VMware vSphere ESXi 4.0 Management Manual page 79

Then, you want this virtual machine to run only on node 1.
1 In the vSphere Client inventory panel, select the virtual machine and select Edit Settings.
2 Select Options and click Advanced.
3 Click the Configuration Parameters button.
4 In the vSphere Client, set memory affinity for the NUMA node to 1.
Completing these two tasks ensures that the virtual machine runs only on NUMA node 1 and, when possible,
allocates memory from the same node.
VMware, Inc.
Chapter 8 Using NUMA Systems with ESX/ESXi
79