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REPLIGEN CTech FlowVPX System User Manual

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CTech™ FlowVPX®
System
User Guide
repligen.com
© 2023 Repligen Corporation. All rights reserved. The trademarks mentioned herein
are the property of Repligen Corporation and/or its affiliate(s) or their respective owners.
DOC0211 eRev. 1.0 8/15/2023

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Summary of Contents for REPLIGEN CTech FlowVPX System

  • Page 1 CTech™ FlowVPX® System User Guide DOC0211 eRev. 1.0 8/15/2023 repligen.com © 2023 Repligen Corporation. All rights reserved. The trademarks mentioned herein are the property of Repligen Corporation and/or its affiliate(s) or their respective owners.
  • Page 2 Product are expressly disclaimed. Customer shall refer to the terms and conditions of sale governing the transaction for any and all warranties for the Product. Repligen Corporation shall not be liable for errors contained herein or for incidental or consequential damages in connection with the furnishing, performance, or use of this material.

  • Page 3: Table Of Contents

    User Guide CTech™ FlowVPX® System Contents 5.2.1 FlowVPX Status Indicator Light ............................12 5.2.2 Power and Integration Connector ..........................12 5.2.3 USB Communications Connector ........................... 12 5.2.4 Flow Smart Input ................................13 5.2.5 Storage ................................... 13 5.7.1 Transmission Tool ................................16 5.8.1 The FlowVPX Power Cable (EC0205) ..........................
  • Page 4 User Guide CTech™ FlowVPX® System 13.2.1 Running a Different Sample (Using a Beams Light Source) .................... 48 13.2.2 Unloading the XSA Unit (Using a Beams Light Source)....................48 List of tables Table 1. Explanation of user attention phrases ............................6 Table 2.
  • Page 5 User Guide CTech™ FlowVPX® System Figure 36. ViPER Login Page ..................................30 Figure 37. My Applications: Quick Kinetics App ............................30 Figure 38. Method Input Menu: Select Flow Cell ............................ 31 Figure 39. Load Button in Instrument Control Menu..........................31 Figure 40.

  • Page 6: Table 1. Explanation Of User Attention Phrases

    ViPER® ANLYTX Software platform integrating data integrity and audit logging, the FlowVPX instrument is an extremely capable and formidable tool for in-line process analytics. This user guide provides general guidance for the use of the CTech FlowVPX System. For further optimization or troubleshooting support, please contact your Repligen Variable Pathlength Technology (VPT) Support Specialist (email: analytics- support@repligen.com;...

  • Page 7: Table 3. Regulatory Information

    Repligen’s Analytics business document: Declaration of Conformity, CTech Beams System CTIDC-0005 CE compliance covers the FlowVPX Head, Detector, Fibrette® Optical Component, Repligen’s Analytics business-provided power supply, three-meter cabling, and smart technology installed in every Flow Cell or System Suitability Adapter that mates with the FlowVPX Head, Beams Source, and Beams Controller.

  • Page 8: Table 4. Mains Supply Information

    User Guide CTech™ FlowVPX® System Table 4. Mains supply information Component Power Voltage and Ratings FlowVPX Instrument Mains Supply Voltage 24 VDC Beams System Mains Supply Voltage 24 VDC FlowVPX AC Power Supply Input Ratings 100 VAC—240 VAC and 47 Hz—63 Hz Beams System AC Power Supply Input Ratings 100 VAC—240 VAC and 47 Hz—63 Hz Beams Instrument Max Rated Current Draw...
  • Page 9 WEEE Compliance Repligen Corporation has met its obligations to the EU WEEE and Battery Directive by registering in those countries to which Repligen Corporation is an importer. Repligen Corporation has also elected to join WEEE and Battery Compliance Schemes in some countries to help manage customer returns at end-of-life.
  • Page 10 WEEE and to increase opportunities for reuse, recycling, and recovery of WEEE. As legislation and disposal facilities may vary throughout the European Union member states, please contact Repligen Corporation (customerserviceus@repligen.com) for further information regarding the proper disposal of products marked with the crossed-out wheeled bin label.

  • Page 11: Figure 1. Ctech Flowvpx Instrument (Fully Assembled) Components

    User Guide CTech™ FlowVPX® System 5.1 CTech FlowVPX Instrument Figure 1. CTech FlowVPX Instrument (Fully Assembled) Components DOC0211 eRev. 1.08/15/2023...

