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Summary of Contents for Knauer Azura ELH 2.1L
- Page 1 Eluent heater ELH 2.1L Instructions HPLC HPLC Dokument no. V6701...
- Page 2 Support in Germany, Austria and Switzerland: Telephone: +49 30 809727-111 (9-17h, Central European Time) Fax: +49 30 8015010 E-mail: support@knauer.net International support: Contact your local KNAUER partner for support: www.knauer.net/de/Support/Handler-weltweit Publisher: KNAUER Wissenschaftliche Geräte GmbH Hegauer Weg 38 14163 Berlin Telephone: +49 30 809727-0...
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Page 3: Table Of Contents
Table of contents 1. General ................1 About these instructions . - Page 4 Table of contents Ambient conditions ........... . . 12 4.2.1 Installation location .
- Page 5 Table of contents 11. Technical data ..............30 11.1 Main features.
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Page 6: General
In addition to the safety and warning instructions in these operating instructions, the local accident prevention regulations and the national industrial safety regulations apply. You can download these and other instructions from the KNAUER web- site: www.knauer.net/library. Warnings Possible dangers related to the device are distinguished in personal and material damages. -
Page 7: Legal Information
1.4.4 Warranty seal A blue or orange warranty seal is affixed to some devices. A blue seal is used by KNAUER’s Manufacturing or Customer Support ƒ for devices to be sold. After repair, the KNAUER service technician attaches an orange seal ƒ... -
Page 8: Basic Safety Instructions
ƒ hol or medication. They have participated in the installation of an instrument or training ƒ by KNAUER or an authorized company. If users do not meet these qualifications, they have to inform their supervisors. Operator responsibility The operator is any person who operates the device himself or leaves it to a third party for use. -
Page 9: Personal Safety Equipment
Basic safety instructions The obligations of the operator are listed below: Know and follow the applicable work safety regulations. ƒ Identify hazards arising from the working conditions at the place of use ƒ in a risk assessment. Set up operating instructions for the operation of the device. ƒ... -
Page 10: Contamination By Health-Threatening Solvents
Basic safety instructions For example, certain chemicals may cause PEEK capillaries to swell or burst (see chapter “13.2 Plastics“ on page 34). Note that organic solvents are toxic above a certain concentration. For ƒ handling solvents dangerous to health see the following section (see chapter “2.6.2 Contamination by health-threatening solvents“... -
Page 11: Specific Environments
Otherwise there is risk of injury due to falling devices or loose parts. 2.7.2 Hazardous areas Never use the system in potentially hazardous areas without appropriate protective equipment. For more information, contact the KNAUER Cus- tomer Support. 2.7.3 Wet room Do not use the device in wet rooms. -
Page 12: Service Request Form And Decontamination Report
Devices which are shipped without the completed document “Service request form and decontamination report” will not be repaired. If you would like to return a device to KNAUER, make sure to enclose the com- pleted document: www.knauer.net/servicerequest. AZURA® Eluent heater ELH 2.1L Instructions V6701... -
Page 13: Product Information
3. Product information AZURA® L characteristics AZURA® L characteristics The design of the device partly corresponds to that of the AZURA® L product line. The front cover serves as a protection for the eluent heater and its ƒ users, but may also be removed. The eluent heater is a sturdy device due to its large base and low cen- ƒ... -
Page 14: Scope Of Delivery
Product information Scope of delivery The following items are included in the scope of delivery: Power adapter with mains cable ƒ LAN cable ƒ Device ƒ Further applicable documents: Instructions Eluent heater ELH 2.1L (V6701) ƒ Declaration of Conformity ƒ Views 3.5.1 Front view Legend... -
Page 15: Rear View
Product information 3.5.2 Rear view You will find the following connections on the back of the device: Legend Column heating sleeve Connection for exter- nal temperature sen- sors Power connection with mains switch Fuse of the power supply LAN connector Fig. -
Page 16: Symbols And Signs
Product information Symbols and signs The following symbols and labels are located on the device: Symbols Meaning Electric shock hazard. Failure to observe this warning may result in loss of life, serious injury or damage or destruction of the device. Risk of electrostatic discharge, damage to the sys- tem, the device or certain components possible. -
Page 17: Installation And Initial Startup
4. Installation and initial startup Before determining the installation location, read the chapter “Technical data“ on page 30. There you will find all device-specific information on the power supply, the permissible ambient conditions, and air humidity. Note: The intended use be ensured only if the requirements for ambient conditions of the operating environment are met. -
Page 18: Space Requirements
Country-specific plugs: Before switching on the device, check wheth- ƒ er the supplied plug is approved for your country. An overview of the device and country-specific plug types from KNAUER can be found at: www.knauer.net/plugs Power strips: When connecting several devices to a single power strip, ƒ... -
Page 19: Integration Of The Device Into An Hplc System
Installation and initial startup Integration of the device into an HPLC system The ELH 2.1L is integrated into the flow path of the HPLC system, usually between the pump and the column. The device has two capillary connec- tions with UNF 10-32 internal thread for the usual HPLC connections for 1/16"... -
Page 20: Connecting The Drainage System
