Metrohm 845 Eluent Synthesizer Manual
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Metrohm 845 Eluent Synthesizer Manual

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845 Eluent Synthesizer
Handbuch
8.845.8001EN

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Summary of Contents for Metrohm 845 Eluent Synthesizer

  • Page 1 845 Eluent Synthesizer Handbuch 8.845.8001EN...
  • Page 3 Metrohm AG CH-9100 Herisau Switzerland Phone +41 71 353 85 85 Fax +41 71 353 89 01 info@metrohm.com www.metrohm.com 845 Eluent Synthesizer Handbuch 8.845.8001EN 08.2008 zst...
  • Page 4 Teachware Metrohm AG CH-9100 Herisau teachware@metrohm.com This documentation is protected by copyright. All rights reserved. Although all the information given in this documentation has been checked with great care, errors cannot be entirely excluded. Should you notice any mistakes please send us your comments using the address given above.

  • Page 5: Table Of Contents

    Adjustment................21 3.3.4 Creating a method...............23 Configuration ................23 3.4.1 Depot ...................23 3.4.2 Components................25 3.4.3 System Settings................26 3.4.4 Report Configuration ..............27 3.4.5 User Administration ..............29 3.4.6 Rinse....................33 Extras..................36 3.5.1 Sign methods ................36 845 Eluent Synthesizer / Instructions for Use 8.845.8001EM...
  • Page 6 List of figures Figure 1: Front of 2.845.0010 ............... 2 Figure 2: Front of 2.845.0020 ............... 3 Figure 3: Rear view of 845 Eluent Synthesizer ..........4 Figure 4: Tubing connections..............12 Figure 5: Dosing unit attachment ............... 46 Figure 6: Connections with one Dosino .............

  • Page 7: Introduction

    Aquatrode, a 10 mL exchange unit and a Remote Box (see Section 5.2.3). The 845 Eluent Synthesizer is connected to a PC via a USB and ope- rated with the «Mix Control» PC software provided. The operation of the software is described in the online help and in Section 3 of these In- structions for Use.

  • Page 8: Front Of 2.845.0010

    There is a built-in magnetic stirrer beneath it. 6 Recesses for magnetic labels For identifying components 1 - 3. 3 Holder for bottle adapter Holder for bottle adapter 21. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 9: Front Of 2.845.0020

    For identifying components 1 - 5. 3 Holder for bottle adapter 7 Dosino 2 outlet Holder for bottle adapter 21. Outlet for components from Dosino 2. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 10: Rear View

    9 Lead-through for stirrer cable vices with a USB cable. 10 Connection "Stirrer / MSB3" 12 Controller connection For connecting a stirrer (cable marked For connecting to a PC. with "Stirrer"). 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...
  • Page 11 (see Sec- sion 2.845.0020). tion 2.5.2). 15 Connection "Remote Box / MSB4" 19 Rear panel For connecting the Remote-Box for pH adjustment with Titrino(s) (see Section 2.6.2). 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 12: Information On The Instructions For Use

    Information on the Instructions for Use Please read through these Instructions for Use carefully before you put the 845 Eluent Synthesizer into operation. The Instructions for Use contain information and warnings to which the user must pay attention in order to assure safe operation of the instrument.

  • Page 13: Notation And Pictograms

    Caution This symbol marks important in- formation. First read the associated directions before you continue. Comment This symbol marks additional in- formation and tips. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 14: Safety Information

    Instructions for Use. 1.4.1 Electrical safety While electrical safety in the handling of the 845 Eluent Synthesizer is assured in the context of the specifications EN / IEC 61010-1, the fol- lowing points should be noted: •...

  • Page 15: Installation

    Setting up the instrument 2.1.1 Packaging The 845 Eluent Synthesizer is supplied together with the separately packed accessories in special packagings containing shock-absorbing foam linings designed to provide excellent protection. Please store all these special packagings as only they assure transport of the instrument free from damage.

  • Page 16: Connection To Pc

    • The LED "Power" 1 lights up when the system test has been completed and the instrument is ready for use. The plug for connection of the 845 Eluent Synthesizer is fitted with a "pull-out protection device" which prevents the cable from being pulled out accidentally.

