shelf temperature LS40/60 Temperature uniformity (between shelves) LS40/60 + 0.6 Temperature uniformity (across each shelf) LS40/60 + 0.3 Temperature control LS40/60 + 0.2... -
Page 10: Installation
L S 4 0 / 6 0 F R E E Z E D R Y E R Vacuum Pump LS40/60 1. Type Edwards RV12 2. Nominal Pumping speed 12 m 3. Pump down time (to 0.5 mbar) Approx 10 minutes... -
Page 11: Preparation Of Vacuum Pump
/ air conditioning to ensure that the temperature at the inlet to the refrigeration heat exchangers is kept below 30 C. Please consult with Severn Science for further details. After placement, remove all panels to carry out initial inspection (see sections 3.3 and 3.4). -
Page 12: Preparation Of Refrigeration System
The oil level in the reservoir can be checked again when the panels are refitted by comparison with the MIN / MAX levels on the panel viewing port. If the oil level is low, do not use the equipment and contact Severn Science immediately. - Page 13 Greyed out wording Black wording Users can be designated during commissioning by the Severn Science engineer or at any time after installation by following the procedure below: a) Log on as per the above procedure taking the id and password information from Table 3 (according to the level of access required).
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Page 14: Switch On Condenser
L S 4 0 / 6 0 F R E E Z E D R Y E R The new user can then log on using the new password at the designated security level. Note: The id is not user adjustable. Table 3. -
Page 15: Switch On Shelf Refrigeration
L S 4 0 / 6 0 F R E E Z E D R Y E R 4.4 SWITCH ON SHELF REFRIGERATION Security level : Operator or supervisor Cooling of the shelves in the drying chamber is provided by a separate refrigeration system. -
Page 16: Running A Freeze Drying Cycle
L S 4 0 / 6 0 F R E E Z E D R Y E R Table 4: Vial Capacity and Inter-shelf Distances Vial Diameter (mm) Vial Capacity 3 shelf 4 shelf 5 Shelf Per Shelf 13.5 2808 3744 4680 22.0... -
Page 17: Run A Program From A Point
L S 4 0 / 6 0 F R E E Z E D R Y E R c) Press the PROGRAMS button. The Load/Save Program screen will be displayed. d) Press the file name field . A list of program names will appear in the Options Menu (see figure 2 (c) ). -
Page 18: Scheduling A Program
L S 4 0 / 6 0 F R E E Z E D R Y E R f) Press the LOAD button. At this stage, the Programmer menu screen will appear. The program name and status will be displayed in the program panel in the top left hand corner of the screen. -
Page 19: End Of Program Sequence (Eps)
L S 4 0 / 6 0 F R E E Z E D R Y E R i) Press the ACCEPT button. The program will automatically start at the date and time shown in green at the top of the screen. 4.6.4 END OF PROGRAM SEQUENCE (EPS) The EPS function allows the user to select a method to complete the cycle after the initial freeze drying program is complete. -
Page 20: Program Monitoring
L S 4 0 / 6 0 F R E E Z E D R Y E R CAUTION When using the stoppering facility (automatic or manual), the stoppering jacks provided must be used. Instructions to set up the stoppering jacks are described in figure 4. -
Page 21: Trends
L S 4 0 / 6 0 F R E E Z E D R Y E R function of time (‘X’ axis). Actual and set point data is colour coded as per the legends displayed on the right hand side of the screen. To review historical data and to zoom in on different parts of the graph, press the OPTIONS printed key (see figure 2(a) ) followed by the VIEW button. -
Page 22: Stoppering
L S 4 0 / 6 0 F R E E Z E D R Y E R Press the ABORT button. The program will abort and the program panel will change to white and read ‘IDLE’. The program can then be run again from the start or a new program loaded (see section 4.6). -
Page 23: Condenser Defrost
L S 4 0 / 6 0 F R E E Z E D R Y E R 4.12 CONDENSER DEFROST Security level : Operator or Supervisor To turn the condenser off, press the field labelled ‘CONDENSER RUNNING’ from the Home screen. - Page 24 L S 4 0 / 6 0 F R E E Z E D R Y E R To configure the segment headings follow the instructions below: a) Press the segment heading that must be modified. A box displaying data about the segment will appear.
