eemagine Medical Imaging Solutions ant neuro eego mylab User Manual

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eego™ extensions

User Manual

eego™ system ES-220 version 9.2

eego™ software version 1.9.2

eego™ amplifier EE-22x and EE-4xx

eego™ extensions User Manual revision 2, February 27, 2021

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Summary of Contents for eemagine Medical Imaging Solutions ant neuro eego mylab

Page 1 User Manual revision 2, February 27, 2021 Related documents: eego™ system User Manual, revision 12 or above eego™ amplifier EE-22x User Manual, revision 7 or above eego™ amplifier EE-41x EE-430 User Manual, revision 2 or above Copyright eemagine Medical Imaging Solutions GmbH. All rights reserved.
Page 2: Intended Use
User Manual MANUFACTURER eemagine Medical Imaging Solutions GmbH Gubener Str. 47 D-10243 Berlin, Germany Phone: +49 (0)30 2904 8404 E-Mail: support@eemagine.com INTENDED USE This document serves as a supplement of the eego™ system user manual, revision 11 and above. It elucidates the advanced research features of the eego™...
Page 3: Table Of Contents
eego™ extensions User Manual TABLE OF CONTENTS INTENDED USE IMPORTANT NOTICES DISCLAIMER 1 GENERAL INFORMATION 2 EEGO™ SOLUTIONS 2.2.1 SOLUTION OVERVIEW 2.2.2 SOLUTION VARIANTS 2.2.3 SOLUTION COMPONENTS, TECHNICAL DATA, AND FEATURE OVERVIEW 2.2.4 AREAS OF APPLICATION 2.3.1 SOLUTION OVERVIEW 2.3.2 SOLUTION VARIANTS 2.3.3 SYSTEM COMPONENTS, TECHNICAL DATA, AND FEATURE OVERVIEW...
Page 4 eego™ extensions User Manual 7 SPO2 SENSOR 8 NETWORK OPERATION 8.6.1 ENABLING EEGO™ REMOTE CONTROL 8.6.2 DATA ACQUISITION CONTROL THROUGH EEGO™ WEB CONTROL 9 DRY ELECTRODE ARTEFACT CORRECTION 9.3.1 STEP 1: SELECTING A COMPATIBLE AMPLIFIER SETUP 9.3.2 STEP 2: SIGNAL QUALITY AND CHANNEL RELIABILITY CHECK 9.3.3 STEP 3: SIGNAL QUALITY AND CHANNEL RELIABILITY CHECK 9.3.4...
Page 5: General Information
eego™ extensions User Manual General Information ABOUT THIS DOCUMENT This document elucidates the advanced research features of the eego software. It is assumed that you are familiar with the system through the eego systems user manual and the use of the basic operation of the eego software.
Page 6: Eego™ Solutions
eego™ extensions User Manual eego™ Solutions OVERVIEW Under the eego portfolio, we offer two main solutions, namely, eego mylab and eego sports for high-density/multimodal and ultra-mobile recordings, respectively. This section will provide an overview of the components in the two solutions. The research features to be introduced in the following sections will also be categorized under one of the two solutions, or as an additional component.
Page 7: Solution Overview
eego™ extensions User Manual EEGO™ MYLAB SYSTEM 2.2.1 SOLUTION OVERVIEW The eego mylab system is the ultimate multi-modal, high-resolution EEG/ERP solution for the acquisition of EEG, bipolar signals like EMGs as well as auxiliary signals such as respiration rate, acceleration, temperature etc. With sampling rates of up to 16384 Hz across all referential channels, it provides the highest temporal resolution and reliable results.
Page 8 eego™ extensions User Manual Table 2-2: eego mylab product range Key features Two cascaded 64 Four cascaded 64 32 channel 64 channel channel eego™ channel eego™ eego™ amplifier, eego™ amplifier, eego™ amplifier amplifier, 16 kHz, amplifier, 16 kHz, 16 kHz, CE Class 16 kHz, CE Class CE Class IIa CE Class IIa...
Page 9 eego™ extensions User Manual 6 months of free 6 months of free 6 months of free 6 months of free Support remote support remote support remote support remote support The components included in the eego mylab solution are listed in Table 2-3. The eego software comes pre-installed on a desktop PC, laptop, or tablet.
Page 10 eego™ extensions User Manual ✓ ✓ ✓ ✓ DB25 to BNC trigger adapter XS-231 ✓ 128ch cascading trigger adapter XS-232 ✓ 256ch cascading trigger adapter XS-233 Sensebox - Adapter for 2 bipolar and ✓ ✓ ✓ ✓ XS-271 4 auxiliary channels * XC-207 is not part of US solution versions ** Please contact your distribution partner about eego™...