  • Page 17: Dosino(S)/Stirrer Connections

    Dosino 1 Dosino 1 MSB2 Dosino 2 Dosino 2 Stirrer Stirrer MSB3 Tubing connections The drainage tubing (Section 2.5.2) and the component inlets and out- lets (Sections 2.5.3/2.5.4) must be connected. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 18: Instrument With Tubing Connections

    6.1838.000 Tubing connections for 6 Recesses for magnetic labels connecting "Dosino 1 outlet" 4 / "Dos- ino 2" outlet 7 to the bottle adapter 21. For identifying components 1 - 5. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 19: Connecting The Drainage Tubing

    2.5.2 Connecting the drainage tubing Connect 6.1816.020 Silicone tubing to connection 18 on the rear panel of the 845 Eluent Synthesizer and place the other end in a waste bottle. 2.5.3 Connections to bottle adapter The tubing should not dip into the produced mixture. Make sure that the FEP- Tubing Connection 6.1838.000...

  • Page 20: Ph Controller

    Eluent bottle head. • Screw off the 6.1838.000 FEP tubing connection(s) 20 from 6.1602.180 Bottle adapter 21. • Screw the 6.1838.000 FEP tubing connection(s) 20 to M6 thread(s) of 6.1602.190 Eluent bottle head. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 21: Ph Controller Cable Connection

    • Connect the end of the 6.2141.210 Cable marked B to the remote input of the second pH Controller. The Metrohm 702 Titrino can be used with the SET method to set the pH to a defined value (see the Instructions for Use of the correspon- ding Titrino).

  • Page 22: Mix Control" Software

    3 «Mix Control» software 3 «Mix Control» software The 845 Eluent Synthesizer is controlled with the «Mix Control» PC software provided. This section explains the ideas behind the software and how to use it. For further information please consult the online help of the software.
  • Page 23 SYSTEM SETTINGS 3.4.3). Report... Opens the window (see sec- REPORT CONFIGURATION tion 3.4.4). User Admin... Opens the window (see sec- USER ADMINISTRATION tion 3.4.5). Rinsing... Opens the window (see section 3.4.6). RINSE 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...
  • Page 24 Firmware Update Opens the window (see section FIRMWARE UPDATE 3.5.5). Service Opens the window (see section 3.5.6). LOGIN SERVICE Menu Help... Help Topics... Opens the Online Help. Info Opens the window. ABOUT 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 25: Description Of The Symbols

    / Save Method Saves the current Method. / Print... For printing the current Method. The sections selected in the window (without the REPORT CONFIGURATION section) get printed. No preview Produced Composition is shown. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 26: Method

    Description [ ] Notes about the currently loaded method. Component X [ ] Components (see section 3.4.2) with names and units (they correspond to the Components specified in the loaded Depot). 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 27: Ph Adjustment

    (i.e. at the end of the mixing process). For automatic pH adjustment 702 Titrinos from Metrohm are intended for use. If the pH needs to be adjusted from both sides (without changing the pH-Controller liquid), two 702 Titrinos are required as pH-Controllers.
  • Page 28 A (of the two-headed 6.2141.210 Cable). pH-Controller B The pH is adjusted with the instrument that is connected with the cable end marked B (of the two-headed 6.2141.210 Cable). 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 29: Creating A Method

    Depot must correspond to the Compo- nents physically connected to the instrument. The concentrations/- amounts defined in the Depot will be used for the volume calculations in the Method. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...
  • Page 30 Date Of First Use [ Date ; current date ] Date of the first use of the Component. If you click on the field the Date window opens, in which you can select the required date. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 31: Components

    • The volume calculated in the Method for must be at Component 1 least 70 mL if one Dosino is used; with two Dosinos it must be at least 140 mL. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 32: System Settings

    Dialog language [ English, German ] Selects the language for the software interface. Any al- teration to the language will only become effective for the Main Window after the software has been restarted. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 33: Report Configuration

    Selection box [ Standard, Full Report, Customized ] Standard The sections Identification Method Depot Pro- are shown in the report. duced Composition Full Report All sections are shown in the report. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...
  • Page 34 PDF-file into the directory chosen below. Export Report As XML The report is exported as soon as the mixture has been prepared as an XML-file into the directory chosen below. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 35: User Administration

    Short name of the user. This short name is always to be entered when the User logs in. Full Name First or given name and last or family name of the user. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...
  • Page 36 7. Leave the field empty. Enter the required pass- Old Password word under , and click on New Password Confirm Passw... [OK]. A return is now made to the window. LOGIN 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...
  • Page 37 This setting applies to all users and administrators. Login with password Login is only possible with a valid password. At next login, a password must be created in the window. CHANGE PASSWORD 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...
  • Page 38 User (the first defined user must be an Administrator). Login: Enter the and click on [OK]. User Password Change password: Click on . The window opens. CHANGE PASSWORD 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 39: Rinse

