Summary of Contents for MDS SCIEX API 4000 LC/MS/MS
- Page 1 API 4000 LC/MS/MS Site Planning Guide P/N 1002198D May 2002 http://www.appliedbiosystems.com...
- Page 2 This document contains information proprietary and confidential to MDS SCIEX, a division of MDS Inc., and is for customer use in the operation and maintenance of MDS SCIEX equipment or is for vendor use in the specification, fabrication, and manufacture of MDS SCIEX designed component parts. Any other use, disclosure to third parties, or reproduction of the information contained herein is strictly forbidden, except as MDS SCIEX may authorize in writing.
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Page 3: Table Of Contents
API 4000 Site Planning Guide Table of Contents Table of Contents About this Manual ............1 International Standards . - Page 4 Table of Contents API Site Planning Guide...
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Page 5: About This Manual
API 4000 Site Planning Guide About this Manual About this Manual This site planning guide contains information intended to familiarize customers with the necessary preparations and procedures for installing the API 4000 product and associated peripherals. The site planning guide contains detailed descriptions of the requirements for laboratory layout and required customer supplies. -
Page 6: International Standards
International Standards API 4000 Site Planning Guide International Standards Federal Communications Commission Compliance This equipment has been tested and found to comply with the limits for a Class A digital device, pursuant to Part 15 of the Federal Communications Commission Compliance (FCC) rules. -
Page 7: Customer Site Setup Check List
API 4000 Site Planning Guide Customer Site Setup Check List Customer Site Setup Check List Customer name _____________________________________________________________ Purchase Order number _____________________________________________________________ Customer Service Representative _____________________________________________________________ Name and number Date _____________________________________________________________ Customer Responsibilities Requirement Preinstallation Action Required Lab Requirement and Supplies A moveable bench for the API system or a fixed bench with 1 m (3.3 ft) of rear clearance and sufficient space underneath for the... - Page 8 One positive flow vent with sufficient tubing to loosely couple the vent to the source exhaust drain vessel supplied by Applied Biosystems/ MDS SCIEX. Safety Requirements Gas cylinders mounted to meet local safety standards. Gas delivery lines as required by local safety standards.
- Page 9 2. Test and qualify the API system to the specifications in the installation test documents. 3. Assemble and set up any Applied Biosystems/MDS SCIEX benches, if ordered with the instrument. 4. Only set up Applied Biosystems/MDS SCIEX supplied and manufactured LC equipment.
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Page 10: The Api 4000 Instrument
The API 4000 Instrument API 4000 Site Planning Guide The API 4000 Instrument The API 4000 LC/MS/MS instrument, in addition to housing a mass spectrometer, provides connection panels for gas inputs and exhaust, and electronic interfaces for the data acquisition system. Introduction The API 4000 LC/MS/MS instrument is a Liquid Chromatography (LC) Mass Spectrometer (MS), which incorporates an Atmospheric Pressure Ionization (API) ion... -
Page 11: Connections
API 4000 Site Planning Guide The API 4000 Instrument Connections Electric power, gas, and exhaust connections to the instrument are located on the two rear bulkheads, which are positioned on the rear corners of the mass spectrometer. The gas and vacuum panel is located on the back of the instrument, closest to the ion source housing. -
Page 12: System Requirements
System Requirements API 4000 Site Planning Guide System Requirements Weights and Dimensions The API 4000 mass spectrometer is 130 cm (53 in) long by 50 cm (20 in.) wide by 52 cm (21.5 in.) high. This instrument weighs approximately 136 kg (299.2 lb), excluding the roughing pump(s) and the Line Adjustment Transformer (LAT) option. -
Page 13: Room Dimensions
API 4000 Site Planning Guide System Requirements Room Dimensions At the time of service, the customer must provide the Customer Service Representative with adequate access around the instrument. Provisions should be made for clearance of approximately 1 m (3.3 ft) to any one side of the unit, as necessary. NOTE: The custom bench option is the recommended bench. -