  • Page 12: Flowvpx Status Indicator Light

    CAUTION: Avoid exposure of the indicator LED housing to harsh chemicals, as it may discolor or add cloudiness to the housing. Acceptable cleaning agents include 0.5M NaOH, de-ionized (DI) water, and 70% isopropyl alcohol. Contact Repligen for further inquiries. 5.2.2 Power and Integration Connector Connects FlowVPX instrument to power supply and allows communication to and from the FlowVPX instrument with process automation systems.

  • Page 13: Flow Smart Input

    User Guide CTech™ FlowVPX® System 5.2.4 Flow Smart Input The FlowVPX instrument is equipped with electrical contacts to read a flash memory device on each Flow Cell to track serial numbers, cycle life, and other critical parameters. 5.2.5 Storage Place connector caps onto connectors when not in use. 5.3 FlowVPX Detector The FlowVPX Detector reads light transmitted from the Flow Fibrette and is designed as a removable module that adapts to a Flow Cell of any size.

  • Page 14: Figure 4. Flowvpx Flow Cell Components

    Each Flow Cell also utilizes an industry-standard tube or pipe fitting. For individual Flow Cell specifications, refer to the corresponding Specification Sheet included with the Flow Cell, available at repligen.com, or upon request at analytics-support@repligen.com Figure 4. FlowVPX Flow Cell Components 5.5 FlowVPX Standard Mount...

  • Page 15: Figure 5. Flowvpx Standard Mount Components

    User Guide CTech™ FlowVPX® System Figure 5. FlowVPX Standard Mount Components 5.6 FlowVPX System Suitability Adapter (XSA) The FlowVPX System Suitability Adapter (XSA) couples with the Detector Validation Adapter (DVA) to allow certified standards to be measured on the FlowVPX System, ensuring overall system function prior to use. Figure 6.

  • Page 16: Transmission Tool

    User Guide CTech™ FlowVPX® System 5.7 FlowVPX Detector Validation Adapter (DVA) The FlowVPX Detector Validation Adapter (DVA) enables raw transmission readings to the Detector, as well as CPV validation with NIST traceable filters and cuvette adapters. Figure 7. Detector Validation Adapter (DVA) Components 5.7.1 Transmission Tool The Transmission Tool snaps directly onto the Detector Validation Adapter to couple either the Delivery Fiber or the Beams source directly to the Detector.

  • Page 17: The Flowvpx Power Cable (Ec0205)

    User Guide CTech™ FlowVPX® System 5.8 Cables Figure 9. FlowVPX-Specific Cabling FlowVPX Extender Power FlowVPX Power Supply—EC0205 Cable—EC0206 (country-specific power cable, FlowVPX Power US pictured) and I/O Splitter Cable—EC0208 FlowVPX I/O External FlowVPX USB Cable—EC0214 Cable—EC0207 5.8.1 The FlowVPX Power Cable (EC0205) The FlowVPX power cable provides 24 VDC power to the FlowVPX Head.

  • Page 18: The Flowvpx Delivery Fiber

    Agilent Technologies’ Cary 60 spectrophotometer uses a Xenon flash lamp light source, which provides a wavelength range of 190 nm–1100 nm. Using the FlowVPX with the Cary 60 light source requires a Fiber Optic Coupler, provided by Repligen, to ensure adequate light transmission through the Delivery Fiber to the FlowVPX instrument.

  • Page 19: Beams Source

    User Guide CTech™ FlowVPX® System Figure 11. Cary 60 Spectrophotometer and Accessories 5.11 Beams System and Accessories The CTech Beams System is a monochromatic LED light source and data acquisition module for integration with the FlowVPX System for single wavelength applications. Designed for manufacturing settings, the Beams System provides light source and detection capabilities in a small package, without sacrificing any functionality of the FlowVPX instrument, such as motion control, I/O output, firmware, and smart cell reading.

  • Page 20: Beams Controller

    The FlowVPX instrument is controlled by CTech™ ViPER® ANLYTX Software applications. The supplied laptop has been selected for compatibility with the ViPER software. See the CTech FlowVPX System Specification Sheet DOC0206 for computer specifications. Note: Please reference documentation included with the computer supplied with the FlowVPX System for component-specific requirements, instructions, and safety considerations.

  • Page 21: Figure 14. Flowvpx Head (Logo Side Down)

    User Guide CTech™ FlowVPX® System 6. Introduction to FlowVPX System Installation For proper FlowVPX System installation, please be sure to take the following precautions. • Secure mounting Use the standard mount provided with shipment, or Use the M6 mounting holes on the FlowVPX Head. •...