Page 11: Areas Of Application
eego™ extensions User Manual Figure 2-2 The eego waveguard case is also part of the eego mylab system delivery 2.2.4 AREAS OF APPLICATION This multi-modal system can be integrated into studies seeking to determine neurophysiological correlates of mental processes, discriminate between different brain disorders and exciting new pursuits in neuroscience, neurodiagnostics and neuromonitoring.
Page 12: Solution Variants
eego™ extensions User Manual 2.3.2 SOLUTION VARIANTS There are six variants of the eego sports system, which depends on the number of EEG and auxiliary channels included with the system. Each variant comes with sampling rates up to 2 kHz. Please refer to Table 3 for an overview of all five variants.
Page 13 eego™ extensions User Manual Table 2-4: eego sports product range Key features Two cascaded 64 8 channel eego™ 32 channel 64 channel channel eego™ amplifier, 2 kHz, eego™ amplifier, eego™ amplifier, eego™ amplifier amplifier, 2 kHz, CE Class IIa 2 kHz, CE Class IIa 2 kHz, CE Class IIa CE Class IIa medical device...
Page 14 eego™ extensions User Manual eego amplifier: 2 years eego amplifier: 2 years eego amplifier: 2 years eego amplifier: 2 years Warranty waveguard cap: 1 year waveguard cap: 1 year waveguard cap: 1 year waveguard cap: 1 year 6 months of free 6 months of free 6 months of free 6 months of free...
Page 15 eego™ extensions User Manual ✓ ✓ ✓ DB25 to BNC trigger adapter XS-231 ✓ 128ch cascading trigger XS-232 adapter ✓ ✓ ✓ ✓ DB25 to MCX trigger adapter XS-432 ✓ BNC to MCX trigger adapter XS-294 Sensebox - Adapter for 2 ✓...
Page 16: Areas Of Application
eego™ extensions User Manual Note: The packaging and components may differ from the image based on the solution and amplifier type. Upon lifting the top layer, you will find another layer of the suitcase that will contain charging accessories for the EE-22x amplifier and the tablet. The Microsoft tablet (XS-225) can also be found seated in this layer (see Figure 2-4).
Page 17: System Connection
eego™ extensions User Manual System connection Note: In the following connection schemes, the power adapter is depicted. To prevent power line contamination, the system should not be connected to the power grid during recording. Note: The Sensebox (XS-271) is powered by an external battery pack (XG-320). In some setups, it is also compatible with the XG-321.
Page 18 eego™ extensions User Manual Figure 3-1 - The typical non-cascaded setup. The desktop PC can be exchanged for a laptop (XS-227) or all-in-one PC (XS-229). Figure 3-1 also applies to cascaded solutions (ES-301, ES-302, ES-235) when only a single amplifier is used.
Page 19 eego™ extensions User Manual Figure 3-2 - The typical 128 channel cascaded setup. The desktop PC can be exchanged for a laptop (XS-227) of all-in-one PC (XS-229). Note: The cascading trigger adapters allow for synchronous recordings on multiple devices. In order to achieve this, they use the 8th bit of the trigger input channel.
Page 20 eego™ extensions User Manual Figure 3-3 - The typical 256 channel cascaded setup. The desktop PC can be exchanged for a laptop (XS-227) or all-in-one PC (XS-229). Note: The cascading trigger adapters allow for synchronous recordings on multiple devices. In order to achieve this, they use the 8th bit of the trigger input channel.
Page 21 eego™ extensions User Manual Figure 3-4 – A cascaded 256 channel setup connected through the optical isolator. The dotted line indicates an optical connection. The desktop PC can be exchanged for a laptop (XS-227) or all-in-one PC (XS-229). When the XG-321 battery is used to power the REX unit of the optical isolator, it may also be used to power the Sensebox (XS-271) at the same time.
Page 22 eego™ extensions User Manual Figure 3-5 - Amplifier application options allow selecting the amplifier types EE-226 and EE-227. These types refer to two or four amplifiers combined in a cascaded setup. The software automatically assigns [A] to [D] according to the serial number of the amplifiers.
Page 23 eego™ extensions User Manual Figure 3-7 - The extended status bar information on the amplifier displays the serial numbers and order of all connected amplifiers. USING FLASH DRIVES FOR MEMORY EXTENSION Some eego solutions may come with an additional SD card. To use this for expanding your storage, please make sure you format it to the NTFS filesystem.
