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Table of Contents
Troubleshooting
Summary of Contents for Gilson VERITY 1810
- Page 1 Conductivity and pH Monitor User’s Guide LT304013-02 www.gilson.com/ContactUs...
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Page 3: Table Of Contents
TABLE OF CONTENTS Safety Symbols and Signs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8 Safety Notices . - Page 4 3 Operation Front Panel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22 Flow Path Diagram .
- Page 5 A Replacement Parts and Accessories VERITY® 1810 Conductivity and pH Monitor . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 Flow Cells .
- Page 7 Failure to comply with these precautions or with warnings described in the user’s guide violates safety standards of design, manufacture, and intended use of the instrument. Gilson assumes no liability for customers failing to comply with these requirements.
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Page 8: Safety
Symbols and Signs The following table explains symbols and labels that are used on the instrument or in the user’s guide: Symbol Meaning Caution Attention Vorsicht Safety Notices The following safety notices may appear in this document: WARNING indicates a potentially hazardous situation which, if not avoided, may result in WARNING serious injury CAUTION indicates a potentially hazardous situation which, if not avoided, may result in... -
Page 9: Sécurité
Le non-respect de ces précautions ou des avertissements spécifiques mentionnés dans ce guide compromet les normes de sécurité de conception, de fabrication et d’utilisation prévue de l’instrument. Gilson décline toute responsabilité en cas d’incapacité du client à se conformer à ces exigences. -
Page 10: Symboles Et Signes
Symboles et Signes Le tableau suivant détaille les symboles et signes utilisés sur l’instrument ou dans le guide de l’utilisateur: Symbole Signification Caution Attention Vorsicht Notes de Sécurité Les notes de sécurité suivantes peuvent apparaitre dans ce document: AVERTISSEMENT: indique une situation potentiellement dangereuse qui, si elle n’est pas WARNING évitée, peut entraîner des blessures graves ATTENTION: indique une situation potentiellement dangereuse qui, si elle n’est pas évitée,... -
Page 11: Introduction
INTRODUCTION 1 Chapter One This chapter provides information on the following topics: ● Description on page 12 ● Unpacking on page 12 ● Technical Specifications on page 14 ● Customer Service on page 16 VERITY 1810 Conductivity and pH Monitor | User’s Guide ®... -
Page 12: Description
Description The VERITY® 1810 Conductivity and pH Monitor is a state-of-the-art detection instrument for biological purifications with a large dynamic range and fast response time for real-time gradient monitoring. It is a compact, integral component for systems performing oligonucleotide, monoclonal antibody (mAb), and other biological separations. -
Page 13: Standard Equipment
● VERITY® 1810 Conductivity and pH Monitor with Installed Conductivity Flow Cell ● USB Cable ● Two Analog Cables ● Inlet and Outlet Fittings ● Gilson Ethernet Utility Documentation The following documentation is provided: ● VERITY® 1810 Conductivity and pH Monitor Documentation CD, which includes: ○... -
Page 14: Technical Specifications
Technical Specifications Please be aware of the following before operating the instrument. Changes or modifications to the instrument not expressly approved by Gilson could void NOTICE the factory-authorized warranty. The instrument complies with part 15 of the FCC Rules. Operation is subject to the following two conditions: (1) This instrument may not cause harmful interference, and (2) this instrument must accept any interference received, including interference that may cause undesired operation. - Page 15 VERITY® 1810 Conductivity and pH Monitor Technical Definition Specification Monitor Channels Three: Conductivity, pH, and Temperature pH Flow Cell ±0.1 units at 25°C Accuracy Maximum 0.1/10 hours at constant conditions Drift 11100001 Part Number Pressure 6.89 0.69 Readable 0–14 pH Range Specification 2–12 pH...