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Page 25: Save / Save As
L S 4 0 / 6 0 F R E E Z E D R Y E R 5.1 SAVE / SAVE AS To save the updated program under the same file name after editing is complete, or to save the program as a new file name, follow the procedure below. To insert or delete segments prior to saving, see sections 5.2 and 5.3 respectively. -
Page 26: Amending The End-Of-Program Sequence
L S 4 0 / 6 0 F R E E Z E D R Y E R 5.4 AMENDING THE END-OF–PROGRAM SEQUENCE (EPS) To amend the set points in the end-of-program sequence, first select the EPS screen. a) Automatic EPD. To amend the pressure rise limit, press the field labelled ‘mbarl/s’. Enter the required rate (in scientific notation) on the numeric keypad and press the green RETURN button. -
Page 27: Changing Logging Configuration
L S 4 0 / 6 0 F R E E Z E D R Y E R 6.1 CHANGING LOGGING CONFIGURATION Several data logging functions (e.g., archive interval, file type/name) are factory set. However, the logging configuration can be changed if necessary, as follows: a) Press the MENU printed key. -
Page 28: Alarms
L S 4 0 / 6 0 F R E E Z E D R Y E R From this screen, pressure and temperature set points and the positions of system valves can be changed by pressing the appropriate field and either selecting an option from the menu or inputting the required value on the keypad. -
Page 29: Alarm Acknowledgment
L S 4 0 / 6 0 F R E E Z E D R Y E R CODE DESCRIPTION CAUSE FAIL-DRY APG Failure of drying chamber pirani APGX1 calibration out of limits/ gauge filament failure FAIL-COND APG Failure of condenser chamber APGX2 calibration out of limits / pirani gauge filament failure. -
Page 30: Alarm History Archive
L S 4 0 / 6 0 F R E E Z E D R Y E R The note is then added to the alarm history, where it is displayed along with its time of entry. 8.4 ALARM HISTORY ARCHIVE Security level: Operator or Supervisor The Archive facility permits the current alarm history to be saved in ASCII format to floppy disc. -
Page 31: Vacuum Pump Oil Level
L S 4 0 / 6 0 F R E E Z E D R Y E R Table 7: Maintenance Plan OPERATION FREQUENCY REFER TO SECTION Check the vacuum pump Weekly oil level Change the oil mist filter 6 Monthly element Inspect the oil drain kit Monthly... -
Page 32: Door Seals
L S 4 0 / 6 0 F R E E Z E D R Y E R pump out of the framework. Inspect and clean the vacuum pump inlet filter, gas ballast control, oil sight glass and motor fan cover, as described in the pump instruction manual. When refitting, ensure that all fittings are correctly reconnected to the vacuum pump. - Page 33 L S 4 0 / 6 0 F R E E Z E D R Y E R Figure 1. Freeze Dryer layout SILICONE OIL RESERVOIR TOUCH SCREEN CONTROLLER DRYING CHAMBER REFRIGERATED SHELVES CONDENSER CHAMBER WITH INTEGRAL VACUUM PUMP DRAIN ACCESS PANEL Publication reference 1HZ204-1...
- Page 34 L S 4 0 / 6 0 F R E E Z E D R Y E R Figure 2(a). Controller Layout TEST PROG IDLE ???? HOME 12:52:29 19/05/01 TEMP . -80.0 C TEMP . -60.0 C PRESS. 1.0E-02 mbar PRESS. 7.0E-01mbar Options key CONDENSER RUNNING REFRIGERATION ON...
- Page 35 L S 4 0 / 6 0 F R E E Z E D R Y E R Figure 2(c). Drop down menu (option list) Selecting certain fields will reveal a drop down menu with an options list. TEST PROG IDLE ???? CONDENSER RUNNING...
- Page 36 L S 4 0 / 6 0 F R E E Z E D R Y E R Figure 2(e). Keyboard Selecting certain fields reveals a keyboard for text entry TEST PROG IDLE ???? HOME 19/05/01 12:52:29 PASSWORD Q W E R T Y U I O P Q W E R T Y U I O P TEMP .
- Page 37 L S 4 0 / 6 0 F R E E Z E D R Y E R Figure 3. Status screen The status screen provides a summery of the present condition of the freeze dryer functions. Note: Any conditions highlighted in RED will prevent an automatic program cycle from running.
- Page 38 L S 4 0 / 6 0 F R E E Z E D R Y E R Figure 4. Stoppering Jacks Height adjustable shaft 19mm jack base Lock nut 49mm jack base Vial height Jack base required Cap screw shaft length required 32mm –...
- Page 39 L S 4 0 / 6 0 F R E E Z E D R Y E R Figure 5. The pre-plot facility TEST PROG IDLE ???? PROG 1 19/05/01 12:52:29 CONDENSER TEMP TEMP . -80.0 C TEMP . -60.0 C Condenser 7.5 deg C temperature...
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Page 40: Manufacturers Literature
L S 4 0 / 6 0 F R E E Z E D R Y E R Appendix 1: Manufacturers Literature a) T800/T2900 Visual Supervisor (Eurotherm Controls) b) 2500 PID controller (Eurotherm Controls) c) 605 series drive unit (Eurotherm Controls) d) Cascade refrigeration system (Ernest West &... -
Page 41: List Of Drawings
L S 4 0 / 6 0 F R E E Z E D R Y E R Appendix 2: List of Drawings Electrical circuit diagram, 7705 rev A Publication reference 1HZ204-1...
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