  • Page 22: Figure 17. Clamp Handle Installation

    User Guide CTech™ FlowVPX® System 4. Install the Clamp Handle from the right side of the Standard Mount Clamp (Figure 17). Figure 17. Clamp Handle Installation 5. Turn until the threaded post on the Clamp Handle starts to appear at the other end of the Standard Mount Clamp (Figure 18).

  • Page 23: Figure 20. Install Flowvpx Head On Mounting Post

    User Guide CTech™ FlowVPX® System Figure 20. Install FlowVPX Head on Mounting Post 8. Carefully lower the FlowVPX® Head so that the clamp slides over the post on the mounting plate (Figure 21). Figure 21. Lower FlowVPX Head on Mounting Post 9.

  • Page 24: Figure 23. Accessory Port In Back Of Cary 60 Spectrophotometer

    User Guide CTech™ FlowVPX® System 8. Connecting the FlowVPX Instrument to the Cary 60 Spectrophotometer and Computer If using the Beams System, skip to section 9 below. CAUTION: Avoid bending the Delivery Fiber past a 2" radius to ensure integrity of internal optical fiber. 1.

  • Page 25: Figure 25. Cary 60 Power Cable And Usb Cable, Back Panel

    User Guide CTech™ FlowVPX® System Figure 25. Cary 60 Power Cable and USB Cable, Back Panel 5. Connect the SMA end of the Delivery Fiber to the threaded splice bushing at the back of the Fiber Optic Coupler (Figure 26). Use the hex nut to securely tighten the connection.

  • Page 26: Table 5. Flowvpx I/O Cable (Ec0214) Pinout

    User Guide CTech™ FlowVPX® System Figure 28. FlowVPX I/O Cable Connections WARNING: Explosion hazard for hazardous locations. Do not connect or disconnect any cabling while energized. 8. Connect the I/O External Cable (EC0214) to the DAQ device (Figure 29). Figure 29. I/O External Cable (EC0214) to FlowVPX Head Table 5.

  • Page 27: Figure 30. Usb Cable (Ec0207) To Flowvpx Head

    User Guide CTech™ FlowVPX® System Figure 30. USB Cable (EC0207) to FlowVPX Head 9. Connect the USB cable (EC0207) to the USB communications connector on top of the FlowVPX Head. 10. Make sure the computer is turned on, and then connect the FlowVPX USB cable (EC0207) to a USB port on the computer (Figure 31).

  • Page 28: Figure 32. System Setup: Beams Controller Connections

    User Guide CTech™ FlowVPX® System 9. Connecting FlowVPX Instrument to Beams System and Computer If using the Cary 60, see section 8 above. 1. Connect the USB Cable (EC0207) to the labeled position on the Beams Controller by aligning the pins of the plug with the connector (see Figure 32).

  • Page 29: Figure 34. Beams Power Brick And Cable

    User Guide CTech™ FlowVPX® System 7. Connect the power brick to the other half of its cable, then plug into an approved outlet. Figure 34. Beams Power Brick and Cable 8. Connect the Beams Controller USB Cable (first EC0207) to a USB port on the computer. Then connect the FlowVPX USB cable (second EC0207) to a different USB port on the computer (Figure 35).

  • Page 30: Figure 36. Viper Login Page

    User Guide CTech™ FlowVPX® System 10. Loading and Unloading the Flow Cell Note: The ViPER software must first be installed and connected to successfully load and unload the Flow Cell. 10.1 Open ViPER Software 1. Run the ViPER software on the computer by double-clicking the appropriate program icon for the connected light source, titled ViPER (Beams) or ViPER (Cary 60), located on the desktop.

  • Page 31: Loading The Flow Cell Using The Cary 60 Light Source

    User Guide CTech™ FlowVPX® System Figure 38. Method Input Menu: Select Flow Cell 6. Click the Load button from Instrument Control. Figure 39. Load Button in Instrument Control Menu 7. Follow the on-screen instructions based on which light source is connected to the FlowVPX instrument. 10.1.1 Loading the Flow Cell Using the Cary 60 Light Source If using the Cary 60 spectrophotometer, finish loading the Flow Cell by completing the following steps.