Page 24: Video Recording And Review
eego™ extensions User Manual Video Recording and Review INTRODUCTION AND REQUIREMENTS The video module of the eego software is an add-on functionality that allows EEG and video to be recorded simultaneously. It is useful for studies where participant activity must be monitored. This system feature allows users to manually correlate observations in the video recording with eventual electrophysiological events.
Page 25 eego™ extensions User Manual SETTING UP THE VIDEO MODULE IN EEGO™ To enable the “Video” module in the eego software, press the “Options” button on the main screen. To select the video recording feature, go to Application Options -> Video -> Enable Video Recording under the “Video Recording”...
Page 26: Step 1: Choose The Video Option In The Record Eeg Workflow
eego™ extensions User Manual Before starting with the EEG acquisition and video recording, subject details must be registered in the eego software. Subject details may be changed and modified at any time during the recording or after. It is also important to choose the correct amplifier and montage setups before proceeding to the recording workflow.
Page 27: Step 2: Record Eeg And Video Streams
eego™ extensions User Manual 4.3.2 STEP 2: RECORD EEG AND VIDEO STREAMS Once both “Video” and “Record” buttons under the EEG header are pressed (switched to ON status), the recorded video stream is automatically stored into the database and it is in synchrony with the acquired EEG data.
Page 28: Reviewing Eeg And Video Recordings
eego™ extensions User Manual REVIEW AND EXPORT OF EEG AND VIDEO STREAMS The “Review & Export” button on the main screen of the eego software must be chosen to review and export both EEG and video streams. The workflow remains the same as in the case of reviewing and exporting acquired EEG data.
Page 29 eego™ extensions User Manual The video data view always shows the frame corresponding to the “EEG time cursor” in the EEG data view. The time cursor is the vertical red line and users can go back and forth through points in the recording.
Page 30: Exporting Eeg And Video Recordings
eego™ extensions User Manual When auto paging, the time cursor is running from left to right over the EEG data view that is updated page wise whenever the cursor reaches the right border of the display window. The cursor then jumps to the very left and moves to the right again (standard speed corresponds to real time recording).
Page 31 eego™ extensions User Manual Figure 4-7: Video Export options in the Review & Export workflow When exporting EEG data, any video file that partially overlaps with the exported time span will be exported as well (to the same folder selected for the EEG). In contrast to the EEG data, the video file is not cut according to the position in time of Markers 1 and 2.
Page 32: Photic Presentation
eego™ extensions User Manual Photic Presentation INTRODUCTION AND REQUIREMENTS The eego photic presentation module facilitates implementation of the Intermittent Light Presentation (ILS) protocol, through an additional hardware, namely, the eelite photic presentation device (XS-107). The eego software follows a fixed ILS protocol, which is routinely adopted in the photic paradigm for investigation of visually evoked potentials.
Page 33 eego™ extensions User Manual Figure 5-1: Setting up the Photic Presentation Module in Application Settings You can verify that the system is ready for photic presentation by checking the eelite status in the status bar (see status bar in Figure 5-2). The eelite (ELI) status must be indicated in green. A grey status control indicates that no photic device and an orange status indicates an error in the eelite hardware.
Page 34 eego™ extensions User Manual STEPS IN THE ILS PHOTIC PRESENTATION PARADIGM The Intermittent Light Presentation (ILS) protocol is the only photic paradigm option available to the user in the eego software. The default visual presentation protocol of the ILS paradigm and associated event codes are defined in Table 4-1.
Page 35 eego™ extensions User Manual Photic light blinks Photic Start - 2010 with the photic 18Hz frequency for the specified Duration Pause Photic Stop - 2011 18Hz Photic light blinks Photic Start - 2012 with the photic 20Hz frequency for the specified duration Pause Photic Stop -...
Page 36 eego™ extensions User Manual Figure 5-3: The start/stop of the photic presentation can be controlled and monitored via event codes UDO-SM-0483 35 of 66 Rev.02, 2021-02-27...
Page 37: Auxiliary Sensors
eego™ extensions User Manual Auxiliary Sensors INTRODUCTION AND REQUIREMENTS Selected models of the eego amplifiers offer the possibility of recording additional physiological signals such as temperature, respiration rate etc. through auxiliary channels, in addition to the standard bipolar channels (for EMG, EOG etc.) described in the eego system user manual.
Page 38 eego™ extensions User Manual or 4000 mV. Each bipolar channel must be enabled for data acquisition and has to be labelled appropriately using the drop-down menu to sample and interpret data correctly, as either one of the following: • Bipolar •...
