Asus H81M-R Manual page 16

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1.4.3 Installing a DIMM
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The default memory operation frequency is dependent on its Serial Presence Detect
(SPD), which is the standard way of accessing information from a memory module.
Under the default state, some memory modules for overclocking may operate at a
lower frequency than the vendor-marked value.
For system stability, use a more efficient memory cooling system to support a full
memory load (2 DIMMs) or overclocking condition.
Refer to www.asus.com for the latest Memory QVL (Qualified Vendors List)
Chapter 1: Product introduction