  • Page 32: Figure 40. Flow Cell Loading Instructions

    User Guide CTech™ FlowVPX® System Figure 40. Flow Cell Loading Instructions 1. With the FlowVPX Head on the Standard Mount, tilt the instrument back so the four alignment posts are facing you. Note: If the FlowVPX Head is not being used with the Standard Mount, instead lay the instrument on its side, with the FlowVPX logo facing up.

  • Page 33: Figure 41. Flow Cell Loading Window: Enter Serial Number

    User Guide CTech™ FlowVPX® System If previously used, after setting the Loaded Flow Cell dropdown menu to Flow Cell Selected, you may select a Flow • Cell serial number from the table displayed. Figure 41. Flow Cell Loading Window: Enter Serial Number 9.

  • Page 34: Loading The Flow Cell Using The Beams Light Source

    User Guide CTech™ FlowVPX® System 10.1.2 Loading the Flow Cell Using the Beams Light Source If using the Beams light source, finish loading the Flow Cell by completing the following steps. If using the Cary 60 spectrophotometer, please see section 10.1.1. Follow the on-screen prompts.

  • Page 35: Figure 44. Correct Beams Fx Connector Nut Orientation

    User Guide CTech™ FlowVPX® System Tighten to 40 in-lbs with the provided torque wrench. • Tighten in a diagonal pattern to equally distribute the torque. • 5. Make sure that the Flow Cell has been loaded, then click Start Detection. 6.

  • Page 36: Unloading The Flow Cell Using The Cary 60 Light Source

    User Guide CTech™ FlowVPX® System Figure 45. Unload Button in the Instrument Control Menu 2. Ensure that no sample is flowing through the Flow Cell. Then click Unload. Figure 46. Unload Flow Cell Confirmation Prompt 10.2.1 Unloading the Flow Cell Using the Cary 60 Light Source If using the Cary 60 light source, finish unloading the Flow Cell by completing the following steps.

  • Page 37: Unloading The Flow Cell Using The Beams Light Source

    User Guide CTech™ FlowVPX® System Figure 47. Flow Cell Unloading Using the Cary 60 Light Source 3. Remove the Detector Cable (EC0196) from the Detector. 4. Unscrew and disconnect the Delivery Fiber from the Fibrette. 5. Remove the FC connector nut from the Fibrette and set it aside. 6.

  • Page 38: Figure 48. Flow Cell Unloading Using The Beams Light Source

    User Guide CTech™ FlowVPX® System Figure 48. Flow Cell Unloading Using the Beams Light Source 3. Remove the Beams Detector Cable (EC0328) from the Detector. 4. Unscrew and disconnect the Beams light source from the Fibrette Optical Component. 5. Remove the Beams FX connector nut from the Fibrette and set it aside. 6.

  • Page 39: Figure 49. Transmission Check Button In Instrument Control Menu

    User Guide CTech™ FlowVPX® System 11. How to Run a Transmission Check (Cary 60) Note: The ViPER software must be first installed and connected to successfully run a transmission check. 1. Run the ViPER software on the computer by double-clicking the appropriate program icon for the connected light source, titled ViPER (Beams) or ViPER (Cary 60), located on the desktop.

  • Page 40: Figure 50. Transmission Check Instructions (Cary 60)

    User Guide CTech™ FlowVPX® System Figure 50. Transmission Check Instructions (Cary 60) 7. Load the Detector into the Detector Validation Adapter (DVA) unit. • Load the FlowVPX Detector into the DVA unit. • Ensure the Detector connector is facing out. 8.

  • Page 41: Figure 51. Quick Check Button In Instrument Control Menu

    User Guide CTech™ FlowVPX® System 12. How to Run a Quick Check (Beams) Note: The ViPER software must be first installed and connected to successfully run a Quick Check. 1. Run the ViPER software on the computer by double-clicking the appropriate program icon for the connected light source, titled ViPER (Beams) or ViPER (Cary 60), located on the desktop.

  • Page 42: Figure 53. Quick Check Results

    User Guide CTech™ FlowVPX® System Note: The Quick Check result may be greater than 100%. This value is relative to a reference measurement taken right after the unit's manufacture. A value greater than 100% does not indicate a problem with the unit. Figure 53.

  • Page 43: Figure 54. My Applications: Validate Vpt App

    User Guide CTech™ FlowVPX® System 13. How to Run a System Suitability Test (Cary 60 or Beams) Note: The ViPER software must first be installed and connected to successfully run a System Suitability test. 1. Run the ViPER software on the computer by double-clicking the appropriate program icon for the connected light source, titled ViPER (Beams) or ViPER (Cary 60), located on the desktop.

