AVONEX AVOSTARTGRIP Instructions For Use Manual

Titration kit; use with avonex (interferon beta-1a) prefilled syringe only

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Use with AVONEX

Read the Instructions for Use before you start using AVONEX and each time you get a

refill. There may be new information. This information does not take the place of talking

to your healthcare provider about your medical condition or your treatment.

Preparing the AVONEX Prefilled Syringe:



Find a well lit, clean, flat work surface like a table and collect all the supplies you will

need to give yourself or receive an injection.



Take 1 AVONEX Administration Dose Pack out of the refrigerator about 30 minutes

before you plan on injecting the AVONEX dose to allow it to reach room temperature.

Do not use external heat sources such as hot water to warm the AVONEX prefilled

syringe.



Check the expiration date printed on the AVONEX prefilled syringe, AVONEX

prefilled syringe Administration Dose Package carton, and the outer carton. Do not

use the AVONEX prefilled syringe past the expiration date.



Wash your hands with soap and water.

Supplies you will need for the AVONEX injection:



1 AVONEX Administration Dose Pack that contains:



1 AVONEX prefilled syringe



23 gauge, 1¼ inch long sterile needle



1 alcohol wipe



1 gauze pad



1 adhesive bandage



a puncture resistant container for disposal of used syringes and needles

Instructions for Use

AVOSTARTGRIP

Titration Kit

(interferon beta-1a) Prefilled Syringe Only

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Summary of Contents for AVONEX AVOSTARTGRIP

Page 1 Use with AVONEX (interferon beta-1a) Prefilled Syringe Only Read the Instructions for Use before you start using AVONEX and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.
Page 2 Identifying parts of the AVONEX prefilled syringe (See Figure A): Preparing the AVONEX injection: Step 1: Hold the AVONEX prefilled syringe with the cap pointing down and with the 0.5 mL mark at eye level (See Figure A).  Check the syringe: o The syringe should not have any cracks or damage.
Page 3 AVONEX prefilled syringe right under the cap and with the cap pointing up (See Figure B). o Make sure you are holding the AVONEX prefilled syringe by the ridged part, directly under the cap. (Figure B) Step 3: With the other hand, grasp the cap and bend it at a 90º...
Page 4 Do not re-use the AVONEX prefilled syringe and AVOSTARTGRIP devices.  You must prepare the AVONEX prefilled syringe and needle before you put it into the AVOSTARTGRIP device. Follow steps 1 to 5 above to prepare the AVONEX prefilled syringe.
Page 5 Identifying the parts of AVOSTARTGRIP titration kit (See Figure G): (Figure G)  AVOSTARTGRIP has a “collar” on top of the device that will stop the syringe from injecting a full dose (See Figure H). The “collar” makes sure that you do not get the full dose of AVONEX.
Page 6 Week 3 Injection: Choose the (Figure K) purple device to give ¾ dose (See Figure K). Step 7: Put the right AVOSTARTGRIP device on a flat surface with the door open (See Figure L). (Figure L) Step 8: Line up the AVONEX prefilled...
Page 7  AVONEX is injected into the muscle (intramuscularly).  AVONEX should be injected into the thigh or upper arm (See Figures P and Q).  Change (rotate) your injection sites for each dose. Do not use the same injection site for each injection.
Page 8 Step 12: Choose an injection site and wipe the skin with an alcohol wipe (See Figures P and Q). Let the injection site dry before injecting the dose.  Do not touch this area again before giving the injection. (Figure P) (Figure Q) Step 13: Pull the protective cover straight off the needle (See Figure R).
Page 9 There may be local or state laws about how to throw away used AVONEX prefilled syringes, AVOSTARTGRIP devices, and needles. Do not throw away used AVONEX prefilled syringes, AVOSTARTGRIP devices, and needles in household trash or recycling bins.