Installation and initial startup Connecting the drainage system The drainage system ensures that leaked liquids automatically flow into a waste bottle. Prerequisite Remove the front cover. ƒ Procedure Process Figure 1. Carefully push the funnel into the center opening of the capillary guide Fig. -
Page 21: Computer Control
(see chapter 3.5.2 Rear view on page 10). Note: HPLC devices from KNAUER only work with IP addresses, which have been assigned by IPv4. IPv6 is not supported. This chapter describes how to set up a chromatography system in a local area network (LAN) and how a network administrator can integrate this LAN into your company network. -
Page 22: Connecting Devices To Lan
Installation and initial startup 4.8.2 Connecting devices to LAN The switch has several LAN connections. The LAN ports serve to set up a network from devices and a computer. To avoid interference, we recom- mend operating the chromatography system separately from the compa- ny network. -
Page 23: Setting Ip Addresses Via Software
Installation and initial startup Setting IP addresses via software Note: Check the IT security standards for your lab before intervening in the LAN settings. PurityChrom® Static IP addresses are required to run certain chromatography software, e.g.(PurityChrom®). For a comprehensive overview on how to set static IP addresses for PurityChrom®, refer to the document "PurityChrom®... -
Page 24: Operation
ƒ If the device is part of an HPLC system, note the following: The network connection to the router has been established. ƒ The chromatography software has been installed by KNAUER or a ƒ company authorized by KNAUER. Switching on After switching on, the ELH 2.1L carries out a self-test. - Page 25 Operation Fig. 10: Touch display, main menu Each heating zone has its own control panel with a presentation for the set temperature (gray) and the actual temperature (white) and two but- tons for switching the heating circuit on and off ("Power") and for setting the set temperature ("Adjust").
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Page 26: Controlling With Chromatography - Software
Operation The temperature sequences are displayed graphically in the field below the presentation of the 4 heating zones. Use buttons 1, 2, 3 and 4 to show and hide the respective channels in the display. The temperature range and the time resolution can be configured via the "Device" keypad. The communication parameters can be set in the "Network"... -
Page 27: Functionality Tests
Installation Qualification (IQ) The customer may request the Installation Qualification, which is free of charge. In case of a request, the technical support of KNAUER or a pro- vider authorized by KNAUER performs this functionality test during the installation. -
Page 28: Troubleshooting
7. Troubleshooting First measures for troubleshooting: Check all cables and fittings ƒ Check whether air has gotten into the supply lines ƒ Check the device for leakages ƒ Further measures: Compare occurring errors with the list of possible errors (see below) ƒ... -
Page 29: Possible Problems And Rectifications
Troubleshooting Possible problems and rectifications Problem Solution Device cannot be Check the mains cable to ensure that it is switched on. connected to the mains. System breakdown Switch the device off to reset the memory in the device, then switch the device on again. -
Page 30: Maintenance And Care
Maintenance contract The following maintenance work on the device may only be performed by KNAUER or a company authorized by KNAUER and is covered by a separate maintenance contract: Opening the device or removing housing parts ƒ... -
Page 31: Check Screw Fittings
Maintenance and care Check screw fittings Risk of burns Depending on the temperature setting, there is a risk of burns when working on the outlet. Wear protective gloves during your work. Note: Make sure that all screw fittings are tight. If screw fittings are leak- ing, tighten them. -
Page 32: Transport And Storage
Transporting the device Carefully prepare the device for transport or storage. If you wish to return your device to KNAUER for repair, please enclose the service request form, which you can download from our website. Device data For a secure transport, note the weight and dimensions of the device (see chapter “9. -
Page 33: Storage
Transport and storage Lifting Grab the device around the center of both sides and lift it into the pack- aging. Do not hold the device by the front cover or the leakage tray. When lifting the device, ensure that the center of gravity is more in the front third. -
Page 34: Disposal
10.1 AVV Marking in Germany According to the German "Abfallverzeichnisverordnung" (AVV) (January, 2001), old devices manufactured by KNAUER are marked as waste elec- trical and electronic equipment: 160214. 10.2 WEEE registration number... -
Page 35: Technical Data
11. Technical data 11.1 Main features Alternative I: Individual heating sections Eluent heater II: Double heating sections Eluent heater Weight I: 16 kg II: 24 kg Max. flow rate 300 ml/min Wetted materials Stainless steel dead volume I: 5.5 ml II: 0.59 ml Max. -
Page 36: General
Technical data 11.3 General Power supply Power input: ƒ 100-230 VAC Maximum power consumption: ƒ I: 1500 W II:3000 W Fuse: ƒ I: 6.3 AT 10 AT Dimensions (W × H × D) 361 mm x 208.2 mm x 523 mm Leak sensor Permitted operating Area of use... -
Page 37: Repeat Orders
For reorders of spare parts use the enclosed packing list. Contact the Technical Support in case there are any questions on spare parts or accessories. Further information Further information on spare parts and accessories can be found online: www.knauer.net. 12.1 Devices Description Order no. Individual heating sections Eluent heater ELH 2.1L A70060-1 Double heating sections Eluent heater ELH 2.1L... - Page 38 Repeat orders Description Order no. Temperature sensor Pt100 for customized heating A57038 sleeves Heating sleeve for a pipe or a custom-made pipe A57042 section, self-limiting heating tape HBRC 85 °C AZURA® Eluent heater ELH 2.1L Instructions V6701...