Page 14: Operating Environment
System Requirements API 4000 Site Planning Guide Operating Environment The site environment should be kept clean and generally dust-free. High standards of cleanliness are expected. The instrument should be located in an area that is: • Free of smoke and corrosive fumes •... -
Page 15: Electrical Requirements
API 4000 Site Planning Guide System Requirements Electrical Requirements Applied Biosystems/MDS SCIEX recommends using two separate, 220 VAC (207-242 VAC), 15 amp circuits at 50/60 Hz to supply power to the following items: • API main console • Rouging (backing) pump... -
Page 16: Gas Requirements
System Requirements API 4000 Site Planning Guide Gas Requirements The API 4000 instrument requires several types of input gas. The recommended purities and pressures of these input gases should be adhered to for proper operation of the instrument. The stated gas purities are given as required at the instrument. NOTE: When switching gas sources while the instrument is running, ensure that a steady supply is available as back up. - Page 17 API 4000 Site Planning Guide System Requirements Suggested Gas Configurations Gas connection schematic using dewar and separate air Gas connection schematic using cylinders or separate air and house air CAUTION! Operation of the API 4000 instrument requires that, if house gases are being supplied, each supply be separately regulated at the instrument.
- Page 18 System Requirements API 4000 Site Planning Guide Gas Cylinder Considerations • Fasten all gas cylinders securely to an immovable bulkhead or to a permanent wall. NOTE: It is the user’s responsibility to permanently install gas supplies that conform to local safety and building codes. •...
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Page 19: Exhaust Requirements
API 4000 Site Planning Guide System Requirements Exhaust Requirements Exhaust from the API 4000 instrument originates from the source exhaust and roughing pump(s). Source Exhaust Pump During operation, solvent vapors and effluent are exhausted from the vent chamber under the ion source housing by the source exhaust pump (venturi pump) to a 1.27 cm (0.50 in.) barbed fitting. -
Page 20: Drain Vessel Considerations
System Requirements API 4000 Site Planning Guide • The length of the duct that enters the blower must be a straight length and at least ten times the duct’s diameter. An elbow entrance into the blower inlet causes a loss in efficiency. -
Page 21: Computer Communications Cable Layout Requirements
Computer system requirements may be upgraded from time to time. Please contact your service representative for the current system requirements. Only computers supplied by Applied Biosystems/MDS SCIEX are fully supported; there is no guarantee that customer- supplied computers can be made to work properly. Applied Biosystems/MDS SCIEX may charge customers for any additional time required to make a customer-supplied computer operable. -
Page 22: Recommended Supplies
The bench space requirements for the pumps, computers, etc. is dependent on the respective manufacturer. Useful Part Numbers and Suppliers The following is a list of part numbers for non-Applied Biosystems/MDS SCIEX supplied products and their manufacturers. Cylinder/ House Gas... -
Page 23: Customer-Supplied Equipment And Facilities
NOTE: The Line Adjustment Transformer (LAT) option is the recommended means of supplying the required voltage if the specification above cannot be met. Applied Biosystems/MDS SCIEX does not recommend or specify powerline conditioners. • Sufficient outlets for autosamplers, LC pumps, and other computer equipment. See manufacturers’... -
Page 24: Regulators
Customer-Supplied Equipment and Facilities API 4000 Site Planning Guide Regulators Customers must supply the appropriate gas regulators for the gas supplies. The required gas regulators are listed in the Gas Regulators table of the Recommended Supplies section. Ventilation The customer must supply ventilation as required by local bylaws and regulations for the roughing pump(s) and the source exhaust pump. -
Page 25: Line Voltage Conditioning
These requirements are not stringent and can normally be met by the local electrical supply authority. Policy Where the electrical supply does not meet Applied Biosystems/MDS SCIEX requirements, the customer should consult their power supplier or a local consultant on line conditioning apparatus to establish the most effective solution to the problem. - Page 26 Appendix A API 4000 Site Planning Guide...
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