cytiva UNICORN 7.9 Manual

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UNICORN™ 7.9

System Control Manual

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Summary of Contents for cytiva UNICORN 7.9

Page 1 UNICORN™ 7.9 System Control Manual cytiva.com...
Page 2: Table Of Contents
Start a method run ............................17 Monitor a run ..............................21 Manual system control ..........................27 Method queue, Design of Experiments, Scouting and BufferPro runs ........29 System Settings ....................32 Troubleshooting ....................35 UNICORN 7.9 System Control Manual 29722732 AA...
Page 3: Introducing Unicorn System Control
Important user information Associated documentation Software declaration of conformity UNICORN 7.9 is technically compatible with all relevant sections of FDA 21 CFR Part 11. A part 11-system assessment checklist is available on request from your local Cytiva representative. UNICORN 7.9 System Control Manual 29722732 AA...
Page 4: About This Manual
(not a regular part of the graphic user interface), is represented by a monospaced typeface: Example: Connection change File system paths are represented by a monospaced typeface: Example: C:\Program Files\Cytiva\UNICORN\ UNICORN 7.9 System Control Manual 29722732 AA...
Page 5: About System Control Of Unicorn
• Using a preprogrammed method without any manual interactions. • Interact with the instrument during a method run by performing manual instruc- tions. • Perform manual runs. This approach may be useful for simpler procedures such as priming tubing with buffer. UNICORN 7.9 System Control Manual 29722732 AA...
Page 6: Important User Information
Do not operate the chromatograpy system in any other way than described in the user documentation. If you do, you may be exposed to hazards that can lead to personal injury and you may cause damage to the equipment. UNICORN 7.9 System Control Manual 29722732 AA...
Page 7: Associated Documentation
Overview and detailed description of the system Control Manual control features in UNICORN. Includes general opera- tion, system settings and instructions on how to perform a run. Dialog box descriptions for UNICORN (from the Help UNICORN Contextual Help menu). UNICORN 7.9 System Control Manual 29722732 AA...
Page 8: General Unicorn Operation
This chapter includes a description of general UNICORN operation which includes log on and log off UNICORN, how to structure files and folders and how to use the Online Help. In this chapter Section See page Log on and log off routines Help functions UNICORN 7.9 System Control Manual 29722732 AA...
Page 9: Log On And Log Off Routines
Click a user name in the User Name list b. enter the password in the Password field. Note: It is also possible to select the Use Windows Authentication check box and enter a network ID in the User Name box. UNICORN 7.9 System Control Manual 29722732 AA...
Page 10 If an edited method or result is open and not saved when you try to exit or log off UNICORN, you will see a warning. Click Yes to save, No to exit without saving, or Cancel to stay logged on. UNICORN 7.9 System Control Manual 29722732 AA...
Page 11: Help Functions
Windows 10 is C:\Program Files (x86). For example, if the path is written as below you have to replace Program Files Path with the correct path for your version of Windows: Program Files Path \Cytiva\UNICORN\. UNICORN 7.9 System Control Manual 29722732 AA...
Page 12: The System Control Module
3 The System Control module The System Control module In this chapter Section See page System Control module overview About this chapter This chapter gives an overview of the System Control module. UNICORN 7.9 System Control Manual 29722732 AA...
Page 13: System Control Module Overview
The illustration below shows the different panes and areas of the System Control module. Part Description Run Data: Presents current run data values. Chromatogram: Illustrates data as curves. Process picture: Illustrates the current flow path. Status bar: Shows information on instrument and database connection. UNICORN 7.9 System Control Manual 29722732 AA...
Page 14 Instrument states Information about the status of instrument connections and chromatography runs are displayed as states. The different states are displayed in the System Control module in Run Data and in the Status bar. UNICORN 7.9 System Control Manual 29722732 AA...
Page 15: How To Perform A Run
In this chapter Section See page Connect to system Start a method run Monitor a run Manual system control Method queue, Design of Experiments, Scouting and BufferPro runs UNICORN 7.9 System Control Manual 29722732 AA...
Page 16: Connect To System
Follow the instruction to connect the instrument to UNICORN. Step Action In the System Control module, • click the Connect to Systems button, a. on the System menu, click Connect to Systems. Result: The Connect to Systems dialog box opens. UNICORN 7.9 System Control Manual 29722732 AA...
Page 17: Start A Method Run
Method Settings phase when a method is created. Some pages are system specific. Page Description Fraction collector Displays the Fraction collector setup; tube type and position. Variable List Displays a list of all method variables and allows changing of variable values. UNICORN 7.9 System Control Manual 29722732 AA...
Page 18 • A signature tab displays information about method signatures, if applicable. System Settings Displays a list of current system settings. Calibration Displays a list of the latest performed calibrations. UNICORN 7.9 System Control Manual 29722732 AA...
