Alesis iO14 Reference Manual page 27

4. To enable MIDI, click on the "Default MIDI Ports" option
on the left-hand side and select IO|14/26's MIDI ports for
input and output. Again, click "Apply" to accept the changes.
Then press "OK" to exit this screen.
5. Now that the IO|14/26 is selected as the audio device,
individual channels must be activated for use. Again, return
to the "Devices" menu, and select "VST inputs."
6. Click the activation buttons for channel pairs that you want to
use.
Getting Started with Cubase LE
Different versions of Cubase
function similarly, but not
exactly, to the examples
shown here.
Some versions of Cubase,
including Cubase LE, do not
allow all of the physical
inputs to be used
simultaneously.
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