    - mode Prepare components Empty - and for which Component(s) the rinsing process is to components be carried out. Window "Rinse" The dialog window can be opened via RINSE Configuration, Rinsing... 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...
  • Page 40 Rinsing Mode "Empty components"" The rinsing mode " " can be selected in the Empty components RINSE window under the parameter Mode What effect has a rinsing process with " "? Mode Empty components 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...
  • Page 41 "Rinsing Mode "Prepare components" The rinsing mode " " can be selected in the Prepare components RINSE window under the parameter Mode 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 42: Extras

    In the window the current Method can be signed. SIGNATURE Enter your name and your (see section 3.4.5), select a user password for signing the method and click on [OK]. reason 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 43: Audit Trail

    Each of these actions is saved as a line in the Audit trail table together with the date, time and name of the logged-in user. Window "Audit trail" window can be opened via AUDIT TRAIL Extras, Audit trail... 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...
  • Page 44 Date and time of the action. User Short name of logged-in user. Category Program part to which the action belongs. Action Short description of the action. Details Detailed information about the action. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 45: Window "Report List

    Cancels the Quick filter function. All Audit trail entries are shown. 3.5.3 Window "Report List" window can be opened via REPORT LIST Extras, Report List... In the window the data of all prepared mixtures is shown. REPORT LIST 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...
  • Page 46 Short name of the User logged in when the mixture was prepared. Prints out the marked, or all (if none have been marked) entries in the report list Prints the marked Reports 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 47: Glp Manager

    GLP MANAGER The date of each validation/service work should be entered in the window. In addition, the date for the next validation or GLP MANAGER next service should also be entered. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...
  • Page 48 Methods. User Information about the logged-in User when validation was carried out. Possibility of entering an SOP (Standard Operation Procedure) name or number. Date Of Last Test Date of last validation. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 49: Firmware Update

    Firmware version can be FIRMWARE UPDATE copied to the instrument. In order to update the instrument Firmware you should first select the file for the parameter that contains the current Firm- Binary-File Path 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 50: Login Service

    The service section of the software can be accessed via the LOGIN window. Only service technicians from a Metrohm agency SERVICE should carry out work in the service section. It is protected by a special service password. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 51: Maintenance - Troubleshooting

    4.1 Care 4 Maintenance - Troubleshooting Care The 845 Eluent Synthesizer requires adequate care. If it becomes ex- cessively dirty then this could interfere with its functions and shorten the working life of its robust mechanism and electronics. Spilt chemicals and solvents must be wiped up immediately. The elec- trical connections on the rear panel of the instrument should be pro- tected against contamination.

  • Page 52: Cleaning

    For attaching the tubing connections to port 2 and 4 4.2.2 Cleaning Cleaning the 807 Dosing unit is described in the 8.807.1008 Instructions for Use – 807 Dosing unit, Section 6. 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 53: Installation

    (Dosing unit seen from below) Figure 6: Connections with one Dosino 29 Component connection strip 4 Dosino 1 outlet Outlet for component to be added 30 Dosing unit (from below) (from Dosino 1). 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 54: Figure 7: Connections With Two Dosinos

    31 Dosing unit from Dosino 2 (from Outlet for the component to be added below) from Dosino 2. 32 T-piece for component 1 For connecting the main component (see Section 3.4.2) 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 55: Troubleshooting

    • Connect instrument to USB of nized at software start- nected to USB the PC (see Section 2.3) up (LED "Power" (1) • USB cable defect • Replace USB cable lights up) 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 56: Annex

    5.1.4 Electromagnetic compatibility (EMC) Emission Standards complied with: - EN/IEC 61326 - EN 55022 / CISPR 22 Immunity Standards complied with: - EN/IEC 61326 845 Eluent Synthesizer / Instructions for Use 8.845.1003...

  • Page 57: Ambient Temperature

    ≤ 60% Instrument status In operation for at least 30 min 5.1.9 Dimensions Housing material Polyurethane Width 314 mm Height 378 mm Depth 280mm Weight 2.844.0010 6920 g 2.844.0020 7639 g 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 58: Standard Equipment

    5 Annex Standard equipment Subject to changes! All dimensions are given in mm. The 845 Eluent Synthesizer is available in the following versions: • 2.845.0010 845 Eluent Synthesizer with 1 Dosino • 2.845.0020 845 Eluent Synthesizer with 2 Dosinos 5.2.1 Standard equipment for 2.845.0010...
  • Page 59 Magnetic shield , 15 x 68 mm, 3 pieces 6.2739.000 Wrench For tightening nipples. 6.2744.170 Pressure screw PEEK UNF 1/4-28, 3 pieces Fixing connecting capillaries from the component containers to the Eluent Synthesizer. Material PEEK 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 60: Standard Equipment For 2.845.0020