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Page 39: Chemical Compatibility Of Wetted Materials
The following list contains information about the chemical compatibility of all wetted materials which are used in devices made by KNAUER. The data bases on a literature research on the manufacturer specifications of the materials. The wetted materials of this device are listed in the chapter “Technical data”. - Page 40 Chemical compatibility of wetted materials Polyimide (Vespel®) This material is wear-resistant and permanent resilient thermically (up to 200 °C) as well as mechanically. It is chemically broadly inert (pH range 1-10) and is especially resistant against acidic to neutral and organic solvents, but vulnerable to pH strong chemical or oxidizing environments: It is incompatible with concentrated mineral acids (such as sulfuric acid), glacial acetic acid, DMSO and THF.
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Page 41: Metals
Chemical compatibility of wetted materials Polychlortrifluorethylene (PCTFE, Kel-F®) The semi-crystalline thermoplastic material is plasticizer-free and dimen- sionally stable, even in a wide temperature range (−240 °C to+205 °C). It is moderately resistant against ether, halogenated solvents and toluene. Do not use halogenated solvents over +60 °C and chlorine gas. Fluorinated rubber (FKM) The elastomer consisting of fluorinated hydrocarbon stands out due to a high resistance against mineral oils, synthetic hydraulic fluids, fuels,... - Page 42 Chemical compatibility of wetted materials Ceramic Ceramic is resistant against corrosion and wear and is fully biocompati- ble. An incompatibility against acids, alkalis and solvents commonly used in HPLC is not known. Alumina (Al Due to their high resistance to wear and corrosion, alumina ceramic is used as a coating for mechanically stressed surfaces.
- Page 43 Customer approval Prior to installation at the customer site, the customer has reviewed the OQ document and agrees with the design and scope. Company name: Name Function Reviewed & approved Date Signature VIQ-Installation-Qualification-Device, Version 3.1 Date: Signature: Revision:...
- Page 44 KNAUER Wissenschaftliche Geräte GmbH. Scope The customer can request the Installation Qualification. In case of a request, the technical support of KNAUER or a provider authorized by KNAUER performs this functionality test during the installation. The IQ is a standardized document and includes the following: ƒ...
- Page 45 Installation Qualification Tests Test Description Specification Passed Failed Comment /LOR No. Identify the device. The name on the device matches the name on the delivery order. Check the device for No transport damage is transport damage. observed. Check the scope of The scope of delivery delivery.
- Page 46 List of rectifications (LOR) Type of Description of Persons LOR No. Test No. Action plan Due date Date/signature deviation* the deviation responsible * Type of deviation: A = acceptable (e.g. not a GMP-critical deviation) N = not acceptable Continuation of qualification activities into the next qualification phase is only possible when deviation is rectified. T = temporarily acceptable a) Release and use of the system is possible, even when the deviation is not rectified.
- Page 47 List of changes to the document Revision no. Description of change Additional information Date/signature VIQ-Installation-Qualification-Device, Version 3.1 Date: Signature: Revision:...
- Page 48 Installation Qualification (IQ) for a Device 10. Certificate and approval A KNAUER employee or an employee authorized by KNAUER has checked the device and performed all tests described in the IQ. The IQ form has to be signed by an authorized person. The scope of the IQ meets the customer‘s requirements.
- Page 49 Appendix: List of supporting documents Test no. Description VIQ-Installation-Qualification-Device, Version 3.1 Date: Signature: Revision:...
- Page 50 Latest KNAUER instructions online: www.knauer.net/library KNAUER Phone: +49 30 809727-0 Wissenschaftliche Geräte GmbH Fax: +49 30 8015010 Hegauer Weg 37-38 E-mail: info@knauer.net 14163 Berlin Internet: www.knauer.net © KNAUER 2024...
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