Page 39 eego™ extensions User Manual Once a sensor type is chosen from the drop-down menu for an input channel, the system assumes that the sensor is attached to the Sensebox which feeds this respective signal to the amplifier. For information on where this bipolar input is present on the amplifier, please refer to the eego amplifier manual as well as the eego system user manual.
Page 40 eego™ extensions User Manual Figure 6-3: Calibration point table for a temperature sensor The Accelerometer and GSR sensor types require a bipolar signal range of 4 Vpp. As the bipolar channel range cannot be adjusted individually per channel, all bipolar channels are automatically set to a signal range to 4 Vpp as long as one sensor of this type is part of the amplifier setup.
Page 41 eego™ extensions User Manual Figure 6-4: Sensor data is displayed under the EEG channel data during data recording and review UDO-SM-0483 40 of 66 Rev.02, 2021-02-27...
Page 42: Spo2 Sensor
eego™ extensions User Manual SpO2 Sensor INTRODUCTION AND REQUIREMENTS SpO2 (peripheral capillary oxygen saturation) sensors are supported by eego software version 1.9.1 or above. These sensors measure the amount of oxygen in the blood stream as well as a number of related (calculated) values.
Page 43 eego™ extensions User Manual RECORDING SPO2 SENSOR DATA After going into the Acquire workflow, tick “Use SpO2 Sensor” in the workflow page on the left pane of the screen. Select the subject that you want to record measurements from and press the “Next” button. At the online EEG view, you will see information collected by the SpO2 sensor including PPG (raw data), Pulse, SpO2, PulseAv (average), SpO2Av, SpO2Fast, SpO2BB.
Page 44 eego™ extensions User Manual Figure 7-3: Export options for SpO2 sensor data UDO-SM-0483 43 of 66 Rev.02, 2021-02-27...
Page 45: Network Operation
eego™ extensions User Manual Network Operation INTRODUCTION AND REQUIREMENTS eego™ supports a number of functions for network (remote) operation, including: • Recording of LSL event streams in the eego™ software; • Streaming EEG, event or impedance data from one eego™ client via the network using LSL streams;...
Page 46 eego™ extensions User Manual Figure 8-1: Enabling Network Events in Application Options Optionally, you can modify the timing of the events received through LSL. If you define a positive offset, the time stamp of the LSL event received will be shifted to the future, i.e. the event will be inserted for a later recording time.
Page 47 eego™ extensions User Manual Figure 8-2: Event View tab has event summary and event details sections EVENT STREAM RECORDING USING LSL Events can be sent to the eego amplifiers from platforms such as MATLAB, Python and their associated toolboxes via Lab Streaming Layer. LSL events need to be formatted as either 32-bit integers or in string format.
Page 48 eego™ extensions User Manual LAN network (ethernet or WiFi) as the one connected with the amplifier. Both computers should have the eego software installed. The EEG data acquired on one of the computers could be streamed via LAN, and then viewed on another computer. RECORDING DATA FROM THE NETWORK USING LSL (REMOTE AMPLIFIER) To activate this feature, go to Application Options →...
Page 49: Enabling Eego™ Remote Control
eego™ extensions User Manual 8.6.1 ENABLING EEGO™ REMOTE CONTROL You can first go into Application Options -> Network Operation -> Remote control and click “Activate remote control”. Enter the IP address to “Webserver IP”. The webserver port and local station name are automatically assigned to your device by the software.
Page 50: Data Acquisition Control Through Eego™ Web Control
eego™ extensions User Manual You will be redirected to the an eego web controller interface in your web browser. You can see also see the IP address at this stage, on the address bar of the web browser (for example, 192.168.0.194 as seen in Figure 8-6).
Page 51 eego™ extensions User Manual To refresh the connected clients list and get most updated information, press the “Refresh” button seen on the eego Web interface. To add annotations during the recording, select the client, enter the message in the “Message” text box, and select the duration (press minus and plus buttons, or manually enter).
Page 52: Dry Electrode Artefact Correction
eego™ extensions User Manual Dry Electrode Artefact Correction INTRODUCTION AND REQUIREMENTS Dry EEG recordings have been made easier through a dedicated “Dry EEG Module” available in eego software version 1.9.1 or above. This optional module provides users with quality and reliability indices of the hardware input as well as EEG channel data.
Page 53 eego™ extensions User Manual Figure 9-1: Dry EEG Module in Application Options AMPLIFIER SETUP Prior to acquiring data with dry electrodes, the correct amplifier setup needs to be chosen. We refer the reader to the eego system user manual where the Edit Amplifier workflow is explained in detail. •...
