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Summary of Contents for MRC 1953
- Page 1 1953...
- Page 2 DNA contains all the information required to make up a living organism**. For example, DNA has instructions to determine your number of fingers, eye and hair colour. That is why DNA is often referred to as the “carrier” Francis Crick sketch 1953. of the genetic information or life’s 'instruction manual'.
- Page 3 Blue blocks represent adenine base.
- Page 4 Clear Blocks represent Hydrogen Green (thymine) pairs with blue Bonds between the bases. These (adenine). When DNA is copied, "weak" bonds hold our DNA these base pairs are 'melted'. strands together. Note that adenine is a larger base than thymine.
- Page 5 Grey Blocks represent the sugar (deoxyribose): one unit of sugar and the nucleobase combined is called a nucleoside.
- Page 8 The black blocks represent You've completed a full the phosphate groups of the nucleotide base pair - backbone. now start building the next tier.
- Page 9 Red blocks represent the base guanine.
- Page 10 Yellow bricks show cytosine, which pairs with guanine - notice the difference between the sizes.
- Page 13 Add this base pair (red/yellow) to the base (blue/green) to make the first turn of your double helix.
- Page 14 Repeat steps 1-8, 10-13. Repeat steps 14-24.
- Page 15 1x 26 1x 27 Add nucleotide 'base pairs' to start forming the helix.
- Page 16 4x 26 3x 27...
- Page 17 100,000,000:1 Sugar Phosphate backbone Adenine 3.4 nm ~34 cm Thymine (34Å) Guanine Cytosine 2 nm ~20 cm One strand of DNA measures about 2 Compare your lego model to the Watson- nanometers in diameter. It would take Crick model - what are the similarities and about 12,500 strands of DNA to equal the differences? Where is the information the diameter of a human hair!
- Page 18 LEGO SCALE MODEL The scale of this Lego model is 1:100,000,000. At this scale just one gene that determines eye colour (called OLA2, 340,457 base pairs) would reach over 10 km. The model contains 11 base pairs, in a human cell there are 6 billion base pairs.
- Page 19 DNA SCALE MODEL If the DNA from all the cells in your body were stretched end-to-end it would reach from the Earth to the Sun and back more than 250 times! How can all this DNA fit? DNA has to be packaged. A chromosome is a single piece of coiled DNA which is packaged up with proteins.
- Page 20 Lego kits were designed by John Schollar at the National Centre for Biotechnology Education. Images were supplied by: The Wellcome Library LMB Visual Aids...
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