  • Page 44: Figure 56. Start System Suitability Test Window

    User Guide CTech™ FlowVPX® System Figure 56. Start System Suitability Test Window 6. Click Continue and follow the on-screen prompts. Click Step Completed to proceed. Figure 57. System Suitability Test Instructions (Cary 60) 7. Remove all Fibrette caps. Then, load the Fibrette Optical Component into the FlowVPX System Suitability Adapter (XSA). Make sure the tip of the Fibrette Optical Component is clean before inserting.

  • Page 45: Figure 58. Reference Standard Information Fields

    User Guide CTech™ FlowVPX® System 12. Affix the FC connector nut by aligning and tightening it by hand on the threaded end of the Fibrette, above the FX connector nut. 13. Load the FlowVPX Detector into the Detector Validation Adapter (DVA) unit. •...

  • Page 46: Running A Different Sample (Using A Cary 60 Light Source)

    User Guide CTech™ FlowVPX® System CAUTION: Do not power off or remove any parts of the instruments. If a Success message is displayed, it will show the resulting tolerance and slope. • If a Retry message is displayed: • The software will prompt the user to perform best practice procedures to correct the error. After three failed attempts, the user must change the sample.
  • Page 47 User Guide CTech™ FlowVPX® System Insert the tip into the XSA Fibrette Holder first, with the threaded end facing up. • Note: Only use the XSA Fibrette; do not attempt to detach a Fibrette Optical Component that is already connected to a Flow Cell.

  • Page 48: Running A Different Sample (Using A Beams Light Source)

    User Guide CTech™ FlowVPX® System 13.2.1 Running a Different Sample (Using a Beams Light Source) In order to run a different sample, follow the on-screen prompts. Change Sample: The screen will display the following text: Do you want to run a different sample or unload the XSA? 1.

  • Page 49: Table 6. Troubleshooting Issues And Responses

    User Guide CTech™ FlowVPX® System 14. Troubleshooting, Maintenance, and Best Practices 14.1 Troubleshooting Table 6. Troubleshooting issues and responses Issue Troubleshooting Flow Cell does not fit onto Ensure proper alignment of Flow Cell holes to posts. The Head posts are positioned to allow the Flow Cell to be Flow Head posts installed in only one orientation.
  • Page 50 User Guide CTech™ FlowVPX® System If problems arise that cannot be solved using the guidelines above, please reference the Repligen’s Analytics business Support Portal or contact Support at the information below. Support Portal: https://support.ctechnologiesinc.com/ Support line: US +1 908-707-1201 Support email: analytics-support@repligen.com...
  • Page 51 User Guide CTech™ FlowVPX® System 2. Replace the gasket/seal pad between the Detector and Flow Cell every time a Flow Cell is loaded. 3. Replace the gasket/seal pad between the Flow Cell and Head every time a Flow Cell is loaded. Perform a Transmission Check (Cary 60) Perform a transmission check after each time a Flow Cell is loaded.
  • Page 52 CTech™ FlowVPX® System 15. Glossary This glossary contains content developed by Repligen subject-matter experts or retrieved (whole or in part) from the American Society for Quality glossary, the International Accreditation Forum website, and Spectroscopy magazine’s “The Molecular Spectroscopy Terminology Guide” online.
  • Page 53 User Guide CTech™ FlowVPX® System Flow Head: Another name for the FlowVPX instrument (excluding the Flow Cell, Flow Fibrette, and Detector Module), it is the key component that enables the variable pathlength technology. Using the Cary 60 spectrophotometer as its power and light source, this serves as the in-line material-measurement instrument that allows dynamic adjustment of the optical pathlength between 0.001 mm (1 micron) and 8.000 mm.
  • Page 54 User Guide CTech™ FlowVPX® System Wavelength: Electromagnetic energy is transmitted in the form of a sinusoidal wave; the wavelength is the physical distance covered by one cycle of this wave. It is defined as the distance from one crest of an electromagnetic wave to the same position on the subsequent wave.
  • Page 55 Repligen Corporation 685 Route 202/206 Bridgewater, NJ 08807 analytics-support@repligen.com (908) 707-1009 DOC0211 eRev. 1.0 8/15/2023 repligen.com © 2023 Repligen Corporation. All rights reserved. The trademarks mentioned herein are the property of Repligen Corporation and/or its affiliate(s) or their respective owners.

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