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Page 16: Customer Service
Gilson, Inc. and its worldwide network of authorized representatives provide customers with the following types of assistance: sales, technical support, applications, and instrument repair. If you need assistance, please contact your local Gilson representative. Specific contact information can be found at www.gilson.com. To help us serve you quickly and efficiently, please refer to Before Calling Us... -
Page 17: Installation
INSTALLATION 2 Chapter Two This chapter explains the steps for setting up the instrument, which includes: ● Plumbing Connections on page 18 ● Rear Panel Connections on page 19 VERITY 1810 Conductivity and pH Monitor | User’s Guide ®... -
Page 18: Plumbing Connections
Plumbing Connections Inlet and outlet tubing are ordered separately so as to be appropriate for the application flow rate. Refer to Replacement Parts and Accessories appendix for part numbers. Fittings are supplied. The flattened end of To make the plumbing connections: the ring should face 1. -
Page 19: Rear Panel Connections
BNC Connector on pH Sensor Cable Output Channels If the VERITY® 1810 Conductivity and pH Monitor is part of a Gilson system, it is not necessary NOTE to make analog output connections. In a Gilson system, make the USB connection between the VERITY®... -
Page 21: Operation
OPERATION 3 Chapter Three Install TRILUTION® LC Software according to the installation instructions provided with the software. This software provides control of the VERITY® 1810 Conductivity and pH Monitor. For more information about TRILUTION® LC Software, refer to its user’s guide, on-line help, and documentation supplied with the software. -
Page 22: Front Panel
Front Panel The front panel of the monitor contains a: Three Line Display ○ The first line displays the conductivity channel reading. ○ The second line displays the pH channel reading. ○ The third line displays the temperature reading. Figure 8 VERITY®... -
Page 23: Control From Trilution® Lc
TRILUTION LC, refer to the software on-line help or user’s guide. Configuration The VERITY 1810 Conductivity and pH Monitor is added to TRILUTION® LC v3.0 after installation of Service Pack 6. The VERITY® 1810 Conductivity and pH Monitor will be detected in a scan, which is the recommended way to add an instrument to the configuration. -
Page 24: Control
The Control tab window in the Method Builder is a graphical interface used to organize the tasks used in a method. Tasks The table below lists the tasks for the VERITY 1810 Conductivity and pH Monitor. VERITY 1810 Conductivity and pH Monitor Tasks Task Icon... -
Page 25: Results
Results From a run, the software produces results containing the channel data collected and stored for all injected samples. Results contain time and signal information for each sample. Results are accessed in the Project Library. Click on an application and double-click the results icon ( ). The Results window is displayed, listing all runs for the selected application. -
Page 26: Temperature Compensation Coefficient
● Click the Start button, and then select All Programs > Gilson Applications > Utilities > GEARS > GEARS Application. Wait briefly for GEARS to detect the instrument. 5. In the Gilson Ethernet Utility, select VERITY 1810 Conductivity and pH Monitor from the list, and then click Connect. -
Page 27: Conductivity Analog Endpoint
● Click the Start button, and then select All Programs > Gilson Applications > Utilities > GEARS > GEARS Application. Wait briefly for GEARS to detect the instrument. 5. In the Gilson Ethernet Utility, select VERITY 1810 Conductivity and pH Monitor from the list, and then click Connect. -
Page 29: Maintenance
You are only permitted to perform the maintenance tasks described in this user’s guide. If additional maintenance is required, contact your local Gilson representative. All smooth surfaces of the instrument can be cleaned with a mild, commercially available cleaning solution, or with isopropanol on a moistened cloth. -
Page 30: Cleaning
Cleaning Exterior Clean the external surfaces by applying one of the following solvents to a clean cloth and wiping. NOTICE Do not maintain contact between the solvent and the surface for more than 15 seconds. The external surfaces of the housing may be cleaned with the following cleaning agents: ●... -
Page 31: Conductivity Flow Cell
Conductivity Flow Cell Calibration It is recommended to calibrate the conductivity flow cell annually. Contact your local Gilson representative for more information and assistance. Replacement Refer to the instructions in this section when replacing the conductivity flow cell. REMOVE INSTALLED FLOW CELL 1. -
Page 32: Inlet And/Or Outlet Tubing Replacement