    Eluent Synthesizer with 2 Dosinos 6.1546.030 Piston rod For PTFE piston of Dosing Unit 6.1602.180 Bottle Adaptor to 845 Adaptor to the eluent bottle of the Elu- ent Synthesizer without pH adjustment 845 Eluent Synthesizer / Instructions for Use 8.845.1003...
  • Page 61 Cable socket Cable connector Type IEC 320/C 13 Type SEV 12 (CH…) 6.2122.020 Type IEC 320/C 13 Type CEE (7), VII (D…) 6.2122.040 Type CEE (22), V Type NEMA 5-15 (USA…) 6.2122.070 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...
  • Page 62 Software for the 845 Eluent Synthesizer. 8.800.1003 Instructions for Use 800 Dosino (e) 8.807.1008 Instructions for Use 807 Dosing Unit (g, e, f, s) 8.845.1003 Instructions for Use 845 Eluent Synthesizer (e) 845 Eluent Synthesizer / Instructions for Use 8.845.1003...

  • Page 63: Accessories For Ph Adjustment (Optional)

    5.2 Standard equipment 5.2.3 Accessories for pH adjustment (optional) The following accessory packages are offered under their own order numbers as an extension to the 845 Eluent Synthesizer for automatic pH adjustment: • 2.702.0120 with 702 Titrino • 6.5329.000 without Titrino The following parts are supplied under the order number 2.702.0120:...
  • Page 64 Buffer solutions pH 4/7/9 Mixed buffer solutions pH 4.00/7.00/9.00 (25 °C) in single use sa- chets, colorless, box of 3 X 10 x 30 mL 6.2308.050 KCl Solution 3 mol/L (50 mL) 845 Eluent Synthesizer / Instructions for Use 8.845.1003...
  • Page 65 Exchange Unit 10 mL Intelligent dosing unit with 10 mL glass cylinder and light protection. PCTFE/PTFE flat stopcock, FEP tubing connection, antidiffusion buret tip and standard amber glass reagent bottle Volume in mL 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...
  • Page 66 Material 6.2141.210 Cable Remote Box MSB-2 x Titrino For the connection of up to two Titrinos to 845 6.2148.010 Remote Box MSB Remote interface for the connection of Titrinos (via 6.2141.210 Cable). 845 Eluent Synthesizer / Instructions for Use 8.845.1003...

  • Page 67: Optional Accessories

    For eluent bottles, with connections for absorber tube and aspiration tubing. Opening ground joint A-14/15 6.1608.030 Bottle / 1000 mL / GL 45 To Exchange Units. Material Clear glass Width (mm) Height (mm) Volume in mL 1000 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

  • Page 68: Producers Of Concentrates And Standards

    Sigma Aldrich (Fluka, Riedel-de Haën) http://www.sigmaaldrich.com 5.2.6 Systems for producing ultra pure water Several manufacturers offer systems for producing ultra pure water. This list is not exhaustive. Producer Internet address Millipore http://www.millipore.com ELGA http://www.elgalabwater.com Barnsted http://www.barnsteadthermolyne.com/index.cfm 845 Eluent Synthesizer / Instructions for Use 8.845.1003...

  • Page 69: Warranty

    Metrohm from any liability to pay compensation. If any instruments and parts have to be returned, the original packaging should be used if at all possible.

  • Page 70: Declaration Of Conformity

    EN 61010-1 Safety requirements for electrical equipment for measurement, control and laboratory Metrohm Ltd. is holder of the SQS-certificate of the quality system ISO 9001 for quality assurance in design/development, production, installation and servicing. The system software, stored in Read Only Memories (ROMs) has been validated in connection with standard operating procedures in respect to functionality and performance.

  • Page 71: Quality Management Principles

    Metrohm Ltd. holds the ISO 9001 Certificate, registration number 10872-02, issued by SQS (Swiss Association for Quality and Management Systems). Internal and external au- dits are carried out periodically to assure that the standards defined by Metrohm’s QM Manual are maintained.

  • Page 72: Index

    Dosing unit Report.........28 Report configuration...... 27 Cleaning........45 Main Window........16 Rinse ........20, 32 Dosing unit attachment ....45 Mains ..........5 Rinsing Dosing units ........44 Mode.......... 33 Mains cable Dosino ......2, 3, 12, 46, 47 845 Eluent Synthesizer / Instructions for Use 8.845.1003...
  • Page 73 Warning ..........7 Total Volume ........21 Standard ........27 Warranty .........62 T-piece for component 1 31 Standard equipment ..... 51 with request........22 Illustration........47 Start ..........20 Transport.......... 9 Stirrer ..........49 845 Eluent Synthesizer / Instructions for Use 8.845. 8001EN...

This manual is also suitable for:

2.845.0010 8452.845.0020

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