Page 19 The following instruction assumes that: • Column Logbook is activated. • A Column type has been selected when the method was created. • A valid column license is used. To register a column, see UNICORN Method Manual. UNICORN 7.9 System Control Manual 29722732 AA...
Page 20 • press and hold the trigger to create a beam. • when the Barcode scanner beeps, the column ID is registered and displayed in the dialog box. Click OK. Result: The run starts. UNICORN 7.9 System Control Manual 29722732 AA...
Page 21: Monitor A Run
Selects which run data to display in the Run Data pane. Run Data Groups Standardize displayed run data by creating run data buttons: groups. • New Group • Edit Group • Delete Group UNICORN 7.9 System Control Manual 29722732 AA...
Page 22 The Run Log pane displays registered actions during the run. Tab in the Customize Customization dialog box Run Log Selects what to display in the log. Note: All information in the run log is saved. The selections define what is displayed. UNICORN 7.9 System Control Manual 29722732 AA...
Page 23 The Process Picture pane The Process Picture pane shows the current flow path during the run. Color indication is applied and real-time data from monitors are shown. The following illustrations show two examples of process pictures. UNICORN 7.9 System Control Manual 29722732 AA...
Page 24 4 How to perform a run 4.3 Monitor a run The following table describes how color indicates used flow paths. Color Indication Green Open flow path Gray Closed flow path UNICORN 7.9 System Control Manual 29722732 AA...
Page 25 Administration module. Note: The users must define their e-mail addresses in the user profile to be able to receive the e-mail notifications. Follow the instructions to enable notifications for alarms, warnings and errors. UNICORN 7.9 System Control Manual 29722732 AA...
Page 26 Separate multiple addresses with a semicolon. Select for which occurrences notifications should be sent in the Notifica- tion on check boxes. Click Test Notification E-mail to test if the e-mail settings are correct. Click OK. UNICORN 7.9 System Control Manual 29722732 AA...
Page 27: Manual System Control
The following instruction is an example of how to manually interact with an ongoing method run. The example shows how to increase the system flow. Step Action Open the Manual Instruction dialog box according to the above instruc- tion. UNICORN 7.9 System Control Manual 29722732 AA...
Page 28 To execute several instructions at the same breakpoint, select and edit an instruction and click Insert. Repeat for several instructions. To update parameter fields during method run, select the Auto update of parameters during run check box. To perform the instructions, click Execute. UNICORN 7.9 System Control Manual 29722732 AA...
Page 29: Method Queue, Design Of Experiments, Scouting And Bufferpro Runs
To view the status of the method queue, on the System menu, click Running methods. To cancel a method, or change method sequence, select the row of the method and use the buttons below the table. UNICORN 7.9 System Control Manual 29722732 AA...
Page 30 Column handling and method start, on page Result: The run starts. Run a BufferPro method For information on how to create BufferPro methods, see UNICORN Method Manual. BufferPro is a system specific function. UNICORN 7.9 System Control Manual 29722732 AA...
Page 31 19. Click Start in the last page of the Start protocol. Select a column in the Select columns dialog box. See Column handling and method start, on page Result: The run starts. UNICORN 7.9 System Control Manual 29722732 AA...
Page 32: System Settings
In the System Control module, on the System menu. click Settings. Result: The System settings dialog box opens with the Instructions displayed. The instructions in the menu differ depending on the specific system. See examples of different menus below. UNICORN 7.9 System Control Manual 29722732 AA...
Page 33 Text Instructions pane in Method Editor, or in the Manual Instructions dialog box in System Control, the changes only affect the current run. Enable power-save Follow the instructions to enable power-save for the instrument. UNICORN 7.9 System Control Manual 29722732 AA...
Page 34 Click On b. enter the number of minutes in the Time box. Note: This is the time the instrument will be in state Ready before power-save mode is entered. c. Click OK. UNICORN 7.9 System Control Manual 29722732 AA...
Page 35: Troubleshooting
The log on dialog box is 1. Verify that no UNICORN window or module is opened. inactive and a pass- 2. Log off from Windows and log on again. word cannot be entered. UNICORN 7.9 System Control Manual 29722732 AA...
Page 36 • Check that the power to the chromatography system is turned on. • Check the connection between the PC and the chromatography system. UNICORN 7.9 System Control Manual 29722732 AA...
Page 37 • Check that the system is configured at initialization. correctly, in System Properties and on the instrument display. • If the above actions do not help, try to restart both the instrument server computer and the instrument. UNICORN 7.9 System Control Manual 29722732 AA...
Page 38 In fact, it is the current instrument configura- tion which is incompatible with the client UNICORN installa- tion. Error messages and alarms If a displayed error message or alarm is incomprehensible, contact your local Cytiva representative. UNICORN 7.9 System Control Manual 29722732 AA...
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Page 40 QR code. cytiva.com/unicorn Cytiva and the Drop logo are trademarks of Life Sciences IP Holdings Corp. or an affiliate doing business as Cytiva. UNICORN is a trademark of Global Life Sciences Solutions USA LLC or an affiliate doing business as Cytiva.