Inlet and/or Outlet Tubing Replacement When replacing the inlet or outlet tubing, refer to the table below for part numbers for replacement tubing and fittings. When replacing the tubing, always replace the fittings too. Tubing and Fittings Flow Rate (mL/min) Part Number Description 0.5–5... -
Page 33: Troubleshooting
TROUBLESHOOTING 5 Chapter Five This chapter provides information on the following topics: ● Troubleshooting on page 34 ● Solvent and Buffer Compatibility on page 34 ● Repair and Return Policies on page 35 VERITY 1810 Conductivity and pH Monitor | User’s Guide ®... -
Page 34: Troubleshooting
Troubleshooting When troubleshooting a problem, first do the following: 1. Check all cabling. 2. Check all fittings. 3. Check for air in the tubing. 4. Check for leaks. Solvent and Buffer Compatibility Chemical Resilience All surfaces of the VERITY® 1810 Conductivity and pH Monitor housing resist limited exposure (less than 30 minutes) to the following solvents and buffers, in addition to any vapors that the chemicals may emit: ●... -
Page 35: Repair And Return Policies
Repair and Return Policies Before Calling Us Your local Gilson representative will be able to serve you more efficiently if you have the following information: ● Serial number and model number of the instruments involved ○ The serial number is located on the underside of the instrument. -
Page 37: A Replacement Parts And Accessories
REPLACEMENT PARTS AND ACCESSORIES A Appendix A VERITY® 1810 Conductivity and pH Monitor Part Description Number 11100000 VERITY® 1810 Conductivity and pH Monitor with Installed Conductivity Flow Cell Flow Cells Part Description Number 11100001 pH Flow Cell Assembly 11000002 Conductivity Flow Cell Assembly Tubing and Fittings Flow Rate (mL/min) Part Number... -
Page 38: Ph Sensor
pH Sensor Part Description Number 11000025 pH Sensor (Replacement) 5464549103 O-Ring Cables Part Description Number 32000012 USB Cable 11000023 Analog Output Cable Replacement Parts and Accessories | VERITY 1810 Conductivity and pH Monitor ®... -
Page 39: B Ph Flow Cell
PH FLOW CELL B Appendix B Figure 16 VERITY® 1810 Conductivity and pH Monitor with Optional pH Flow Cell Technical Specifications pH Flow Cell Technical Definition Specification pH Flow Cell ±0.1 units at 25°C Accuracy 0.1/10 hours at constant conditions Maximum Drift 11100001 Part Number... -
Page 40: Setup
Setup The pH Flow Cell requires some assembly. There are four parts: the base, the O-ring, the pH sensor, and the securing nut. When unpacking and storing the pH sensor, refer to the manufacturer’s instructions provided with the pH sensor. The O-ring provided in the soaker bottle with the pH sensor is not required for NOTE this setup and should remain in the soaker bottle cap for future storage of the pH... -
Page 41: Plumbing Connections
Plumbing Connections Tubing and fittings for inlet and outlet tubing connections are ordered separately so as to be appropriate for the application flow rate. The arrows on the base indicate the flow path. Tubing and Fittings Flow Rate (mL/min) Part Number Description 0.5–5 49951059... -
Page 42: Connection To The Verity® 1810 Conductivity And Ph Monitor
Connection to the VERITY® 1810 Conductivity and pH Monitor Refer to the diagram when making the pH sensor cable connection. pH Sensor input pH Sensor The pH sensor cable has a BNC connector. Connect the pH sensor cable to the pH Sensor input, and then twist clockwise 1/4 turn to lock. -
Page 43: Verity® 1810 Monitor Ph Calibration Utility
Before running samples for the first time, calibrate the pH sensor/flow cell using the VERITY® 1810 Monitor pH Calibration Utility. The VERITY® 1810 Monitor pH Calibration Utility is supplied on the Gilson Software USB, which is provided with the pH flow cell. -
Page 44: Start The Verity® 1810 Monitor Ph Calibration Utility
To start the VERITY® 1810 Monitor pH Calibration Utility, click the Start button and then select All Programs > Gilson Applications > VERITY 1810 Conductivity and pH Monitor > VERITY 1810 Monitor pH Calibration Utility. ● If prompted to exit the GEARS Application, right-click on the icon ( ) in the Windows system tray, and then select Exit. -
Page 45: Close The Verity® 1810 Monitor Ph Calibration Utility
pH 4 Calibration 1. Click pH 4. 2. Wipe the outside of the pH sensor with a lint-free cloth. 3. Use a transfer pipet to rinse the outside of the pH sensor with pH 4 solution. 4. Submerge the pH sensor in the pH 4 solution. 5. -
Page 46: Maintenance
Maintenance pH Sensor Replacement If after running the VERITY® 1810 Monitor pH Calibration Utility, O-ring it is determined that the pH sensor (part number is out of calibration, the pH sensor 5464549103) (part number 11000025) and optionally, the O-ring (part number 5464549103) should be replaced.