Page 54: Step 1: Selecting A Compatible Amplifier Setup
eego™ extensions User Manual Figure 9-2: The "Edit Amplifier" workflow for dry electrode recordings ACQUIRE WORKFLOW 9.3.1 STEP 1: SELECTING A COMPATIBLE AMPLIFIER SETUP Now you can proceed to acquire data in the “Acquire” Workflow. • Amplifier Setup: In the “Recording Parameters” workflow chose the correct amplifier setup (e.g. EEG64-CY-261) and make sure that the “Dry EEG module”...
Page 55: Step 2: Signal Quality And Channel Reliability Check
eego™ extensions User Manual Figure 9-3: Subject selection for dry electrode recordings 9.3.2 STEP 2: SIGNAL QUALITY AND CHANNEL RELIABILITY CHECK Press “Next” to proceed to the data view. You can inspect the impedances of the electrodes by pressing “Impedance”. The “Quality Check”...
Page 56 eego™ extensions User Manual Figure 9-4: Quality check for Artifact Detected Mode – Green positions indicate sufficient signal quality (100%), White positions indicate insufficient signal quality (0%) Figure 9-5: Quality check for Virtual Channels – the Plot on the right side indicates the positions of the virtual channels and their respective channel reliability ranging from 0 to 100%.
Page 57: Step 3: Signal Quality And Channel Reliability Check
eego™ extensions User Manual 9.3.3 STEP 3: SIGNAL QUALITY AND CHANNEL RELIABILIT Y CHECK Press the “Dry EEG module” ribbon tab at the top of the application. Here, you can switch between Raw EEG, Artifact Detected, Artifact Corrected, and Virtual Channels via the drop-down menu in the top left corner (see Figure 7-7) Figure 9-7: Data type selection in dry EEG module •...
Page 58 eego™ extensions User Manual • Artifact Detected: channels with detected artifacts are displayed opaque to better visually distinguish them from non-artefactual channels. Figure 9-9: Example “Artefact detected” dry electrode EEG data view – The raw data is shown without processing by the dry EEG functions;...
Page 59: Parameter Selection For The Dry Electrode Functions
eego™ extensions User Manual • Virtual Channels: Spatially interpolated data are displayed on a 10/20 layout. Figure 9-11: Example “Virtual channels” dry electrode EEG data view – The data is shown after processing by the dry EEG functions; Artefactual channels are corrected and the output is interpolated to a virtual 10-20 layout; The resulting chanel reliability index is displayed on the left side of the traces.
Page 60 eego™ extensions User Manual ▪ Window Size [ms] determines the length of the time window for artifact detection. According to the enabled criterion and time window length, if the value in one channel exceeds the threshold, it would be labelled as a bad channel.
Page 61: Mobile Use Of The Eego™ System
eego™ extensions User Manual Mobile use of the eego™ system INTRODUCTION AND REQUIREMENTS Mobile use is one of the core features in all eego sports systems. If you have purchased an eego mylab solution, you may have also purchased a XS-371 mobility kit. The mobility kit allows you to use (up to two of the) amplifier(s) in your eego mylab solution in a mobile setting.
Page 62 eego™ extensions User Manual Once the subject is prepared for recording (see eego system user manual), simply detach amplifier and tablet from their charger cables. Figure 10-1: Layout of the items that are required for a basic mobile experiment Next, slide the amplifier in the middle compartment with the USB connector facing downwards.
Page 63 eego™ extensions User Manual Figure 10-3 - The net exterior allows access to the tablet whilst recording There is an opening between the first and middle compartments. It allows access to the amplifier to turn it on and off, but also allows the USB cable to connect with the amplifier.
Page 64 eego™ extensions User Manual you are ready for recording. Make sure the straps of the backpack are tightened, so the backpack is close to the body at any time during exercise. You can either operate the tablet through the net, or log into it using Microsoft Remote Desktop using another Figure 10-6 - Subjects ready to begin recording Note: It should be made sure that the equipment does not fall out into the ground.
Page 65 eego™ extensions User Manual UDO-SM-0483 64 of 66 Rev.02, 2021-02-27...
Page 66: Appendix A: Explanation Of Symbols
eego™ extensions User Manual APPENDIX A: EXPLANATION OF SYMBOLS Manufacturer symbol: indicated with name, address Catalogue number Serial number Year of manufacture Conformité Europeenne, CE mark, with number of Notified Body involved in the conformity assessment Follow the instructions for use (i.e., this user manual) Warning sign: warnings apply Special waste disposal regulations apply (EU) Safety according to class II electrical equipment (IEC 60601-1)