Related Manuals for XCell ATF4
Summarization of Contents
Description of XCell ATF System and Process
XCell ATF System Control Scope and Objectives
Details the scope and objectives for controlling XCell ATF systems with the C410:V3 controller.
XCell ATF Pump Housing and Controller Pairings
Lists the compatible pairings between XCell ATF pump housings and C410:V3 controllers.
XCell System Interconnectivity Drawing
Illustrates the interconnectivity between the C410:V3 controller and XCell ATF system components.
C410:V3 Controller Layout
General Layout
Describes the modular design of the controller's E-Box and P-Box components and their interconnections.
Filtration Assembly
Details the components included in the Filtration Assembly, such as the pump and housing.
Primary Pneumatic Services
Explains the air inlet and exhaust/vacuum lines connected to the Pneumatic Box (P-Box).
Primary Electric Services
Details the electric plug, power switch, and stop buttons located on the E-Box and P-Box.
Signal
Describes sensor input plugs, Ethernet communication, and relay outputs on the controller.
C410:V3 Ethernet set-up and Connectivity
Covers Profinet communication, Ethernet configuration, and IP settings for HMI and PLC.
C410:V3 Controller Process and Control
Interface and screens
Details the Operator Interface Terminal (OIT) screens and features available to the user.
Control Overview
Provides fundamental rules for diaphragm motion and stroke travel for optimal system results.
Start-up
Guides users through the initial setup and connection of the XCell ATF System to a bioreactor.
Examples
Offers examples of process control settings to assist users in selecting operating conditions.
Hollow Fiber Module and Diaphragm Replacement
Separating the Filtration Assembly from the bioreactor
Step-by-step instructions for disconnecting the Filtration Assembly from the bioreactor.
HFM removal
Procedure for removing the Hollow Fiber Module (HFM) from the filter housing.
HFM insertion
Guidance on inserting a new Hollow Fiber Module (HFM) into the filter housing.
Screen Module replacement
Instructions for replacing the Screen Module (SM) if used, directing users to contact Repligen.
Diaphragm replacement
Procedures for replacing the diaphragm in the Diaphragm Pump for various XCell ATF system models.
Assembly
Guidance on fully assembling the Diaphragm Pump, Filter Housing, and accessories post-replacement.
Use
Instructions for reconnecting the Filtration Assembly to the bioreactor after replacement and testing.
Sterilization
Preparation of Filtration Assembly for autoclaving
Checklist and procedures for preparing the Filtration Assembly for steam sterilization (autoclaving).
Autoclave Cycle
Details typical autoclave conditions and cycle parameters for effective system sterilization.
Sterilization of Filtrate / Harvest line
Guidance on sterilizing the filtrate and harvest lines, including tubing and connection methods.
Connection to Bioreactor
Hard Connection
Procedure for making a hard connection, typically used with stainless steel bioreactors and steam.
Maintenance
Diaphragm
Recommendations for diaphragm replacement and proper seating for optimal performance.
Pump Air Inlet Filter
Information on replacing the pump air inlet filter based on system configuration and autoclaving.
"O" Rings, gaskets and Quick Connects
Guidance on periodic replacement of O-rings, gaskets, and quick connects for system reliability.
Controller Maintenance
Details bi-annual and four-year maintenance tasks for the C410:V3 controller and associated components.
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